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The map label for this gene is adh-3 [H]

Identifier: 15898072

GI number: 15898072

Start: 1059884

End: 1060972

Strand: Direct

Name: adh-3 [H]

Synonym: SSO1220

Alternate gene names: 15898072

Gene position: 1059884-1060972 (Clockwise)

Preceding gene: 15898070

Following gene: 15898073

Centisome position: 35.42

GC content: 38.02

Gene sequence:

>1089_bases
TTGATGAAGGCAGCTAGATTAGTGGAGTTTCAAAAACCTCTTAAAATAGAGGATCTAGATGTTCCTAAAGTGGGAAAAGG
AGATGTACTTCTGAAAGTGATAAGCTGTGGAATATGCAGATCAGATTGGCATCTATGGCGTGGAGATCCTGCTTTGGTAG
CATACATGCAGTGGAGTGGTGGTAAGTTACCAATAACTCAAGGTCACGAGGTTTATGGAGAAATTGTAGAGGTTGGAGAG
AGTGTAACTAGATTAAATAAGGGAGATAAAGTAGTTATGCCTGCTTCTTCTACCGGAGATAATAGGACATGCAAATACTG
TATGGAAGGAGATTCAAATGTTTGTGAACACTTAGTAATAGCTGGTTATGGAATTAATGGATGCTTTGCCGAGTACATGC
TAATCCCAGAGAGGTCAGTAATTGATCTAGTTAAAGTACCAGATGGAATAAAGTCAGAGTGGGCTGCTCTAAGTTCTTGT
GGTTTTGGAACTTCATGGAATGCGTTTACAATGAAGACTAATTTAAAGCCCAGTGACATAGTGGTCATAATCGGAGCAGG
TGGAATGGGTTTGAGTGGTATAGCAATAGCTAACGCTCTTGGAGCTAAAGTGATAGCTATAGACGTTAACGAACGATCTT
TAGAGAAAGCTAAGATGTTAGGTAGCGTTGAGACTTATAGACACTCTGGTAAGTCTGAGGAATTGAATAAAATAGTAGAG
GATATTATGAAGAAGTATGGTTCAGTGGACGTAATATATGATACTACCGGAATTCCAGAGGCTGTCATTCCATTTTTGCC
TCTCCTTAAAGTACATGGAACATTGCTATTAGCGGGGCTTATGATGAAGGGGAAAGAGATTTTTCCATTGCCAGCAGATT
TAGTAGTAGCAAGGGAAATCAGAATACAAGGAGTATTAATGTTACCAGCTCAAAAATTCGATACAATATTTAAATTAATG
AAGGAAGGAAAGATTAACCTAGATCCGGTTATTTACAAGACTATAAGCATCTATGATGTCAATGATGCCTACAAGGAAAT
GAGCGAGTACAAAAATGCAGGAAGAATTATTATTAATAAGTTTAGTTAA

Upstream 100 bases:

>100_bases
ATTATTGATATTTTAATTAATTTATTCATCTAATTTACTTTATTTTTCATATCGAACATGTTAGAGAAATCCATTTTAGT
AGAGTAAGATAAAATTTCTT

Downstream 100 bases:

>100_bases
TTTTTCTCTTTTTTCCTAATTATAAAACAAGTTTTAGAAAGGTTTATTAAGACAAGGAGAGAAAAAACAATATGGAAGAA
ATACGTCCTTACTATAATAC

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MMKAARLVEFQKPLKIEDLDVPKVGKGDVLLKVISCGICRSDWHLWRGDPALVAYMQWSGGKLPITQGHEVYGEIVEVGE
SVTRLNKGDKVVMPASSTGDNRTCKYCMEGDSNVCEHLVIAGYGINGCFAEYMLIPERSVIDLVKVPDGIKSEWAALSSC
GFGTSWNAFTMKTNLKPSDIVVIIGAGGMGLSGIAIANALGAKVIAIDVNERSLEKAKMLGSVETYRHSGKSEELNKIVE
DIMKKYGSVDVIYDTTGIPEAVIPFLPLLKVHGTLLLAGLMMKGKEIFPLPADLVVAREIRIQGVLMLPAQKFDTIFKLM
KEGKINLDPVIYKTISIYDVNDAYKEMSEYKNAGRIIINKFS

Sequences:

>Translated_362_residues
MMKAARLVEFQKPLKIEDLDVPKVGKGDVLLKVISCGICRSDWHLWRGDPALVAYMQWSGGKLPITQGHEVYGEIVEVGE
SVTRLNKGDKVVMPASSTGDNRTCKYCMEGDSNVCEHLVIAGYGINGCFAEYMLIPERSVIDLVKVPDGIKSEWAALSSC
GFGTSWNAFTMKTNLKPSDIVVIIGAGGMGLSGIAIANALGAKVIAIDVNERSLEKAKMLGSVETYRHSGKSEELNKIVE
DIMKKYGSVDVIYDTTGIPEAVIPFLPLLKVHGTLLLAGLMMKGKEIFPLPADLVVAREIRIQGVLMLPAQKFDTIFKLM
KEGKINLDPVIYKTISIYDVNDAYKEMSEYKNAGRIIINKFS
>Mature_362_residues
MMKAARLVEFQKPLKIEDLDVPKVGKGDVLLKVISCGICRSDWHLWRGDPALVAYMQWSGGKLPITQGHEVYGEIVEVGE
SVTRLNKGDKVVMPASSTGDNRTCKYCMEGDSNVCEHLVIAGYGINGCFAEYMLIPERSVIDLVKVPDGIKSEWAALSSC
GFGTSWNAFTMKTNLKPSDIVVIIGAGGMGLSGIAIANALGAKVIAIDVNERSLEKAKMLGSVETYRHSGKSEELNKIVE
DIMKKYGSVDVIYDTTGIPEAVIPFLPLLKVHGTLLLAGLMMKGKEIFPLPADLVVAREIRIQGVLMLPAQKFDTIFKLM
KEGKINLDPVIYKTISIYDVNDAYKEMSEYKNAGRIIINKFS

Specific function: Threonine catabolism; first step. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=383, Percent_Identity=27.154046997389, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI262073058, Length=383, Percent_Identity=27.154046997389, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI71565152, Length=387, Percent_Identity=25.8397932816537, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=28.3422459893048, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=28.0748663101604, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4501929, Length=384, Percent_Identity=26.5625, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI71565154, Length=380, Percent_Identity=26.3157894736842, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4501939, Length=385, Percent_Identity=25.4545454545455, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI156523966, Length=385, Percent_Identity=25.4545454545455, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI156627571, Length=337, Percent_Identity=24.3323442136499, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1790045, Length=369, Percent_Identity=27.10027100271, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1786552, Length=389, Percent_Identity=28.2776349614396, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788407, Length=356, Percent_Identity=26.4044943820225, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=30.4477611940298, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788073, Length=368, Percent_Identity=26.6304347826087, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI226510992, Length=341, Percent_Identity=27.2727272727273, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082125, Length=354, Percent_Identity=28.8135593220339, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786518, Length=376, Percent_Identity=26.063829787234, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1787863, Length=347, Percent_Identity=27.3775216138329, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786825, Length=285, Percent_Identity=27.3684210526316, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788075, Length=377, Percent_Identity=24.9336870026525, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790718, Length=335, Percent_Identity=22.089552238806, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=27.4052478134111, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=211, Percent_Identity=33.175355450237, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=367, Percent_Identity=25.3405994550409, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=376, Percent_Identity=26.063829787234, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=378, Percent_Identity=26.1904761904762, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=25.0712250712251, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=346, Percent_Identity=24.8554913294798, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=346, Percent_Identity=25.4335260115607, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=29.8780487804878, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=328, Percent_Identity=29.8780487804878, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=330, Percent_Identity=27.5757575757576, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=337, Percent_Identity=25.5192878338279, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=25, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=361, Percent_Identity=25.4847645429363, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=365, Percent_Identity=25.4794520547945, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=350, Percent_Identity=25.1428571428571, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=221, Percent_Identity=29.8642533936652, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=208, Percent_Identity=29.8076923076923, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=203, Percent_Identity=29.5566502463054, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17737895, Length=322, Percent_Identity=26.7080745341615, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737897, Length=355, Percent_Identity=27.6056338028169, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39683; Mature: 39683

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKAARLVEFQKPLKIEDLDVPKVGKGDVLLKVISCGICRSDWHLWRGDPALVAYMQWSG
CCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCEEEEEEECCC
GKLPITQGHEVYGEIVEVGESVTRLNKGDKVVMPASSTGDNRTCKYCMEGDSNVCEHLVI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHEE
AGYGINGCFAEYMLIPERSVIDLVKVPDGIKSEWAALSSCGFGTSWNAFTMKTNLKPSDI
ECCCCHHHHHHHEECCCCCHHHHEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCE
VVIIGAGGMGLSGIAIANALGAKVIAIDVNERSLEKAKMLGSVETYRHSGKSEELNKIVE
EEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DIMKKYGSVDVIYDTTGIPEAVIPFLPLLKVHGTLLLAGLMMKGKEIFPLPADLVVAREI
HHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHEEEEE
RIQGVLMLPAQKFDTIFKLMKEGKINLDPVIYKTISIYDVNDAYKEMSEYKNAGRIIINK
EEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCHHHHHHHHHCCCCEEEEEE
FS
CC
>Mature Secondary Structure
MMKAARLVEFQKPLKIEDLDVPKVGKGDVLLKVISCGICRSDWHLWRGDPALVAYMQWSG
CCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCEEEEEEECCC
GKLPITQGHEVYGEIVEVGESVTRLNKGDKVVMPASSTGDNRTCKYCMEGDSNVCEHLVI
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHEE
AGYGINGCFAEYMLIPERSVIDLVKVPDGIKSEWAALSSCGFGTSWNAFTMKTNLKPSDI
ECCCCHHHHHHHEECCCCCHHHHEECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCE
VVIIGAGGMGLSGIAIANALGAKVIAIDVNERSLEKAKMLGSVETYRHSGKSEELNKIVE
EEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
DIMKKYGSVDVIYDTTGIPEAVIPFLPLLKVHGTLLLAGLMMKGKEIFPLPADLVVAREI
HHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHEEEEE
RIQGVLMLPAQKFDTIFKLMKEGKINLDPVIYKTISIYDVNDAYKEMSEYKNAGRIIINK
EEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCHHHHHHHHHCCCCEEEEEE
FS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]