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The map label for this gene is yhcA [H]

Identifier: 15898017

GI number: 15898017

Start: 1002143

End: 1003558

Strand: Direct

Name: yhcA [H]

Synonym: SSO1162

Alternate gene names: 15898017

Gene position: 1002143-1003558 (Clockwise)

Preceding gene: 15898011

Following gene: 15898019

Centisome position: 33.49

GC content: 39.05

Gene sequence:

>1416_bases
ATGAACTCAAGCAATCTAGCACTTCTAGTTCTAGTCTTTGGGACTTTGATGTCAGCAATAGATACCACAATAGTAATTTT
GGCAATACCAACAATAACTGAAGACTTACATGCAGACCTATTCATTATGATCTGGGTAATCATTTTGTATTTACTAGTTA
TAGCAGTATTCACTACTCAGTTGGGAAGATTGGGCGACATATATGGAAGGGCGAAATTTTACAACTTAGGCTTTGCAATC
TTTACCTTAGGTTCAGCGTTATGTGGGGCGTCTCCCAATGCGATTTATTTAGTAGTCTTTAGGGGTATTCAAGGTATTGG
GGCAGCTATGATGCAAGCCAATGCAGGGGCAATAATAGCGGATATTTTTCCTCCAAATAGAAGAGGAAGGGCTTATGGAT
ATACTGCAATAGGTTGGAATGCTGGAGCTACATTGGGTATAGTCCTAGGTGGATTTATTACTACCTTCGTTGGTTGGCGT
TACATATTTTACATTAATGTACCGATAGGAATTATCGCATTGATCTTAGGTTTAAGGTACATCAAAACCTTAGAAACTAG
GAAAGTTAAATTGGATATTGCTGGAATGGGTACTCTATTAGTCGCATTGTCATCCATGGTTTATGGCGCTGTCGATATTG
CTGGATATGGGATTAGAGCTTTGAATATGGTCTTGATTTCCCTTGGTCTAGTAATTTTGCTAATATTCTTCTGGTTAGAG
GGAAGACATGAATTCCCAATAATTGACTTAAGGGTCTTTAAGGGTAATAGAGTCTTCACGTTTTCATTGTTAGCGTCTTT
CTTACAAAGTACTGGTTATTTAGCTACGGCGTTTATTATAATAATGTATTTACAAGGCATAAGAGCTCTGTCACCTCTTA
ATGCGTCCCTTCTTCTCGTTCCCGGTTATGTCTTAGCCAGTCTAGTAGCTCCATTTACTGGTAGATTATCTGATAAGATA
GGTGCTAGAATGCCCGCTACTATAGGGTTAAGTTTAATGATAGTTGCTGTCTTAATTTACCTCACTCTCTCCCTGAATAC
CCCACTCTATATTGTAATATTGGCTTCTACAATTGGAGGCATAGGTTCTTCATTGTTTTTCCCTGCCAATAACAGCGCGA
TCATGGCAAATGCTCCTAAGGGATTTTATGGTGGTGCGTCTGGACTAGCAAGGACATTAGCCAACTTAGGGAGTATAATC
AGTTATACAATAGCAATTAGCGTATCATCTATCGTCATTCCTAGATATGTGGCATTTGAGGTTTTCCTAGGGACTTCAAA
CCTTATAGGTGGTGTGGCTTCTGCGTTTCTAACAGGATTAAAGGCCGCATTTTACGTTTCCTTAGCTATCTTAGCAATAG
CGTTAGTACTTTCTGCAATTAGAGGTAAGGAGGTTAGAACTCAAGTTTCAAAGTGA

Upstream 100 bases:

>100_bases
TCTAGACTCACGTTAGGGTATGAAATTATCTCATCCTAATTTTTATTTGGCATAACGCTAATATGAAAAACATAAATAGT
TAGAGTGTTAACTATTAATT

Downstream 100 bases:

>100_bases
ACAATTGAGATGCTTTTTGATCTATTGAATATATTTTTACTATTAGACTACAATCATGTACTCGTTTCAATTCCTGTACG
GATGTACAATTTAGCTTCGT

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MNSSNLALLVLVFGTLMSAIDTTIVILAIPTITEDLHADLFIMIWVIILYLLVIAVFTTQLGRLGDIYGRAKFYNLGFAI
FTLGSALCGASPNAIYLVVFRGIQGIGAAMMQANAGAIIADIFPPNRRGRAYGYTAIGWNAGATLGIVLGGFITTFVGWR
YIFYINVPIGIIALILGLRYIKTLETRKVKLDIAGMGTLLVALSSMVYGAVDIAGYGIRALNMVLISLGLVILLIFFWLE
GRHEFPIIDLRVFKGNRVFTFSLLASFLQSTGYLATAFIIIMYLQGIRALSPLNASLLLVPGYVLASLVAPFTGRLSDKI
GARMPATIGLSLMIVAVLIYLTLSLNTPLYIVILASTIGGIGSSLFFPANNSAIMANAPKGFYGGASGLARTLANLGSII
SYTIAISVSSIVIPRYVAFEVFLGTSNLIGGVASAFLTGLKAAFYVSLAILAIALVLSAIRGKEVRTQVSK

Sequences:

>Translated_471_residues
MNSSNLALLVLVFGTLMSAIDTTIVILAIPTITEDLHADLFIMIWVIILYLLVIAVFTTQLGRLGDIYGRAKFYNLGFAI
FTLGSALCGASPNAIYLVVFRGIQGIGAAMMQANAGAIIADIFPPNRRGRAYGYTAIGWNAGATLGIVLGGFITTFVGWR
YIFYINVPIGIIALILGLRYIKTLETRKVKLDIAGMGTLLVALSSMVYGAVDIAGYGIRALNMVLISLGLVILLIFFWLE
GRHEFPIIDLRVFKGNRVFTFSLLASFLQSTGYLATAFIIIMYLQGIRALSPLNASLLLVPGYVLASLVAPFTGRLSDKI
GARMPATIGLSLMIVAVLIYLTLSLNTPLYIVILASTIGGIGSSLFFPANNSAIMANAPKGFYGGASGLARTLANLGSII
SYTIAISVSSIVIPRYVAFEVFLGTSNLIGGVASAFLTGLKAAFYVSLAILAIALVLSAIRGKEVRTQVSK
>Mature_471_residues
MNSSNLALLVLVFGTLMSAIDTTIVILAIPTITEDLHADLFIMIWVIILYLLVIAVFTTQLGRLGDIYGRAKFYNLGFAI
FTLGSALCGASPNAIYLVVFRGIQGIGAAMMQANAGAIIADIFPPNRRGRAYGYTAIGWNAGATLGIVLGGFITTFVGWR
YIFYINVPIGIIALILGLRYIKTLETRKVKLDIAGMGTLLVALSSMVYGAVDIAGYGIRALNMVLISLGLVILLIFFWLE
GRHEFPIIDLRVFKGNRVFTFSLLASFLQSTGYLATAFIIIMYLQGIRALSPLNASLLLVPGYVLASLVAPFTGRLSDKI
GARMPATIGLSLMIVAVLIYLTLSLNTPLYIVILASTIGGIGSSLFFPANNSAIMANAPKGFYGGASGLARTLANLGSII
SYTIAISVSSIVIPRYVAFEVFLGTSNLIGGVASAFLTGLKAAFYVSLAILAIALVLSAIRGKEVRTQVSK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=406, Percent_Identity=29.064039408867, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790195, Length=413, Percent_Identity=29.2978208232446, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788392, Length=409, Percent_Identity=27.1393643031785, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788710, Length=398, Percent_Identity=28.1407035175879, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789042, Length=415, Percent_Identity=25.5421686746988, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324954, Length=393, Percent_Identity=26.972010178117, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323735, Length=240, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319770, Length=349, Percent_Identity=25.7879656160458, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50173; Mature: 50173

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSNLALLVLVFGTLMSAIDTTIVILAIPTITEDLHADLFIMIWVIILYLLVIAVFTTQ
CCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGRLGDIYGRAKFYNLGFAIFTLGSALCGASPNAIYLVVFRGIQGIGAAMMQANAGAIIA
HHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEE
DIFPPNRRGRAYGYTAIGWNAGATLGIVLGGFITTFVGWRYIFYINVPIGIIALILGLRY
ECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHH
IKTLETRKVKLDIAGMGTLLVALSSMVYGAVDIAGYGIRALNMVLISLGLVILLIFFWLE
HHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GRHEFPIIDLRVFKGNRVFTFSLLASFLQSTGYLATAFIIIMYLQGIRALSPLNASLLLV
CCCCCCEEEEEEECCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
PGYVLASLVAPFTGRLSDKIGARMPATIGLSLMIVAVLIYLTLSLNTPLYIVILASTIGG
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCC
IGSSLFFPANNSAIMANAPKGFYGGASGLARTLANLGSIISYTIAISVSSIVIPRYVAFE
CCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLGTSNLIGGVASAFLTGLKAAFYVSLAILAIALVLSAIRGKEVRTQVSK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MNSSNLALLVLVFGTLMSAIDTTIVILAIPTITEDLHADLFIMIWVIILYLLVIAVFTTQ
CCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGRLGDIYGRAKFYNLGFAIFTLGSALCGASPNAIYLVVFRGIQGIGAAMMQANAGAIIA
HHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEE
DIFPPNRRGRAYGYTAIGWNAGATLGIVLGGFITTFVGWRYIFYINVPIGIIALILGLRY
ECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHH
IKTLETRKVKLDIAGMGTLLVALSSMVYGAVDIAGYGIRALNMVLISLGLVILLIFFWLE
HHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GRHEFPIIDLRVFKGNRVFTFSLLASFLQSTGYLATAFIIIMYLQGIRALSPLNASLLLV
CCCCCCEEEEEEECCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
PGYVLASLVAPFTGRLSDKIGARMPATIGLSLMIVAVLIYLTLSLNTPLYIVILASTIGG
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCC
IGSSLFFPANNSAIMANAPKGFYGGASGLARTLANLGSIISYTIAISVSSIVIPRYVAFE
CCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLGTSNLIGGVASAFLTGLKAAFYVSLAILAIALVLSAIRGKEVRTQVSK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]