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The map label for this gene is ahcY [H]

Identifier: 15897655

GI number: 15897655

Start: 639120

End: 640448

Strand: Direct

Name: ahcY [H]

Synonym: SSO0755

Alternate gene names: 15897655

Gene position: 639120-640448 (Clockwise)

Preceding gene: 161777474

Following gene: 15897659

Centisome position: 21.36

GC content: 38.45

Gene sequence:

>1329_bases
GTGATAAAATTTGCATACTTGGATAAACAGATAAAAATCCTAAGCTTTTTATGTTCTTTCGATAAAAAACTTCCGATGAG
CTACAAAATAAAAGACCTTTCTCTCGCAAGTGAGGGAAAAAAGCAAATAGAATGGGCAGAAAGACACATGCCAACATTGA
TGGAAATAAGGAAGAGATTTAAAGCTGAAAAACCACTAAAAGGTATTAACATATCAGCAGTGCTTCACGTTACCAAGGAA
ACAGCAGCACTAGTTAAAACACTTAAAATAGGTGGAGCTAACGTTGCTTTAGCTGGAAGTAATCCCCTTTCAACTCAAGA
TGATGTAGCAGCAGCCTTAGTAGAGGAAGGAATCTCAGTATTCGCATGGAAAGGAGAAAATGAGACAGAATATTATTCCA
ATATTGAAAGTATTGTAAAGATTCACGAGCCAAATATTGTAATGGATGATGGTGCTGATTTACACGCTTACATTCATGAA
AAGGTAAGTTCTAAACTTGATATTTATGGCGGAACTGAAGAAACCACAACTGGTGTTATTAGACTTAAGGCAATGGAGAA
GGACGGTGTCCTTAAGTATCCTCTCGTCGCAGTAAACAACGCGTATACCAAGTACCTTTTCGATAATAGATATGGAACTG
GACAAAGTGCCATAGATGGAATACTTAGGGCTACAAACATTCTAATTGCAGGGAAAATTGCAGTTGTAGCTGGATATGGA
TGGGTAGGCAGGGGCATAGCTAATAGATTAAGAGGAATGGGCGCTAGAGTCATAGTAACTGAAGTAGATCCAATAAGAGC
TCTTGAAGCAGTGATGGACGGCTTTGACGTTATGCCTATTGCAGAGGCCTCAAAGGTTGGTGACATATTCGTAACAGCTA
CCGGAAATACAAAGGCTATAAGAGTAGAGCACATGCTCAATATGAAAGATGGCGCAATATTATCTAATGCAGGTCACTTT
AACGTAGAGGTGGACGTAAAAGGGTTAAAGGAGACTGCGGTTAAGGTAAGAAACATAAGACCTTATGTTGATGAATATAC
TTTACCTAACGGTAAGAGAGTATACTTGTTAGCAGATGGTAGGTTAGTGAATTTAGCTGCAGCAGAGGGTCATCCTAGCG
AAGTAATGGATATGAGCTTTGCCAATCAAGCTTTAGCTGTAGAATACCTAGTTAAGAATAGAGGAAAATTGGAGAAGAAA
GTATACAATATGCCAATGGAGTTGGATTATGAAGTGGCTAGAATAAAGTTGAAATCTATGGGCATTCAAATTGATGAGTT
AACAGAGGAGCAAAAAGAGTACTTGGAACAATGGAAATCAGGAACCTAA

Upstream 100 bases:

>100_bases
CTACTTTATTTAAGTGCGGGGGTGCCCGAGCTAGGTCGAAGGGGGTAGGCTCAGGCCCTACTGGTGAAGGCCTTCGCGGG
TTCAAATCCCGCCCCCCGCA

Downstream 100 bases:

>100_bases
AGGTTTAAACGCAAGTCTTAAAAACAGTTTTTCGGTTATTGTATATGTGGGCCCGTAGCTTAGCTCGGTAGAGCGCTCGG
CTCATAACCGAGTGGTCAGG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MIKFAYLDKQIKILSFLCSFDKKLPMSYKIKDLSLASEGKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKE
TAALVKTLKIGGANVALAGSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIVMDDGADLHAYIHE
KVSSKLDIYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYLFDNRYGTGQSAIDGILRATNILIAGKIAVVAGYG
WVGRGIANRLRGMGARVIVTEVDPIRALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHF
NVEVDVKGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALAVEYLVKNRGKLEKK
VYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWKSGT

Sequences:

>Translated_442_residues
MIKFAYLDKQIKILSFLCSFDKKLPMSYKIKDLSLASEGKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKE
TAALVKTLKIGGANVALAGSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIVMDDGADLHAYIHE
KVSSKLDIYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYLFDNRYGTGQSAIDGILRATNILIAGKIAVVAGYG
WVGRGIANRLRGMGARVIVTEVDPIRALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHF
NVEVDVKGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALAVEYLVKNRGKLEKK
VYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWKSGT
>Mature_442_residues
MIKFAYLDKQIKILSFLCSFDKKLPMSYKIKDLSLASEGKKQIEWAERHMPTLMEIRKRFKAEKPLKGINISAVLHVTKE
TAALVKTLKIGGANVALAGSNPLSTQDDVAAALVEEGISVFAWKGENETEYYSNIESIVKIHEPNIVMDDGADLHAYIHE
KVSSKLDIYGGTEETTTGVIRLKAMEKDGVLKYPLVAVNNAYTKYLFDNRYGTGQSAIDGILRATNILIAGKIAVVAGYG
WVGRGIANRLRGMGARVIVTEVDPIRALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAIRVEHMLNMKDGAILSNAGHF
NVEVDVKGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADGRLVNLAAAEGHPSEVMDMSFANQALAVEYLVKNRGKLEKK
VYNMPMELDYEVARIKLKSMGIQIDELTEEQKEYLEQWKSGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=416, Percent_Identity=50, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=50.3856041131105, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI298286489, Length=418, Percent_Identity=40.9090909090909, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI195539349, Length=418, Percent_Identity=40.9090909090909, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI195539337, Length=418, Percent_Identity=40.9090909090909, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI24308043, Length=418, Percent_Identity=40.9090909090909, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI21361647, Length=419, Percent_Identity=39.8568019093079, Blast_Score=295, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=46.875, Blast_Score=353, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6320882, Length=428, Percent_Identity=47.8971962616822, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24642172, Length=419, Percent_Identity=48.2100238663485, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24656245, Length=407, Percent_Identity=40.7862407862408, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI45553385, Length=417, Percent_Identity=41.2470023980815, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI45553387, Length=417, Percent_Identity=41.2470023980815, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 48938; Mature: 48938

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKFAYLDKQIKILSFLCSFDKKLPMSYKIKDLSLASEGKKQIEWAERHMPTLMEIRKRF
CEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCHHHHHHHHHCCCHHHHHHHHH
KAEKPLKGINISAVLHVTKETAALVKTLKIGGANVALAGSNPLSTQDDVAAALVEEGISV
CCCCCCCCCCEEEEEEEHHHHHHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHHCCCEE
FAWKGENETEYYSNIESIVKIHEPNIVMDDGADLHAYIHEKVSSKLDIYGGTEETTTGVI
EEECCCCCHHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCCEEEE
RLKAMEKDGVLKYPLVAVNNAYTKYLFDNRYGTGQSAIDGILRATNILIAGKIAVVAGYG
EEEEECCCCCEECCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEEEEEEEECCC
WVGRGIANRLRGMGARVIVTEVDPIRALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAI
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEE
RVEHMLNMKDGAILSNAGHFNVEVDVKGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADG
EEEEHHCCCCCCEEECCCEEEEEEEECCCHHHHHHHHCCCCCHHHCCCCCCCEEEEEECC
RLVNLAAAEGHPSEVMDMSFANQALAVEYLVKNRGKLEKKVYNMPMELDYEVARIKLKSM
EEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHEEEHHHH
GIQIDELTEEQKEYLEQWKSGT
CCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKFAYLDKQIKILSFLCSFDKKLPMSYKIKDLSLASEGKKQIEWAERHMPTLMEIRKRF
CEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCHHHHHHHHHCCCHHHHHHHHH
KAEKPLKGINISAVLHVTKETAALVKTLKIGGANVALAGSNPLSTQDDVAAALVEEGISV
CCCCCCCCCCEEEEEEEHHHHHHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHHCCCEE
FAWKGENETEYYSNIESIVKIHEPNIVMDDGADLHAYIHEKVSSKLDIYGGTEETTTGVI
EEECCCCCHHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCCEEEE
RLKAMEKDGVLKYPLVAVNNAYTKYLFDNRYGTGQSAIDGILRATNILIAGKIAVVAGYG
EEEEECCCCCEECCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEEEEEEEECCC
WVGRGIANRLRGMGARVIVTEVDPIRALEAVMDGFDVMPIAEASKVGDIFVTATGNTKAI
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEE
RVEHMLNMKDGAILSNAGHFNVEVDVKGLKETAVKVRNIRPYVDEYTLPNGKRVYLLADG
EEEEHHCCCCCCEEECCCEEEEEEEECCCHHHHHHHHCCCCCHHHCCCCCCCEEEEEECC
RLVNLAAAEGHPSEVMDMSFANQALAVEYLVKNRGKLEKKVYNMPMELDYEVARIKLKSM
EEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHEEEHHHH
GIQIDELTEEQKEYLEQWKSGT
CCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8921839; 10701121; 11427726 [H]