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The map label for this gene is pyrH

Identifier: 15897855

GI number: 15897855

Start: 834557

End: 835240

Strand: Direct

Name: pyrH

Synonym: SSO0976

Alternate gene names: 15897855

Gene position: 834557-835240 (Clockwise)

Preceding gene: 15897854

Following gene: 15897856

Centisome position: 27.89

GC content: 36.26

Gene sequence:

>684_bases
GTGATGAACATTATTTTAAAGATAAGTGGTAAGTTTTTTGATGAAGATAATGTAGATAATTTAATAGTGTTAAGACAGAG
TATCAAAGAGCTCGCTGATAACGGTTTCAGAGTAGGTATTGTAACAGGTGGAGGTTCTACTGCTAGAAGGTATATAAAGC
TAGCAAGAGAAATCGGAATAGGTGAAGCCTATTTAGATCTTTTAGGTATATGGGCGTCAAGACTTAACGCCTATTTAGTG
ATGTTTTCTTTGCAAGATTTAGCATATATGCACGTTCCTCAAAGTTTAGAAGAATTTATACAAGATTGGTCTCATGGAAA
GGTAGTAGTTACTGGTGGATTTCAGCCTGGCCAATCAACTGCTGCTGTAGCTGCGTTAGTTGCTGAGGCATCCTCTTCAA
AAACCTTAGTTGTTGCGACTAATGTGGATGGTGTCTACGAGAAAGATCCACGGATATATGCAGATGTAAAACTCATACCT
CATTTAACCACTCAAGACTTACGGAAAATTTTAGAGGGTTCCCAATCTGTCCAAGCTGGTACATATGAATTATTAGATCC
TCTAGCAATAAAGATAGTTGAACGTTCAAAGATAAGGGTTATAGTAATGAATTATAGAAAACTTAATAGGATAATTGACA
TATTAAAAGGAGAGGAGGTTTCATCAATAATAGAGCCAGTGTGA

Upstream 100 bases:

>100_bases
TAGGTTTATTTAAAGATCCAGAAACTGGGAAATACTTCAGACATAAGCTACCAGATGATTATCCAATATAACTTTAAAAT
TATTTCCTCTTTTTTGTAAA

Downstream 100 bases:

>100_bases
TGGCTATGTCAATATTAGAAGATCCAGAATTTGTAAAATTAAGACAATTTAAAGGTAAAGTAAATTTCAATTTAGTTATG
CAGATACTGGATGAGATAGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MMNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRYIKLAREIGIGEAYLDLLGIWASRLNAYLV
MFSLQDLAYMHVPQSLEEFIQDWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPRIYADVKLIP
HLTTQDLRKILEGSQSVQAGTYELLDPLAIKIVERSKIRVIVMNYRKLNRIIDILKGEEVSSIIEPV

Sequences:

>Translated_227_residues
MMNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRYIKLAREIGIGEAYLDLLGIWASRLNAYLV
MFSLQDLAYMHVPQSLEEFIQDWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPRIYADVKLIP
HLTTQDLRKILEGSQSVQAGTYELLDPLAIKIVERSKIRVIVMNYRKLNRIIDILKGEEVSSIIEPV
>Mature_227_residues
MMNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRYIKLAREIGIGEAYLDLLGIWASRLNAYLV
MFSLQDLAYMHVPQSLEEFIQDWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPRIYADVKLIP
HLTTQDLRKILEGSQSVQAGTYELLDPLAIKIVERSKIRVIVMNYRKLNRIIDILKGEEVSSIIEPV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_SULSO (Q97ZE2)

Other databases:

- EMBL:   AE006641
- PIR:   C90249
- RefSeq:   NP_342460.1
- PDB:   2J4J
- PDB:   2J4K
- PDB:   2J4L
- PDBsum:   2J4J
- PDBsum:   2J4K
- PDBsum:   2J4L
- ProteinModelPortal:   Q97ZE2
- SMR:   Q97ZE2
- GeneID:   1455217
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0976
- NMPDR:   fig|273057.1.peg.883
- HOGENOM:   HBG497552
- OMA:   AREYIEI
- ProtClustDB:   PRK00358
- BioCyc:   SSOL273057:SSO0976-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25120; Mature: 25120

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: BINDING 44-44 BINDING 45-45 BINDING 49-49 BINDING 66-66 BINDING 140-140 BINDING 141-141 BINDING 146-146 BINDING 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRYIKLAREIGI
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCC
GEAYLDLLGIWASRLNAYLVMFSLQDLAYMHVPQSLEEFIQDWSHGKVVVTGGFQPGQST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCHH
AAVAALVAEASSSKTLVVATNVDGVYEKDPRIYADVKLIPHLTTQDLRKILEGSQSVQAG
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCC
TYELLDPLAIKIVERSKIRVIVMNYRKLNRIIDILKGEEVSSIIEPV
HHHHHHHHHHHEECCCCEEEEEECHHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MMNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRYIKLAREIGI
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCC
GEAYLDLLGIWASRLNAYLVMFSLQDLAYMHVPQSLEEFIQDWSHGKVVVTGGFQPGQST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCHH
AAVAALVAEASSSKTLVVATNVDGVYEKDPRIYADVKLIPHLTTQDLRKILEGSQSVQAG
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCC
TYELLDPLAIKIVERSKIRVIVMNYRKLNRIIDILKGEEVSSIIEPV
HHHHHHHHHHHEECCCCEEEEEECHHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726