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The map label for this gene is 15899699

Identifier: 15899699

GI number: 15899699

Start: 2731824

End: 2732801

Strand: Reverse

Name: 15899699

Synonym: SSO2989

Alternate gene names: NA

Gene position: 2732801-2731824 (Counterclockwise)

Preceding gene: 15899700

Following gene: 15899697

Centisome position: 91.33

GC content: 34.97

Gene sequence:

>978_bases
GTGTTAAAGTCTGTAACAGTTTCTGCACCGTCAAATATAGCCGTTGTAAAGTACTGGGGAAAAAGGGGAGATGAAAGACT
AAATTTACCGCTCAACAACTCATTATCGATTACTTTAGATGATCAGTTATCAGTGATTACCAAAGTAACCTTAAACGATA
AGAATATTGTAATAGTTAACGATAGGATCTTATCAGAAGATGAAATGAAAGAGTATGCTGGAAGGGTCTTGGATACCTTT
AAGAAAATCGTTGGCAAGGAATTTCACGTTAAAGTTGAGTCAAAGTCAAAATTTCCTATTAATGCGGGATTAGCGTCTTC
TGCAGCAGGGATTGCAGCGTTAGCCTTTAGTCTAAATGAGTTACTGGAGTTAAACCTCAAATCCGAAGAGCTTTCCAAAA
TAGCTAGACTGGGATCTGGAAGTGCATGTAGAAGTATGTTTGGAGGATTTGTAGTATGGAATAAGGGGGAGAGAGAAGAT
GGAGAGGATTCTTATTGTTATCAAATCTTCCGGCATGACTATTGGAGTGAATTAGTGGATATTATTCCTATATTAAGTGA
GAAAGAAAAGAAAATCTCTTCTAGAAAGGGTATGATAAGATCAGCTGAAACTTCAGAACTAATGGAATGTAGGCTTAAAT
ACATTGAGAAGACATTTAATGAAGTTATTGAGGCTATAAGGAATAGGGATGAGAAGAAATTCTACTATCTTATGATGAGA
CATAGTAATAGTATGCACGCAGTAATATTGGATAGTTGGCCATCCTTCTTTTACTTAAACGATACTTCCATAAGGATTAT
GGAATGGATACATGATTATGGGAAGGCTGGTTATACATTTGATGCTGGACCAAATCCTCACATTTTTACTACAGAAAGAA
ATATAGGAGATATTTTAGAATTCTTAAAATCTCTAGAAATAAAGAGAATAATAGTATCTAAAGTAGGAGATGGACCAAAA
GTATTAAGTAGAGAATGA

Upstream 100 bases:

>100_bases
AATCAGCAAGAAGGGAATATTTAAAAAGGGTAATGAAGTGTCTAAAAAGGAATTATATGAGCTAGTTAAAGTTAATAAGT
AATGGAGTATTCTTACAATC

Downstream 100 bases:

>100_bases
AAATTTAGTTAGATTCGAGCCTTAATCCCTCGTCTTCTTTCACATCAATTATGAAAATACCTCTTTTACTCCACGCCTCC
CTTACCCTATTTAAATCATT

Product: diphosphomevalonate decarboxylase, putative

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase; GHMP Kinase; Ghmp Kinase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLNDKNIVIVNDRILSEDEMKEYAGRVLDTF
KKIVGKEFHVKVESKSKFPINAGLASSAAGIAALAFSLNELLELNLKSEELSKIARLGSGSACRSMFGGFVVWNKGERED
GEDSYCYQIFRHDYWSELVDIIPILSEKEKKISSRKGMIRSAETSELMECRLKYIEKTFNEVIEAIRNRDEKKFYYLMMR
HSNSMHAVILDSWPSFFYLNDTSIRIMEWIHDYGKAGYTFDAGPNPHIFTTERNIGDILEFLKSLEIKRIIVSKVGDGPK
VLSRE

Sequences:

>Translated_325_residues
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLNDKNIVIVNDRILSEDEMKEYAGRVLDTF
KKIVGKEFHVKVESKSKFPINAGLASSAAGIAALAFSLNELLELNLKSEELSKIARLGSGSACRSMFGGFVVWNKGERED
GEDSYCYQIFRHDYWSELVDIIPILSEKEKKISSRKGMIRSAETSELMECRLKYIEKTFNEVIEAIRNRDEKKFYYLMMR
HSNSMHAVILDSWPSFFYLNDTSIRIMEWIHDYGKAGYTFDAGPNPHIFTTERNIGDILEFLKSLEIKRIIVSKVGDGPK
VLSRE
>Mature_325_residues
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLNDKNIVIVNDRILSEDEMKEYAGRVLDTF
KKIVGKEFHVKVESKSKFPINAGLASSAAGIAALAFSLNELLELNLKSEELSKIARLGSGSACRSMFGGFVVWNKGERED
GEDSYCYQIFRHDYWSELVDIIPILSEKEKKISSRKGMIRSAETSELMECRLKYIEKTFNEVIEAIRNRDEKKFYYLMMR
HSNSMHAVILDSWPSFFYLNDTSIRIMEWIHDYGKAGYTFDAGPNPHIFTTERNIGDILEFLKSLEIKRIIVSKVGDGPK
VLSRE

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=383, Percent_Identity=36.8146214099217, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17537201, Length=328, Percent_Identity=36.280487804878, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17537203, Length=223, Percent_Identity=38.5650224215247, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324371, Length=323, Percent_Identity=38.6996904024768, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28571205, Length=378, Percent_Identity=35.7142857142857, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 37028; Mature: 37028

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLNDKNIVIVN
CCCEEEECCCCCEEEEEEECCCCCCEECCCCCCCEEEEECCCEEEEEEEEECCCEEEEEE
DRILSEDEMKEYAGRVLDTFKKIVGKEFHVKVESKSKFPINAGLASSAAGIAALAFSLNE
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
LLELNLKSEELSKIARLGSGSACRSMFGGFVVWNKGEREDGEDSYCYQIFRHDYWSELVD
HHHCCCCHHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
IIPILSEKEKKISSRKGMIRSAETSELMECRLKYIEKTFNEVIEAIRNRDEKKFYYLMMR
HHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
HSNSMHAVILDSWPSFFYLNDTSIRIMEWIHDYGKAGYTFDAGPNPHIFTTERNIGDILE
CCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCEEECCCCHHHHHH
FLKSLEIKRIIVSKVGDGPKVLSRE
HHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLKSVTVSAPSNIAVVKYWGKRGDERLNLPLNNSLSITLDDQLSVITKVTLNDKNIVIVN
CCCEEEECCCCCEEEEEEECCCCCCEECCCCCCCEEEEECCCEEEEEEEEECCCEEEEEE
DRILSEDEMKEYAGRVLDTFKKIVGKEFHVKVESKSKFPINAGLASSAAGIAALAFSLNE
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
LLELNLKSEELSKIARLGSGSACRSMFGGFVVWNKGEREDGEDSYCYQIFRHDYWSELVD
HHHCCCCHHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
IIPILSEKEKKISSRKGMIRSAETSELMECRLKYIEKTFNEVIEAIRNRDEKKFYYLMMR
HHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
HSNSMHAVILDSWPSFFYLNDTSIRIMEWIHDYGKAGYTFDAGPNPHIFTTERNIGDILE
CCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCEEECCCCHHHHHH
FLKSLEIKRIIVSKVGDGPKVLSRE
HHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA