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The map label for this gene is purC

Identifier: 15897542

GI number: 15897542

Start: 542822

End: 543523

Strand: Direct

Name: purC

Synonym: SSO0626

Alternate gene names: 15897542

Gene position: 542822-543523 (Clockwise)

Preceding gene: 15897538

Following gene: 15897543

Centisome position: 18.14

GC content: 32.62

Gene sequence:

>702_bases
ATGGAAGTTAACAAGATTTCTGAGGGAAAGACCAAGATAGTTTATGATTTTGATAAAGATCACGTATTACTCGAGTTTAA
GGATGACATAACCGCGGGTGATGGTCAAAAAAGAGATATATTGGAGGGTAAGGGCGTTTTAAACGCTCAAACATCAGCAT
TCTTCTTCAGATTACTAGAAAGAAATGGTATAGAAACACACTACGTAGGGATGAAGGATGAAAGAACGATGATAGTAAAG
AAATTAAAGATGATACCAGTAGAAGTTGTATTAAGAAACATTGCTACAGGTAGTATAGTTAAGCGATTACCAATTAAAGA
AGGTGAAGTCTTTGAATCGCCAATAGTGGAATTTTTCTTAAAGGATGACTTACGTCATGATCCCCTACTTAACTATTACC
ATATGGAACATCTTAAATTAATGAATAGGAAAGAGGCTCAGCATATAGAAGATATAATGATGAAGGTGAACGATGTACTA
TTCAATTTTATTAAAAGCAAAGGATTTATATTATATGACTTTAAACTAGAATTTGGCCGTTTGGGCGATAAACTAGTAAT
TGGAGATGAAATATCGTTAGATAGTATGAGAATTAGAGATGGTAATTCCAGAATTTATGATAAGGATTTATATAGGAAGG
GTTACGATTTAAAAACAGTAAAATCCTCGTATGAGGAATTTCTAAAAAGAATTACCTCATGA

Upstream 100 bases:

>100_bases
CATTGGTGAAGAATTATAAGGATTTTGATTTACATAATGAAGTAAAAGTTTATACTTATTTGAAGCTAACTTTTTATATC
GGTTATGTAAAATTGTCGTA

Downstream 100 bases:

>100_bases
GGGCCCCTTTATGAAATACTATGTAGAATTGATAATAATAAATAAAGACTCAGTTAGAGATCCAGAAGGAGAAACAATAC
AAAAATATGTAATTGAGAAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MEVNKISEGKTKIVYDFDKDHVLLEFKDDITAGDGQKRDILEGKGVLNAQTSAFFFRLLERNGIETHYVGMKDERTMIVK
KLKMIPVEVVLRNIATGSIVKRLPIKEGEVFESPIVEFFLKDDLRHDPLLNYYHMEHLKLMNRKEAQHIEDIMMKVNDVL
FNFIKSKGFILYDFKLEFGRLGDKLVIGDEISLDSMRIRDGNSRIYDKDLYRKGYDLKTVKSSYEEFLKRITS

Sequences:

>Translated_233_residues
MEVNKISEGKTKIVYDFDKDHVLLEFKDDITAGDGQKRDILEGKGVLNAQTSAFFFRLLERNGIETHYVGMKDERTMIVK
KLKMIPVEVVLRNIATGSIVKRLPIKEGEVFESPIVEFFLKDDLRHDPLLNYYHMEHLKLMNRKEAQHIEDIMMKVNDVL
FNFIKSKGFILYDFKLEFGRLGDKLVIGDEISLDSMRIRDGNSRIYDKDLYRKGYDLKTVKSSYEEFLKRITS
>Mature_233_residues
MEVNKISEGKTKIVYDFDKDHVLLEFKDDITAGDGQKRDILEGKGVLNAQTSAFFFRLLERNGIETHYVGMKDERTMIVK
KLKMIPVEVVLRNIATGSIVKRLPIKEGEVFESPIVEFFLKDDLRHDPLLNYYHMEHLKLMNRKEAQHIEDIMMKVNDVL
FNFIKSKGFILYDFKLEFGRLGDKLVIGDEISLDSMRIRDGNSRIYDKDLYRKGYDLKTVKSSYEEFLKRITS

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=242, Percent_Identity=34.7107438016529, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI5453539, Length=242, Percent_Identity=34.7107438016529, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI119220559, Length=249, Percent_Identity=33.7349397590361, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1788820, Length=225, Percent_Identity=37.3333333333333, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17531275, Length=233, Percent_Identity=34.7639484978541, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319326, Length=236, Percent_Identity=25.8474576271186, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI18860083, Length=236, Percent_Identity=38.5593220338983, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24583917, Length=245, Percent_Identity=35.9183673469388, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI160714955, Length=97, Percent_Identity=45.360824742268, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_SULSO (Q9UX20)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   B90210
- RefSeq:   NP_342147.1
- ProteinModelPortal:   Q9UX20
- SMR:   Q9UX20
- GeneID:   1454904
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0626
- NMPDR:   fig|273057.1.peg.570
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q9UX20
- ProtClustDB:   PRK09362
- BioCyc:   SSOL273057:SSO0626-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27283; Mature: 27283

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVNKISEGKTKIVYDFDKDHVLLEFKDDITAGDGQKRDILEGKGVLNAQTSAFFFRLLE
CCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHH
RNGIETHYVGMKDERTMIVKKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFESPIVEFFL
HCCCCEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHH
KDDLRHDPLLNYYHMEHLKLMNRKEAQHIEDIMMKVNDVLFNFIKSKGFILYDFKLEFGR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCC
LGDKLVIGDEISLDSMRIRDGNSRIYDKDLYRKGYDLKTVKSSYEEFLKRITS
CCCEEEECCCCCCCCEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEVNKISEGKTKIVYDFDKDHVLLEFKDDITAGDGQKRDILEGKGVLNAQTSAFFFRLLE
CCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHH
RNGIETHYVGMKDERTMIVKKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFESPIVEFFL
HCCCCEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHH
KDDLRHDPLLNYYHMEHLKLMNRKEAQHIEDIMMKVNDVLFNFIKSKGFILYDFKLEFGR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCC
LGDKLVIGDEISLDSMRIRDGNSRIYDKDLYRKGYDLKTVKSSYEEFLKRITS
CCCEEEECCCCCCCCEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726