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The map label for this gene is gcvT [H]

Identifier: 15897806

GI number: 15897806

Start: 782382

End: 783422

Strand: Direct

Name: gcvT [H]

Synonym: SSO0919

Alternate gene names: 15897806

Gene position: 782382-783422 (Clockwise)

Preceding gene: 15897803

Following gene: 15897807

Centisome position: 26.15

GC content: 34.97

Gene sequence:

>1041_bases
ATGTTTGTTTCACCTTTTCATGACGTTGAGGAAAAGTTGGGAGCAAATTTTGGAGAGTTTGCTGGTTGGGAAATGCCAAT
GAGCTTCACCAGTTATGCAGAAGAGCATATGTGTGTGAGAAATTCAGTAGCGTTTTTTAACTTATCTCATATGGGCAGAC
TAAGGGTTAAAGGCAATCCAAGGGAGTTTGAGATGTTAGTAGCTAAGGAAGTTAATAAGGCGAATTCTGGAATTATGATA
GGACCTACTGCATTTTTGAATGATAAAGCTGGTTTTAAAGATGATGTCATGGTTTATAAAGTATCTGAGAATGAATGGTT
AATTGTAACAAATGCAATAAATAGAGAAAAAATTGTAAATTGGATAAAATCAAATTCAAATTTGGATGTGGAAGATCTAA
CATTCAAATATGGTATGATTGCCATACAAGGTAGGAAATTAGAGGAGATTTTGGGTAAAAATGAATTAAAGCAATTAGAA
TTTAAGCTTAATACTAGATTTATGGGATATGACGTTTTTTTAATAAGTAGATCTGGCTGGACAGGCGAAAATGGGTTAGA
AGTTTGGGTTACATTAGATGTTGGTAGACAACTAATGATGGATTTAGTGAAAATCGGAATAAAGCCTGCCGGTTTGATTG
CAAGAGATAGTTTAAGGCAAGAGATGGGCTTTGTCCTTTACGGGGAGGATATTGATGAGACCATTACTCCAGTTGAGGCC
AGATATTGGGTTTTCTCGTTAGAAAAGGATTTTATAGGAAAGGATAGTTTAGTTGAACGTATAAGGAGTGGTATTGATAA
AGTTAGGATAGGCTTTAAGATGAGAAAAGGTGAGAGAACTATACCTAGGCATCAATCTAAAATATACTCAATTGGAAATG
AAGTAGGTTATGTGACGAGTAGTACTTTTTCCCCTTACTTAAATAGAGTTATAGGTATGGGTTATGTAAACCCCAAGTAC
TTCTACCTCGGCTATAGTTTAACTGGCGAAATTAGGGGTAAACAGTATGATATAAAAATCGATGAGTTTCCATTTATCTA
G

Upstream 100 bases:

>100_bases
TACTCCTATCTCTTTCAACATCTCATCTGTTAGGTCTAGGTTTGGAAGCCAAGGATGCTTATACATAAGCCTTAATACAA
CTTTAATGCATTTTTAATAT

Downstream 100 bases:

>100_bases
GTGAATATTATATGAATGAAATGAAAGTAGGTAGATACGTAGTTCTGACAGATAGATTATACACAGAGACTGACGAATGG
GTGGTGCTTTCTAATGATAA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MFVSPFHDVEEKLGANFGEFAGWEMPMSFTSYAEEHMCVRNSVAFFNLSHMGRLRVKGNPREFEMLVAKEVNKANSGIMI
GPTAFLNDKAGFKDDVMVYKVSENEWLIVTNAINREKIVNWIKSNSNLDVEDLTFKYGMIAIQGRKLEEILGKNELKQLE
FKLNTRFMGYDVFLISRSGWTGENGLEVWVTLDVGRQLMMDLVKIGIKPAGLIARDSLRQEMGFVLYGEDIDETITPVEA
RYWVFSLEKDFIGKDSLVERIRSGIDKVRIGFKMRKGERTIPRHQSKIYSIGNEVGYVTSSTFSPYLNRVIGMGYVNPKY
FYLGYSLTGEIRGKQYDIKIDEFPFI

Sequences:

>Translated_346_residues
MFVSPFHDVEEKLGANFGEFAGWEMPMSFTSYAEEHMCVRNSVAFFNLSHMGRLRVKGNPREFEMLVAKEVNKANSGIMI
GPTAFLNDKAGFKDDVMVYKVSENEWLIVTNAINREKIVNWIKSNSNLDVEDLTFKYGMIAIQGRKLEEILGKNELKQLE
FKLNTRFMGYDVFLISRSGWTGENGLEVWVTLDVGRQLMMDLVKIGIKPAGLIARDSLRQEMGFVLYGEDIDETITPVEA
RYWVFSLEKDFIGKDSLVERIRSGIDKVRIGFKMRKGERTIPRHQSKIYSIGNEVGYVTSSTFSPYLNRVIGMGYVNPKY
FYLGYSLTGEIRGKQYDIKIDEFPFI
>Mature_346_residues
MFVSPFHDVEEKLGANFGEFAGWEMPMSFTSYAEEHMCVRNSVAFFNLSHMGRLRVKGNPREFEMLVAKEVNKANSGIMI
GPTAFLNDKAGFKDDVMVYKVSENEWLIVTNAINREKIVNWIKSNSNLDVEDLTFKYGMIAIQGRKLEEILGKNELKQLE
FKLNTRFMGYDVFLISRSGWTGENGLEVWVTLDVGRQLMMDLVKIGIKPAGLIARDSLRQEMGFVLYGEDIDETITPVEA
RYWVFSLEKDFIGKDSLVERIRSGIDKVRIGFKMRKGERTIPRHQSKIYSIGNEVGYVTSSTFSPYLNRVIGMGYVNPKY
FYLGYSLTGEIRGKQYDIKIDEFPFI

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=366, Percent_Identity=30.6010928961749, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI257796258, Length=351, Percent_Identity=30.4843304843305, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI257796254, Length=356, Percent_Identity=27.5280898876405, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI257796256, Length=292, Percent_Identity=31.5068493150685, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI194306651, Length=361, Percent_Identity=24.6537396121884, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI24797151, Length=380, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789272, Length=359, Percent_Identity=30.3621169916435, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17560118, Length=370, Percent_Identity=30.2702702702703, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32563613, Length=368, Percent_Identity=23.0978260869565, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=389, Percent_Identity=32.133676092545, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20129441, Length=371, Percent_Identity=31.5363881401617, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI28571104, Length=297, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39724; Mature: 39724

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVSPFHDVEEKLGANFGEFAGWEMPMSFTSYAEEHMCVRNSVAFFNLSHMGRLRVKGNP
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCC
REFEMLVAKEVNKANSGIMIGPTAFLNDKAGFKDDVMVYKVSENEWLIVTNAINREKIVN
HHHHHHHHHHHCCCCCCEEECCHHEECCCCCCCCCEEEEEECCCCEEEEEECCCHHHHHH
WIKSNSNLDVEDLTFKYGMIAIQGRKLEEILGKNELKQLEFKLNTRFMGYDVFLISRSGW
HHHCCCCCCHHHEEEEEEEEEECCCHHHHHHCCCHHHEEEEEECCEEEEEEEEEEECCCC
TGENGLEVWVTLDVGRQLMMDLVKIGIKPAGLIARDSLRQEMGFVLYGEDIDETITPVEA
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEE
RYWVFSLEKDFIGKDSLVERIRSGIDKVRIGFKMRKGERTIPRHQSKIYSIGNEVGYVTS
EEEEEEECHHHCCCHHHHHHHHHCHHHEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEC
STFSPYLNRVIGMGYVNPKYFYLGYSLTGEIRGKQYDIKIDEFPFI
CCHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCCEEEEEECCCCCC
>Mature Secondary Structure
MFVSPFHDVEEKLGANFGEFAGWEMPMSFTSYAEEHMCVRNSVAFFNLSHMGRLRVKGNP
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCC
REFEMLVAKEVNKANSGIMIGPTAFLNDKAGFKDDVMVYKVSENEWLIVTNAINREKIVN
HHHHHHHHHHHCCCCCCEEECCHHEECCCCCCCCCEEEEEECCCCEEEEEECCCHHHHHH
WIKSNSNLDVEDLTFKYGMIAIQGRKLEEILGKNELKQLEFKLNTRFMGYDVFLISRSGW
HHHCCCCCCHHHEEEEEEEEEECCCHHHHHHCCCHHHEEEEEECCEEEEEEEEEEECCCC
TGENGLEVWVTLDVGRQLMMDLVKIGIKPAGLIARDSLRQEMGFVLYGEDIDETITPVEA
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCEE
RYWVFSLEKDFIGKDSLVERIRSGIDKVRIGFKMRKGERTIPRHQSKIYSIGNEVGYVTS
EEEEEEECHHHCCCHHHHHHHHHCHHHEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEC
STFSPYLNRVIGMGYVNPKYFYLGYSLTGEIRGKQYDIKIDEFPFI
CCHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]