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The map label for this gene is accC [H]

Identifier: 15899209

GI number: 15899209

Start: 2236007

End: 2237539

Strand: Reverse

Name: accC [H]

Synonym: SSO2466

Alternate gene names: 15899209

Gene position: 2237539-2236007 (Counterclockwise)

Preceding gene: 15899210

Following gene: 15899208

Centisome position: 74.78

GC content: 38.62

Gene sequence:

>1533_bases
ATGTCACCCTTTAATAAAGTTCTCGTAGCCAACAGAGGAGAAATTGCCATAAGGGTTATGAAAGCCGTAAAAGAAATGGG
AATGAAGGCAGTTGCTGTATATTCTGATGCTGATAAATATGCCCCCCACGTTAAATATGCAGATGAAGCTTATTGGATAG
GGCCACCTCCAGCTTTAGAAAGTTACTTGAATATTGAAAGAATTATCGATGCGGCAGAAAAGGCTCATGCAGATGCTGTA
CATCCCGGTTATGGGTTCCTTTCCGAAAACGCGTCTTTTGTAGAAGCTGTTGAAAAAGCTGGAATGGTTTTCATAGGACC
TTCTGCTTCTGTAATGAATAGAATCAAGGACAAATTGGAAGGAAAGATGATAGCTAGAAAGGCTGGTGTCCCCACGTCCC
CTGGACCTTTAACACCAATTGAAAATGTAGATGAGGCGTTAAAGATAGCTGGAGAAATAGGATATCCCATAATGTTGAAG
GCTGCGGGAGGTGGAGCAGGAGTGGGTATTATAAAGGTTGATAATCCTAGTGAACTAGCTGAGGCTTTTGAAAGAAGCAA
AAGATTAGCGTACTCTGCCTTTGGCAGGGCAGAAATTTACATAGAAAAGGCTGCTATAAAACCAAAACACATTGAAACGC
AATTGATAGGAGATAAGTATGGAAATTACGTAGTCGCCTTTGAAAGAGAATGCACAATTCAAAGAAGGAACCAAAAGTTA
ATCGAAGAAGCCCCCTCTCCATCCATTAAAGAAGAGGAAAGAAAGGAGATTATTGAGGCGTCAATAAGATTTGGGAAAGA
AATTAACTACTTTACCTTAGGTACCATGGAGTTCGTGTTCTCACCAGTTACTCGTGAATTTTACTTCTTAGAAATTAATA
AAAGAGTTCAAGTAGAGCACACAGTCACTGAGTTCATAACTGGAATAGACTTAGTCAAATTACAGATAAGACTAGCTGCT
GGTGAATATTTACCTTTTTCTCAAGAAGACTTGAAAATAAGAGGACATGCAATACAGTTTAGAATTAACGCTGAGGACCC
ATTAAATAACTTCACGCCTCAATCCGGATACATAACCTATTATAAGGAACCAACTGGTCCCGGTGTGAGAGTGGATAGCG
GTATAGAACTTGGTTCATGGGTTCCACCATATTATGATCCCCTTGTTTCCAAGTTAATTGTTTATGGACAAAGTAGAGAC
TACGCGATTCAAGTCGGACTAAGGGCTCTAAACGATTATAAAATAGGAGGAGTTAAAACTACAATTCCATTATATAAGTT
GATCTTGCAAGATCCAGACTTCTGGGAAGGTAATTTCACTACTGCATATATATCTGAGAAAGCAGAGTACTTTACGACCA
AATTAAAAGAAGAACAAGAGATACAAATTGCAATAGCCATTTCGATTTATAATAGGGGATTGATGAAGAAGAAAAAAACT
GAACAGAAAGTACCCATCTCAACTAGTAATGGTAAAAGTAATTGGAAAACTTATGGTATCATATTCCAATCCTCTCCAAG
GGTGTTGTGGTAA

Upstream 100 bases:

>100_bases
TGCATAAAGGATTTTATAATGAAAATTTTTTAAAAAATCGACTAAGCCCAAATTCCTAATGTTAAAAACTTTTAAACCAG
TCTAACTATATTAATATAGT

Downstream 100 bases:

>100_bases
TGAGATTATTTAGACTTTATAGCGAATTGGGAGATATGTATTTAGTATCTTATGAACAGAGCAACAACAGTCTTGATAAA
ATAAAAATAGGAGATAAAAA

Product: biotin carboxylase a subunit of propionyl-CoA carboxylase (accC)

Products: NA

Alternate protein names: Pyruvic carboxylase A [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSPFNKVLVANRGEIAIRVMKAVKEMGMKAVAVYSDADKYAPHVKYADEAYWIGPPPALESYLNIERIIDAAEKAHADAV
HPGYGFLSENASFVEAVEKAGMVFIGPSASVMNRIKDKLEGKMIARKAGVPTSPGPLTPIENVDEALKIAGEIGYPIMLK
AAGGGAGVGIIKVDNPSELAEAFERSKRLAYSAFGRAEIYIEKAAIKPKHIETQLIGDKYGNYVVAFERECTIQRRNQKL
IEEAPSPSIKEEERKEIIEASIRFGKEINYFTLGTMEFVFSPVTREFYFLEINKRVQVEHTVTEFITGIDLVKLQIRLAA
GEYLPFSQEDLKIRGHAIQFRINAEDPLNNFTPQSGYITYYKEPTGPGVRVDSGIELGSWVPPYYDPLVSKLIVYGQSRD
YAIQVGLRALNDYKIGGVKTTIPLYKLILQDPDFWEGNFTTAYISEKAEYFTTKLKEEQEIQIAIAISIYNRGLMKKKKT
EQKVPISTSNGKSNWKTYGIIFQSSPRVLW

Sequences:

>Translated_510_residues
MSPFNKVLVANRGEIAIRVMKAVKEMGMKAVAVYSDADKYAPHVKYADEAYWIGPPPALESYLNIERIIDAAEKAHADAV
HPGYGFLSENASFVEAVEKAGMVFIGPSASVMNRIKDKLEGKMIARKAGVPTSPGPLTPIENVDEALKIAGEIGYPIMLK
AAGGGAGVGIIKVDNPSELAEAFERSKRLAYSAFGRAEIYIEKAAIKPKHIETQLIGDKYGNYVVAFERECTIQRRNQKL
IEEAPSPSIKEEERKEIIEASIRFGKEINYFTLGTMEFVFSPVTREFYFLEINKRVQVEHTVTEFITGIDLVKLQIRLAA
GEYLPFSQEDLKIRGHAIQFRINAEDPLNNFTPQSGYITYYKEPTGPGVRVDSGIELGSWVPPYYDPLVSKLIVYGQSRD
YAIQVGLRALNDYKIGGVKTTIPLYKLILQDPDFWEGNFTTAYISEKAEYFTTKLKEEQEIQIAIAISIYNRGLMKKKKT
EQKVPISTSNGKSNWKTYGIIFQSSPRVLW
>Mature_509_residues
SPFNKVLVANRGEIAIRVMKAVKEMGMKAVAVYSDADKYAPHVKYADEAYWIGPPPALESYLNIERIIDAAEKAHADAVH
PGYGFLSENASFVEAVEKAGMVFIGPSASVMNRIKDKLEGKMIARKAGVPTSPGPLTPIENVDEALKIAGEIGYPIMLKA
AGGGAGVGIIKVDNPSELAEAFERSKRLAYSAFGRAEIYIEKAAIKPKHIETQLIGDKYGNYVVAFERECTIQRRNQKLI
EEAPSPSIKEEERKEIIEASIRFGKEINYFTLGTMEFVFSPVTREFYFLEINKRVQVEHTVTEFITGIDLVKLQIRLAAG
EYLPFSQEDLKIRGHAIQFRINAEDPLNNFTPQSGYITYYKEPTGPGVRVDSGIELGSWVPPYYDPLVSKLIVYGQSRDY
AIQVGLRALNDYKIGGVKTTIPLYKLILQDPDFWEGNFTTAYISEKAEYFTTKLKEEQEIQIAIAISIYNRGLMKKKKTE
QKVPISTSNGKSNWKTYGIIFQSSPRVLW

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=478, Percent_Identity=44.5606694560669, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI295821183, Length=475, Percent_Identity=44.8421052631579, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI65506442, Length=475, Percent_Identity=44.8421052631579, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI116805327, Length=497, Percent_Identity=41.851106639839, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI106049528, Length=457, Percent_Identity=42.6695842450766, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=457, Percent_Identity=42.6695842450766, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=457, Percent_Identity=42.6695842450766, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI38679960, Length=500, Percent_Identity=27.8, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI38679977, Length=500, Percent_Identity=27.8, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI38679967, Length=500, Percent_Identity=27.8, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI38679974, Length=500, Percent_Identity=27.8, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI38679971, Length=500, Percent_Identity=27.8, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=29.6222664015905, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=46.9662921348315, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1786216, Length=328, Percent_Identity=24.0853658536585, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=503, Percent_Identity=43.1411530815109, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17562816, Length=456, Percent_Identity=45.3947368421053, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=469, Percent_Identity=42.2174840085288, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=535, Percent_Identity=28.0373831775701, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=463, Percent_Identity=28.9416846652268, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=463, Percent_Identity=28.9416846652268, Blast_Score=191, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=438, Percent_Identity=42.0091324200913, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319695, Length=454, Percent_Identity=42.7312775330396, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=454, Percent_Identity=44.273127753304, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=29.9785867237687, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324343, Length=509, Percent_Identity=27.5049115913556, Blast_Score=213, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24652212, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=457, Percent_Identity=43.9824945295405, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651757, Length=498, Percent_Identity=37.5502008032129, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651759, Length=458, Percent_Identity=36.8995633187773, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI161076409, Length=496, Percent_Identity=28.2258064516129, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586458, Length=496, Percent_Identity=28.2258064516129, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI161076407, Length=496, Percent_Identity=28.2258064516129, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586460, Length=496, Percent_Identity=28.2258064516129, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 57114; Mature: 56983

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50975 ATP_GRASP ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPFNKVLVANRGEIAIRVMKAVKEMGMKAVAVYSDADKYAPHVKYADEAYWIGPPPALE
CCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHCCCCCEECCCEEECCCCHHHH
SYLNIERIIDAAEKAHADAVHPGYGFLSENASFVEAVEKAGMVFIGPSASVMNRIKDKLE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHC
GKMIARKAGVPTSPGPLTPIENVDEALKIAGEIGYPIMLKAAGGGAGVGIIKVDNPSELA
CCEEHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCHHHHH
EAFERSKRLAYSAFGRAEIYIEKAAIKPKHIETQLIGDKYGNYVVAFERECTIQRRNQKL
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCHHHHHHHHH
IEEAPSPSIKEEERKEIIEASIRFGKEINYFTLGTMEFVFSPVTREFYFLEINKRVQVEH
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCCCCEEEEEEECCEEEEHH
TVTEFITGIDLVKLQIRLAAGEYLPFSQEDLKIRGHAIQFRINAEDPLNNFTPQSGYITY
HHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEE
YKEPTGPGVRVDSGIELGSWVPPYYDPLVSKLIVYGQSRDYAIQVGLRALNDYKIGGVKT
EECCCCCCEEECCCCCCCCCCCCHHHHHHHHHEEECCCCCEEEEEEHHHHCCEECCCEEH
TIPLYKLILQDPDFWEGNFTTAYISEKAEYFTTKLKEEQEIQIAIAISIYNRGLMKKKKT
HHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHHCC
EQKVPISTSNGKSNWKTYGIIFQSSPRVLW
CCCCCEECCCCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure 
SPFNKVLVANRGEIAIRVMKAVKEMGMKAVAVYSDADKYAPHVKYADEAYWIGPPPALE
CCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHCCCCCEECCCEEECCCCHHHH
SYLNIERIIDAAEKAHADAVHPGYGFLSENASFVEAVEKAGMVFIGPSASVMNRIKDKLE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHC
GKMIARKAGVPTSPGPLTPIENVDEALKIAGEIGYPIMLKAAGGGAGVGIIKVDNPSELA
CCEEHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCHHHHH
EAFERSKRLAYSAFGRAEIYIEKAAIKPKHIETQLIGDKYGNYVVAFERECTIQRRNQKL
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCHHHHHHHHH
IEEAPSPSIKEEERKEIIEASIRFGKEINYFTLGTMEFVFSPVTREFYFLEINKRVQVEH
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCCCCEEEEEEECCEEEEHH
TVTEFITGIDLVKLQIRLAAGEYLPFSQEDLKIRGHAIQFRINAEDPLNNFTPQSGYITY
HHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEE
YKEPTGPGVRVDSGIELGSWVPPYYDPLVSKLIVYGQSRDYAIQVGLRALNDYKIGGVKT
EECCCCCCEEECCCCCCCCCCCCHHHHHHHHHEEECCCCCEEEEEEHHHHCCEECCCEEH
TIPLYKLILQDPDFWEGNFTTAYISEKAEYFTTKLKEEQEIQIAIAISIYNRGLMKKKKT
HHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHHCC
EQKVPISTSNGKSNWKTYGIIFQSSPRVLW
CCCCCEECCCCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 11195096 [H]