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The map label for this gene is serA-1 [H]

Identifier: 15897792

GI number: 15897792

Start: 769622

End: 770602

Strand: Direct

Name: serA-1 [H]

Synonym: SSO0905

Alternate gene names: 15897792

Gene position: 769622-770602 (Clockwise)

Preceding gene: 15897791

Following gene: 15897793

Centisome position: 25.72

GC content: 34.86

Gene sequence:

>981_bases
GTGATAAGTATGGAGACTATACAAGGTGTAAACTCTATAGGCAAATTAGATTTCAAAGTATTAATAACTGATCCAGTAGA
TCAATATATGATAAGAACTTTACAAAATAATGGACTAATTGTCGATTATAAGCCCGAAATCACAAGAGAGGAATTACTAA
AGATAATAGACCAGTACCAAGTTTTAATAGTAAGAAGCAGAACTAAGGTAGACAAGGAGATAATCCGTTATGGTGTTAAT
CTTAAGATTATAGCCAGAGCTGGGATAGGACTAGACAATATAGATACAGAGGAGGCGTCTAAGAGAAATATAAAAATTGT
GTATGCGCCCGGGGCTTCTACAGATTCTGCAGCAGAACTTACTATAGGATTACTTATCGCCGCAGCTAGAAAACTATATG
ATTCCATGAATATGGCAAAGGGTGGCATATTCAAGAAGATAGAGGGAATTGAATTAGCAGGGAAGACAATAGGTATTGTT
GGATTCGGTAGAATAGGTACCAAAGTAGCTAAGGTATGTAAGGCATTAGATATGAACGTAATTGCATATGACGTTATTAA
TATAAAGGAAAAGGCGAATATAGTTGGAGTCAGAGTAGCTGAAAGTTTAGAAGAATTACTAAAGAACTCAGATGTGATAA
CCTTTCATGTTACAGTAGGTAAAGATGCTAAGCCAATCCTTAACAAAGATACATTTAATTACATTAAAGATAATGCAATC
ATAATCAACACCAGTAGAGCTGTAGTGATAGATGGGAAAGCATTACTAGAATATATTGATAAAAAACACTTAACTTACGC
TACAGATGTTTTGTGGAATGAACCACCTAAAGAAGATTGGGAGATTAAATTATTAAGACACGAGAGAGTGATAGTAACTA
CTCACATTGGTGCCCAAACTAAAGAAGCACAGCATAGAGTTGCGGTAGTTACAACAGATAATCTCATTACTGCTTTAAAG
GAAATCGGTGTTCTCAAATGA

Upstream 100 bases:

>100_bases
TTAAGTAAATTTTATCTTATTATTATTTTATTCTTTTCATCTTTCTCAAGCTCATTCTCATCATCATGTTAAACTAGAAT
CACATTCTTGAAAGTTCTGG

Downstream 100 bases:

>100_bases
TGTTAATTCCCGGTCCAGTTAATGTGCCGTATAGTGTTTTACAAGCCTCTCTTAATTTAGTGAATCATAGATCGGAGAAA
TTTAGAGAAACAGTAAAAAC

Product: D-3-phosphoglycerate dehydrogenase (serA-1)

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MISMETIQGVNSIGKLDFKVLITDPVDQYMIRTLQNNGLIVDYKPEITREELLKIIDQYQVLIVRSRTKVDKEIIRYGVN
LKIIARAGIGLDNIDTEEASKRNIKIVYAPGASTDSAAELTIGLLIAAARKLYDSMNMAKGGIFKKIEGIELAGKTIGIV
GFGRIGTKVAKVCKALDMNVIAYDVINIKEKANIVGVRVAESLEELLKNSDVITFHVTVGKDAKPILNKDTFNYIKDNAI
IINTSRAVVIDGKALLEYIDKKHLTYATDVLWNEPPKEDWEIKLLRHERVIVTTHIGAQTKEAQHRVAVVTTDNLITALK
EIGVLK

Sequences:

>Translated_326_residues
MISMETIQGVNSIGKLDFKVLITDPVDQYMIRTLQNNGLIVDYKPEITREELLKIIDQYQVLIVRSRTKVDKEIIRYGVN
LKIIARAGIGLDNIDTEEASKRNIKIVYAPGASTDSAAELTIGLLIAAARKLYDSMNMAKGGIFKKIEGIELAGKTIGIV
GFGRIGTKVAKVCKALDMNVIAYDVINIKEKANIVGVRVAESLEELLKNSDVITFHVTVGKDAKPILNKDTFNYIKDNAI
IINTSRAVVIDGKALLEYIDKKHLTYATDVLWNEPPKEDWEIKLLRHERVIVTTHIGAQTKEAQHRVAVVTTDNLITALK
EIGVLK
>Mature_326_residues
MISMETIQGVNSIGKLDFKVLITDPVDQYMIRTLQNNGLIVDYKPEITREELLKIIDQYQVLIVRSRTKVDKEIIRYGVN
LKIIARAGIGLDNIDTEEASKRNIKIVYAPGASTDSAAELTIGLLIAAARKLYDSMNMAKGGIFKKIEGIELAGKTIGIV
GFGRIGTKVAKVCKALDMNVIAYDVINIKEKANIVGVRVAESLEELLKNSDVITFHVTVGKDAKPILNKDTFNYIKDNAI
IINTSRAVVIDGKALLEYIDKKHLTYATDVLWNEPPKEDWEIKLLRHERVIVTTHIGAQTKEAQHRVAVVTTDNLITALK
EIGVLK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=293, Percent_Identity=37.542662116041, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI6912396, Length=288, Percent_Identity=27.7777777777778, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557497, Length=205, Percent_Identity=29.2682926829268, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI61743967, Length=205, Percent_Identity=29.2682926829268, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI145580575, Length=207, Percent_Identity=28.5024154589372, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI145580578, Length=207, Percent_Identity=28.5024154589372, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4557499, Length=207, Percent_Identity=28.5024154589372, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1789279, Length=312, Percent_Identity=31.0897435897436, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1787645, Length=258, Percent_Identity=27.1317829457364, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082289, Length=265, Percent_Identity=27.1698113207547, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=36.4238410596026, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI25147481, Length=231, Percent_Identity=25.974025974026, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=307, Percent_Identity=30.2931596091205, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=307, Percent_Identity=29.3159609120521, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324055, Length=296, Percent_Identity=25.3378378378378, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=252, Percent_Identity=27.3809523809524, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=35.0993377483444, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28571528, Length=313, Percent_Identity=32.2683706070287, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574286, Length=318, Percent_Identity=30.5031446540881, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45552429, Length=324, Percent_Identity=28.7037037037037, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24585514, Length=324, Percent_Identity=28.7037037037037, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28574282, Length=324, Percent_Identity=28.7037037037037, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28574284, Length=324, Percent_Identity=28.7037037037037, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=28.7037037037037, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646446, Length=207, Percent_Identity=31.8840579710145, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646448, Length=207, Percent_Identity=31.8840579710145, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646452, Length=207, Percent_Identity=31.8840579710145, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646450, Length=207, Percent_Identity=31.8840579710145, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI62472511, Length=207, Percent_Identity=31.8840579710145, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585516, Length=317, Percent_Identity=25.5520504731861, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36221; Mature: 36221

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISMETIQGVNSIGKLDFKVLITDPVDQYMIRTLQNNGLIVDYKPEITREELLKIIDQYQ
CCCHHHHHCCHHCCCEEEEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHE
VLIVRSRTKVDKEIIRYGVNLKIIARAGIGLDNIDTEEASKRNIKIVYAPGASTDSAAEL
EEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
TIGLLIAAARKLYDSMNMAKGGIFKKIEGIELAGKTIGIVGFGRIGTKVAKVCKALDMNV
HHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCCEEEEEEECHHHHHHHHHHHHHCCCE
IAYDVINIKEKANIVGVRVAESLEELLKNSDVITFHVTVGKDAKPILNKDTFNYIKDNAI
EEEEEEEEHHHCCEEEEHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHCCCCEE
IINTSRAVVIDGKALLEYIDKKHLTYATDVLWNEPPKEDWEIKLLRHERVIVTTHIGAQT
EEECCCEEEECHHHHHHHHHHCCCEEEHHHHCCCCCCCCCEEEEEECCEEEEEEECCCCC
KEAQHRVAVVTTDNLITALKEIGVLK
CCCCCEEEEEECCHHHHHHHHHCCCC
>Mature Secondary Structure
MISMETIQGVNSIGKLDFKVLITDPVDQYMIRTLQNNGLIVDYKPEITREELLKIIDQYQ
CCCHHHHHCCHHCCCEEEEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHE
VLIVRSRTKVDKEIIRYGVNLKIIARAGIGLDNIDTEEASKRNIKIVYAPGASTDSAAEL
EEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHH
TIGLLIAAARKLYDSMNMAKGGIFKKIEGIELAGKTIGIVGFGRIGTKVAKVCKALDMNV
HHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEECCCEEEEEEECHHHHHHHHHHHHHCCCE
IAYDVINIKEKANIVGVRVAESLEELLKNSDVITFHVTVGKDAKPILNKDTFNYIKDNAI
EEEEEEEEHHHCCEEEEHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHCCCCEE
IINTSRAVVIDGKALLEYIDKKHLTYATDVLWNEPPKEDWEIKLLRHERVIVTTHIGAQT
EEECCCEEEECHHHHHHHHHHCCCEEEHHHHCCCCCCCCCEEEEEECCEEEEEEECCCCC
KEAQHRVAVVTTDNLITALKEIGVLK
CCCCCEEEEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]