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The map label for this gene is secY

Identifier: 15897601

GI number: 15897601

Start: 599801

End: 601210

Strand: Reverse

Name: secY

Synonym: SSO0695

Alternate gene names: 15897601

Gene position: 601210-599801 (Counterclockwise)

Preceding gene: 15897602

Following gene: 15897600

Centisome position: 20.09

GC content: 35.67

Gene sequence:

>1410_bases
ATGTCATTCATCGATTCACTCGCTACTCTTGGACAATACTTACCAGCAGTTACTAAACCCAAAGAGAAACCTTCACTTGG
TCAAAAGTTAGTTTGGTCTTTAGTAGCAGTAATAATTTATCTGATAATGGCTTCAACACCACTATATGGGATAACATCAG
CTTCTTTTTTCAAAAACCTTATTTTAGAGCAGATTATTTTCGCTTCTACTACAGGGACCTTAGCACAATTAGGAATAGGT
CCTATAATAACTGCAGGTTTGATTATGCAAATACTAGCCGGATCTAAGTTAATAAGTATTGATCTAAATGATCCTGACGA
TAGGGTTAAATTTACAGAAGCGCAAAAGGGTTTGGCATTTATCTTTATTCTAGTGGAATCAGCTTTATTTGGTTACGTAT
TAGCTAGAACTTCAACAACCATAAATGCGTCAATATTATTCATTGCAGGGATAGTGATAGCTCAGCTTATTGTAGCCACA
TATTTGATCTTACTGTTAGATGAGCTGATACAGAAGGGTTGGGGTTTAGGATCGGGAGTTAGTCTGTTTATATTAGCTGG
AGTTATGAAAATTATGTTTTGGGACATGTTTGGAATTGCTAGTGTTAGTTCCCAGAATTTACCGATAGGATTCTTTCCTG
CATTATTTACCGCTTTAGCATCTCATAGTGACGTTCTTAATTTAATAGTTAATACTTCAACTAAAAATCTCTTTCAGCCA
GATTTAGTTGGTTTAGTAACTACTATAGCACTGATAATTATAACAATTTATCTAACTACAATGACTATAGAGATTCCAGT
AACTTCCCAGAAGTTAAGAGGAATAAGGAGGACAATTCCGTTAAACTTCTTATATGTTAGTAGTATACCAGTAATATTTG
TTGCAGTACTAGGTTCTGATATCCAGTTATTCGCTTCATTAGCTTCTTATGTCTCACCCTCAGCTTCAAATATATTAAAT
ACCGTTAGTGGAGTCTTCTTTTTCCCTCCTCCAAATTCAGCAATACCCCATAGTATATATGCTGTAGTTTTAGATCCGTT
AGGCGCGCTTGAATATGCTGTAGTTTTCATAGTTCTTAGTATCTTGTTTGGCATATTATGGGTAGATGTAGCTGGTTTAG
ATCCTGCTACTCAAGCTCAACAGCTAGTTGAAGCTGGTATTGAAATTCCTGGAGTCAGAAACAATCCAAAGATTATAGAG
GGAATATTAGCTAGGTACATCTATCCGCTGGCATTCTTCAGTTCCATAATTGTAGGTCTGATTGCAGTATTTGCTACGCT
CCTAGGTGCATATGGTACCGGCATAGGGATATTATTGGCAGTAACAATAGCAATACAATACTATAGCTTATTAGCTTACG
AAAGATCTTTAGAAATGTACCCATTATTAAAGAGGTTAATAGGTGAATAG

Upstream 100 bases:

>100_bases
ATAAAAGTAGGTAAGGCTACTAATAAGGCAATACAGAAAGTGAAGGAGATGGGAGGAGAAGTAATATTAAGCCCAACTGA
GTAATTTTTTTGAGTAAATT

Downstream 100 bases:

>100_bases
ACATGAAAATAGGTATAGTAACTGGTATACCCGGTGTAGGCAAGACAACTGTCCTTTCTTTTGCAGATAAAATTCTAACT
GAAAAGGGTATATCACACAA

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSFIDSLATLGQYLPAVTKPKEKPSLGQKLVWSLVAVIIYLIMASTPLYGITSASFFKNLILEQIIFASTTGTLAQLGIG
PIITAGLIMQILAGSKLISIDLNDPDDRVKFTEAQKGLAFIFILVESALFGYVLARTSTTINASILFIAGIVIAQLIVAT
YLILLLDELIQKGWGLGSGVSLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTALASHSDVLNLIVNTSTKNLFQP
DLVGLVTTIALIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSDIQLFASLASYVSPSASNILN
TVSGVFFFPPPNSAIPHSIYAVVLDPLGALEYAVVFIVLSILFGILWVDVAGLDPATQAQQLVEAGIEIPGVRNNPKIIE
GILARYIYPLAFFSSIIVGLIAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE

Sequences:

>Translated_469_residues
MSFIDSLATLGQYLPAVTKPKEKPSLGQKLVWSLVAVIIYLIMASTPLYGITSASFFKNLILEQIIFASTTGTLAQLGIG
PIITAGLIMQILAGSKLISIDLNDPDDRVKFTEAQKGLAFIFILVESALFGYVLARTSTTINASILFIAGIVIAQLIVAT
YLILLLDELIQKGWGLGSGVSLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTALASHSDVLNLIVNTSTKNLFQP
DLVGLVTTIALIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSDIQLFASLASYVSPSASNILN
TVSGVFFFPPPNSAIPHSIYAVVLDPLGALEYAVVFIVLSILFGILWVDVAGLDPATQAQQLVEAGIEIPGVRNNPKIIE
GILARYIYPLAFFSSIIVGLIAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE
>Mature_468_residues
SFIDSLATLGQYLPAVTKPKEKPSLGQKLVWSLVAVIIYLIMASTPLYGITSASFFKNLILEQIIFASTTGTLAQLGIGP
IITAGLIMQILAGSKLISIDLNDPDDRVKFTEAQKGLAFIFILVESALFGYVLARTSTTINASILFIAGIVIAQLIVATY
LILLLDELIQKGWGLGSGVSLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTALASHSDVLNLIVNTSTKNLFQPD
LVGLVTTIALIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSDIQLFASLASYVSPSASNILNT
VSGVFFFPPPNSAIPHSIYAVVLDPLGALEYAVVFIVLSILFGILWVDVAGLDPATQAQQLVEAGIEIPGVRNNPKIIEG
ILARYIYPLAFFSSIIVGLIAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family

Homologues:

Organism=Homo sapiens, GI7019415, Length=475, Percent_Identity=32.4210526315789, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI14589847, Length=484, Percent_Identity=30.9917355371901, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI217330618, Length=484, Percent_Identity=30.1652892561983, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI217330616, Length=428, Percent_Identity=29.2056074766355, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17543770, Length=480, Percent_Identity=31.6666666666667, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323411, Length=470, Percent_Identity=30.6382978723404, Blast_Score=192, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6319760, Length=452, Percent_Identity=26.7699115044248, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19920826, Length=479, Percent_Identity=31.9415448851775, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECY_SULSO (Q9UX84)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   E90217
- RefSeq:   NP_342206.1
- ProteinModelPortal:   Q9UX84
- GeneID:   1454963
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0695
- NMPDR:   fig|273057.1.peg.629
- HOGENOM:   HBG589438
- OMA:   WSDTSAG
- PhylomeDB:   Q9UX84
- ProtClustDB:   PRK08568
- BioCyc:   SSOL273057:SSO0695-MONOMER
- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561
- PANTHER:   PTHR10906
- PIRSF:   PIRSF004557

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY; SSF103491 SecY

EC number: NA

Molecular weight: Translated: 50494; Mature: 50363

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00755 SECY_1; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xce25b54)-; HASH(0xd57e764)-; HASH(0xcaed900)-; HASH(0xce7af60)-; HASH(0xd4c34dc)-; HASH(0xd27d80c)-; HASH(0xd51afb4)-; HASH(0xcbcfcf4)-; HASH(0xd16249c)-; HASH(0xc772afc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIDSLATLGQYLPAVTKPKEKPSLGQKLVWSLVAVIIYLIMASTPLYGITSASFFKNL
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILEQIIFASTTGTLAQLGIGPIITAGLIMQILAGSKLISIDLNDPDDRVKFTEAQKGLAF
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHH
IFILVESALFGYVLARTSTTINASILFIAGIVIAQLIVATYLILLLDELIQKGWGLGSGV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTALASHSDVLNLIVNTSTKNLFQP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCH
DLVGLVTTIALIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSD
HHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCH
IQLFASLASYVSPSASNILNTVSGVFFFPPPNSAIPHSIYAVVLDPLGALEYAVVFIVLS
HHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILFGILWVDVAGLDPATQAQQLVEAGIEIPGVRNNPKIIEGILARYIYPLAFFSSIIVGL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCH
>Mature Secondary Structure 
SFIDSLATLGQYLPAVTKPKEKPSLGQKLVWSLVAVIIYLIMASTPLYGITSASFFKNL
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILEQIIFASTTGTLAQLGIGPIITAGLIMQILAGSKLISIDLNDPDDRVKFTEAQKGLAF
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHH
IFILVESALFGYVLARTSTTINASILFIAGIVIAQLIVATYLILLLDELIQKGWGLGSGV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
SLFILAGVMKIMFWDMFGIASVSSQNLPIGFFPALFTALASHSDVLNLIVNTSTKNLFQP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCH
DLVGLVTTIALIIITIYLTTMTIEIPVTSQKLRGIRRTIPLNFLYVSSIPVIFVAVLGSD
HHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCH
IQLFASLASYVSPSASNILNTVSGVFFFPPPNSAIPHSIYAVVLDPLGALEYAVVFIVLS
HHHHHHHHHHHCCCHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILFGILWVDVAGLDPATQAQQLVEAGIEIPGVRNNPKIIEGILARYIYPLAFFSSIIVGL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAVFATLLGAYGTGIGILLAVTIAIQYYSLLAYERSLEMYPLLKRLIGE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726