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The map label for this gene is pcm [H]

Identifier: 15899326

GI number: 15899326

Start: 2363401

End: 2364111

Strand: Direct

Name: pcm [H]

Synonym: SSO2599

Alternate gene names: 15899326

Gene position: 2363401-2364111 (Clockwise)

Preceding gene: 15899323

Following gene: 15899327

Centisome position: 78.98

GC content: 35.02

Gene sequence:

>711_bases
ATGAGTGCAAAAGACGACATATTAAGGTCCATAAAGAATTCAAAATTAGCAAATGCGTTTATAAAGGTTAATAGGGAGGA
TTTTTTGCCACAATTACTGAAAAAATATGCATATGATCCTAATTATGTAGACAAGCCCTTTTACATAACGCCTAATGTGA
CGACAACTGCATTAAGTTTAGGCATGTATATGCTCGATATTCTTAATTTGGGAGAAACTCAGAAAGTTTTAGAGATAGGT
ACGGGCATAGGTTATTATACTGCGTTAATGGCTGAAGTTGTTGGCGATAATAACGTTATCTCATTAGAAATTGATGATAC
GATATTTGAATACGCTAAAAATATTCTTCTGCCGAAATATCCGCGAATCAAATTAATTAAGACTGATGGAAGTCTAGGAT
ATGATAAGGAGGCTCCTTATGATAGGATCATAATATGGGCAGCTGCGCCAACAGTCCCTTGTAAACTGTACGATCAACTT
AGGGAGAACGGTATTATGGTAGTACCGATAGGTAGTGAAAAAGCGCAAGGTCTCTATAGAATTACTAAAATTGGATATGA
ACCTAAGATAGAAAGACTTGGAGATGTAATATTTATGAAAATGAGAGGATTATTTGGATTTTATGAGGATGACGATCCGA
ATGAGAGGAGAATAAAGAAAATAGAGGAGAAGGTTAATAGATTACTGTCAAAATTTATGAGCCAGAGCTAG

Upstream 100 bases:

>100_bases
ATGCCTGTTATTTAAATTTTAAGGCTTACAAGGTATTCTCAGTTAAGTTGAGGAGTTATCAACATATTTATTAAAAATCA
TCTTTAAATAGTTAATAAGT

Downstream 100 bases:

>100_bases
CTTGCAAGGTTAGATTAAAGGTTAATAATAAGGTGGTAAATTTATATTACATAATGCTCTTGAATGTTAGAAACCTTACA
GTGAGATATGGTTCTTTTAT

Product: L-isoaspartyl protein carboxyl methyltransferase (pcm)

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSAKDDILRSIKNSKLANAFIKVNREDFLPQLLKKYAYDPNYVDKPFYITPNVTTTALSLGMYMLDILNLGETQKVLEIG
TGIGYYTALMAEVVGDNNVISLEIDDTIFEYAKNILLPKYPRIKLIKTDGSLGYDKEAPYDRIIIWAAAPTVPCKLYDQL
RENGIMVVPIGSEKAQGLYRITKIGYEPKIERLGDVIFMKMRGLFGFYEDDDPNERRIKKIEEKVNRLLSKFMSQS

Sequences:

>Translated_236_residues
MSAKDDILRSIKNSKLANAFIKVNREDFLPQLLKKYAYDPNYVDKPFYITPNVTTTALSLGMYMLDILNLGETQKVLEIG
TGIGYYTALMAEVVGDNNVISLEIDDTIFEYAKNILLPKYPRIKLIKTDGSLGYDKEAPYDRIIIWAAAPTVPCKLYDQL
RENGIMVVPIGSEKAQGLYRITKIGYEPKIERLGDVIFMKMRGLFGFYEDDDPNERRIKKIEEKVNRLLSKFMSQS
>Mature_235_residues
SAKDDILRSIKNSKLANAFIKVNREDFLPQLLKKYAYDPNYVDKPFYITPNVTTTALSLGMYMLDILNLGETQKVLEIGT
GIGYYTALMAEVVGDNNVISLEIDDTIFEYAKNILLPKYPRIKLIKTDGSLGYDKEAPYDRIIIWAAAPTVPCKLYDQLR
ENGIMVVPIGSEKAQGLYRITKIGYEPKIERLGDVIFMKMRGLFGFYEDDDPNERRIKKIEEKVNRLLSKFMSQS

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=165, Percent_Identity=35.7575757575758, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789100, Length=199, Percent_Identity=32.1608040201005, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71983477, Length=171, Percent_Identity=32.7485380116959, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193207222, Length=171, Percent_Identity=32.7485380116959, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17981723, Length=189, Percent_Identity=26.4550264550265, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 26973; Mature: 26842

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDDILRSIKNSKLANAFIKVNREDFLPQLLKKYAYDPNYVDKPFYITPNVTTTALSL
CCCHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHH
GMYMLDILNLGETQKVLEIGTGIGYYTALMAEVVGDNNVISLEIDDTIFEYAKNILLPKY
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCC
PRIKLIKTDGSLGYDKEAPYDRIIIWAAAPTVPCKLYDQLRENGIMVVPIGSEKAQGLYR
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHH
ITKIGYEPKIERLGDVIFMKMRGLFGFYEDDDPNERRIKKIEEKVNRLLSKFMSQS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAKDDILRSIKNSKLANAFIKVNREDFLPQLLKKYAYDPNYVDKPFYITPNVTTTALSL
CCHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHH
GMYMLDILNLGETQKVLEIGTGIGYYTALMAEVVGDNNVISLEIDDTIFEYAKNILLPKY
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCC
PRIKLIKTDGSLGYDKEAPYDRIIIWAAAPTVPCKLYDQLRENGIMVVPIGSEKAQGLYR
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHH
ITKIGYEPKIERLGDVIFMKMRGLFGFYEDDDPNERRIKKIEEKVNRLLSKFMSQS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA