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The map label for this gene is argF

Identifier: 15897764

GI number: 15897764

Start: 743017

End: 743940

Strand: Direct

Name: argF

Synonym: SSO0871

Alternate gene names: 15897764

Gene position: 743017-743940 (Clockwise)

Preceding gene: 15897758

Following gene: 15897770

Centisome position: 24.83

GC content: 37.12

Gene sequence:

>924_bases
ATGTTTAGAGGAAAAAGTTTGTTATGTCTGCTTGATTTTCAAACACATGAAATAGAGAAAATGCTAGAAGTCTCATTCTT
GATGAAAAGTTATGTTTATTATAATAAAGTTCCAAATTCATTAAGCGGTAAGAGGGTCGCATTACTTTTCGAGAAACCGA
GTACTAGGACTAGGGTTAGTACTGAATTAGCAGTATCGTTATTAGGTGGAATTCCTATTGTCCTTAATAAGCAAGATTTG
CAATGGTCTAGGGGAGAGCTTATCGAAGATACTGGAAGGGTTTTAGGCAGAGTCGTTAATGGAATAGGGGCCAGAGTACT
AAATCACTTAACCCTAGTTAAACTAAAGGAATCATCCGGAGTTCCAGTATTTAATTTATTAAGCGATCTTTCTCATCCCT
TGCAAGCACTAGCTGACTTAATGACAATTAGGGAAAGGTTTGGTAATAATCTTGTGAAGATCGCATTTGTTGGCGATGGG
AGTGATAATGTATTATTAAGCTTAATGGCTATTGTGGCTAAATTAGGATTAGAGTTACATGTAGCAACTCCTAAAGAACT
TAAGCCTAGGGACGATTTGTATAAGATAATAAGTGAGATTGCAGAAGATACTGGCAGTGTTATAGAATTTCATGAGGATC
CCTATGAGGCTGTTAGGGGTGTACATGTAGTCTATACTGACGTTTGGGTTAGCATGGGTCAAGAGAATATTGCTGAACAG
AAGAAGAGAATGTTACAAAACTATAGGGTTACCGCAGATCTAATGAAGTATGCGGTTAAAGATGCGATATTTATGCACTG
TTTGCCTGCAAATAGGGGAGAGGAAGTAGACCCTGAGGTAATAGATGGATCTAAAAGTGCGGTCTGGGATCAAGCTGAAA
ATAGATTGTATACAACAATGGCAGTATTTTCATTATTTATTTGA

Upstream 100 bases:

>100_bases
TTCATCGAATTTAGGCTTATTGCCTTGTCTGGTCTCTACAGCTTTGGTAAGCACAATCTGGATATCCATATTTAAATATG
TGATTAGATAGATTAAAATT

Downstream 100 bases:

>100_bases
AGAAATCATAAATTGATTTTTGATTGATTAGACTATTTATCGTTCGTAGTTCAAATAAGTTTATTTTGGCTTTTAATTTT
TTATTTACTTCTGATATGGC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MFRGKSLLCLLDFQTHEIEKMLEVSFLMKSYVYYNKVPNSLSGKRVALLFEKPSTRTRVSTELAVSLLGGIPIVLNKQDL
QWSRGELIEDTGRVLGRVVNGIGARVLNHLTLVKLKESSGVPVFNLLSDLSHPLQALADLMTIRERFGNNLVKIAFVGDG
SDNVLLSLMAIVAKLGLELHVATPKELKPRDDLYKIISEIAEDTGSVIEFHEDPYEAVRGVHVVYTDVWVSMGQENIAEQ
KKRMLQNYRVTADLMKYAVKDAIFMHCLPANRGEEVDPEVIDGSKSAVWDQAENRLYTTMAVFSLFI

Sequences:

>Translated_307_residues
MFRGKSLLCLLDFQTHEIEKMLEVSFLMKSYVYYNKVPNSLSGKRVALLFEKPSTRTRVSTELAVSLLGGIPIVLNKQDL
QWSRGELIEDTGRVLGRVVNGIGARVLNHLTLVKLKESSGVPVFNLLSDLSHPLQALADLMTIRERFGNNLVKIAFVGDG
SDNVLLSLMAIVAKLGLELHVATPKELKPRDDLYKIISEIAEDTGSVIEFHEDPYEAVRGVHVVYTDVWVSMGQENIAEQ
KKRMLQNYRVTADLMKYAVKDAIFMHCLPANRGEEVDPEVIDGSKSAVWDQAENRLYTTMAVFSLFI
>Mature_307_residues
MFRGKSLLCLLDFQTHEIEKMLEVSFLMKSYVYYNKVPNSLSGKRVALLFEKPSTRTRVSTELAVSLLGGIPIVLNKQDL
QWSRGELIEDTGRVLGRVVNGIGARVLNHLTLVKLKESSGVPVFNLLSDLSHPLQALADLMTIRERFGNNLVKIAFVGDG
SDNVLLSLMAIVAKLGLELHVATPKELKPRDDLYKIISEIAEDTGSVIEFHEDPYEAVRGVHVVYTDVWVSMGQENIAEQ
KKRMLQNYRVTADLMKYAVKDAIFMHCLPANRGEEVDPEVIDGSKSAVWDQAENRLYTTMAVFSLFI

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=308, Percent_Identity=40.5844155844156, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI18105007, Length=304, Percent_Identity=24.0131578947368, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786469, Length=322, Percent_Identity=36.6459627329193, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1790703, Length=325, Percent_Identity=35.3846153846154, Blast_Score=174, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI193204318, Length=288, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322373, Length=277, Percent_Identity=35.0180505415162, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322331, Length=314, Percent_Identity=25.796178343949, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24642586, Length=308, Percent_Identity=25.6493506493506, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_SULSO (Q97ZM1)

Other databases:

- EMBL:   AE006641
- PIR:   H90237
- RefSeq:   NP_342369.1
- ProteinModelPortal:   Q97ZM1
- SMR:   Q97ZM1
- GeneID:   1455126
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0871
- NMPDR:   fig|273057.1.peg.792
- HOGENOM:   HBG579429
- OMA:   FMTIKEH
- PhylomeDB:   Q97ZM1
- ProtClustDB:   PRK00779
- BioCyc:   SSOL273057:SSO0871-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34440; Mature: 34440

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 105-105 BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGKSLLCLLDFQTHEIEKMLEVSFLMKSYVYYNKVPNSLSGKRVALLFEKPSTRTRVS
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHH
TELAVSLLGGIPIVLNKQDLQWSRGELIEDTGRVLGRVVNGIGARVLNHLTLVKLKESSG
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
VPVFNLLSDLSHPLQALADLMTIRERFGNNLVKIAFVGDGSDNVLLSLMAIVAKLGLELH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEE
VATPKELKPRDDLYKIISEIAEDTGSVIEFHEDPYEAVRGVHVVYTDVWVSMGQENIAEQ
ECCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCEEEHHHHHHCCHHHHHHH
KKRMLQNYRVTADLMKYAVKDAIFMHCLPANRGEEVDPEVIDGSKSAVWDQAENRLYTTM
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHCCCCHHHHHHHHCHHHHHH
AVFSLFI
HHHHHHC
>Mature Secondary Structure
MFRGKSLLCLLDFQTHEIEKMLEVSFLMKSYVYYNKVPNSLSGKRVALLFEKPSTRTRVS
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHH
TELAVSLLGGIPIVLNKQDLQWSRGELIEDTGRVLGRVVNGIGARVLNHLTLVKLKESSG
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
VPVFNLLSDLSHPLQALADLMTIRERFGNNLVKIAFVGDGSDNVLLSLMAIVAKLGLELH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEE
VATPKELKPRDDLYKIISEIAEDTGSVIEFHEDPYEAVRGVHVVYTDVWVSMGQENIAEQ
ECCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCEEEHHHHHHCCHHHHHHH
KKRMLQNYRVTADLMKYAVKDAIFMHCLPANRGEEVDPEVIDGSKSAVWDQAENRLYTTM
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHCCCCHHHHHHHHCHHHHHH
AVFSLFI
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726