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The map label for this gene is msr

Identifier: 15898331

GI number: 15898331

Start: 1357488

End: 1358021

Strand: Direct

Name: msr

Synonym: SSO1503

Alternate gene names: 15898331

Gene position: 1357488-1358021 (Clockwise)

Preceding gene: 15898330

Following gene: 15898333

Centisome position: 45.37

GC content: 37.83

Gene sequence:

>534_bases
ATGGAAGTTGCCACATTAGGAGGAGGTTGCTTTTGGTGCACAGAAGCAGTATATAAGAGAGTTAAGGGAGTGATAAGTGT
TAAGCCAGGCTATTCTGGTGGTCACGTACCTAATCCTACATATGAGGATGTGTGCACAGATACAACTGGACATGCGGAGG
TAGTTCAGATAACCTTTGATTCCTCTATTATTTCATATAGGGAAATTCTGGAAATCTTCTTCGAGATTCACGATCCTACT
ACGCTTAATAGGCAGGGAAACGATGTTGGAACACAATATAGGTCCATAATATTGTACCATAATGAAGAGCAGAGGAAAAT
AGCTGAGGAAATGATAAGAGAGGTTGAGAAAAGGATAGGAAAGAAAGTTGTGACTGAACTAAAGCCTTTCGAAGTATTTT
ACGAGGCAGAGGATTATCATCACGATTTCTATGACAAACATAAGTACAATCCTTACTGTAGATTAGTTATAAGCCCTAAA
GTAAAAAAATTTATGAAACTATTCCCTGATAAAGTTAAGATTCACGAAGGATAG

Upstream 100 bases:

>100_bases
CTTCTAACCCTCTCTTCCTTTTTCAATGGTGAAAGAAGAAGAACTGCCACATTAGATTTTTTTAACATAAGTTAAAAGGT
TAGTTTTCGTTAGTATTATT

Downstream 100 bases:

>100_bases
GTGAGCTACCCCCTCATAAATGAGGGAGCTTCCTGCTTCACAGCTCTGCCATGCCAGAGTACTGGTAGAGGGCGGAGCTC
CACACTAAGGGTCGCTCCGA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MEVATLGGGCFWCTEAVYKRVKGVISVKPGYSGGHVPNPTYEDVCTDTTGHAEVVQITFDSSIISYREILEIFFEIHDPT
TLNRQGNDVGTQYRSIILYHNEEQRKIAEEMIREVEKRIGKKVVTELKPFEVFYEAEDYHHDFYDKHKYNPYCRLVISPK
VKKFMKLFPDKVKIHEG

Sequences:

>Translated_177_residues
MEVATLGGGCFWCTEAVYKRVKGVISVKPGYSGGHVPNPTYEDVCTDTTGHAEVVQITFDSSIISYREILEIFFEIHDPT
TLNRQGNDVGTQYRSIILYHNEEQRKIAEEMIREVEKRIGKKVVTELKPFEVFYEAEDYHHDFYDKHKYNPYCRLVISPK
VKKFMKLFPDKVKIHEG
>Mature_177_residues
MEVATLGGGCFWCTEAVYKRVKGVISVKPGYSGGHVPNPTYEDVCTDTTGHAEVVQITFDSSIISYREILEIFFEIHDPT
TLNRQGNDVGTQYRSIILYHNEEQRKIAEEMIREVEKRIGKKVVTELKPFEVFYEAEDYHHDFYDKHKYNPYCRLVISPK
VKKFMKLFPDKVKIHEG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=158, Percent_Identity=40.5063291139241, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=40.5063291139241, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=38.9380530973451, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=42.1052631578947, Blast_Score=134, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=35.8108108108108, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=36.875, Blast_Score=114, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24664627, Length=163, Percent_Identity=35.5828220858896, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664631, Length=163, Percent_Identity=34.9693251533742, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45553131, Length=157, Percent_Identity=35.031847133758, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_SULSO (Q97Y45)

Other databases:

- EMBL:   AE006641
- PIR:   G90308
- RefSeq:   NP_342936.1
- ProteinModelPortal:   Q97Y45
- SMR:   Q97Y45
- GeneID:   1454505
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO1503
- NMPDR:   fig|273057.1.peg.1359
- HOGENOM:   HBG748152
- OMA:   RAGTFWP
- PhylomeDB:   Q97Y45
- ProtClustDB:   PRK14054
- BioCyc:   SSOL273057:SSO1503-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 20571; Mature: 20571

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVATLGGGCFWCTEAVYKRVKGVISVKPGYSGGHVPNPTYEDVCTDTTGHAEVVQITFD
CCEEECCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEC
SSIISYREILEIFFEIHDPTTLNRQGNDVGTQYRSIILYHNEEQRKIAEEMIREVEKRIG
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHH
KKVVTELKPFEVFYEAEDYHHDFYDKHKYNPYCRLVISPKVKKFMKLFPDKVKIHEG
HHHHHHCCCHHEEECCCHHCCHHHHCCCCCCEEEEEECHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MEVATLGGGCFWCTEAVYKRVKGVISVKPGYSGGHVPNPTYEDVCTDTTGHAEVVQITFD
CCEEECCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEC
SSIISYREILEIFFEIHDPTTLNRQGNDVGTQYRSIILYHNEEQRKIAEEMIREVEKRIG
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHH
KKVVTELKPFEVFYEAEDYHHDFYDKHKYNPYCRLVISPKVKKFMKLFPDKVKIHEG
HHHHHHCCCHHEEECCCHHCCHHHHCCCCCCEEEEEECHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726