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The map label for this gene is copA [H]

Identifier: 15899608

GI number: 15899608

Start: 2647129

End: 2649216

Strand: Reverse

Name: copA [H]

Synonym: SSO2896

Alternate gene names: 15899608

Gene position: 2649216-2647129 (Counterclockwise)

Preceding gene: 15899611

Following gene: 15899607

Centisome position: 88.54

GC content: 30.65

Gene sequence:

>2088_bases
TTGATGTCACAAGAACAAAATAATATAACTAAATTTTACGTAGGTGGTATGGCTTGCGCATTTTGTGCTTCAACTATAGA
GAAGGGTTTAAAGAAAATAGAAGGGGTTAATGAAGTAAAAGTCGTCCTGGAATCGAGTGAGGTGTTTGTAAAGTATGATA
ACTCATTGGTTAGCTCAGAAATTATTAAAAAGGAGATAGAAAAGCTGGGATATTATGTGTCTGATAGGAGTCTTTTCTCG
GATGAACTATTAAAAGATTCAAGGAGAAGATCTATAATTAGTTGGAGTTTAACTACACTTTTAGGCTTACTGTATTTCTT
TGAATATTATAATATAATATTTCGTGTTACTATAATATTATTAGTGACTACAAATTTATTTTATATAGCATTGCCAATTT
ACAAGGGAGCTTCACATGCAATAGGAAAAGGAATATTAAATGAACATGTTTTATACGGTGTTGCTGGAATATCCTCCTAT
ATTTTGGGGATTGTGGGATTTTTGGAATTTAATAAAAATTTATTTGGTTTCCTATTCATATCATCTTTACTTACATCATT
GCACTTATCGGCTGGATGGATGGGAGCAATATTAAATAATAAAGTTGAAAAGGCATTACATAAAGTCATCGAATTAAGAC
CTCCTTATGCTCATTTGATTAATGGCGAGGACGTGCCAGTAACTAAACTAAAGAAAGGGGATATAGTTATAGTTAAGCCA
GGGGAGAAAATACCTTTAGATGGAGTAGTAGTTGATGGGGAAAGTGAAGTTAGTGAAGCAATAATAACTGGCGAATCTGA
ACCAGTTTCAAAGGGAAAAGGTGATTTTGTTATTGGGGGATCAACTAACGGTAGTGGATATCTAAAGGTAAAAATCACAG
AAGATTATAACAATAGTTATTTATCGAAAATAATTGGTTTAGTAAATTATTCAAAACAGAAAAAATCCGCTATATTAACT
TTCTTTGATAAAGTAATTGATAAAATATGGGTGCCATTAGCTTTAGCTATATCAATAATTACCGTAATAGCATGGGGGCT
ATATGGTATTTTAATAGGTAAAGATTTATGGTTATATGGTATTATTAATGGTCTACTTGTATCGACTATAGCTTATCCAT
GTGCTATAGGTTTTTCAAGTCCTTCTATGGCTCTTTCATTATACGAAAAAATGTTACATAAAGGGATGATAATTAAGAAT
TCAAACGTATACGAAAAAATCAAGGAGATAGATACTATCATTTTCGATAAAACTGGTACTCTCACTTATGGCACTCCGAT
TGTTACACAGTTTATTGGTGACTCTCTTAGTTTAGCTTATGCAGCATCTGTTGAGGCATTATCATCTCACCCTATAGCTA
AGGCTATAGTTAAATATGCTAAAGAGCAAGGAGTAAAGATATTAGAAGTTAAAGATTTTAAAGAAATTTCAGGGATTGGT
GTTAGAGGAAAAATAAGTGATAAAATCATAGAAGTAAAAAAGGCTGAGAATAATAATGATATAGCAGTTTACATAAATGG
AGAACCAATAGCAAGTTTTAATATCTCCGATGTTCCAAGGCCTAACCTAAAAGATTACTTAGAAAAACTGAAAAATGAGG
GATTAAAAATCATAATTTTAAGTGGTGATAAAGAGGATAAAGTAAAAGAACTTTCTAAAGAATTAAATATTCAAGAGTAT
TATTCGAATTTATCACCAGAAGATAAAGTGAGAATAATTGAAAAGTTAAAGCAAAATGGAAATAAAGTTTTAATGATAGG
TGATGGTGTTAATGATGCAGCAGCATTAGCTTTAGCAGATGTTTCTGTTGCAATGGGTAATGGTGTAGATATTTCAAAGA
ATGTAGCAGATATTATCCTAGTTAGTAACGATATTGGAACTTTATTAGGGTTAATCAAAAACAGGAAAAGATTAAGTAAT
GCTATTCCATCTAATGTAATACTAGCATTAACATATAATGGGATTGGTATACCATTAGCGATATTTGGGATATTGACCAT
GAAGTTTGCAATGATTATAATGATATTAAGTTTGTTTTCAATATTTATTAATTCTAGAGTATTTGTTAACATAATAGGAT
TTGATTAG

