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The map label for this gene is purE

Identifier: 15897932

GI number: 15897932

Start: 922767

End: 923243

Strand: Direct

Name: purE

Synonym: SSO1064

Alternate gene names: 15897932

Gene position: 922767-923243 (Clockwise)

Preceding gene: 15897930

Following gene: 15897933

Centisome position: 30.84

GC content: 39.83

Gene sequence:

>477_bases
GTGCCAAAAGTAGCTGTAATTATGGGAAGTAAAAATGACTGGGAATATATGAGAGAAGCTGTAGAGATTTTGAAACAATT
CGGGATAGACTATGAGGCTAGAGTGGTTTCAGCTCATAGAACACCAGAATTTATGATGCAATACGCTAAAGAAGCAGAAA
AAAGAGGAATAGAAGTAATTATTGCTGGGGCTGGTGGAGCAGCTCATTTGCCAGGCATGGTTGCTTCACTTACAAGTCTT
CCAGTTATTGGTGTTCCTATTCCCTCAAAGAATCTAAATGGTCTTGACTCGCTTCTTTCAATAGTGCAAATGCCCTATGG
AGTCCCAGTAGCTACTGTGGCAATAGGTGGTGCCAAAAACGCTGCGCTACTGGCAATTAGGATTTTAGGAATAAAATATA
AGGAATTAGCAGATAAAATTAAAAAATTCTCAGAGGATATGAGGAACGATGTTCTCAGTACTAGACTGGAAGCCTAA

Upstream 100 bases:

>100_bases
AATTATCTGAAAGACCTCATTCTCATCAGCTGGGTTTACTTCTAACACAAATATTATCTTAATCAAAAAGATATTTAACC
ATAAAACCCACCTACCTAGT

Downstream 100 bases:

>100_bases
AATTGGAATATTAGGAGGAGGACAGCTCGGCTGGATGATAGTATTAGAGGGTAGAAAATACCCATTTACTTTTTACGTAT
TAGAGAACGATAAGAATGCT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit (purE)

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MPKVAVIMGSKNDWEYMREAVEILKQFGIDYEARVVSAHRTPEFMMQYAKEAEKRGIEVIIAGAGGAAHLPGMVASLTSL
PVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLAIRILGIKYKELADKIKKFSEDMRNDVLSTRLEA

Sequences:

>Translated_158_residues
MPKVAVIMGSKNDWEYMREAVEILKQFGIDYEARVVSAHRTPEFMMQYAKEAEKRGIEVIIAGAGGAAHLPGMVASLTSL
PVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLAIRILGIKYKELADKIKKFSEDMRNDVLSTRLEA
>Mature_157_residues
PKVAVIMGSKNDWEYMREAVEILKQFGIDYEARVVSAHRTPEFMMQYAKEAEKRGIEVIIAGAGGAAHLPGMVASLTSLP
VIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKNAALLAIRILGIKYKELADKIKKFSEDMRNDVLSTRLEA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=55.8558558558559, Blast_Score=134, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17531275, Length=111, Percent_Identity=36.9369369369369, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=56.953642384106, Blast_Score=168, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_SULSO (O06456)

Other databases:

- EMBL:   Y13143
- EMBL:   AE006641
- PIR:   H90258
- RefSeq:   NP_342537.1
- ProteinModelPortal:   O06456
- SMR:   O06456
- GeneID:   1454106
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO1064
- NMPDR:   fig|273057.1.peg.960
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- PhylomeDB:   O06456
- ProtClustDB:   CLSK802986
- BioCyc:   SSOL273057:SSO1064-MONOMER
- BRENDA:   4.1.1.21
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 17096; Mature: 16965

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 13-13 BINDING 40-40

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVAVIMGSKNDWEYMREAVEILKQFGIDYEARVVSAHRTPEFMMQYAKEAEKRGIEVI
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHHHHHCCCEEE
IAGAGGAAHLPGMVASLTSLPVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKN
EECCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
AALLAIRILGIKYKELADKIKKFSEDMRNDVLSTRLEA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PKVAVIMGSKNDWEYMREAVEILKQFGIDYEARVVSAHRTPEFMMQYAKEAEKRGIEVI
CCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHHHHHCCCEEE
IAGAGGAAHLPGMVASLTSLPVIGVPIPSKNLNGLDSLLSIVQMPYGVPVATVAIGGAKN
EECCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
AALLAIRILGIKYKELADKIKKFSEDMRNDVLSTRLEA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726