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The map label for this gene is idh [H]

Identifier: 15898961

GI number: 15898961

Start: 2007306

End: 2008547

Strand: Direct

Name: idh [H]

Synonym: SSO2182

Alternate gene names: 15898961

Gene position: 2007306-2008547 (Clockwise)

Preceding gene: 15898959

Following gene: 15898962

Centisome position: 67.08

GC content: 35.91

Gene sequence:

>1242_bases
TTGATGCAAAAGATACCAGAAGATGGAGAAGTAATTAAATTTGAAAATGGGAAATGGATTGTACCAAAAAAGCCAATAAT
TCTGTATGTTGAAGGGGATGGAATAGGGCATGAAATAACACATGCTGCTATGAAGGTTATAAACAAAGCAGTGGAAAAAG
CTTATGGATCTGATAGAGAAATTAAGTGGGTAGAAGTTCTAGCAGGAGATAAGGCAGAAAAGCTAACCGGAAATAGATTT
CCTAAAGAGTCAGAGGAATTGATAGAGAAGTATAGAGTCTTATTAAAAGGTCCCCTAGAAACACCAATAGGCAAAGGCTG
GAAATCCATCAATGTAGCAATTAGATTAATGTTGGATCTTTATGCAAATATAAGACCAGTAAAATACATTCCAGGTATAG
AAAGTCCAATTAAGAACGCAGATAAGATTGACCTTATAATATTTAGGGAAAATACTGATGATTTGTACAGAGGAATAGAG
TATCCTTATGACAGTGAACAAGCAAAGAAAATTAGAGATTTTCTAAGAAAGGAGCTAGGAGTGGAAGTGGAAGATGATAC
TGGAATTGGTATAAAACTTATCAGTAGATTTAAGACGCAAAGGATTGCGAGAATGGCTATAAAATACGCTATAGACCATA
AACGAAAGAAAGTTACAATAATGCATAAAGGTAATGTGATGAAATATACCGAAGGAGCATTTAGAGAATGGTCATATGAA
GTTGCAACAAAAGAATTTAGAGATTATATAGTTACTGAGGAAGAGGTAACAAAGAATTATAATGGAGTACCTCCTTCTGG
GAAGGTCATAATAAATGATAGGATAGCTGATAACATGTTCCAACAGATAATTATCAGACCAGACGAGTACGATATAATAT
TAGCACCTAACGTAAATGGGGATTACATATCGGATGCTGCGGGCGCACTGGTAGGAAATATTGGTATGTTAGGCGGTGCA
AATATAGGAGATACTGGAGGTATGTTCGAGGCAATACATGGTACCGCACCTAAGTATGCTGGTAAGAATGTTGCAAACCC
CACTGGAATAATAAAAGGTGGTGAGTTAATGTTAAGATTTATGGGATGGGATAAGGCTGCTGAGTTAATAGATTCTGCAA
TCATGGAATCTATAAGACAGAAGAAGGTTACTCAGGATTTAGCTAGATTTATGGGTGTAAGAGCCTTATCAACTACTGAA
TATACTGACGAGCTAATTGCGATAATCGATACACTATCATAA

Upstream 100 bases:

>100_bases
GAAGCTTGAAAACTTTTAATTAGAGAACATAATAATCACTAGACTTTAGTGCTAAAAAGGTTAGCAATGATTTTAAATTT
ATACATAGTAGAGTTAGAGT

Downstream 100 bases:

>100_bases
ATTTTACAGTAAATTTCCTACGTTTCTATAACACTTTCGTACCCTAATCTCTCAATACAATTGTCTCTGTGTAAATTTCC
TACGTTTCATCTGAAAATCT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MMQKIPEDGEVIKFENGKWIVPKKPIILYVEGDGIGHEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNRF
PKESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPIKNADKIDLIIFRENTDDLYRGIE
YPYDSEQAKKIRDFLRKELGVEVEDDTGIGIKLISRFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWSYE
VATKEFRDYIVTEEEVTKNYNGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGA
NIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAAELIDSAIMESIRQKKVTQDLARFMGVRALSTTE
YTDELIAIIDTLS

Sequences:

>Translated_413_residues
MMQKIPEDGEVIKFENGKWIVPKKPIILYVEGDGIGHEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNRF
PKESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPIKNADKIDLIIFRENTDDLYRGIE
YPYDSEQAKKIRDFLRKELGVEVEDDTGIGIKLISRFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWSYE
VATKEFRDYIVTEEEVTKNYNGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGA
NIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAAELIDSAIMESIRQKKVTQDLARFMGVRALSTTE
YTDELIAIIDTLS
>Mature_413_residues
MMQKIPEDGEVIKFENGKWIVPKKPIILYVEGDGIGHEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNRF
PKESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPIKNADKIDLIIFRENTDDLYRGIE
YPYDSEQAKKIRDFLRKELGVEVEDDTGIGIKLISRFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWSYE
VATKEFRDYIVTEEEVTKNYNGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGA
NIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAAELIDSAIMESIRQKKVTQDLARFMGVRALSTTE
YTDELIAIIDTLS

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=363, Percent_Identity=32.5068870523416, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI28178838, Length=370, Percent_Identity=28.3783783783784, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4758582, Length=365, Percent_Identity=28.7671232876712, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI28178821, Length=390, Percent_Identity=27.4358974358974, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI28178816, Length=388, Percent_Identity=27.319587628866, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI28178819, Length=224, Percent_Identity=29.0178571428571, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1787381, Length=409, Percent_Identity=48.6552567237164, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI87081683, Length=394, Percent_Identity=30.2030456852792, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788101, Length=379, Percent_Identity=26.1213720316623, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71986051, Length=362, Percent_Identity=32.5966850828729, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144293, Length=359, Percent_Identity=28.9693593314763, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17505779, Length=300, Percent_Identity=32, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17550882, Length=386, Percent_Identity=25.1295336787565, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322097, Length=393, Percent_Identity=32.5699745547074, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324709, Length=386, Percent_Identity=30.3108808290155, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324291, Length=393, Percent_Identity=29.2620865139949, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24643270, Length=384, Percent_Identity=33.0729166666667, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24643268, Length=384, Percent_Identity=33.0729166666667, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24661184, Length=382, Percent_Identity=31.9371727748691, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI161078635, Length=295, Percent_Identity=31.864406779661, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI161078637, Length=295, Percent_Identity=31.864406779661, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI161078633, Length=295, Percent_Identity=31.864406779661, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24650122, Length=295, Percent_Identity=31.864406779661, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI161078639, Length=295, Percent_Identity=31.864406779661, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281362242, Length=365, Percent_Identity=29.8630136986301, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24648872, Length=365, Percent_Identity=29.8630136986301, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI20130355, Length=382, Percent_Identity=25.9162303664921, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46451; Mature: 46451

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQKIPEDGEVIKFENGKWIVPKKPIILYVEGDGIGHEITHAAMKVINKAVEKAYGSDRE
CCCCCCCCCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC
IKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDL
EEEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YANIRPVKYIPGIESPIKNADKIDLIIFRENTDDLYRGIEYPYDSEQAKKIRDFLRKELG
HHCCCCEEECCCCCCHHCCCCCEEEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHHHC
VEVEDDTGIGIKLISRFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWSYE
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHHHHH
VATKEFRDYIVTEEEVTKNYNGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNG
HHHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHEECCCCCCEEECCCCCC
DYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF
CHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEECHHHEEEE
MGWDKAAELIDSAIMESIRQKKVTQDLARFMGVRALSTTEYTDELIAIIDTLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMQKIPEDGEVIKFENGKWIVPKKPIILYVEGDGIGHEITHAAMKVINKAVEKAYGSDRE
CCCCCCCCCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC
IKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDL
EEEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YANIRPVKYIPGIESPIKNADKIDLIIFRENTDDLYRGIEYPYDSEQAKKIRDFLRKELG
HHCCCCEEECCCCCCHHCCCCCEEEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHHHC
VEVEDDTGIGIKLISRFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWSYE
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHHHHH
VATKEFRDYIVTEEEVTKNYNGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNG
HHHHHHHHHHCCHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHEECCCCCCEEECCCCCC
DYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF
CHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEECHHHEEEE
MGWDKAAELIDSAIMESIRQKKVTQDLARFMGVRALSTTEYTDELIAIIDTLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8951037 [H]