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The map label for this gene is flpA [H]

Identifier: 15897821

GI number: 15897821

Start: 798966

End: 799664

Strand: Direct

Name: flpA [H]

Synonym: SSO0940

Alternate gene names: 15897821

Gene position: 798966-799664 (Clockwise)

Preceding gene: 15897820

Following gene: 15897822

Centisome position: 26.7

GC content: 36.19

Gene sequence:

>699_bases
ATGTCTGAAGTAATTACCGTAAAACAAACCAATATGGAAAATATTTATGAATGTGAGTTTAACGATGGTAGTTTTCGATT
ATGTACAAGAAACCTAGTACCGAATTTTAACGTTTACGGCGAAAGGCTGATCAAGTATGAGGGTGTTGAATACAGGGAGT
GGAACGCATTTAGAAGTAAATTAGCGGGCGCAATACTTAAAGGTCTTAAGACTAATCCGATTAGAAAAGGTACTAAGGTC
TTATATTTAGGTGCTGCTTCTGGAACTACAATAAGCCATGTATCTGATATTATAGAGCTAAACGGCAAGGCTTATGGAGT
GGAATTTTCTCCTAGAGTTGTAAGAGAATTATTACTAGTAGCTCAAAGGAGGCCTAATATCTTTCCACTATTGGCTGATG
CAAGATTTCCTCAGAGTTATAAGTCAGTAGTGGAGAACGTTGACGTACTTTATGTTGATATTGCCCAACCGGATCAGACG
GATATTGCAATATACAATGCCAAATTCTTCCTCAAAGTAAATGGAGATATGCTTCTAGTAATTAAAGCGAGGAGTATTGA
CGTCACCAAAGACCCTAAGGAAATATATAAGACCGAAGTAGAGAAATTAGAGAATTCTAACTTCGAGACGATTCAAATTA
TTAATCTAGACCCATATGATAAAGATCATGCAATAGTTCTTAGCAAATATAAAGGGTAG

Upstream 100 bases:

>100_bases
ACCTAAAAAGCCGCAACAACAAAAGCCACAGCAACCACAAAAACAGCAAGCAAAAGGTAAAAAAGGTGGAAAGAGAAGAG
GTAAAAGAAAGTGATAAAAA

Downstream 100 bases:

>100_bases
GAGTTTGATAGATAAGATTTTTGAGATTGGACTTAAAGATATATTCTCTTCTTCTCCCGCTGAGTATGTAACTATTAAAG
ATGCATTAGATGGTAAATTA

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSEVITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKV
LYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQT
DIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYKG

Sequences:

>Translated_232_residues
MSEVITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKV
LYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQT
DIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYKG
>Mature_231_residues
SEVITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSKLAGAILKGLKTNPIRKGTKVL
YLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTD
IAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYKG

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=231, Percent_Identity=44.5887445887446, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17563672, Length=209, Percent_Identity=46.4114832535885, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6320190, Length=215, Percent_Identity=45.5813953488372, Blast_Score=198, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17647425, Length=233, Percent_Identity=42.9184549356223, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24646406, Length=212, Percent_Identity=31.6037735849057, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 26423; Mature: 26291

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00566 FIBRILLARIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSK
CCCEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCCCCHHEEEEECCCCEEHHHHHHHH
LAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLV
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
AQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLV
HHCCCCEEEEEECCCCCHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEEECCCEEEE
IKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYKG
EEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SEVITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREWNAFRSK
CCEEEEEECCCCCEEEEEECCCCEEEEEECCCCCCCCCHHEEEEECCCCEEHHHHHHHH
LAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKAYGVEFSPRVVRELLLV
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
AQRRPNIFPLLADARFPQSYKSVVENVDVLYVDIAQPDQTDIAIYNAKFFLKVNGDMLLV
HHCCCCEEEEEECCCCCHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEEECCCEEEE
IKARSIDVTKDPKEIYKTEVEKLENSNFETIQIINLDPYDKDHAIVLSKYKG
EEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA