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The map label for this gene is adh-11 [H]

Identifier: 15899432

GI number: 15899432

Start: 2469166

End: 2470119

Strand: Reverse

Name: adh-11 [H]

Synonym: SSO2717

Alternate gene names: 15899432

Gene position: 2470119-2469166 (Counterclockwise)

Preceding gene: 15899433

Following gene: 15899426

Centisome position: 82.55

GC content: 31.03

Gene sequence:

>954_bases
TTGTGGAAGGTATTTTTTATTAATGGAAATTTCGTTAAAGAAAATGTTAGAGATGAGCTTCCTAAACCGAATGAAGTAAA
GGTTTTTCCTAAATACATAGGAATATGTGGTACTGATAAGAATATTTATTTAGGTAAAAAGCCAGTTAAGGAACCACTTG
TCTTAGGACATGAAATATCCGGGATAACTGAAAAAGGGGAGAAGGTAGCTATTTTCCCAAATTATTGGTGCGGTTACTGT
AATAATTGTAGAAGAGGATTTTATAACAGTTGTAAAAATAAAATATCAATTGGAGTTAATGCTGATGGCGGAATGGCGGA
ATATATCAACGTACCTAAAGATTTCGTGTTTAGAATACCCTACACCTTAGATTTGAAATTAGGAGCTTTAGTAGAACCTA
CGGCAGTTGCTGTTGCTGCGTTAAATAAGATAGACAAAGAGATAGAGAAGGTAATAATAATAGGAGGCGGTAGCACTGGA
ACTCTGGTTTCAATAGTAGCTGAAATAAATGGATTAGAAACTTTCGTTATAGAGAAGGATAGTAGAAAGGAAGAAATCCT
TAAGGAGAAGGGCTTTAGAACAACTAAGGAATTAAAATTTGATGACAGAGTTGCAGTGATAGATACTATAAATAATCAAG
AGAGTATGGTACTAGCCCAGTCAATTCTCAAAAATTCTATAGCTAGATCTGAGTTAATAATTACCGGATTAGATAATGAA
CAGATCAGTTTAAATAGAGATATTATAGTTAGAAATGAAGTAATAATTAGAGGTTCAATAATATATAGTAAAGATGATTT
TTTAAATTCCATAAAGATAGTTAGTGAAAATCAAGAAAAATTTAACAAAATAGTGGATAAGGTAGGTTATATAGACAATA
TTAACGAGTGGTTCAGAAAATATGTAATAGAACTACCTAACATAAAAGTACTAATAAAAATGGATTCTATTTGA

Upstream 100 bases:

>100_bases
CATATCTCTTAGGAATGGAAATCTTAATTGGGATAGGTCTTATATACTTCATCGGAACAGTAATAATAACTAACTATAGG
CAAATAAAGGTGAGCTAAGA

Downstream 100 bases:

>100_bases
TGGCACTTTCTTGAGTTTTCCCACTCATAAAAGAGAATATCATAGCTACTACTATTATAATCGAAGATATGAGAAAAGCA
AAATGTAATCCATTAACAAA

Product: zinc-containing alcohol dehydrogenase

Products: L-tagatose phosphate; NADH [C]

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MWKVFFINGNFVKENVRDELPKPNEVKVFPKYIGICGTDKNIYLGKKPVKEPLVLGHEISGITEKGEKVAIFPNYWCGYC
NNCRRGFYNSCKNKISIGVNADGGMAEYINVPKDFVFRIPYTLDLKLGALVEPTAVAVAALNKIDKEIEKVIIIGGGSTG
TLVSIVAEINGLETFVIEKDSRKEEILKEKGFRTTKELKFDDRVAVIDTINNQESMVLAQSILKNSIARSELIITGLDNE
QISLNRDIIVRNEVIIRGSIIYSKDDFLNSIKIVSENQEKFNKIVDKVGYIDNINEWFRKYVIELPNIKVLIKMDSI

Sequences:

>Translated_317_residues
MWKVFFINGNFVKENVRDELPKPNEVKVFPKYIGICGTDKNIYLGKKPVKEPLVLGHEISGITEKGEKVAIFPNYWCGYC
NNCRRGFYNSCKNKISIGVNADGGMAEYINVPKDFVFRIPYTLDLKLGALVEPTAVAVAALNKIDKEIEKVIIIGGGSTG
TLVSIVAEINGLETFVIEKDSRKEEILKEKGFRTTKELKFDDRVAVIDTINNQESMVLAQSILKNSIARSELIITGLDNE
QISLNRDIIVRNEVIIRGSIIYSKDDFLNSIKIVSENQEKFNKIVDKVGYIDNINEWFRKYVIELPNIKVLIKMDSI
>Mature_317_residues
MWKVFFINGNFVKENVRDELPKPNEVKVFPKYIGICGTDKNIYLGKKPVKEPLVLGHEISGITEKGEKVAIFPNYWCGYC
NNCRRGFYNSCKNKISIGVNADGGMAEYINVPKDFVFRIPYTLDLKLGALVEPTAVAVAALNKIDKEIEKVIIIGGGSTG
TLVSIVAEINGLETFVIEKDSRKEEILKEKGFRTTKELKFDDRVAVIDTINNQESMVLAQSILKNSIARSELIITGLDNE
QISLNRDIIVRNEVIIRGSIIYSKDDFLNSIKIVSENQEKFNKIVDKVGYIDNINEWFRKYVIELPNIKVLIKMDSI

Specific function: Converts Galactitol 1-Phosphate To Tagatose 6-Phosphate. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=336, Percent_Identity=24.1071428571429, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788407, Length=323, Percent_Identity=25.077399380805, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787863, Length=265, Percent_Identity=27.9245283018868, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI226510992, Length=322, Percent_Identity=25.776397515528, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790045, Length=177, Percent_Identity=32.2033898305085, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788073, Length=161, Percent_Identity=33.5403726708075, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790718, Length=260, Percent_Identity=26.5384615384615, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082125, Length=197, Percent_Identity=27.4111675126904, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=317, Percent_Identity=25.5520504731861, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=173, Percent_Identity=31.2138728323699, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=325, Percent_Identity=27.0769230769231, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=290, Percent_Identity=25.1724137931034, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=290, Percent_Identity=25.1724137931034, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=231, Percent_Identity=23.8095238095238, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=203, Percent_Identity=29.5566502463054, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17737897, Length=211, Percent_Identity=29.8578199052133, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137530, Length=233, Percent_Identity=28.755364806867, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221457811, Length=170, Percent_Identity=25.2941176470588, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=170, Percent_Identity=25.2941176470588, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=170, Percent_Identity=25.2941176470588, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.251 [C]

Molecular weight: Translated: 35833; Mature: 35833

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKVFFINGNFVKENVRDELPKPNEVKVFPKYIGICGTDKNIYLGKKPVKEPLVLGHEIS
CEEEEEEECCEECCCHHHHCCCCCCEEEEHHHEEEECCCCCEEECCCCCCCCCEECCCCC
GITEKGEKVAIFPNYWCGYCNNCRRGFYNSCKNKISIGVNADGGMAEYINVPKDFVFRIP
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCHHEEECC
YTLDLKLGALVEPTAVAVAALNKIDKEIEKVIIIGGGSTGTLVSIVAEINGLETFVIEKD
EEEEEEECCEECHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCEEEEEECC
SRKEEILKEKGFRTTKELKFDDRVAVIDTINNQESMVLAQSILKNSIARSELIITGLDNE
CHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCC
QISLNRDIIVRNEVIIRGSIIYSKDDFLNSIKIVSENQEKFNKIVDKVGYIDNINEWFRK
EEEECCCEEEECEEEEEEEEEECCHHHHCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHH
YVIELPNIKVLIKMDSI
HHHCCCCEEEEEEECCC
>Mature Secondary Structure
MWKVFFINGNFVKENVRDELPKPNEVKVFPKYIGICGTDKNIYLGKKPVKEPLVLGHEIS
CEEEEEEECCEECCCHHHHCCCCCCEEEEHHHEEEECCCCCEEECCCCCCCCCEECCCCC
GITEKGEKVAIFPNYWCGYCNNCRRGFYNSCKNKISIGVNADGGMAEYINVPKDFVFRIP
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCHHEEECC
YTLDLKLGALVEPTAVAVAALNKIDKEIEKVIIIGGGSTGTLVSIVAEINGLETFVIEKD
EEEEEEECCEECHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCEEEEEECC
SRKEEILKEKGFRTTKELKFDDRVAVIDTINNQESMVLAQSILKNSIARSELIITGLDNE
CHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCC
QISLNRDIIVRNEVIIRGSIIYSKDDFLNSIKIVSENQEKFNKIVDKVGYIDNINEWFRK
EEEECCCEEEECEEEEEEEEEECCHHHHCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHH
YVIELPNIKVLIKMDSI
HHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Galactitol-phosphate; NAD+ [C]

Specific reaction: Galactitol-phosphate + NAD+ = L-tagatose phosphate + NADH [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]