Upstream 100 bases:

>100_bases
CTATTAATGGGCAACTCTGCTGTTTAATAACTTTATTTCTCTTTACCATATTACTTACTATAAACTTTATAGTTTATAAA
CTTACGTAACTATTCAATAC

Downstream 100 bases:

>100_bases
GGAAAAAGAAATTAGAGAATAATGGACTACAACTTAGCCTTGTTGAACGTTATGTTTCCTCACGTGTTTTCAAGAGAGAA
TTCCTATGTGGGAGTTTGGG

Product: copper-transporting ATPase

Products: ADP; phosphate; H+; K+

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MMSQEQNNITKFYVGGMACAFCASTIEKGLKKIEGVNEVKVVLESSEVFVKYDNSLVSSEIIKKEIEKLGYYVSDRSLFS
DELLKDSRRRSIISWSLTTLLGLLYFFEYYNIIFRVTIILLVTTNLFYIALPIYKGASHAIGKGILNEHVLYGVAGISSY
ILGIVGFLEFNKNLFGFLFISSLLTSLHLSAGWMGAILNNKVEKALHKVIELRPPYAHLINGEDVPVTKLKKGDIVIVKP
GEKIPLDGVVVDGESEVSEAIITGESEPVSKGKGDFVIGGSTNGSGYLKVKITEDYNNSYLSKIIGLVNYSKQKKSAILT
FFDKVIDKIWVPLALAISIITVIAWGLYGILIGKDLWLYGIINGLLVSTIAYPCAIGFSSPSMALSLYEKMLHKGMIIKN
SNVYEKIKEIDTIIFDKTGTLTYGTPIVTQFIGDSLSLAYAASVEALSSHPIAKAIVKYAKEQGVKILEVKDFKEISGIG
VRGKISDKIIEVKKAENNNDIAVYINGEPIASFNISDVPRPNLKDYLEKLKNEGLKIIILSGDKEDKVKELSKELNIQEY
YSNLSPEDKVRIIEKLKQNGNKVLMIGDGVNDAAALALADVSVAMGNGVDISKNVADIILVSNDIGTLLGLIKNRKRLSN
AIPSNVILALTYNGIGIPLAIFGILTMKFAMIIMILSLFSIFINSRVFVNIIGFD

Sequences:

>Translated_695_residues
MMSQEQNNITKFYVGGMACAFCASTIEKGLKKIEGVNEVKVVLESSEVFVKYDNSLVSSEIIKKEIEKLGYYVSDRSLFS
DELLKDSRRRSIISWSLTTLLGLLYFFEYYNIIFRVTIILLVTTNLFYIALPIYKGASHAIGKGILNEHVLYGVAGISSY
ILGIVGFLEFNKNLFGFLFISSLLTSLHLSAGWMGAILNNKVEKALHKVIELRPPYAHLINGEDVPVTKLKKGDIVIVKP
GEKIPLDGVVVDGESEVSEAIITGESEPVSKGKGDFVIGGSTNGSGYLKVKITEDYNNSYLSKIIGLVNYSKQKKSAILT
FFDKVIDKIWVPLALAISIITVIAWGLYGILIGKDLWLYGIINGLLVSTIAYPCAIGFSSPSMALSLYEKMLHKGMIIKN
SNVYEKIKEIDTIIFDKTGTLTYGTPIVTQFIGDSLSLAYAASVEALSSHPIAKAIVKYAKEQGVKILEVKDFKEISGIG
VRGKISDKIIEVKKAENNNDIAVYINGEPIASFNISDVPRPNLKDYLEKLKNEGLKIIILSGDKEDKVKELSKELNIQEY
YSNLSPEDKVRIIEKLKQNGNKVLMIGDGVNDAAALALADVSVAMGNGVDISKNVADIILVSNDIGTLLGLIKNRKRLSN
AIPSNVILALTYNGIGIPLAIFGILTMKFAMIIMILSLFSIFINSRVFVNIIGFD
>Mature_695_residues
MMSQEQNNITKFYVGGMACAFCASTIEKGLKKIEGVNEVKVVLESSEVFVKYDNSLVSSEIIKKEIEKLGYYVSDRSLFS
DELLKDSRRRSIISWSLTTLLGLLYFFEYYNIIFRVTIILLVTTNLFYIALPIYKGASHAIGKGILNEHVLYGVAGISSY
ILGIVGFLEFNKNLFGFLFISSLLTSLHLSAGWMGAILNNKVEKALHKVIELRPPYAHLINGEDVPVTKLKKGDIVIVKP
GEKIPLDGVVVDGESEVSEAIITGESEPVSKGKGDFVIGGSTNGSGYLKVKITEDYNNSYLSKIIGLVNYSKQKKSAILT
FFDKVIDKIWVPLALAISIITVIAWGLYGILIGKDLWLYGIINGLLVSTIAYPCAIGFSSPSMALSLYEKMLHKGMIIKN
SNVYEKIKEIDTIIFDKTGTLTYGTPIVTQFIGDSLSLAYAASVEALSSHPIAKAIVKYAKEQGVKILEVKDFKEISGIG
VRGKISDKIIEVKKAENNNDIAVYINGEPIASFNISDVPRPNLKDYLEKLKNEGLKIIILSGDKEDKVKELSKELNIQEY
YSNLSPEDKVRIIEKLKQNGNKVLMIGDGVNDAAALALADVSVAMGNGVDISKNVADIILVSNDIGTLLGLIKNRKRLSN
AIPSNVILALTYNGIGIPLAIFGILTMKFAMIIMILSLFSIFINSRVFVNIIGFD

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=572, Percent_Identity=27.6223776223776, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI55743071, Length=550, Percent_Identity=27.0909090909091, Blast_Score=179, Evalue=1e-44,
Organism=Homo sapiens, GI55743073, Length=311, Percent_Identity=31.8327974276527, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI48762687, Length=165, Percent_Identity=32.7272727272727, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI48762685, Length=165, Percent_Identity=32.7272727272727, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI48762689, Length=165, Percent_Identity=32.7272727272727, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI48762691, Length=165, Percent_Identity=32.7272727272727, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI118498343, Length=112, Percent_Identity=38.3928571428571, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1786691, Length=729, Percent_Identity=26.0631001371742, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1789879, Length=687, Percent_Identity=25.6186317321689, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1786914, Length=504, Percent_Identity=25.5952380952381, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI2367363, Length=155, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=785, Percent_Identity=24.8407643312102, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71997262, Length=163, Percent_Identity=30.0613496932515, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997269, Length=163, Percent_Identity=30.0613496932515, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997275, Length=163, Percent_Identity=30.0613496932515, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531459, Length=122, Percent_Identity=31.9672131147541, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559224, Length=218, Percent_Identity=24.7706422018349, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=612, Percent_Identity=29.4117647058824, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=591, Percent_Identity=28.4263959390863, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6321271, Length=167, Percent_Identity=32.3353293413174, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320245, Length=177, Percent_Identity=27.683615819209, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320244, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320243, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321432, Length=70, Percent_Identity=45.7142857142857, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221329854, Length=823, Percent_Identity=25.5164034021871, Blast_Score=184, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24668704, Length=150, Percent_Identity=32, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24668708, Length=150, Percent_Identity=32, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281366617, Length=150, Percent_Identity=32, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24668696, Length=150, Percent_Identity=32, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161085803, Length=150, Percent_Identity=32, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281366676, Length=208, Percent_Identity=26.4423076923077, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.10

Molecular weight: Translated: 76331; Mature: 76331

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSQEQNNITKFYVGGMACAFCASTIEKGLKKIEGVNEVKVVLESSEVFVKYDNSLVSSE
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHH
IIKKEIEKLGYYVSDRSLFSDELLKDSRRRSIISWSLTTLLGLLYFFEYYNIIFRVTIIL
HHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTTNLFYIALPIYKGASHAIGKGILNEHVLYGVAGISSYILGIVGFLEFNKNLFGFLFI
HHHHCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SSLLTSLHLSAGWMGAILNNKVEKALHKVIELRPPYAHLINGEDVPVTKLKKGDIVIVKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEECCCCEEEECC
GEKIPLDGVVVDGESEVSEAIITGESEPVSKGKGDFVIGGSTNGSGYLKVKITEDYNNSY
CCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHH
LSKIIGLVNYSKQKKSAILTFFDKVIDKIWVPLALAISIITVIAWGLYGILIGKDLWLYG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IINGLLVSTIAYPCAIGFSSPSMALSLYEKMLHKGMIIKNSNVYEKIKEIDTIIFDKTGT
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHEECCCCC
LTYGTPIVTQFIGDSLSLAYAASVEALSSHPIAKAIVKYAKEQGVKILEVKDFKEISGIG
EEECCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCHHHHHCCC
VRGKISDKIIEVKKAENNNDIAVYINGEPIASFNISDVPRPNLKDYLEKLKNEGLKIIIL
CCCCCCHHHEEEEECCCCCCEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHCCEEEEEE
SGDKEDKVKELSKELNIQEYYSNLSPEDKVRIIEKLKQNGNKVLMIGDGVNDAAALALAD
ECCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
VSVAMGNGVDISKNVADIILVSNDIGTLLGLIKNRKRLSNAIPSNVILALTYNGIGIPLA
HHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
IFGILTMKFAMIIMILSLFSIFINSRVFVNIIGFD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure
MMSQEQNNITKFYVGGMACAFCASTIEKGLKKIEGVNEVKVVLESSEVFVKYDNSLVSSE
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHH
IIKKEIEKLGYYVSDRSLFSDELLKDSRRRSIISWSLTTLLGLLYFFEYYNIIFRVTIIL
HHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTTNLFYIALPIYKGASHAIGKGILNEHVLYGVAGISSYILGIVGFLEFNKNLFGFLFI
HHHHCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SSLLTSLHLSAGWMGAILNNKVEKALHKVIELRPPYAHLINGEDVPVTKLKKGDIVIVKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEECCCCEEEECC
GEKIPLDGVVVDGESEVSEAIITGESEPVSKGKGDFVIGGSTNGSGYLKVKITEDYNNSY
CCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHH
LSKIIGLVNYSKQKKSAILTFFDKVIDKIWVPLALAISIITVIAWGLYGILIGKDLWLYG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IINGLLVSTIAYPCAIGFSSPSMALSLYEKMLHKGMIIKNSNVYEKIKEIDTIIFDKTGT
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHEECCCCC
LTYGTPIVTQFIGDSLSLAYAASVEALSSHPIAKAIVKYAKEQGVKILEVKDFKEISGIG
EEECCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCHHHHHCCC
VRGKISDKIIEVKKAENNNDIAVYINGEPIASFNISDVPRPNLKDYLEKLKNEGLKIIIL
CCCCCCHHHEEEEECCCCCCEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHCCEEEEEE
SGDKEDKVKELSKELNIQEYYSNLSPEDKVRIIEKLKQNGNKVLMIGDGVNDAAALALAD
ECCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
VSVAMGNGVDISKNVADIILVSNDIGTLLGLIKNRKRLSNAIPSNVILALTYNGIGIPLA
HHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
IFGILTMKFAMIIMILSLFSIFINSRVFVNIIGFD
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+; K+

Specific reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA