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The map label for this gene is acsA-3 [H]

Identifier: 15898699

GI number: 15898699

Start: 1720018

End: 1721391

Strand: Direct

Name: acsA-3 [H]

Synonym: SSO1903

Alternate gene names: 15898699

Gene position: 1720018-1721391 (Clockwise)

Preceding gene: 15898695

Following gene: 15898701

Centisome position: 57.48

GC content: 38.86

Gene sequence:

>1374_bases
ATGGTGAGTTATGAAGAAGTTAGAAGGAGTTTTTCATGGAATGAGGTAATTAAATTTTTAGATAAGAACCCACTAGACGT
GTTGACTTCTCACGATGGCATAGCAATTAAAAGGTTCACTAAGGACGTTGTAGAGGACATAAGCTTCTCAGATCTTAAAA
GAAAGGCGTTAAGACTTGCCTTATATTTAAGAGAGTTCCATGACGTTAAGAAGGGAGACGTGATAGCTGTATTGGCTTCA
AAGAAAATAGAACAAGTTATAGTACTTTTGGCAACGTTCTCTCTGGGAGCAATTTATCAGCCATTATTCACTGCATTTGG
ACCGGAAGCGATTAAGATGAGGACTAGGGATGCAAAGCCAAAAGTTATCTTTTACCAAGATGATCAAAAGGATAAGGTAA
GTGACGCGATACCTTTCTCCAAGTTCGATGAATTATTAAGTTATGGTGAATTGAAGAATATTGAAAAGATAAATTGGGAT
GACCCAATAGTTTTACTATACACTTCTGGTACTACTGGAGCGCCTAAAGGAGCGCTAATCGCTAAGAGATTATTACTCAA
CACTTATGTTTACATGAAATATGGTATAGGTATTAGGGATAGTGACGTATTTTGGAACCCTGCAGATCCTGGATGGGCTT
ATGGATTGTATTATGGTATAATAGGACCACTGATGTTCGGAAAGACCGTTATTTTCCTTGACGAGCCGTTTAACCCGGAG
AGGACAATGGAGTTTATGGAGGAGAAAAAGGTTACTAATTTTGCCTTCGCACCCACGGCATATAGGATGATAGCTGGAAC
GATTAAGAGGAAATATGATTTAGTATTAGAAAGAGCTAGTTCTGCTGGTGAACCACTTAACCCAGAAGTTATAAGATGGT
TTATGGACAATTACAATGTTACTATCAAAGATCATTACGGACAAACCGAAGTTGGAATGGTTGTTTACAACGGCTGGGGA
TATGAAACAAAAATAAAAATAGGGAGTATGGGACTACCAGCTCCCGGTTATGAGATAGATGTAATAGAGGATACTATAGC
TGTCAAAAGGGATTCACCGGGTTTTCACTTCTTAGGATATTTAAATAATCCTGAGAAGACCAAGGAGTCATTTAGAGGCG
ATTGGTACTTAACCGGTGACAACGCGTATAAGGATGAGGAAGGATATTTCTGGTTTGTTGGAAGGAAGGATGATGTGGTT
AAGGTATCCGGTTATAGGGTTGGACCATTTGAAGTTGAGAGCGTACTTCTAGAATTTCCCGCAGTACTAGAGTCGGCTGT
TGTTGCCGACGAAGATCCAATACGGGGACAGTGGTGTTTCACCAAATTATTTCATTTGAAAGATATAATATTAGTCCTTT
CAAAAAGAGATTGA

Upstream 100 bases:

>100_bases
TTCAAAGCGGAAGATTGGTAGTGAAGAATAAGTTAATTAAAGATTAAGTTTATCTTCTCTTTTTATAAAGTCTTTTAAGT
TTTGAATGTATAGTTAACCT

Downstream 100 bases:

>100_bases
TATAGAGAAAAACAATAAAATTATTATGAAACATAACATGTTAAAATAATTTGCAAAAAATATAGCGTACAATTCTAATA
ATAAGAGGAGAATTCTGAAT

Product: Acetyl-CoA synthetase (acetate-CoA ligase) amino-end fragment. (acsA-3)

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MVSYEEVRRSFSWNEVIKFLDKNPLDVLTSHDGIAIKRFTKDVVEDISFSDLKRKALRLALYLREFHDVKKGDVIAVLAS
KKIEQVIVLLATFSLGAIYQPLFTAFGPEAIKMRTRDAKPKVIFYQDDQKDKVSDAIPFSKFDELLSYGELKNIEKINWD
DPIVLLYTSGTTGAPKGALIAKRLLLNTYVYMKYGIGIRDSDVFWNPADPGWAYGLYYGIIGPLMFGKTVIFLDEPFNPE
RTMEFMEEKKVTNFAFAPTAYRMIAGTIKRKYDLVLERASSAGEPLNPEVIRWFMDNYNVTIKDHYGQTEVGMVVYNGWG
YETKIKIGSMGLPAPGYEIDVIEDTIAVKRDSPGFHFLGYLNNPEKTKESFRGDWYLTGDNAYKDEEGYFWFVGRKDDVV
KVSGYRVGPFEVESVLLEFPAVLESAVVADEDPIRGQWCFTKLFHLKDIILVLSKRD

Sequences:

>Translated_457_residues
MVSYEEVRRSFSWNEVIKFLDKNPLDVLTSHDGIAIKRFTKDVVEDISFSDLKRKALRLALYLREFHDVKKGDVIAVLAS
KKIEQVIVLLATFSLGAIYQPLFTAFGPEAIKMRTRDAKPKVIFYQDDQKDKVSDAIPFSKFDELLSYGELKNIEKINWD
DPIVLLYTSGTTGAPKGALIAKRLLLNTYVYMKYGIGIRDSDVFWNPADPGWAYGLYYGIIGPLMFGKTVIFLDEPFNPE
RTMEFMEEKKVTNFAFAPTAYRMIAGTIKRKYDLVLERASSAGEPLNPEVIRWFMDNYNVTIKDHYGQTEVGMVVYNGWG
YETKIKIGSMGLPAPGYEIDVIEDTIAVKRDSPGFHFLGYLNNPEKTKESFRGDWYLTGDNAYKDEEGYFWFVGRKDDVV
KVSGYRVGPFEVESVLLEFPAVLESAVVADEDPIRGQWCFTKLFHLKDIILVLSKRD
>Mature_457_residues
MVSYEEVRRSFSWNEVIKFLDKNPLDVLTSHDGIAIKRFTKDVVEDISFSDLKRKALRLALYLREFHDVKKGDVIAVLAS
KKIEQVIVLLATFSLGAIYQPLFTAFGPEAIKMRTRDAKPKVIFYQDDQKDKVSDAIPFSKFDELLSYGELKNIEKINWD
DPIVLLYTSGTTGAPKGALIAKRLLLNTYVYMKYGIGIRDSDVFWNPADPGWAYGLYYGIIGPLMFGKTVIFLDEPFNPE
RTMEFMEEKKVTNFAFAPTAYRMIAGTIKRKYDLVLERASSAGEPLNPEVIRWFMDNYNVTIKDHYGQTEVGMVVYNGWG
YETKIKIGSMGLPAPGYEIDVIEDTIAVKRDSPGFHFLGYLNNPEKTKESFRGDWYLTGDNAYKDEEGYFWFVGRKDDVV
KVSGYRVGPFEVESVLLEFPAVLESAVVADEDPIRGQWCFTKLFHLKDIILVLSKRD

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=427, Percent_Identity=32.5526932084309, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI122937307, Length=425, Percent_Identity=32.2352941176471, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI38505220, Length=434, Percent_Identity=30.4147465437788, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI58082049, Length=425, Percent_Identity=30.3529411764706, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI157311624, Length=425, Percent_Identity=30.1176470588235, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI157311622, Length=425, Percent_Identity=30.1176470588235, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI115511026, Length=428, Percent_Identity=30.1401869158879, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI8923896, Length=484, Percent_Identity=26.8595041322314, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI13375727, Length=476, Percent_Identity=27.7310924369748, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI28416953, Length=461, Percent_Identity=28.6334056399132, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI253970489, Length=321, Percent_Identity=32.398753894081, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI42544134, Length=349, Percent_Identity=27.5071633237822, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI195947378, Length=405, Percent_Identity=23.7037037037037, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI187761345, Length=454, Percent_Identity=23.7885462555066, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI187761343, Length=454, Percent_Identity=23.7885462555066, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI156151445, Length=337, Percent_Identity=28.1899109792285, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI38524616, Length=307, Percent_Identity=25.7328990228013, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790505, Length=462, Percent_Identity=29.4372294372294, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786529, Length=506, Percent_Identity=27.0750988142292, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI145693145, Length=427, Percent_Identity=24.5901639344262, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786801, Length=410, Percent_Identity=24.6341463414634, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788107, Length=444, Percent_Identity=23.8738738738739, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI221142682, Length=445, Percent_Identity=22.9213483146067, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789201, Length=309, Percent_Identity=25.2427184466019, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71982997, Length=443, Percent_Identity=27.5395033860045, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983001, Length=443, Percent_Identity=27.5395033860045, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=399, Percent_Identity=29.8245614035088, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17558820, Length=411, Percent_Identity=28.7104622871046, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=464, Percent_Identity=25, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=350, Percent_Identity=24.8571428571429, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=350, Percent_Identity=24.8571428571429, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994694, Length=350, Percent_Identity=24.8571428571429, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=338, Percent_Identity=24.8520710059172, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=303, Percent_Identity=25.4125412541254, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=325, Percent_Identity=28, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319264, Length=458, Percent_Identity=31.4410480349345, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323182, Length=453, Percent_Identity=30.4635761589404, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319699, Length=297, Percent_Identity=22.8956228956229, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62472339, Length=474, Percent_Identity=28.9029535864979, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24667955, Length=507, Percent_Identity=28.7968441814596, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24667959, Length=433, Percent_Identity=29.5612009237875, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21355225, Length=462, Percent_Identity=26.1904761904762, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356947, Length=424, Percent_Identity=24.2924528301887, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21358303, Length=425, Percent_Identity=24, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922652, Length=440, Percent_Identity=24.0909090909091, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24648260, Length=419, Percent_Identity=24.3436754176611, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581924, Length=331, Percent_Identity=25.6797583081571, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24653035, Length=415, Percent_Identity=23.1325301204819, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20130357, Length=418, Percent_Identity=23.2057416267943, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI161076582, Length=407, Percent_Identity=22.8501228501229, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI18859661, Length=429, Percent_Identity=23.5431235431235, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281364798, Length=433, Percent_Identity=24.2494226327945, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24583465, Length=433, Percent_Identity=24.2494226327945, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583463, Length=433, Percent_Identity=24.2494226327945, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24648257, Length=286, Percent_Identity=26.5734265734266, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21355181, Length=441, Percent_Identity=24.9433106575964, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 52245; Mature: 52245

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSYEEVRRSFSWNEVIKFLDKNPLDVLTSHDGIAIKRFTKDVVEDISFSDLKRKALRLA
CCCHHHHHHCCCHHHHHHHHCCCCHHEEECCCCEEHHHHHHHHHHHCCHHHHHHHHHHHH
LYLREFHDVKKGDVIAVLASKKIEQVIVLLATFSLGAIYQPLFTAFGPEAIKMRTRDAKP
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCC
KVIFYQDDQKDKVSDAIPFSKFDELLSYGELKNIEKINWDDPIVLLYTSGTTGAPKGALI
CEEEEECCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHH
AKRLLLNTYVYMKYGIGIRDSDVFWNPADPGWAYGLYYGIIGPLMFGKTVIFLDEPFNPE
HHHHHHHHEEEEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHH
RTMEFMEEKKVTNFAFAPTAYRMIAGTIKRKYDLVLERASSAGEPLNPEVIRWFMDNYNV
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCE
TIKDHYGQTEVGMVVYNGWGYETKIKIGSMGLPAPGYEIDVIEDTIAVKRDSPGFHFLGY
EEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCEEEEEECEEEEECCCCCEEEEEE
LNNPEKTKESFRGDWYLTGDNAYKDEEGYFWFVGRKDDVVKVSGYRVGPFEVESVLLEFP
CCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCEEECCHHHHHHHHHHH
AVLESAVVADEDPIRGQWCFTKLFHLKDIILVLSKRD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MVSYEEVRRSFSWNEVIKFLDKNPLDVLTSHDGIAIKRFTKDVVEDISFSDLKRKALRLA
CCCHHHHHHCCCHHHHHHHHCCCCHHEEECCCCEEHHHHHHHHHHHCCHHHHHHHHHHHH
LYLREFHDVKKGDVIAVLASKKIEQVIVLLATFSLGAIYQPLFTAFGPEAIKMRTRDAKP
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCC
KVIFYQDDQKDKVSDAIPFSKFDELLSYGELKNIEKINWDDPIVLLYTSGTTGAPKGALI
CEEEEECCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHH
AKRLLLNTYVYMKYGIGIRDSDVFWNPADPGWAYGLYYGIIGPLMFGKTVIFLDEPFNPE
HHHHHHHHEEEEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHH
RTMEFMEEKKVTNFAFAPTAYRMIAGTIKRKYDLVLERASSAGEPLNPEVIRWFMDNYNV
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCE
TIKDHYGQTEVGMVVYNGWGYETKIKIGSMGLPAPGYEIDVIEDTIAVKRDSPGFHFLGY
EEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCEEEEEECEEEEECCCCCEEEEEE
LNNPEKTKESFRGDWYLTGDNAYKDEEGYFWFVGRKDDVVKVSGYRVGPFEVESVLLEFP
CCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCEEECCHHHHHHHHHHH
AVLESAVVADEDPIRGQWCFTKLFHLKDIILVLSKRD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]