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The map label for this gene is argE [C]

Identifier: 15899453

GI number: 15899453

Start: 2491146

End: 2492459

Strand: Reverse

Name: argE [C]

Synonym: SSO2737

Alternate gene names: 15899453

Gene position: 2492459-2491146 (Counterclockwise)

Preceding gene: 15899455

Following gene: 15899452

Centisome position: 83.3

GC content: 36.91

Gene sequence:

>1314_bases
GTGGACGAGGAACTTTATACTTTAATTGAATTTCTAAAGAAACCCTCCATATCTGCAACTGGAGAGGGAATAGATGAAAC
AGCAAACTATCTTAAGGAAACTGTTGAGAAGTTATTAGGTGTAAAGGCGAATCTTGAGAAGACTAAAGGTCATCCCGTAG
TATACGCTGAAATTAACGTTAATGCCAAAAAGACACTACTTATTTACAACCATTATGATGTCCAACCGGTGGATCCAATA
AGTGAGTGGAAAAGAGCGCCCTTTTCAGCAACAATTGAAAATGATAGAATTTACGCTAGGGGAGCCTCTGACAATAAAGG
AACATTAATGGCAAGACTATTTGCTATTAAACACTTACTAGATAAGAACGAATTAAATGTTAACGTGAAGTTACTTTACG
AGGGAGAAGAGGAAATAGGTAGTGTGAATTTGGAGGACTATATCGAAAAGAATACAAATAAACTGAAGGCAGACTCAGTC
ATAATGGAGGGAGCTGGCTTAGACCCCAAAGGAAGGCCACAAATAGTACTAGGGGTAAAAGGATTATTATACGTTGAACT
AGTTCTTGACTATGGAACTAAAGATCTACACTCTTCTAATGCACCATTAGTCAGAAATCCATGCATAGATCTAGCTAAGA
TAATATCTACATTGGTAGACATGGGAGGAAGAGTGTTAATTGAAGGGTTTTATGATGACGTGAGAGAATTAACAGAAGAG
GAAAGAGAGCTAATAAAGAAATACGATATCGATGTAGAGGAATTAAAGAAGGCGTTAGGGTTTAAGGAATTAAAGTATAA
TGAAAAGGAAAAGATTGCTGAGGCATTACTAACTTACCCAACATGTAATGTTGATGGGTTCGAATGCGGGTATACTGGAA
AGGGTAGCAAAACTATCGTACCACATAGAGCATTTGCAAAATTAGATTTTAGGCTAGTACCTAATCAAGATCCATATAAA
GTTTTCGAGTTACTGAAAAAACACCTTCAAAAGGCTGGTTTCAATGGGGAGATATTAGCACATGGCTTTGAATATCCTGT
TAGAACTTCGGTTAACTCTACAGTAGTCAAAGCAATGATAGAATCCGCTAAAAAAGTATATGGTACTGAACCACAAGTAA
TTCCTAATTCAGCCGGCACTCAACCCATGGGGTTGTTTGTGTATAAGCTAGGGATAAGGGATGCAGTTAGCGCAATAGGT
GCTGGAGGATATTACTCAAATGCTCATGCACCCAATGAAAACATTAAGATAGATGACTATTATAAAGCTATAAAACATAC
CGAGGAATTTCTAAAATTATACCCAATACTATAA

Upstream 100 bases:

>100_bases
GTTATATATATGCCAATAAATATAATTATAAAAACTTTATGACTAACCATTTCAAAATTCTAACCAACACACTTAAAAAG
GCAGAATATATTAGTTTATA

Downstream 100 bases:

>100_bases
TATAAATCTTAATAAACGAGAAAGCAAAAGATTTCATGTGGAGCTTCCAGGTTATGATTATATCATAGTATATAAGGATA
TCCATTTTGGGAGACCTTTT

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: Peptidase; M20/M25/M40 Family Peptidase; ArgE/DapE/Acy1 Family Protein; Peptidase Family; Succinyl-Diaminopimelate Desuccinylase; Peptidase Dimerisation Domain-Containing Protein; Succinyl-Diaminopimelate Desuccinylase Protein; Peptidase Dimerisation Domain Protein; Beta-Ala-His Dipeptidase; Peptidase Dimerization Domain Protein; Deacylase; N-Acyl-L-Amino Acid Amidohydrolase; Acetylornithine Deacetylase; Twin-Arginine Translocation Pathway Signal; N-Succinyl-Diaminopimelate Deacylase; Desuccinylase Deacetylase Or Peptidase; ArgE/DapE/Acy1 Family Peptidase; Nonspecific Dipeptidase; Peptidase Dimerisation; M20 Family Peptidase

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MDEELYTLIEFLKKPSISATGEGIDETANYLKETVEKLLGVKANLEKTKGHPVVYAEINVNAKKTLLIYNHYDVQPVDPI
SEWKRAPFSATIENDRIYARGASDNKGTLMARLFAIKHLLDKNELNVNVKLLYEGEEEIGSVNLEDYIEKNTNKLKADSV
IMEGAGLDPKGRPQIVLGVKGLLYVELVLDYGTKDLHSSNAPLVRNPCIDLAKIISTLVDMGGRVLIEGFYDDVRELTEE
ERELIKKYDIDVEELKKALGFKELKYNEKEKIAEALLTYPTCNVDGFECGYTGKGSKTIVPHRAFAKLDFRLVPNQDPYK
VFELLKKHLQKAGFNGEILAHGFEYPVRTSVNSTVVKAMIESAKKVYGTEPQVIPNSAGTQPMGLFVYKLGIRDAVSAIG
AGGYYSNAHAPNENIKIDDYYKAIKHTEEFLKLYPIL

