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The map label for this gene is hdb-3 [H]

Identifier: 15899707

GI number: 15899707

Start: 2737693

End: 2738847

Strand: Direct

Name: hdb-3 [H]

Synonym: SSO2996

Alternate gene names: 15899707

Gene position: 2737693-2738847 (Clockwise)

Preceding gene: 15899705

Following gene: 15899714

Centisome position: 91.49

GC content: 36.19

Gene sequence:

>1155_bases
ATGAGTATAAAAAAGATAGGTGTAGTTGGAGCAGGAACAATGGGTCACGGAATTGCGGAAGTTTCAGCACTAGCTAACTA
TAATGTGAGTGTAGTAGATATATCTTGGGATTTTTTAAATAGGGCAAAGGAGAGGATAATGGAATCATTAAACAAGTTTT
ACGAAAAGGGACAAATAAAGGAAAAACCAGAAGATATAATGAAAAGAATTGAATTTTCAACTTCTTATGATGTAATGCGA
GATGCGGATTTTGTTATAGAGGCGGTACCTGAAATTATAGAGCTCAAAAGAAAGGTATTTGAGACGTTAGATAGTATAAC
CCCTTCACATACATTTTTAGCCTCAAACACTTCATCAATCCCTATATCAACTATAGCTGAAGTAACCAAGAGGAAGGAGA
AAATAATCGGAATGCACTTCTTTAATCCCCCACCAATTATGAAGTTAGTAGAGATAGTTCCTAGTAAGTACACTTCTGAC
GAGACCATTGAAGTCACCATAGATTTAGCTAAAAAGATGAACAAAATACCAGTTAAGCTCAAGGTTGAAGTACCAGGTTT
TGTTAGCAATAGAATATTTCTGAGATTAATGCAAGAGGCTTGCAGGGAGGTTGAAGATGGTGAAGCAACCATTGAGGAAG
TTGATAGTGCAGCTAGGAATGGGCTCAAGTTACCCATGGGCATCTTTGAACTATCAGACTATGTGGGAATAGATGTTGCG
GTGGATTTATGGAACGTGATAGTTAGTAGCGGTACTGCTCAAGATGTAAAGTGTGAAATGTATAAGAGGAAGTTTGAGGC
TAAAGAATTAGGTGTTAAGACTGGGAAGGGATTCTATAATTATCCAGCTCCCGGGAAATATAGGAAAGTTGAATTACAAG
TAACAAGTAAAGTTGACCCAGCTAGACTAATATCTTTAGCAGTAAATGAGGGAGCTTGGCTAATACAAAATGGTATAGTG
AATGCTAAAGATATAGACACTGTAATGATCTATGGCTTCAATTTCCCTAAGGGTTTAATGGAAATCGCTGATGAATTAGG
TATAAGGAATATTTACAACCATCTAGTTGATATTTATTCAAAGGGATATGTAGCGTATAGGCCTAATAGTTTGATTGAGG
AGTTAATAAATACAAGTAAAGGTTTCTATATGTGA

Upstream 100 bases:

>100_bases
CTCAGTATATATATTCTTTACGCCTAATCGTAAATGTATATGTTTGTTTATGATGAAACAAAGCTTCACTTTAAATTCTT
AAAATCATAATATATCTCTC

Downstream 100 bases:

>100_bases
GTTTTTTCCTATCATAACTTCCAGTGAGTTAAAGGAGGAGAAAATCTCATTTCTTTGGTATGTTCATAACTCATAAGTTG
GCCAATATTTTCTCATTACC

Product: 3-hydroxyacyl-CoA dehydrogenase (hdb-3)

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSIKKIGVVGAGTMGHGIAEVSALANYNVSVVDISWDFLNRAKERIMESLNKFYEKGQIKEKPEDIMKRIEFSTSYDVMR
DADFVIEAVPEIIELKRKVFETLDSITPSHTFLASNTSSIPISTIAEVTKRKEKIIGMHFFNPPPIMKLVEIVPSKYTSD
ETIEVTIDLAKKMNKIPVKLKVEVPGFVSNRIFLRLMQEACREVEDGEATIEEVDSAARNGLKLPMGIFELSDYVGIDVA
VDLWNVIVSSGTAQDVKCEMYKRKFEAKELGVKTGKGFYNYPAPGKYRKVELQVTSKVDPARLISLAVNEGAWLIQNGIV
NAKDIDTVMIYGFNFPKGLMEIADELGIRNIYNHLVDIYSKGYVAYRPNSLIEELINTSKGFYM

Sequences:

>Translated_384_residues
MSIKKIGVVGAGTMGHGIAEVSALANYNVSVVDISWDFLNRAKERIMESLNKFYEKGQIKEKPEDIMKRIEFSTSYDVMR
DADFVIEAVPEIIELKRKVFETLDSITPSHTFLASNTSSIPISTIAEVTKRKEKIIGMHFFNPPPIMKLVEIVPSKYTSD
ETIEVTIDLAKKMNKIPVKLKVEVPGFVSNRIFLRLMQEACREVEDGEATIEEVDSAARNGLKLPMGIFELSDYVGIDVA
VDLWNVIVSSGTAQDVKCEMYKRKFEAKELGVKTGKGFYNYPAPGKYRKVELQVTSKVDPARLISLAVNEGAWLIQNGIV
NAKDIDTVMIYGFNFPKGLMEIADELGIRNIYNHLVDIYSKGYVAYRPNSLIEELINTSKGFYM
>Mature_383_residues
SIKKIGVVGAGTMGHGIAEVSALANYNVSVVDISWDFLNRAKERIMESLNKFYEKGQIKEKPEDIMKRIEFSTSYDVMRD
ADFVIEAVPEIIELKRKVFETLDSITPSHTFLASNTSSIPISTIAEVTKRKEKIIGMHFFNPPPIMKLVEIVPSKYTSDE
TIEVTIDLAKKMNKIPVKLKVEVPGFVSNRIFLRLMQEACREVEDGEATIEEVDSAARNGLKLPMGIFELSDYVGIDVAV
DLWNVIVSSGTAQDVKCEMYKRKFEAKELGVKTGKGFYNYPAPGKYRKVELQVTSKVDPARLISLAVNEGAWLIQNGIVN
AKDIDTVMIYGFNFPKGLMEIADELGIRNIYNHLVDIYSKGYVAYRPNSLIEELINTSKGFYM

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=39.3103448275862, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=37.1335504885993, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI20127408, Length=409, Percent_Identity=30.5623471882641, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI261878539, Length=399, Percent_Identity=31.328320802005, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI68989263, Length=399, Percent_Identity=31.328320802005, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI115430219, Length=221, Percent_Identity=31.6742081447964, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787661, Length=299, Percent_Identity=36.1204013377926, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788682, Length=385, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790281, Length=370, Percent_Identity=31.0810810810811, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=37.7162629757785, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=36.3321799307958, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=34.0277777777778, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=418, Percent_Identity=30.8612440191388, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=418, Percent_Identity=30.8612440191388, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=413, Percent_Identity=28.8135593220339, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25144276, Length=292, Percent_Identity=34.2465753424658, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71985923, Length=359, Percent_Identity=27.2980501392758, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=384, Percent_Identity=25.78125, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193203623, Length=193, Percent_Identity=33.160621761658, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI115533614, Length=193, Percent_Identity=33.160621761658, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19921000, Length=413, Percent_Identity=29.5399515738499, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24583077, Length=413, Percent_Identity=29.5399515738499, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24583079, Length=413, Percent_Identity=29.5399515738499, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20129993, Length=232, Percent_Identity=32.7586206896552, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45549573, Length=222, Percent_Identity=31.0810810810811, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 43167; Mature: 43035

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKKIGVVGAGTMGHGIAEVSALANYNVSVVDISWDFLNRAKERIMESLNKFYEKGQIK
CCCCEEEEEECCHHHCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCC
EKPEDIMKRIEFSTSYDVMRDADFVIEAVPEIIELKRKVFETLDSITPSHTFLASNTSSI
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
PISTIAEVTKRKEKIIGMHFFNPPPIMKLVEIVPSKYTSDETIEVTIDLAKKMNKIPVKL
CHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCCCEEE
KVEVPGFVSNRIFLRLMQEACREVEDGEATIEEVDSAARNGLKLPMGIFELSDYVGIDVA
EEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHH
VDLWNVIVSSGTAQDVKCEMYKRKFEAKELGVKTGKGFYNYPAPGKYRKVELQVTSKVDP
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCH
ARLISLAVNEGAWLIQNGIVNAKDIDTVMIYGFNFPKGLMEIADELGIRNIYNHLVDIYS
HHHHHEEECCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHH
KGYVAYRPNSLIEELINTSKGFYM
CCEEEECCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIKKIGVVGAGTMGHGIAEVSALANYNVSVVDISWDFLNRAKERIMESLNKFYEKGQIK
CCCEEEEEECCHHHCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCC
EKPEDIMKRIEFSTSYDVMRDADFVIEAVPEIIELKRKVFETLDSITPSHTFLASNTSSI
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
PISTIAEVTKRKEKIIGMHFFNPPPIMKLVEIVPSKYTSDETIEVTIDLAKKMNKIPVKL
CHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCCCEEE
KVEVPGFVSNRIFLRLMQEACREVEDGEATIEEVDSAARNGLKLPMGIFELSDYVGIDVA
EEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHH
VDLWNVIVSSGTAQDVKCEMYKRKFEAKELGVKTGKGFYNYPAPGKYRKVELQVTSKVDP
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCH
ARLISLAVNEGAWLIQNGIVNAKDIDTVMIYGFNFPKGLMEIADELGIRNIYNHLVDIYS
HHHHHEEECCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHH
KGYVAYRPNSLIEELINTSKGFYM
CCEEEECCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]