BacMap

Definition	Sulfolobus solfataricus P2 chromosome, complete genome.
Accession	NC_002754
Length	2,992,245

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The map label for this gene is acsA-2 [H]

Identifier: 15898181

GI number: 15898181

Start: 1176148

End: 1176930

Strand: Reverse

Name: acsA-2 [H]

Synonym: SSO1340

Alternate gene names: 15898181

Gene position: 1176930-1176148 (Counterclockwise)

Preceding gene: 15898183

Following gene: 15898177

Centisome position: 39.33

GC content: 38.31

Gene sequence:

>783_bases
TTGCGCTTTCATCCCCCTACGGCTTTAAGAATGATTAGGAAGGAAGTTAGTAGTCCAAGGAGAGATTACGATTTAAGATT
AAGAGCAGTTAGTAGTGCTGGAGAAGCTGTGGGAGGAGACTTGATTGAGTGGGCAATGAAAGAGTTATCCCCCAATGTTA
ATGAATTTTATGGTTGTACAGAGGCTAATCTAGTGACCGTAAATAACTCCATGTGGCGTAAGATAGGATCTGTAGGTAAA
CCTACTCCCGGTCATGAGATAGCAGTCATTGATGAAAAAGGTAATGAGGTAATAAATCAAGTTGGAGAAATAGCAGTAAG
GATAGAGGATCCTGTATTATTTCTAGGATATTATAAGAATCCGGAAGCTACCGCTAAGAAGTTTAGAGGACATTGGTTCT
TAATGGGAGACCTAGGTTTAATGGATCAAAATGGTTATATTTGGTTTAAAGGGAGAGGGGATGACGTAATAAAGGTTTCC
GGCTATAGATTGGGACCGGAGGAGATAGAGAGTATTATATTACAACATCCCGCAGTTCAAGAAGTTGCTGTAATAGGTAA
GCCGGATAGGTTGAGAGGAAATGTAATAAAGGCATTTATAGTACTAAAGGATGGATATTCTCCATCTGATAGTCTAGTAG
AGGAAATTCAACAATTTGTAAAAAGCAGACTAGCCTTATATGCGTATCCTAGAGAAATAGAATTCGTTAAAGAATTACCT
AGAACGGAGACCGGTAAATTGAAGAGATTTGAGCTAAGAAAAAGAGAAGAAGAAAAAAGTTGA

Upstream 100 bases:

>100_bases
GTGTATTTCGTTATTTTCCTATTTTAACTTTTCTACAAAGGGATCCGCCTCAAAGAGAAGTTTTCCGCCCCCTTTGAACC
CCCGTCTGTTATAAGGTTAC

Downstream 100 bases:

>100_bases
CTTTTTTCAACTAAGTTGCATTCCCACTTTATCAGGTGGTGATAGTAAAGCGGCTATTCCTCCTAATATTGAAGCAGATA
TATCAAAAACTGCAATCCTA

Product: Acetyl-CoA synthetase (acetate-CoA ligase) carboxy-end fragment. (acsA-2)

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MRFHPPTALRMIRKEVSSPRRDYDLRLRAVSSAGEAVGGDLIEWAMKELSPNVNEFYGCTEANLVTVNNSMWRKIGSVGK
PTPGHEIAVIDEKGNEVINQVGEIAVRIEDPVLFLGYYKNPEATAKKFRGHWFLMGDLGLMDQNGYIWFKGRGDDVIKVS
GYRLGPEEIESIILQHPAVQEVAVIGKPDRLRGNVIKAFIVLKDGYSPSDSLVEEIQQFVKSRLALYAYPREIEFVKELP
RTETGKLKRFELRKREEEKS

Sequences:

>Translated_260_residues
MRFHPPTALRMIRKEVSSPRRDYDLRLRAVSSAGEAVGGDLIEWAMKELSPNVNEFYGCTEANLVTVNNSMWRKIGSVGK
PTPGHEIAVIDEKGNEVINQVGEIAVRIEDPVLFLGYYKNPEATAKKFRGHWFLMGDLGLMDQNGYIWFKGRGDDVIKVS
GYRLGPEEIESIILQHPAVQEVAVIGKPDRLRGNVIKAFIVLKDGYSPSDSLVEEIQQFVKSRLALYAYPREIEFVKELP
RTETGKLKRFELRKREEEKS
>Mature_260_residues
MRFHPPTALRMIRKEVSSPRRDYDLRLRAVSSAGEAVGGDLIEWAMKELSPNVNEFYGCTEANLVTVNNSMWRKIGSVGK
PTPGHEIAVIDEKGNEVINQVGEIAVRIEDPVLFLGYYKNPEATAKKFRGHWFLMGDLGLMDQNGYIWFKGRGDDVIKVS
GYRLGPEEIESIILQHPAVQEVAVIGKPDRLRGNVIKAFIVLKDGYSPSDSLVEEIQQFVKSRLALYAYPREIEFVKELP
RTETGKLKRFELRKREEEKS

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=260, Percent_Identity=42.3076923076923, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI157311624, Length=263, Percent_Identity=40.3041825095057, Blast_Score=185, Evalue=3e-47,
Organism=Homo sapiens, GI157311622, Length=263, Percent_Identity=40.3041825095057, Blast_Score=185, Evalue=3e-47,
Organism=Homo sapiens, GI122937307, Length=261, Percent_Identity=42.1455938697318, Blast_Score=185, Evalue=3e-47,
Organism=Homo sapiens, GI38505220, Length=258, Percent_Identity=41.0852713178295, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI58082049, Length=263, Percent_Identity=39.9239543726236, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI115511026, Length=209, Percent_Identity=49.7607655502392, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI13375727, Length=266, Percent_Identity=34.2105263157895, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI28416953, Length=278, Percent_Identity=33.4532374100719, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI156151445, Length=208, Percent_Identity=33.1730769230769, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI187761345, Length=223, Percent_Identity=32.7354260089686, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI187761343, Length=223, Percent_Identity=32.7354260089686, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI253970489, Length=264, Percent_Identity=30.3030303030303, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI8923896, Length=264, Percent_Identity=30.3030303030303, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI195947378, Length=144, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788107, Length=202, Percent_Identity=40.0990099009901, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790505, Length=264, Percent_Identity=31.0606060606061, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI145693145, Length=203, Percent_Identity=35.9605911330049, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI221142682, Length=185, Percent_Identity=33.5135135135135, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1786810, Length=256, Percent_Identity=28.515625, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786529, Length=268, Percent_Identity=32.089552238806, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789201, Length=237, Percent_Identity=24.8945147679325, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538037, Length=262, Percent_Identity=32.824427480916, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559526, Length=264, Percent_Identity=31.4393939393939, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=259, Percent_Identity=32.4324324324324, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17531443, Length=254, Percent_Identity=33.0708661417323, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=236, Percent_Identity=32.6271186440678, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=201, Percent_Identity=32.3383084577114, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=206, Percent_Identity=32.5242718446602, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=206, Percent_Identity=32.5242718446602, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560140, Length=232, Percent_Identity=30.1724137931034, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994703, Length=206, Percent_Identity=32.5242718446602, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=201, Percent_Identity=30.8457711442786, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982997, Length=271, Percent_Identity=29.1512915129151, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=243, Percent_Identity=30.0411522633745, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71996755, Length=208, Percent_Identity=29.8076923076923, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560308, Length=248, Percent_Identity=30.241935483871, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17556552, Length=153, Percent_Identity=31.3725490196078, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=230, Percent_Identity=33.9130434782609, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319264, Length=271, Percent_Identity=33.5793357933579, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323182, Length=278, Percent_Identity=32.7338129496403, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356947, Length=210, Percent_Identity=32.3809523809524, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24667959, Length=265, Percent_Identity=28.3018867924528, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI62472339, Length=265, Percent_Identity=28.3018867924528, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24667955, Length=265, Percent_Identity=28.3018867924528, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18859661, Length=263, Percent_Identity=30.4182509505703, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21355225, Length=263, Percent_Identity=30.0380228136882, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24653035, Length=205, Percent_Identity=34.6341463414634, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581924, Length=234, Percent_Identity=30.3418803418803, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19922652, Length=179, Percent_Identity=32.9608938547486, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20130357, Length=268, Percent_Identity=30.2238805970149, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656500, Length=209, Percent_Identity=30.1435406698565, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI161076582, Length=211, Percent_Identity=32.7014218009479, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355181, Length=261, Percent_Identity=29.8850574712644, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358303, Length=175, Percent_Identity=35.4285714285714, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356441, Length=211, Percent_Identity=33.175355450237, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24648260, Length=257, Percent_Identity=26.8482490272374, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281365686, Length=176, Percent_Identity=34.0909090909091, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648257, Length=198, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24648253, Length=211, Percent_Identity=29.3838862559242, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648255, Length=259, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 29551; Mature: 29551

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFHPPTALRMIRKEVSSPRRDYDLRLRAVSSAGEAVGGDLIEWAMKELSPNVNEFYGCT
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHCCCC
EANLVTVNNSMWRKIGSVGKPTPGHEIAVIDEKGNEVINQVGEIAVRIEDPVLFLGYYKN
CCCEEEECHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCEEEEEEECC
PEATAKKFRGHWFLMGDLGLMDQNGYIWFKGRGDDVIKVSGYRLGPEEIESIILQHPAVQ
CHHHHHHHCCCEEEEECCCEEECCCEEEEEECCCCEEEECCEECCHHHHHHHHHCCCCHH
EVAVIGKPDRLRGNVIKAFIVLKDGYSPSDSLVEEIQQFVKSRLALYAYPREIEFVKELP
HHEECCCCCHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
RTETGKLKRFELRKREEEKS
CCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRFHPPTALRMIRKEVSSPRRDYDLRLRAVSSAGEAVGGDLIEWAMKELSPNVNEFYGCT
CCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHCCCC
EANLVTVNNSMWRKIGSVGKPTPGHEIAVIDEKGNEVINQVGEIAVRIEDPVLFLGYYKN
CCCEEEECHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCEEEEEEECC
PEATAKKFRGHWFLMGDLGLMDQNGYIWFKGRGDDVIKVSGYRLGPEEIESIILQHPAVQ
CHHHHHHHCCCEEEEECCCEEECCCEEEEEECCCCEEEECCEECCHHHHHHHHHCCCCHH
EVAVIGKPDRLRGNVIKAFIVLKDGYSPSDSLVEEIQQFVKSRLALYAYPREIEFVKELP
HHEECCCCCHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
RTETGKLKRFELRKREEEKS
CCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]