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The map label for this gene is acaB-8

Identifier: 15899415

GI number: 15899415

Start: 2450948

End: 2452078

Strand: Direct

Name: acaB-8

Synonym: SSO2697

Alternate gene names: NA

Gene position: 2450948-2452078 (Clockwise)

Preceding gene: 15899414

Following gene: 15899418

Centisome position: 81.91

GC content: 38.9

Gene sequence:

>1131_bases
ATGGTTGCAATTATTGACGCAAGCATAACCCGATTCGGAAAGAGAAAGGAGAGCTTATTAGAGCTTGCTGGAGAGGTTGC
ATTACCATTAATAGGGAAATACGAAATTGATTTTGTAGTAGTTTCTAACAGCTATTCTGGGGAGTTTAACTCCTTATCTG
GGATAAATAATTTAATTACAACTTATTTATCAGTAGATAAAGTACCATCAATTAGGGTCGATAATACTAGTGGAAGTGGG
GGTTCTGCAATATTGGTAGCTAAATCACTACTTGATTCTAAAATTACTAAAACTGTATTAGTCTTAGGAGTCGAGAAGAT
GTCTGAGAAGAATACCAAACAAGTTACATCTGTCATAGCCTCATTATTATCACCGGAGGAAAAAATTGTCGGACTAACTC
TACCTTCACTAGCAGGATTAATGACTAAGGAGTATATGAGGAGATATAACGCGTCCAGAGAAGCCTTTGCCTTAGTAGCA
GTCAAAAATCACTATAACGGATCTTTAAATCCCTTTGCTCACATACAGAAGGTGGTGTCATTAGAGGAAGTTTTGAATTC
CCCTATCATAGCAGATCCCTTAACCCTTTACGAATTTACCCCAATTAGTGATGGGGCTTCAGCAATAGTTATGGTAAGGG
ATGAGGACGCTTATAGTTTTACCAAGAAGCCTGTATTTATAAAAGGTATGGGTGCTTCTTCAGATACGTCATATTTATCT
GAACGTGAGGATATATTAACAATGAATGCGGTGAGAATTGCTGGATTGACCGCTAGGAAAATGGCAAAGGTTGATAAGGT
TGATTTCGCTGAGCTTCACGATATGGCCACAGTTCTGGAAATAGTTGAGGCTGAAGAGTTAGGCTTATTAAAGAAAGGAG
AAGGATGGAAAGCATATTACGACGACTACACCAAAATTAATGGCGAAATGCCAATAAACACTAGTGGAGGGTTAAATTCT
AAAGGTCATCCAATAGGGGCAAGTGGTATAGCCCAAGCAGTTGAGGCATTTTTACAAATTAGGAATCAAGCGGGAAGTAG
GCAAGTTAGAAATGCTAGAGTTGGGCTATCCCTAAGTATGGCTGGTTTCGGAAATTCCGCAACTGTAATAATTTACGGTG
ATGAGCCTTGA

Upstream 100 bases:

>100_bases
TTATTAACAAGTACTATTGTTGTTTTTGCTCTAGAAATGAAGTTTATGTTCTCTTTATTGGAAGTTCAATTTTATATTTT
AAATGTGGAATCTCACATGA

Downstream 100 bases:

>100_bases
TCTATGTATGTAAAAATTGCGGTTATTCGTTTTGGGTTAAGAGGGCCAGATGTCCAAGGTGTTATTCAACTGAATTTAAC
ATTAAGGATAATATAAGAGA

Product: Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-8)

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MVAIIDASITRFGKRKESLLELAGEVALPLIGKYEIDFVVVSNSYSGEFNSLSGINNLITTYLSVDKVPSIRVDNTSGSG
GSAILVAKSLLDSKITKTVLVLGVEKMSEKNTKQVTSVIASLLSPEEKIVGLTLPSLAGLMTKEYMRRYNASREAFALVA
VKNHYNGSLNPFAHIQKVVSLEEVLNSPIIADPLTLYEFTPISDGASAIVMVRDEDAYSFTKKPVFIKGMGASSDTSYLS
EREDILTMNAVRIAGLTARKMAKVDKVDFAELHDMATVLEIVEAEELGLLKKGEGWKAYYDDYTKINGEMPINTSGGLNS
KGHPIGASGIAQAVEAFLQIRNQAGSRQVRNARVGLSLSMAGFGNSATVIIYGDEP

Sequences:

>Translated_376_residues
MVAIIDASITRFGKRKESLLELAGEVALPLIGKYEIDFVVVSNSYSGEFNSLSGINNLITTYLSVDKVPSIRVDNTSGSG
GSAILVAKSLLDSKITKTVLVLGVEKMSEKNTKQVTSVIASLLSPEEKIVGLTLPSLAGLMTKEYMRRYNASREAFALVA
VKNHYNGSLNPFAHIQKVVSLEEVLNSPIIADPLTLYEFTPISDGASAIVMVRDEDAYSFTKKPVFIKGMGASSDTSYLS
EREDILTMNAVRIAGLTARKMAKVDKVDFAELHDMATVLEIVEAEELGLLKKGEGWKAYYDDYTKINGEMPINTSGGLNS
KGHPIGASGIAQAVEAFLQIRNQAGSRQVRNARVGLSLSMAGFGNSATVIIYGDEP
>Mature_376_residues
MVAIIDASITRFGKRKESLLELAGEVALPLIGKYEIDFVVVSNSYSGEFNSLSGINNLITTYLSVDKVPSIRVDNTSGSG
GSAILVAKSLLDSKITKTVLVLGVEKMSEKNTKQVTSVIASLLSPEEKIVGLTLPSLAGLMTKEYMRRYNASREAFALVA
VKNHYNGSLNPFAHIQKVVSLEEVLNSPIIADPLTLYEFTPISDGASAIVMVRDEDAYSFTKKPVFIKGMGASSDTSYLS
EREDILTMNAVRIAGLTARKMAKVDKVDFAELHDMATVLEIVEAEELGLLKKGEGWKAYYDDYTKINGEMPINTSGGLNS
KGHPIGASGIAQAVEAFLQIRNQAGSRQVRNARVGLSLSMAGFGNSATVIIYGDEP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=394, Percent_Identity=29.6954314720812, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI302344760, Length=328, Percent_Identity=32.0121951219512, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI302344767, Length=323, Percent_Identity=32.1981424148607, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI302344762, Length=296, Percent_Identity=32.4324324324324, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI55956775, Length=253, Percent_Identity=31.2252964426877, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17537653, Length=309, Percent_Identity=32.6860841423948, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI19921506, Length=396, Percent_Identity=28.7878787878788, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24585051, Length=326, Percent_Identity=31.2883435582822, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40529; Mature: 40529

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAIIDASITRFGKRKESLLELAGEVALPLIGKYEIDFVVVSNSYSGEFNSLSGINNLIT
CEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
TYLSVDKVPSIRVDNTSGSGGSAILVAKSLLDSKITKTVLVLGVEKMSEKNTKQVTSVIA
HHHHHCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SLLSPEEKIVGLTLPSLAGLMTKEYMRRYNASREAFALVAVKNHYNGSLNPFAHIQKVVS
HHHCCCHHEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHH
LEEVLNSPIIADPLTLYEFTPISDGASAIVMVRDEDAYSFTKKPVFIKGMGASSDTSYLS
HHHHHCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHH
EREDILTMNAVRIAGLTARKMAKVDKVDFAELHDMATVLEIVEAEELGLLKKGEGWKAYY
HHHHHEEECHHHECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
DDYTKINGEMPINTSGGLNSKGHPIGASGIAQAVEAFLQIRNQAGSRQVRNARVGLSLSM
CCHHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHEECEEEEE
AGFGNSATVIIYGDEP
CCCCCCEEEEEECCCC
>Mature Secondary Structure
MVAIIDASITRFGKRKESLLELAGEVALPLIGKYEIDFVVVSNSYSGEFNSLSGINNLIT
CEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
TYLSVDKVPSIRVDNTSGSGGSAILVAKSLLDSKITKTVLVLGVEKMSEKNTKQVTSVIA
HHHHHCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SLLSPEEKIVGLTLPSLAGLMTKEYMRRYNASREAFALVAVKNHYNGSLNPFAHIQKVVS
HHHCCCHHEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHH
LEEVLNSPIIADPLTLYEFTPISDGASAIVMVRDEDAYSFTKKPVFIKGMGASSDTSYLS
HHHHHCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHH
EREDILTMNAVRIAGLTARKMAKVDKVDFAELHDMATVLEIVEAEELGLLKKGEGWKAYY
HHHHHEEECHHHECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
DDYTKINGEMPINTSGGLNSKGHPIGASGIAQAVEAFLQIRNQAGSRQVRNARVGLSLSM
CCHHEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHEECEEEEE
AGFGNSATVIIYGDEP
CCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]