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The map label for this gene is eiF2B

Identifier: 15899687

GI number: 15899687

Start: 2721225

End: 2722325

Strand: Reverse

Name: eiF2B

Synonym: SSO2978

Alternate gene names: NA

Gene position: 2722325-2721225 (Counterclockwise)

Preceding gene: 15899689

Following gene: 15899686

Centisome position: 90.98

GC content: 38.24

Gene sequence:

>1101_bases
ATGAAGCTAACAGTTAAGGAAGTTAAAGAGGTTTATAAACCAAAGTTACTACCTATAATTTGGAAGGACGAAAATAATAC
TTTGACAATCCTGGATCAATCGTTATTACCATTCCAAAAGGTCTACGTAGATTTAAAGGACGTTGATAGTACAGCATTAG
CCATAAAGAACATGCAAGTTAGAGGTGCTCCAGCAATAGGAATTACTGCCGGGTACGGAATGGTATTGGCGTTAACTAGT
AACAAGAATGTAAAGACATTAGATGAGGCTATTAGAGAATTGACTAGGGCTAAAGCCATATTGGATTCAGCTAGACCTAC
AGCTGTTAATTTGGTTTGGGCGACTTCAAGAATGTTAACTTTAGCTAAAAATGCAGTGGAAAACGGTAACGCTAAGACCA
TAAATGAGCTAATAGACCTTATGAAAGTTGAGGCTAAGAGGATTTTTGATGAGGAATATGACGCTGAAATACAAATGGGA
CTTTACGGTTTAGAGAAATTAAACGACAGTGATACAGTACTGACGCAGTGTAATGCTGGTGGTTTGGCGACTGGTACTGG
GTTGGGGACTGCATTGTCTCCAGTGAAATTGGCTAAAGCCTTAGGGATGAACGTCTCAGTTATCGCTCCAGAGACTAGAC
CTTGGTTACAAGGTAGTAGGTTAACCGTTTACGAATTAATGGAGGAAGGAATAAAAGTCACATTGATTACCGACACTGCA
GTTGGTTTGGTAATGTATCGAGGAATGGTTAATAGCGTCATGGTTGGGGCTGATAGGATATTAAGAGATGGGCATGTTTT
CAATAAAATAGGAACATATAAGGAAGCTGTCATAGCTCACGAATTAGGGATACCGTTTTACGCATTAGCCCCGACTTCAA
GTTTCGATTTAAAGAGCAACGTTAACGAAATTAAGATCGAGGAGAGGGATCCTAATGAAGTTAGGACAATTAGGGGAATA
CCAATAGCTCCAGAAAACGTAAATGTATATAATCCTGTATTTGATGTTACTCCACCTAAATATATTGCTGGGATAATAAC
TGAAAAGGGAATAATATATCCGCCATTTCATGAGAATATTAAAAGAATTGTAGAAAGATAA

Upstream 100 bases:

>100_bases
ATTATCTCTCAAAACGTTACTCTCAAATTCAATAATAGTTAAGTTCATGTACCCATCTTCCTTCCCTAAGCTTTAAATCT
TCCTTTTTTCATTATATCAT

Downstream 100 bases:

>100_bases
CTCTTAGGAAAAGTAATTTAAATATCAAGATCATAATTAACCTTAATGAGAGTTTTAACAAAGCTTATCTTGATAGTTTT
CGTATTTGAGGTAGTATTAT

Product: translation initiation factor IF-2B subunit alpha

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKLTVKEVKEVYKPKLLPIIWKDENNTLTILDQSLLPFQKVYVDLKDVDSTALAIKNMQVRGAPAIGITAGYGMVLALTS
NKNVKTLDEAIRELTRAKAILDSARPTAVNLVWATSRMLTLAKNAVENGNAKTINELIDLMKVEAKRIFDEEYDAEIQMG
LYGLEKLNDSDTVLTQCNAGGLATGTGLGTALSPVKLAKALGMNVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
VGLVMYRGMVNSVMVGADRILRDGHVFNKIGTYKEAVIAHELGIPFYALAPTSSFDLKSNVNEIKIEERDPNEVRTIRGI
PIAPENVNVYNPVFDVTPPKYIAGIITEKGIIYPPFHENIKRIVER

Sequences:

>Translated_366_residues
MKLTVKEVKEVYKPKLLPIIWKDENNTLTILDQSLLPFQKVYVDLKDVDSTALAIKNMQVRGAPAIGITAGYGMVLALTS
NKNVKTLDEAIRELTRAKAILDSARPTAVNLVWATSRMLTLAKNAVENGNAKTINELIDLMKVEAKRIFDEEYDAEIQMG
LYGLEKLNDSDTVLTQCNAGGLATGTGLGTALSPVKLAKALGMNVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
VGLVMYRGMVNSVMVGADRILRDGHVFNKIGTYKEAVIAHELGIPFYALAPTSSFDLKSNVNEIKIEERDPNEVRTIRGI
PIAPENVNVYNPVFDVTPPKYIAGIITEKGIIYPPFHENIKRIVER
>Mature_366_residues
MKLTVKEVKEVYKPKLLPIIWKDENNTLTILDQSLLPFQKVYVDLKDVDSTALAIKNMQVRGAPAIGITAGYGMVLALTS
NKNVKTLDEAIRELTRAKAILDSARPTAVNLVWATSRMLTLAKNAVENGNAKTINELIDLMKVEAKRIFDEEYDAEIQMG
LYGLEKLNDSDTVLTQCNAGGLATGTGLGTALSPVKLAKALGMNVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
VGLVMYRGMVNSVMVGADRILRDGHVFNKIGTYKEAVIAHELGIPFYALAPTSSFDLKSNVNEIKIEERDPNEVRTIRGI
PIAPENVNVYNPVFDVTPPKYIAGIITEKGIIYPPFHENIKRIVER

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=339, Percent_Identity=38.3480825958702, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI23943880, Length=334, Percent_Identity=34.7305389221557, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI78000158, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI78000156, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI187607323, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=346, Percent_Identity=33.8150289017341, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17557123, Length=158, Percent_Identity=32.9113924050633, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=397, Percent_Identity=34.0050377833753, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322878, Length=158, Percent_Identity=33.5443037974684, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357667, Length=370, Percent_Identity=37.8378378378378, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24651647, Length=370, Percent_Identity=37.8378378378378, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI21358605, Length=133, Percent_Identity=36.8421052631579, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 40339; Mature: 40339

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTVKEVKEVYKPKLLPIIWKDENNTLTILDQSLLPFQKVYVDLKDVDSTALAIKNMQV
CCCCHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCHHHHEEEHHCCCCHHEEEECEEE
RGAPAIGITAGYGMVLALTSNKNVKTLDEAIRELTRAKAILDSARPTAVNLVWATSRMLT
CCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHH
LAKNAVENGNAKTINELIDLMKVEAKRIFDEEYDAEIQMGLYGLEKLNDSDTVLTQCNAG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCEEEECCCC
GLATGTGLGTALSPVKLAKALGMNVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
CCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEEECHH
VGLVMYRGMVNSVMVGADRILRDGHVFNKIGTYKEAVIAHELGIPFYALAPTSSFDLKSN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
VNEIKIEERDPNEVRTIRGIPIAPENVNVYNPVFDVTPPKYIAGIITEKGIIYPPFHENI
CCEEEEECCCCCHHHEEECCCCCCCCCEEECCEECCCCHHHHHHHHHCCCEECCCHHHHH
KRIVER
HHHHCC
>Mature Secondary Structure
MKLTVKEVKEVYKPKLLPIIWKDENNTLTILDQSLLPFQKVYVDLKDVDSTALAIKNMQV
CCCCHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCHHHHEEEHHCCCCHHEEEECEEE
RGAPAIGITAGYGMVLALTSNKNVKTLDEAIRELTRAKAILDSARPTAVNLVWATSRMLT
CCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHH
LAKNAVENGNAKTINELIDLMKVEAKRIFDEEYDAEIQMGLYGLEKLNDSDTVLTQCNAG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCEEEECCCC
GLATGTGLGTALSPVKLAKALGMNVSVIAPETRPWLQGSRLTVYELMEEGIKVTLITDTA
CCCCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEEECHH
VGLVMYRGMVNSVMVGADRILRDGHVFNKIGTYKEAVIAHELGIPFYALAPTSSFDLKSN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
VNEIKIEERDPNEVRTIRGIPIAPENVNVYNPVFDVTPPKYIAGIITEKGIIYPPFHENI
CCEEEEECCCCCHHHEEECCCCCCCCCEEECCEECCCCHHHHHHHHHCCCEECCCHHHHH
KRIVER
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA