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The map label for this gene is bcp-2 [C]

Identifier: 15898905

GI number: 15898905

Start: 1945703

End: 1946350

Strand: Direct

Name: bcp-2 [C]

Synonym: SSO2121

Alternate gene names: 15898905

Gene position: 1945703-1946350 (Clockwise)

Preceding gene: 15898904

Following gene: 15898907

Centisome position: 65.02

GC content: 37.81

Gene sequence:

>648_bases
ATGAGTGAGGAAAGAATTCCATTAATAGGAGAAAGATTCCCAGAAATGGAAGTTATAACTACGCAAGGCAGGATAAAACT
ACCTGATGACTATAAAGGGAGATGGTTTGTATTATTTAGCCATCCTGGAGATTTCACACCGGTGTGCACTACGGAGTTCT
ACTCATTTGCAAAGAAATACGAGGAGTTCAAGAAGTTGAATACTGAACTAATAGGACTTTCAGTAGATAGTAACATTTCA
CACATCGAATGGATAATGTGGATAGAGAAAAACCTAAAGGTTGAAATTCCGTTTCCAATAATCGCTGATCCAATGGGCAA
TGTTGCTAAAAGACTAGGTATGATCCATGCGCAGTCCTCTACAGCTACAGTTAGAGCAGTATTCGTAGTTGACGATAAGG
GGGTAGTGAGATTAATTCTGTACTATCCGATGGAGATAGGAAGAAATATTGATGAAATTCTTAGAGCTATTAGAGCACTA
CAATTAGTTGACAAAGCAGGAGTAGTAACTCCAGCTAACTGGCCTAATAATGAACTAATAGGAGATAAGGTCATTAATCC
AGCTCCTAGAACGATAAAAGATGCAAAGATGAGATTAGGTCAGCCCTTTGATTGGTGGTTCACTTATAAAGAAGTTAAAA
CAACATAA

Upstream 100 bases:

>100_bases
TCTAAGGAATTTGGAGCTACTTTAATTTAAAAGTTACATTTTAATGAGAATGAGTTAATTTTAAATAGGAGTCACTCCAA
ATTAAATACTAGGTGAAAAA

Downstream 100 bases:

>100_bases
CATGAATGGGTAAAATTAAATTTATTTTTTGATTCTCTCAAATACATTAGCTAATTTTAGAACCTTGTCTTCTTCAAAAT
GCCTTCCTATTATCATCAGA

Product: putative peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSEERIPLIGERFPEMEVITTQGRIKLPDDYKGRWFVLFSHPGDFTPVCTTEFYSFAKKYEEFKKLNTELIGLSVDSNIS
HIEWIMWIEKNLKVEIPFPIIADPMGNVAKRLGMIHAQSSTATVRAVFVVDDKGVVRLILYYPMEIGRNIDEILRAIRAL
QLVDKAGVVTPANWPNNELIGDKVINPAPRTIKDAKMRLGQPFDWWFTYKEVKTT

Sequences:

>Translated_215_residues
MSEERIPLIGERFPEMEVITTQGRIKLPDDYKGRWFVLFSHPGDFTPVCTTEFYSFAKKYEEFKKLNTELIGLSVDSNIS
HIEWIMWIEKNLKVEIPFPIIADPMGNVAKRLGMIHAQSSTATVRAVFVVDDKGVVRLILYYPMEIGRNIDEILRAIRAL
QLVDKAGVVTPANWPNNELIGDKVINPAPRTIKDAKMRLGQPFDWWFTYKEVKTT
>Mature_214_residues
SEERIPLIGERFPEMEVITTQGRIKLPDDYKGRWFVLFSHPGDFTPVCTTEFYSFAKKYEEFKKLNTELIGLSVDSNISH
IEWIMWIEKNLKVEIPFPIIADPMGNVAKRLGMIHAQSSTATVRAVFVVDDKGVVRLILYYPMEIGRNIDEILRAIRALQ
LVDKAGVVTPANWPNNELIGDKVINPAPRTIKDAKMRLGQPFDWWFTYKEVKTT

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI4505591, Length=153, Percent_Identity=40.5228758169935, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI32455266, Length=153, Percent_Identity=40.5228758169935, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI32455264, Length=153, Percent_Identity=40.5228758169935, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI5453549, Length=153, Percent_Identity=39.2156862745098, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI4758638, Length=187, Percent_Identity=40.6417112299465, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI32189392, Length=153, Percent_Identity=38.562091503268, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI5802974, Length=174, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI32483377, Length=174, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI33188454, Length=56, Percent_Identity=50, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786822, Length=150, Percent_Identity=36.6666666666667, Blast_Score=97, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17554494, Length=163, Percent_Identity=33.7423312883436, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25153706, Length=188, Percent_Identity=35.6382978723404, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI32565831, Length=153, Percent_Identity=37.9084967320261, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193204376, Length=153, Percent_Identity=37.9084967320261, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319407, Length=201, Percent_Identity=47.2636815920398, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323613, Length=169, Percent_Identity=33.7278106508876, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320661, Length=147, Percent_Identity=30.6122448979592, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17975518, Length=175, Percent_Identity=44.5714285714286, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24652436, Length=175, Percent_Identity=44.5714285714286, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24652434, Length=175, Percent_Identity=44.5714285714286, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24581278, Length=172, Percent_Identity=45.3488372093023, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17157991, Length=151, Percent_Identity=40.3973509933775, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24641739, Length=151, Percent_Identity=40.3973509933775, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17738015, Length=151, Percent_Identity=37.0860927152318, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656348, Length=168, Percent_Identity=37.5, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17864676, Length=168, Percent_Identity=37.5, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357347, Length=146, Percent_Identity=34.9315068493151, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): TDXH_SULSO (P95895)

Other databases:

- EMBL:   Y08256
- EMBL:   AE006641
- PIR:   S74033
- RefSeq:   NP_343510.1
- ProteinModelPortal:   P95895
- SMR:   P95895
- GeneID:   1453627
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO2121
- NMPDR:   fig|273057.1.peg.1933
- HOGENOM:   HBG493509
- OMA:   EVKTTHG
- PhylomeDB:   P95895
- ProtClustDB:   PRK13191
- BioCyc:   SSOL273057:SSO2121-MONOMER
- BRENDA:   1.11.1.15
- HAMAP:   MF_00401
- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 24745; Mature: 24614

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 49-49

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEERIPLIGERFPEMEVITTQGRIKLPDDYKGRWFVLFSHPGDFTPVCTTEFYSFAKKY
CCCCCCCHHHCCCCCEEEEECCCEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
EEFKKLNTELIGLSVDSNISHIEWIMWIEKNLKVEIPFPIIADPMGNVAKRLGMIHAQSS
HHHHHCCCEEEEEEECCCCCCEEEEEEEECCCEEEECCCEECCCHHHHHHHHHEEEECCC
TATVRAVFVVDDKGVVRLILYYPMEIGRNIDEILRAIRALQLVDKAGVVTPANWPNNELI
CEEEEEEEEECCCCEEEEEEEECHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCC
GDKVINPAPRTIKDAKMRLGQPFDWWFTYKEVKTT
CCCCCCCCCCHHHHHHHHCCCCCHHEEEEEEEECC
>Mature Secondary Structure 
SEERIPLIGERFPEMEVITTQGRIKLPDDYKGRWFVLFSHPGDFTPVCTTEFYSFAKKY
CCCCCCHHHCCCCCEEEEECCCEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
EEFKKLNTELIGLSVDSNISHIEWIMWIEKNLKVEIPFPIIADPMGNVAKRLGMIHAQSS
HHHHHCCCEEEEEEECCCCCCEEEEEEEECCCEEEECCCEECCCHHHHHHHHHEEEECCC
TATVRAVFVVDDKGVVRLILYYPMEIGRNIDEILRAIRALQLVDKAGVVTPANWPNNELI
CEEEEEEEEECCCCEEEEEEEECHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCC
GDKVINPAPRTIKDAKMRLGQPFDWWFTYKEVKTT
CCCCCCCCCCHHHHHHHHCCCCCHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726