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The map label for this gene is fadH [C]

Identifier: 15898816

GI number: 15898816

Start: 1838292

End: 1839959

Strand: Direct

Name: fadH [C]

Synonym: SSO2025

Alternate gene names: 15898816

Gene position: 1838292-1839959 (Clockwise)

Preceding gene: 15898815

Following gene: 15898818

Centisome position: 61.44

GC content: 39.09

Gene sequence:

>1668_bases
ATGGATCTATCGAAGCTACTGGAACCAATAAGAATTGGAGATATTGTTTTAAAGAATAGAATAGCCATGTCACCAATGAT
CAGTAATCTAGGTACGCCGGAGGGTTATCCTAGTGATGCTCATATAGCTTACTTAGCTGAGAGAGCTAAGGGAGGAGTTG
GGTTAATAATAACAGAATACACATACGTTAATCACGTAGACGCTAGGGGATCAGTTAACGAACTGGGAATGGATTCAGAT
GAGTTAACGCCAAAGTTCATGAGGTTAACTGAGTTAATTCACGCTTTGGGAAGTAAGATTTTTGTGCAACTAGTTCACGT
TGGTAGGAAGACTAGAAAGGATATAATTTGGGGTAACAAACCAATAGCCCCTTCTCCCATTCCTATAATGGACGAAGTAA
GGGAGATGACTAAGGAGGATATAGAGAGGGTTAAAAACGATTTCATAGACGCATCAATAAGAGCTAAGAGGGCTGGATTT
GACGGAATAGAACTTCATGGAGCTCATGGGTATCTATTAGCCCAATTCTTATCTCCCGCGACAAATAAGAGGAATGATGA
GTACAAAGATGGTGTAAGGTTTATAGAGGAAATCCTTAAGGGCATAAAGGAAAAAGCTAAAATCACTGTAGGTATAAGAA
TCAGTGTAACCGAATTCGACAATGAGGGCTTAACTCCAGAAATTGTTGCTGAAATAGGTAAAAAGTTGGAGAAGGCTGGG
ATAGATTATATTCACTTATCAGCTGGAAGAGATGGTCCTTTGGGTTCCAGCATGCCATACTACTATAAGAGATTGGCATT
TCTTGAAGAGGCAAAGGTAGTAAGGGATGCAGTTAATATTCCAATATTTCTTGTTGGATCTGTGATAACTCCAGTAGATG
CGATTAAGGCGAGAGAAATTGCTGACGTCGTTGTATTAGGAAGACAATTATTAGCCGATCCCTATTGGCTAGAGAAAGCT
AAAAGGGATCTACCAATAAGACCATGTATTAGGTGTAATCAGACATGTAGAGGGGTTGTATATAAAGAGGTAAGATGTGA
TGTCAACCCCGAATTAGGATGGGAGTTGTTACCACCATTAGAGAAGGGCAAGGGAGAGGTTATTGTAGTGGGAGGAGGCG
TAATGGGTTTAGAAGCTGCTAGAGTCTTAGCTTTGAGGGGCTTCACGGTAACTTTATATGAGCAAAACAATAAGTTAGGA
GGACAGTTCCTACTTTACAAGGATCCTTGGAAAGTTAAGGAGTTCCAAGAGTTAATTAATTACTATGAGAGGGAGTTAAA
GAGACTTAATGTTGAGGTTAAGCTTAACTCTAAGATTGAGTGCTCTGACTGTATAATGGCTATACCTGACTATGAAATAC
CTAAAATGCCCGACGTCAAGGGAGAAAAATTGCTGATAGATTCTAACCTTTACGTTTATCATGACTATGCGTTTGAGCTA
GCTAAATATAATGAGATTTACATTACTGAGAGATCGTTTAAGGGATTGGATAGAACTAGGGAGTACCTCCTAAGAAAGGA
GTTAAGTGAAGTTGGTGTGAAGTTCTTAGAGGAAAAAAATAGTATGAAGTTTGACGTGGAAATACATAATATTGCTGATG
ACCAGCCGAGTATTGGTAAGGCTATACAAAGAGGTTATTGGTTAGGTAGAACTTTCAAGTCATATTAA

Upstream 100 bases:

>100_bases
AAACACTTTTTATATATTACATTCATCTAAGATTTAGTATTTCTATGAAAATACAGAGCCTTACAGTTAACTTTTTAACT
ATCACATTCTAATATCCCTC

Downstream 100 bases:

>100_bases
AAACATTTCATCACGTTTTTTCAGTCCTGGCCACTTTAATCATTCAAATGACATATTGTGTTAACTCTTTTTAAAACTTA
TGAAGAATATGGTCGGAAAC

Product: NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MDLSKLLEPIRIGDIVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEYTYVNHVDARGSVNELGMDSD
ELTPKFMRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNKPIAPSPIPIMDEVREMTKEDIERVKNDFIDASIRAKRAGF
DGIELHGAHGYLLAQFLSPATNKRNDEYKDGVRFIEEILKGIKEKAKITVGIRISVTEFDNEGLTPEIVAEIGKKLEKAG
IDYIHLSAGRDGPLGSSMPYYYKRLAFLEEAKVVRDAVNIPIFLVGSVITPVDAIKAREIADVVVLGRQLLADPYWLEKA
KRDLPIRPCIRCNQTCRGVVYKEVRCDVNPELGWELLPPLEKGKGEVIVVGGGVMGLEAARVLALRGFTVTLYEQNNKLG
GQFLLYKDPWKVKEFQELINYYERELKRLNVEVKLNSKIECSDCIMAIPDYEIPKMPDVKGEKLLIDSNLYVYHDYAFEL
AKYNEIYITERSFKGLDRTREYLLRKELSEVGVKFLEEKNSMKFDVEIHNIADDQPSIGKAIQRGYWLGRTFKSY

Sequences:

>Translated_555_residues
MDLSKLLEPIRIGDIVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEYTYVNHVDARGSVNELGMDSD
ELTPKFMRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNKPIAPSPIPIMDEVREMTKEDIERVKNDFIDASIRAKRAGF
DGIELHGAHGYLLAQFLSPATNKRNDEYKDGVRFIEEILKGIKEKAKITVGIRISVTEFDNEGLTPEIVAEIGKKLEKAG
IDYIHLSAGRDGPLGSSMPYYYKRLAFLEEAKVVRDAVNIPIFLVGSVITPVDAIKAREIADVVVLGRQLLADPYWLEKA
KRDLPIRPCIRCNQTCRGVVYKEVRCDVNPELGWELLPPLEKGKGEVIVVGGGVMGLEAARVLALRGFTVTLYEQNNKLG
GQFLLYKDPWKVKEFQELINYYERELKRLNVEVKLNSKIECSDCIMAIPDYEIPKMPDVKGEKLLIDSNLYVYHDYAFEL
AKYNEIYITERSFKGLDRTREYLLRKELSEVGVKFLEEKNSMKFDVEIHNIADDQPSIGKAIQRGYWLGRTFKSY
>Mature_555_residues
MDLSKLLEPIRIGDIVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEYTYVNHVDARGSVNELGMDSD
ELTPKFMRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNKPIAPSPIPIMDEVREMTKEDIERVKNDFIDASIRAKRAGF
DGIELHGAHGYLLAQFLSPATNKRNDEYKDGVRFIEEILKGIKEKAKITVGIRISVTEFDNEGLTPEIVAEIGKKLEKAG
IDYIHLSAGRDGPLGSSMPYYYKRLAFLEEAKVVRDAVNIPIFLVGSVITPVDAIKAREIADVVVLGRQLLADPYWLEKA
KRDLPIRPCIRCNQTCRGVVYKEVRCDVNPELGWELLPPLEKGKGEVIVVGGGVMGLEAARVLALRGFTVTLYEQNNKLG
GQFLLYKDPWKVKEFQELINYYERELKRLNVEVKLNSKIECSDCIMAIPDYEIPKMPDVKGEKLLIDSNLYVYHDYAFEL
AKYNEIYITERSFKGLDRTREYLLRKELSEVGVKFLEEKNSMKFDVEIHNIADDQPSIGKAIQRGYWLGRTFKSY

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=487, Percent_Identity=29.9794661190965, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1787939, Length=358, Percent_Identity=31.8435754189944, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI72001454, Length=312, Percent_Identity=29.4871794871795, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17540738, Length=342, Percent_Identity=28.3625730994152, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17564188, Length=344, Percent_Identity=28.7790697674419, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17565138, Length=334, Percent_Identity=31.1377245508982, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559804, Length=308, Percent_Identity=28.8961038961039, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559802, Length=334, Percent_Identity=28.1437125748503, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17566914, Length=230, Percent_Identity=26.9565217391304, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325086, Length=275, Percent_Identity=30.9090909090909, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321973, Length=233, Percent_Identity=28.3261802575107, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 62890; Mature: 62890

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSKLLEPIRIGDIVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEE
TYVNHVDARGSVNELGMDSDELTPKFMRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNK
EEEECCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIAPSPIPIMDEVREMTKEDIERVKNDFIDASIRAKRAGFDGIELHGAHGYLLAQFLSPA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEECCCHHHHHHHHCCC
TNKRNDEYKDGVRFIEEILKGIKEKAKITVGIRISVTEFDNEGLTPEIVAEIGKKLEKAG
CCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCC
IDYIHLSAGRDGPLGSSMPYYYKRLAFLEEAKVVRDAVNIPIFLVGSVITPVDAIKAREI
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCHHHHHHHHH
ADVVVLGRQLLADPYWLEKAKRDLPIRPCIRCNQTCRGVVYKEVRCDVNPELGWELLPPL
HHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHCCCHHHHHEEEEEECCCCCCCCCEECCCC
EKGKGEVIVVGGGVMGLEAARVLALRGFTVTLYEQNNKLGGQFLLYKDPWKVKEFQELIN
CCCCCCEEEEECCCHHHHHHHHHEECCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHH
YYERELKRLNVEVKLNSKIECSDCIMAIPDYEIPKMPDVKGEKLLIDSNLYVYHDYAFEL
HHHHHHHHEEEEEEECCCCCHHHHEEECCCCCCCCCCCCCCCEEEEECCEEEEEHHHHHH
AKYNEIYITERSFKGLDRTREYLLRKELSEVGVKFLEEKNSMKFDVEIHNIADDQPSIGK
HCCCEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHH
AIQRGYWLGRTFKSY
HHHHCCHHCCHHCCC
>Mature Secondary Structure
MDLSKLLEPIRIGDIVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEE
TYVNHVDARGSVNELGMDSDELTPKFMRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNK
EEEECCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIAPSPIPIMDEVREMTKEDIERVKNDFIDASIRAKRAGFDGIELHGAHGYLLAQFLSPA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEECCCHHHHHHHHCCC
TNKRNDEYKDGVRFIEEILKGIKEKAKITVGIRISVTEFDNEGLTPEIVAEIGKKLEKAG
CCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCC
IDYIHLSAGRDGPLGSSMPYYYKRLAFLEEAKVVRDAVNIPIFLVGSVITPVDAIKAREI
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCHHHHHHHHH
ADVVVLGRQLLADPYWLEKAKRDLPIRPCIRCNQTCRGVVYKEVRCDVNPELGWELLPPL
HHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHCCCHHHHHEEEEEECCCCCCCCCEECCCC
EKGKGEVIVVGGGVMGLEAARVLALRGFTVTLYEQNNKLGGQFLLYKDPWKVKEFQELIN
CCCCCCEEEEECCCHHHHHHHHHEECCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHH
YYERELKRLNVEVKLNSKIECSDCIMAIPDYEIPKMPDVKGEKLLIDSNLYVYHDYAFEL
HHHHHHHHEEEEEEECCCCCHHHHEEECCCCCCCCCCCCCCCEEEEECCEEEEEHHHHHH
AKYNEIYITERSFKGLDRTREYLLRKELSEVGVKFLEEKNSMKFDVEIHNIADDQPSIGK
HCCCEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHH
AIQRGYWLGRTFKSY
HHHHCCHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]