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The map label for this gene is nrd [H]

Identifier: 15897814

GI number: 15897814

Start: 790181

End: 792706

Strand: Direct

Name: nrd [H]

Synonym: SSO0929

Alternate gene names: 15897814

Gene position: 790181-792706 (Clockwise)

Preceding gene: 15897813

Following gene: 15897815

Centisome position: 26.41

GC content: 38.0

Gene sequence:

>2526_bases
TTGAAGGAAATGGAGCAGCTATTATACTCTACATCTTTAAGAAAGATTAAAGTAATCAAACGAGACGGTAAGGTTGATGA
GTTCAAATTAGAAAAGATACTATCTAAACTTTCTTCCGTCCCAGATGAGGTAACAGATGGCATAGTCAATGATGTACAAG
CTAATGTAAAAGATAATGCTATAGATACTAGGGTAATTGCGGATATAGTTGAAAGAAACCTCATAGAGAACTCACTAAAG
TATCCTTTCTTAATGGAATTAGCAAAACGATATGTCTTAGCTAGAATTTACAATCATGTTTTCGGTAAAGGGAAATGGAA
AGATTTCGATGAGAAGGATTTGCTTCTCTCTTACAACGCATTAAAAGTATTGGAAGCTAGATACTTATTGAAAGATCCTA
ATACTTTGCGTTATATTGAGACACCACAGATGTTATTCAGAAGAGTAGCTAGATTTCTCGCATCAGTTGAGAGAAAATAT
GGTAAATCTGAGGCTGAAGTTAAACAGCTAGAAGATAAGTTTTACGAAATGATAAGTGACTTGAAGTTTGTACCCAATTC
GCCAACACTGATGAATAGTGAAACTAGACTAGGCATCTTATCAGCATGTTTTGTAATTCCAGTTAAAGACGCTATGACTA
CGCCAGAGGGAGATGGAATATATGACGCGTTAAGAGCTACTGCCCTTGTTCACCAACAAGGTGGAGGGACTGGTTTCGAT
TTCTCAGAATTAAGACCTAAGGGAGACGTAGTAGCTTCAACTGCGGGTGTGGCGTCTGGTCCGGTTTCATTTATGAAAGT
ATTTGATGCCTCTACTGATGTTATAAAGCAAGGTGGAAAGAGAAGAGGAGCTAACATGGGAGTGATGCACGCATGGCACG
CTGATATTGAAGATTTCATTCGTGCTAAGACTGGTCAGCTAAAAGATGTTCAGTTACAGAATTTCAATATTTCTGTAGGT
GCTTATGACTACTTTATGGATGCTGTTGTGAAAGGCGAGAGTGTACCTTTAATTAACCCTAGAAAGACCAAGATAGCAGG
GAGAGATCATGAATATTATATTACAAAGGCTAGGGGTTATATGAGTGAGGAGTGGATTCAAGAGGTCATACTATCAGAGT
TAGAGGAAAAAGGTGGAGTAGTTTCTCTAGATGAGAGTAAGATTATTACGGTTGACGAAGCACTAGTAATAGCCTCAAAG
GAGGGGGCTGTTGTCAAGTATGTTAATGCAAAATCATTATTCGATGAAATAGTGAAGGGGGCATGGGATAGTGGTGACCC
TGGCCTTCTCTTTATCGATACTATTAATAGGAGACATCCTGTTTGGTATTTAGGTAAGATTAATGCTACAAATCCATGTG
GTGAAGAGCCACTATTACCTTGGGAGAGTTGTAATTTAGGCTCTATAAATCTAGAGAAATTTGTTATAGAAAGAGATGGC
AAAGCGGCGATAGATTGGGATGGATTAGCCGAAATTATTAGGTACGGGGTAAGGTTTCTGGATAACGTGATTGATGCTAA
TCGTTATCCGTTAAAGCAAATTGAAGATGCAACCAAGAGAACTAGGAAAGTAGGTTTAGGTGTTATGGGACTAGCTAGAA
TGTTTATTAAATTAGGTATTGCTTATGATAGTGTAGACGCAATATACTTGTCATACCAATTAGCCAAGTTCATATTTTAC
CATGCGTATAAGGCATCTATTGAGATAGCTAAGGAGAAGGGTACATTTCCTACATATGATGCGAGGCTGTATAGGGATAT
TTGGGAGAGTGCATTGGACTTCGATTCATTGCTACAAACTGCTGAAATTAGTGATAAACCCTCAGATTACGTTAAAAAGT
TAACTAGTGTGGTGGATAAGTTAGATTTTGATTTGCTAAAAGGTGAGAGATTAAAATATGGTTTAAGGAATTCCACTGTA
GTTTCTATAGCCCCAACGGGTACTATCTCAATAATAGCTGGGACATCATCTTCAATAGAACCACTATTTGCATTAGCGTT
TGTTAGAAATGTCGCAGTTGGGAAGTTCATCGAAATTGATCCGCTTTTCCTAGAATATCTAAGAAAATATGAGTTAGATG
ACCCAGAGGTTATTCAGAAAATAGCTGAAAGCGGGATAATTGGGGATAACGTATTTATGCCAAGATCATTAAGGAAATTG
TTTAGAACTGCTCATGAGGTTCCACCAATTTATCACGTCATGCATCAAGCAGCTTGGCAACAGTGGAATGATTCCGGGAC
TTCCAAGACTATTAACTTAAGATCAGAGGAGCCACCGGAGACTGTAGAGAAGGTCTATTTATTAGCGTGGAAACTTGGAA
TAAAAGGTATAACTGTCTATAGGGATAAGAGTAAGCAACAGCAAGTGATCTATTTCGGCGTTAAGAAAGAAAGGGAGGAA
TATGAGAAGAAAAAGGAAGAGGTGGAAAAGAAAACGCAATTACTTCCTTCTAGTTTAAGGATGGAGAAGAAATTTGTTGA
AGTTTCAGAGACATATGCAGGTGGATGTAAGACGTGTGAACTATAA