Sequences:

>Translated_437_residues
MDEELYTLIEFLKKPSISATGEGIDETANYLKETVEKLLGVKANLEKTKGHPVVYAEINVNAKKTLLIYNHYDVQPVDPI
SEWKRAPFSATIENDRIYARGASDNKGTLMARLFAIKHLLDKNELNVNVKLLYEGEEEIGSVNLEDYIEKNTNKLKADSV
IMEGAGLDPKGRPQIVLGVKGLLYVELVLDYGTKDLHSSNAPLVRNPCIDLAKIISTLVDMGGRVLIEGFYDDVRELTEE
ERELIKKYDIDVEELKKALGFKELKYNEKEKIAEALLTYPTCNVDGFECGYTGKGSKTIVPHRAFAKLDFRLVPNQDPYK
VFELLKKHLQKAGFNGEILAHGFEYPVRTSVNSTVVKAMIESAKKVYGTEPQVIPNSAGTQPMGLFVYKLGIRDAVSAIG
AGGYYSNAHAPNENIKIDDYYKAIKHTEEFLKLYPIL
>Mature_437_residues
MDEELYTLIEFLKKPSISATGEGIDETANYLKETVEKLLGVKANLEKTKGHPVVYAEINVNAKKTLLIYNHYDVQPVDPI
SEWKRAPFSATIENDRIYARGASDNKGTLMARLFAIKHLLDKNELNVNVKLLYEGEEEIGSVNLEDYIEKNTNKLKADSV
IMEGAGLDPKGRPQIVLGVKGLLYVELVLDYGTKDLHSSNAPLVRNPCIDLAKIISTLVDMGGRVLIEGFYDDVRELTEE
ERELIKKYDIDVEELKKALGFKELKYNEKEKIAEALLTYPTCNVDGFECGYTGKGSKTIVPHRAFAKLDFRLVPNQDPYK
VFELLKKHLQKAGFNGEILAHGFEYPVRTSVNSTVVKAMIESAKKVYGTEPQVIPNSAGTQPMGLFVYKLGIRDAVSAIG
AGGYYSNAHAPNENIKIDDYYKAIKHTEEFLKLYPIL

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI21071039, Length=391, Percent_Identity=29.156010230179, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI271398239, Length=387, Percent_Identity=29.7157622739018, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI271398277, Length=327, Percent_Identity=29.0519877675841, Blast_Score=121, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193211059, Length=380, Percent_Identity=27.8947368421053, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17563146, Length=435, Percent_Identity=27.816091954023, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321159, Length=398, Percent_Identity=29.8994974874372, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319758, Length=458, Percent_Identity=24.4541484716157, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585880, Length=377, Percent_Identity=31.8302387267904, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 48962; Mature: 48962

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEELYTLIEFLKKPSISATGEGIDETANYLKETVEKLLGVKANLEKTKGHPVVYAEINV
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEEEC
NAKKTLLIYNHYDVQPVDPISEWKRAPFSATIENDRIYARGASDNKGTLMARLFAIKHLL
CCEEEEEEEECCCCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHH
DKNELNVNVKLLYEGEEEIGSVNLEDYIEKNTNKLKADSVIMEGAGLDPKGRPQIVLGVK
CCCCCEEEEEEEECCHHHHCCCCHHHHHHCCCCCEECCCEEEECCCCCCCCCCEEEEECC
GLLYVELVLDYGTKDLHSSNAPLVRNPCIDLAKIISTLVDMGGRVLIEGFYDDVRELTEE
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
ERELIKKYDIDVEELKKALGFKELKYNEKEKIAEALLTYPTCNVDGFECGYTGKGSKTIV
HHHHHHHHCCCHHHHHHHHCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEC
PHRAFAKLDFRLVPNQDPYKVFELLKKHLQKAGFNGEILAHGFEYPVRTSVNSTVVKAMI
CCHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHH
ESAKKVYGTEPQVIPNSAGTQPMGLFVYKLGIRDAVSAIGAGGYYSNAHAPNENIKIDDY
HHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
YKAIKHTEEFLKLYPIL
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDEELYTLIEFLKKPSISATGEGIDETANYLKETVEKLLGVKANLEKTKGHPVVYAEINV
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEEEC
NAKKTLLIYNHYDVQPVDPISEWKRAPFSATIENDRIYARGASDNKGTLMARLFAIKHLL
CCEEEEEEEECCCCCCCCCHHHHHCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHH
DKNELNVNVKLLYEGEEEIGSVNLEDYIEKNTNKLKADSVIMEGAGLDPKGRPQIVLGVK
CCCCCEEEEEEEECCHHHHCCCCHHHHHHCCCCCEECCCEEEECCCCCCCCCCEEEEECC
GLLYVELVLDYGTKDLHSSNAPLVRNPCIDLAKIISTLVDMGGRVLIEGFYDDVRELTEE
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
ERELIKKYDIDVEELKKALGFKELKYNEKEKIAEALLTYPTCNVDGFECGYTGKGSKTIV
HHHHHHHHCCCHHHHHHHHCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEC
PHRAFAKLDFRLVPNQDPYKVFELLKKHLQKAGFNGEILAHGFEYPVRTSVNSTVVKAMI
CCHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHH
ESAKKVYGTEPQVIPNSAGTQPMGLFVYKLGIRDAVSAIGAGGYYSNAHAPNENIKIDDY
HHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
YKAIKHTEEFLKLYPIL
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA