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The map label for this gene is adh-5 [C]

Identifier: 15898464

GI number: 15898464

Start: 1498101

End: 1499135

Strand: Direct

Name: adh-5 [C]

Synonym: SSO1646

Alternate gene names: 15898464

Gene position: 1498101-1499135 (Clockwise)

Preceding gene: 15898463

Following gene: 15898467

Centisome position: 50.07

GC content: 40.48

Gene sequence:

>1035_bases
ATGAAAGCAGTTAGAATTCATGAATATAATAAACCTTTGTCCTTAGATGAGGTTAATAAACCTAGGGTCTCTGGACCATA
TGATATAGTAGTTAGAATTAGAGGAGCGGGAGTCTGTAGGACTGACTTGCACATTATCGAAGGAGTATGGAAAGACGTAC
TAAATCCTAAGTTACCATTTACCATAGGTCACGAAAACGTCGGTATAATAGAGGAAAAGGGTAATGCCGTAGACTGGTTA
GATGTGGGAGATCAAGTAATATTACATCCCTACATTACTTGTAGACATTGTAGAGCGTGTAGGTCTGGAAACGATATGCA
TTGTCCATATGGGAAATTCCCTGGATTAGACGGTACTGATGGCGGTTATGCAGAATATTTAAGGACCTCAGCTTTCTCTG
CCATAAAGATCCCCAAGGGGATTGATATAATACCAATGGCACCCTTAGCTGATGCCGGAATAACTGCATACCATGCCGTA
AAGAAGATTTCTCAATACCTCTATCCTGGAAGCATTGTAGGTGTTATTGGTGTTGGTGGACTAGGCCATATTGGTATTCA
AGCCCTTAAGGCAATCACTCCAGCTAGAGTTATTGCAATAGATATAAGTGAAGAGAAGACTAAGCTAGCTAAGGAATTGG
GTGCTGATGAAGTAGTAATAGCGGGAAAGGATAGTGGCGTTAGTGATGTCTTGAAATTGACCGACAACATAGGTGTTGAC
GCAATCATAGATTTTGTCGGGGAACACTCCACTCCTCAAAATGCCTTAAGGATGATAAGGAAGGGAGGAATATACTCAAT
TGTTGGCTATGGCGGAGAATTTAAAAATAGCACTTTAGATTTCATAAATAGGGAGATCATGGTGGTTGGTAATCTAGTGG
GTACTTATAATGAGTTAAGCGAGTTAGTAACCTTATACGTTCAAAATAAGGTAAAATTAAAGGTAAAGACGTTCCCCTTA
GAGGAGGCTAATAGCGCACTTGAGGAGTTGAAAGCTGGAAGGATTTTAGGAAGGGCAGTCTTAGTGCCTAGCTAA

Upstream 100 bases:

>100_bases
AAAGATTTAGGGTAAAAAGGGAGAGGGATGATAGGCTAAGTAAGCTAACGCTAAGTATAAATGGCGAGTTTTGTAGACTA
ATATATGAGGCTAAAAGAAA

Downstream 100 bases:

>100_bases
TCTAATTTCCAGCAATTTTCTCTTATCATCTTCGAATAACCATTTCAAATCGTTTTTTATATCCCTTGATTCCTTAGCCT
CAAATCCATAGGCTAATGCA

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKAVRIHEYNKPLSLDEVNKPRVSGPYDIVVRIRGAGVCRTDLHIIEGVWKDVLNPKLPFTIGHENVGIIEEKGNAVDWL
DVGDQVILHPYITCRHCRACRSGNDMHCPYGKFPGLDGTDGGYAEYLRTSAFSAIKIPKGIDIIPMAPLADAGITAYHAV
KKISQYLYPGSIVGVIGVGGLGHIGIQALKAITPARVIAIDISEEKTKLAKELGADEVVIAGKDSGVSDVLKLTDNIGVD
AIIDFVGEHSTPQNALRMIRKGGIYSIVGYGGEFKNSTLDFINREIMVVGNLVGTYNELSELVTLYVQNKVKLKVKTFPL
EEANSALEELKAGRILGRAVLVPS

Sequences:

>Translated_344_residues
MKAVRIHEYNKPLSLDEVNKPRVSGPYDIVVRIRGAGVCRTDLHIIEGVWKDVLNPKLPFTIGHENVGIIEEKGNAVDWL
DVGDQVILHPYITCRHCRACRSGNDMHCPYGKFPGLDGTDGGYAEYLRTSAFSAIKIPKGIDIIPMAPLADAGITAYHAV
KKISQYLYPGSIVGVIGVGGLGHIGIQALKAITPARVIAIDISEEKTKLAKELGADEVVIAGKDSGVSDVLKLTDNIGVD
AIIDFVGEHSTPQNALRMIRKGGIYSIVGYGGEFKNSTLDFINREIMVVGNLVGTYNELSELVTLYVQNKVKLKVKTFPL
EEANSALEELKAGRILGRAVLVPS
>Mature_344_residues
MKAVRIHEYNKPLSLDEVNKPRVSGPYDIVVRIRGAGVCRTDLHIIEGVWKDVLNPKLPFTIGHENVGIIEEKGNAVDWL
DVGDQVILHPYITCRHCRACRSGNDMHCPYGKFPGLDGTDGGYAEYLRTSAFSAIKIPKGIDIIPMAPLADAGITAYHAV
KKISQYLYPGSIVGVIGVGGLGHIGIQALKAITPARVIAIDISEEKTKLAKELGADEVVIAGKDSGVSDVLKLTDNIGVD
AIIDFVGEHSTPQNALRMIRKGGIYSIVGYGGEFKNSTLDFINREIMVVGNLVGTYNELSELVTLYVQNKVKLKVKTFPL
EEANSALEELKAGRILGRAVLVPS

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=378, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI34577061, Length=380, Percent_Identity=28.1578947368421, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4501929, Length=379, Percent_Identity=26.9129287598945, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI71743840, Length=377, Percent_Identity=28.9124668435013, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI262073058, Length=376, Percent_Identity=28.9893617021277, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI156627571, Length=317, Percent_Identity=26.813880126183, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI71565154, Length=370, Percent_Identity=27.5675675675676, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=26.2734584450402, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI71565152, Length=381, Percent_Identity=25.7217847769029, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=26.3013698630137, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI194239674, Length=343, Percent_Identity=23.6151603498542, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI13236495, Length=343, Percent_Identity=23.6151603498542, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87081918, Length=320, Percent_Identity=34.0625, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786518, Length=354, Percent_Identity=28.2485875706215, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788073, Length=265, Percent_Identity=25.6603773584906, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082401, Length=320, Percent_Identity=31.5625, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790045, Length=271, Percent_Identity=29.1512915129151, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI226510992, Length=294, Percent_Identity=28.2312925170068, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790718, Length=307, Percent_Identity=27.3615635179153, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788075, Length=319, Percent_Identity=27.8996865203762, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787863, Length=221, Percent_Identity=31.6742081447964, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788407, Length=254, Percent_Identity=29.1338582677165, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=24.1279069767442, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786825, Length=378, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786552, Length=359, Percent_Identity=25.6267409470752, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=28.4883720930233, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=337, Percent_Identity=26.4094955489614, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=346, Percent_Identity=29.1907514450867, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=344, Percent_Identity=26.453488372093, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=27.7511961722488, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=262, Percent_Identity=27.4809160305344, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=30.9248554913295, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324486, Length=346, Percent_Identity=30.0578034682081, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=352, Percent_Identity=29.8295454545455, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=346, Percent_Identity=29.7687861271676, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320033, Length=380, Percent_Identity=27.3684210526316, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=23.4756097560976, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=328, Percent_Identity=23.4756097560976, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=224, Percent_Identity=27.6785714285714, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=325, Percent_Identity=25.5384615384615, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=329, Percent_Identity=24.3161094224924, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=362, Percent_Identity=27.3480662983425, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=336, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=316, Percent_Identity=25.6329113924051, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=323, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=26.4437689969605, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=26.0162601626016, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37254; Mature: 37254

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVRIHEYNKPLSLDEVNKPRVSGPYDIVVRIRGAGVCRTDLHIIEGVWKDVLNPKLPF
CCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEHHHHHHHHHHHHHHCCCCCCE
TIGHENVGIIEEKGNAVDWLDVGDQVILHPYITCRHCRACRSGNDMHCPYGKFPGLDGTD
EECCCCCEEEECCCCEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GGYAEYLRTSAFSAIKIPKGIDIIPMAPLADAGITAYHAVKKISQYLYPGSIVGVIGVGG
CHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
LGHIGIQALKAITPARVIAIDISEEKTKLAKELGADEVVIAGKDSGVSDVLKLTDNIGVD
CHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHH
AIIDFVGEHSTPQNALRMIRKGGIYSIVGYGGEFKNSTLDFINREIMVVGNLVGTYNELS
HHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCEEEEEECHHHHHHHHH
ELVTLYVQNKVKLKVKTFPLEEANSALEELKAGRILGRAVLVPS
HHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCHHHCCEEECCC
>Mature Secondary Structure
MKAVRIHEYNKPLSLDEVNKPRVSGPYDIVVRIRGAGVCRTDLHIIEGVWKDVLNPKLPF
CCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEHHHHHHHHHHHHHHCCCCCCE
TIGHENVGIIEEKGNAVDWLDVGDQVILHPYITCRHCRACRSGNDMHCPYGKFPGLDGTD
EECCCCCEEEECCCCEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GGYAEYLRTSAFSAIKIPKGIDIIPMAPLADAGITAYHAVKKISQYLYPGSIVGVIGVGG
CHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
LGHIGIQALKAITPARVIAIDISEEKTKLAKELGADEVVIAGKDSGVSDVLKLTDNIGVD
CHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHH
AIIDFVGEHSTPQNALRMIRKGGIYSIVGYGGEFKNSTLDFINREIMVVGNLVGTYNELS
HHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCEEEEEECHHHHHHHHH
ELVTLYVQNKVKLKVKTFPLEEANSALEELKAGRILGRAVLVPS
HHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHCHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]