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The map label for this gene is nadA

Identifier: 15897874

GI number: 15897874

Start: 855569

End: 856504

Strand: Direct

Name: nadA

Synonym: SSO0998

Alternate gene names: 15897874

Gene position: 855569-856504 (Clockwise)

Preceding gene: 15897870

Following gene: 15897875

Centisome position: 28.59

GC content: 36.65

Gene sequence:

>936_bases
ATGACAAGAGTTGAAGAGTTACTCAGTCAAATAAAGAACCTAAAAACTGAAAAGAATGCAATAATTTTAGGACATAATTA
CATGGAATACTCTGTTCAGTTAGTTTCAGACTTCACTGGAGATTCTTACGACTTGGCAGTTAAGGCAATGAAGACAAACG
CTAAGATAATATTATTTGCAGGAGTGTACTTCATGGCAGAACAAGCCTCAGCATTAAATCCAAACAAGAAAGTACTCTCC
CCAGATCCTAATGCGGGTTGTACGTTATCTGATTCACTTGACGTTAAAACATTGCAAGAATATAAAGAGAAGTACCCTAA
TGCCCCAGTAGTGCTTTACATAAATACCAGCATTTATGCTAAGGCTTTAGCAGATTACATAGTAACATCTTCAACTGCAG
TGAAAGTCGTGCAGAAACTAAACGCAGATACAATACTATTTGGACCAGATGCTAATCTAGCTAACTACGTTCAACAAAAA
GTTCCCAATAAGAAGATTATTAAAGTACCGCCAAATGGTAGATGTATAGTACATGCCAACTATACTAAACAACTAGTAGA
ACTAGCAAGGAAGAAGTACCCTAATGCTCTATTAATGGCTCATCCAGAGGCACCATTAGAAATTTTAGAAAGCGCAGATT
TCGTGGGATCCACTAATCAAATGATACAATTCTCAAAAGAGAACAAAAATGAGGAGTTCATAGTTGCAACGGAAATAGGT
ATGATAAATGCTCTGAAGATTAAGAATCCGAGTAAGAAATTCTATCCACTCGTTACGACGGAAGCTTGTGCTTGTGCTAG
GTGCCCATATATGAATATGATAAATTTGGAAAAGGTAAAGAGGTCTTTAGAGGAAGAGGTTTACGAGGTTAAGGTACCAG
AGGATATTGCAGAAAGGGTTAAAAGGGCATTTGAAAATACTATGAAGTTGCTATAA

Upstream 100 bases:

>100_bases
AAATGTAGATCATACTCGAACATATGTTCGACCAAATAAAAAGTTTTTTATTAGCCAAAAGTTTTTATACCAGGTTACTA
TACGAACATATGTTCGGAAA

Downstream 100 bases:

>100_bases
TGATAAAAATTGATTTTATTAAATATACGGTTTTTAGCTTTCTTTTCGCTATATATTATTTAAATTTATTCCATATTTCC
TATACCAAATATCTAGTTAT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTRVEELLSQIKNLKTEKNAIILGHNYMEYSVQLVSDFTGDSYDLAVKAMKTNAKIILFAGVYFMAEQASALNPNKKVLS
PDPNAGCTLSDSLDVKTLQEYKEKYPNAPVVLYINTSIYAKALADYIVTSSTAVKVVQKLNADTILFGPDANLANYVQQK
VPNKKIIKVPPNGRCIVHANYTKQLVELARKKYPNALLMAHPEAPLEILESADFVGSTNQMIQFSKENKNEEFIVATEIG
MINALKIKNPSKKFYPLVTTEACACARCPYMNMINLEKVKRSLEEEVYEVKVPEDIAERVKRAFENTMKLL

Sequences:

>Translated_311_residues
MTRVEELLSQIKNLKTEKNAIILGHNYMEYSVQLVSDFTGDSYDLAVKAMKTNAKIILFAGVYFMAEQASALNPNKKVLS
PDPNAGCTLSDSLDVKTLQEYKEKYPNAPVVLYINTSIYAKALADYIVTSSTAVKVVQKLNADTILFGPDANLANYVQQK
VPNKKIIKVPPNGRCIVHANYTKQLVELARKKYPNALLMAHPEAPLEILESADFVGSTNQMIQFSKENKNEEFIVATEIG
MINALKIKNPSKKFYPLVTTEACACARCPYMNMINLEKVKRSLEEEVYEVKVPEDIAERVKRAFENTMKLL
>Mature_310_residues
TRVEELLSQIKNLKTEKNAIILGHNYMEYSVQLVSDFTGDSYDLAVKAMKTNAKIILFAGVYFMAEQASALNPNKKVLSP
DPNAGCTLSDSLDVKTLQEYKEKYPNAPVVLYINTSIYAKALADYIVTSSTAVKVVQKLNADTILFGPDANLANYVQQKV
PNKKIIKVPPNGRCIVHANYTKQLVELARKKYPNALLMAHPEAPLEILESADFVGSTNQMIQFSKENKNEEFIVATEIGM
INALKIKNPSKKFYPLVTTEACACARCPYMNMINLEKVKRSLEEEVYEVKVPEDIAERVKRAFENTMKLL

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=302, Percent_Identity=35.0993377483444, Blast_Score=185, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_SULSO (Q97ZC4)

Other databases:

- EMBL:   AE006641
- PIR:   F90251
- RefSeq:   NP_342479.1
- ProteinModelPortal:   Q97ZC4
- GeneID:   1455236
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0998
- NMPDR:   fig|273057.1.peg.902
- HOGENOM:   HBG291157
- OMA:   CPVHEFL
- PhylomeDB:   Q97ZC4
- ProtClustDB:   PRK09375
- BioCyc:   SSOL273057:SSO0998-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 34885; Mature: 34754

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: BINDING 25-25 BINDING 42-42 BINDING 113-113 BINDING 130-130 BINDING 201-201 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVEELLSQIKNLKTEKNAIILGHNYMEYSVQLVSDFTGDSYDLAVKAMKTNAKIILFA
CCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHEEEHHCCCCCCEEEEEEEECCCEEEEEE
GVYFMAEQASALNPNKKVLSPDPNAGCTLSDSLDVKTLQEYKEKYPNAPVVLYINTSIYA
HHHHHHHHHHHCCCCCCEECCCCCCCCEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHH
KALADYIVTSSTAVKVVQKLNADTILFGPDANLANYVQQKVPNKKIIKVPPNGRCIVHAN
HHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCEEEECCCCEEEEEEC
YTKQLVELARKKYPNALLMAHPEAPLEILESADFVGSTNQMIQFSKENKNEEFIVATEIG
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHEEECCCCCCCCEEEEEECC
MINALKIKNPSKKFYPLVTTEACACARCPYMNMINLEKVKRSLEEEVYEVKVPEDIAERV
CEEEEEECCCCCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHEEECCHHHHHHH
KRAFENTMKLL
HHHHHHHHHCC
>Mature Secondary Structure 
TRVEELLSQIKNLKTEKNAIILGHNYMEYSVQLVSDFTGDSYDLAVKAMKTNAKIILFA
CHHHHHHHHHHCCCCCCCEEEEECCHHHHHHEEEHHCCCCCCEEEEEEEECCCEEEEEE
GVYFMAEQASALNPNKKVLSPDPNAGCTLSDSLDVKTLQEYKEKYPNAPVVLYINTSIYA
HHHHHHHHHHHCCCCCCEECCCCCCCCEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHH
KALADYIVTSSTAVKVVQKLNADTILFGPDANLANYVQQKVPNKKIIKVPPNGRCIVHAN
HHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCEEEECCCCEEEEEEC
YTKQLVELARKKYPNALLMAHPEAPLEILESADFVGSTNQMIQFSKENKNEEFIVATEIG
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHEEECCCCCCCCEEEEEECC
MINALKIKNPSKKFYPLVTTEACACARCPYMNMINLEKVKRSLEEEVYEVKVPEDIAERV
CEEEEEECCCCCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHEEECCHHHHHHH
KRAFENTMKLL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726