Upstream 100 bases:

>100_bases
TTTAATTTCTGAAAGCTAGATATTATCTTTTTGAAACATGATATGGTAATACTCCTCTCTTTACAACATAAAGTTAAATT
GATACAAGTCATAATAATTC

Downstream 100 bases:

>100_bases
AAACATTTTTATTTATCTGTTTTTTATATTATATTGGACTGAAGTGTATTAACCATGTCATTACAATTACCATGTGAATT
TTCAGTAAGGGAGATTTTAC

Product: ribonucleotide reductase (nrd)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 841; Mature: 841

Protein sequence:

>841_residues
MKEMEQLLYSTSLRKIKVIKRDGKVDEFKLEKILSKLSSVPDEVTDGIVNDVQANVKDNAIDTRVIADIVERNLIENSLK
YPFLMELAKRYVLARIYNHVFGKGKWKDFDEKDLLLSYNALKVLEARYLLKDPNTLRYIETPQMLFRRVARFLASVERKY
GKSEAEVKQLEDKFYEMISDLKFVPNSPTLMNSETRLGILSACFVIPVKDAMTTPEGDGIYDALRATALVHQQGGGTGFD
FSELRPKGDVVASTAGVASGPVSFMKVFDASTDVIKQGGKRRGANMGVMHAWHADIEDFIRAKTGQLKDVQLQNFNISVG
AYDYFMDAVVKGESVPLINPRKTKIAGRDHEYYITKARGYMSEEWIQEVILSELEEKGGVVSLDESKIITVDEALVIASK
EGAVVKYVNAKSLFDEIVKGAWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVIERDG
KAAIDWDGLAEIIRYGVRFLDNVIDANRYPLKQIEDATKRTRKVGLGVMGLARMFIKLGIAYDSVDAIYLSYQLAKFIFY
HAYKASIEIAKEKGTFPTYDARLYRDIWESALDFDSLLQTAEISDKPSDYVKKLTSVVDKLDFDLLKGERLKYGLRNSTV
VSIAPTGTISIIAGTSSSIEPLFALAFVRNVAVGKFIEIDPLFLEYLRKYELDDPEVIQKIAESGIIGDNVFMPRSLRKL
FRTAHEVPPIYHVMHQAAWQQWNDSGTSKTINLRSEEPPETVEKVYLLAWKLGIKGITVYRDKSKQQQVIYFGVKKEREE
YEKKKEEVEKKTQLLPSSLRMEKKFVEVSETYAGGCKTCEL

Sequences:

>Translated_841_residues
MKEMEQLLYSTSLRKIKVIKRDGKVDEFKLEKILSKLSSVPDEVTDGIVNDVQANVKDNAIDTRVIADIVERNLIENSLK
YPFLMELAKRYVLARIYNHVFGKGKWKDFDEKDLLLSYNALKVLEARYLLKDPNTLRYIETPQMLFRRVARFLASVERKY
GKSEAEVKQLEDKFYEMISDLKFVPNSPTLMNSETRLGILSACFVIPVKDAMTTPEGDGIYDALRATALVHQQGGGTGFD
FSELRPKGDVVASTAGVASGPVSFMKVFDASTDVIKQGGKRRGANMGVMHAWHADIEDFIRAKTGQLKDVQLQNFNISVG
AYDYFMDAVVKGESVPLINPRKTKIAGRDHEYYITKARGYMSEEWIQEVILSELEEKGGVVSLDESKIITVDEALVIASK
EGAVVKYVNAKSLFDEIVKGAWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVIERDG
KAAIDWDGLAEIIRYGVRFLDNVIDANRYPLKQIEDATKRTRKVGLGVMGLARMFIKLGIAYDSVDAIYLSYQLAKFIFY
HAYKASIEIAKEKGTFPTYDARLYRDIWESALDFDSLLQTAEISDKPSDYVKKLTSVVDKLDFDLLKGERLKYGLRNSTV
VSIAPTGTISIIAGTSSSIEPLFALAFVRNVAVGKFIEIDPLFLEYLRKYELDDPEVIQKIAESGIIGDNVFMPRSLRKL
FRTAHEVPPIYHVMHQAAWQQWNDSGTSKTINLRSEEPPETVEKVYLLAWKLGIKGITVYRDKSKQQQVIYFGVKKEREE
YEKKKEEVEKKTQLLPSSLRMEKKFVEVSETYAGGCKTCEL
>Mature_841_residues
MKEMEQLLYSTSLRKIKVIKRDGKVDEFKLEKILSKLSSVPDEVTDGIVNDVQANVKDNAIDTRVIADIVERNLIENSLK
YPFLMELAKRYVLARIYNHVFGKGKWKDFDEKDLLLSYNALKVLEARYLLKDPNTLRYIETPQMLFRRVARFLASVERKY
GKSEAEVKQLEDKFYEMISDLKFVPNSPTLMNSETRLGILSACFVIPVKDAMTTPEGDGIYDALRATALVHQQGGGTGFD
FSELRPKGDVVASTAGVASGPVSFMKVFDASTDVIKQGGKRRGANMGVMHAWHADIEDFIRAKTGQLKDVQLQNFNISVG
AYDYFMDAVVKGESVPLINPRKTKIAGRDHEYYITKARGYMSEEWIQEVILSELEEKGGVVSLDESKIITVDEALVIASK
EGAVVKYVNAKSLFDEIVKGAWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVIERDG
KAAIDWDGLAEIIRYGVRFLDNVIDANRYPLKQIEDATKRTRKVGLGVMGLARMFIKLGIAYDSVDAIYLSYQLAKFIFY
HAYKASIEIAKEKGTFPTYDARLYRDIWESALDFDSLLQTAEISDKPSDYVKKLTSVVDKLDFDLLKGERLKYGLRNSTV
VSIAPTGTISIIAGTSSSIEPLFALAFVRNVAVGKFIEIDPLFLEYLRKYELDDPEVIQKIAESGIIGDNVFMPRSLRKL
FRTAHEVPPIYHVMHQAAWQQWNDSGTSKTINLRSEEPPETVEKVYLLAWKLGIKGITVYRDKSKQQQVIYFGVKKEREE
YEKKKEEVEKKTQLLPSSLRMEKKFVEVSETYAGGCKTCEL

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=704, Percent_Identity=27.6988636363636, Blast_Score=231, Evalue=3e-60,
Organism=Escherichia coli, GI1789030, Length=609, Percent_Identity=24.9589490968801, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI2367133, Length=596, Percent_Identity=23.6577181208054, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17555242, Length=844, Percent_Identity=25.7109004739337, Blast_Score=221, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322123, Length=843, Percent_Identity=25.2669039145907, Blast_Score=214, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6320914, Length=697, Percent_Identity=27.403156384505, Blast_Score=211, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17352481, Length=852, Percent_Identity=25.9389671361502, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 95215; Mature: 95215

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEMEQLLYSTSLRKIKVIKRDGKVDEFKLEKILSKLSSVPDEVTDGIVNDVQANVKDNA
CCHHHHHHHHHCHHHEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
IDTRVIADIVERNLIENSLKYPFLMELAKRYVLARIYNHVFGKGKWKDFDEKDLLLSYNA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHH
LKVLEARYLLKDPNTLRYIETPQMLFRRVARFLASVERKYGKSEAEVKQLEDKFYEMISD
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
LKFVPNSPTLMNSETRLGILSACFVIPVKDAMTTPEGDGIYDALRATALVHQQGGGTGFD
CEECCCCCCEECCCCHHHHHHHHHHEECHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
FSELRPKGDVVASTAGVASGPVSFMKVFDASTDVIKQGGKRRGANMGVMHAWHADIEDFI
HHHCCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCCEEHHHHCCHHHHH
RAKTGQLKDVQLQNFNISVGAYDYFMDAVVKGESVPLINPRKTKIAGRDHEYYITKARGY
HHCCCCCCEEEEECEEEEECHHHHHHHHHHCCCCCCCCCCCCCEECCCCCEEEEEECCCC
MSEEWIQEVILSELEEKGGVVSLDESKIITVDEALVIASKEGAVVKYVNAKSLFDEIVKG
CCHHHHHHHHHHHHHHCCCEEEECCCEEEEECCEEEEECCCCCEEEEECHHHHHHHHHHC
AWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVIERDG
CCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHEEEECCC
KAAIDWDGLAEIIRYGVRFLDNVIDANRYPLKQIEDATKRTRKVGLGVMGLARMFIKLGI
CCEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AYDSVDAIYLSYQLAKFIFYHAYKASIEIAKEKGTFPTYDARLYRDIWESALDFDSLLQT
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
AEISDKPSDYVKKLTSVVDKLDFDLLKGERLKYGLRNSTVVSIAPTGTISIIAGTSSSIE
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCEEEEEECCCCCHH
PLFALAFVRNVAVGKFIEIDPLFLEYLRKYELDDPEVIQKIAESGIIGDNVFMPRSLRKL
HHHHHHHHHHHHHCCEEECCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
FRTAHEVPPIYHVMHQAAWQQWNDSGTSKTINLRSEEPPETVEKVYLLAWKLGIKGITVY
HHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEE
RDKSKQQQVIYFGVKKEREEYEKKKEEVEKKTQLLPSSLRMEKKFVEVSETYAGGCKTCE
ECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCC
L
C
>Mature Secondary Structure
MKEMEQLLYSTSLRKIKVIKRDGKVDEFKLEKILSKLSSVPDEVTDGIVNDVQANVKDNA
CCHHHHHHHHHCHHHEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
IDTRVIADIVERNLIENSLKYPFLMELAKRYVLARIYNHVFGKGKWKDFDEKDLLLSYNA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHH
LKVLEARYLLKDPNTLRYIETPQMLFRRVARFLASVERKYGKSEAEVKQLEDKFYEMISD
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
LKFVPNSPTLMNSETRLGILSACFVIPVKDAMTTPEGDGIYDALRATALVHQQGGGTGFD
CEECCCCCCEECCCCHHHHHHHHHHEECHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
FSELRPKGDVVASTAGVASGPVSFMKVFDASTDVIKQGGKRRGANMGVMHAWHADIEDFI
HHHCCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCCEEHHHHCCHHHHH
RAKTGQLKDVQLQNFNISVGAYDYFMDAVVKGESVPLINPRKTKIAGRDHEYYITKARGY
HHCCCCCCEEEEECEEEEECHHHHHHHHHHCCCCCCCCCCCCCEECCCCCEEEEEECCCC
MSEEWIQEVILSELEEKGGVVSLDESKIITVDEALVIASKEGAVVKYVNAKSLFDEIVKG
CCHHHHHHHHHHHHHHCCCEEEECCCEEEEECCEEEEECCCCCEEEEECHHHHHHHHHHC
AWDSGDPGLLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFVIERDG
CCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHEEEECCC
KAAIDWDGLAEIIRYGVRFLDNVIDANRYPLKQIEDATKRTRKVGLGVMGLARMFIKLGI
CCEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AYDSVDAIYLSYQLAKFIFYHAYKASIEIAKEKGTFPTYDARLYRDIWESALDFDSLLQT
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
AEISDKPSDYVKKLTSVVDKLDFDLLKGERLKYGLRNSTVVSIAPTGTISIIAGTSSSIE
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCEEEEEECCCCCHH
PLFALAFVRNVAVGKFIEIDPLFLEYLRKYELDDPEVIQKIAESGIIGDNVFMPRSLRKL
HHHHHHHHHHHHHCCEEECCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
FRTAHEVPPIYHVMHQAAWQQWNDSGTSKTINLRSEEPPETVEKVYLLAWKLGIKGITVY
HHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEE
RDKSKQQQVIYFGVKKEREEYEKKKEEVEKKTQLLPSSLRMEKKFVEVSETYAGGCKTCE
ECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]