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The map label for this gene is speH

Identifier: 15897503

GI number: 15897503

Start: 513790

End: 514164

Strand: Reverse

Name: speH

Synonym: SSO0585

Alternate gene names: 15897503

Gene position: 514164-513790 (Counterclockwise)

Preceding gene: 15897506

Following gene: 15897502

Centisome position: 17.18

GC content: 37.07

Gene sequence:

>375_bases
TTGATGATGGGGGTAGAGTTAGCTTTTCCTAAAGTAGTAGGAAAGCAAGTATATGGAAGCTTATATGAGTGTGATGAGGA
CGTTTTAAAAGATACTAAGAGGTTGGAGCAAATAATAAAGGAGGCTGCAGATATAGGCAATATGAACATTCTTGATATAA
AGTCATGGAAAATTGGGGAGGGAGTAAGCGTAGTGGCGATTATATTAGAAAGTCATATAACTATACATACATGGCCGGAG
TATAGATTCGCAACAGTCGATGTATACTCTTGTGGTCCACATACTAGCCCCCTAAATGCATTTAGGTATATAGTTGAAAA
ATTAGGGGCTAAGAGATATACTATAAATGAGGCTGATAGATCATCAGAGTTCTAA

Upstream 100 bases:

>100_bases
TACATTAGTATTTATCAATTAGCATTAAAAACTTACTTTTAACCGTGATCAGGCAGAAATAAATTTATAAATAATAAAGT
AGAGGGGTTTAAGTGGGGGG

Downstream 100 bases:

>100_bases
TAGTAGGTGGAGGAGTAGCTGGTCTATTATTAGCGTATAATATAATGGATTTTGATCCAATAGTTTTCGATAGAAGACGT
TTTCCGGGTAAGAAGTGTAC

Product: S-adenosylmethionine decarboxylase proenzyme

Products: NA

Alternate protein names: AdoMetDC; SAMDC

Number of amino acids: Translated: 124; Mature: 124

Protein sequence:

>124_residues
MMMGVELAFPKVVGKQVYGSLYECDEDVLKDTKRLEQIIKEAADIGNMNILDIKSWKIGEGVSVVAIILESHITIHTWPE
YRFATVDVYSCGPHTSPLNAFRYIVEKLGAKRYTINEADRSSEF

Sequences:

>Translated_124_residues
MMMGVELAFPKVVGKQVYGSLYECDEDVLKDTKRLEQIIKEAADIGNMNILDIKSWKIGEGVSVVAIILESHITIHTWPE
YRFATVDVYSCGPHTSPLNAFRYIVEKLGAKRYTINEADRSSEF
>Mature_124_residues
MMMGVELAFPKVVGKQVYGSLYECDEDVLKDTKRLEQIIKEAADIGNMNILDIKSWKIGEGVSVVAIILESHITIHTWPE
YRFATVDVYSCGPHTSPLNAFRYIVEKLGAKRYTINEADRSSEF

Specific function: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine. Has no arginine decarboxylase (ArgDC) act

COG id: COG1586

COG function: function code E; S-adenosylmethionine decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEH_SULSO (Q9UWY8)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   C90205
- RefSeq:   NP_342108.1
- ProteinModelPortal:   Q9UWY8
- SMR:   Q9UWY8
- GeneID:   1454865
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0585
- NMPDR:   fig|273057.1.peg.531
- HOGENOM:   HBG485559
- OMA:   ISNKFEP
- ProtClustDB:   PRK00458
- BioCyc:   SSOL273057:SSO0585-MONOMER
- BRENDA:   4.1.1.50
- HAMAP:   MF_00464
- InterPro:   IPR003826
- InterPro:   IPR016067
- InterPro:   IPR017716
- Gene3D:   G3DSA:3.60.90.10
- TIGRFAMs:   TIGR03330

Pfam domain/function: PF02675 AdoMet_dc; SSF56276 S-AdenosylMet_decarbase_core

EC number: =4.1.1.50

Molecular weight: Translated: 14044; Mature: 14044

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: ACT_SITE 71-71 ACT_SITE 76-76 ACT_SITE 91-91

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMGVELAFPKVVGKQVYGSLYECDEDVLKDTKRLEQIIKEAADIGNMNILDIKSWKIGE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
GVSVVAIILESHITIHTWPEYRFATVDVYSCGPHTSPLNAFRYIVEKLGAKRYTINEADR
CHHHHHHHHHCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCC
SSEF
CCCC
>Mature Secondary Structure
MMMGVELAFPKVVGKQVYGSLYECDEDVLKDTKRLEQIIKEAADIGNMNILDIKSWKIGE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
GVSVVAIILESHITIHTWPEYRFATVDVYSCGPHTSPLNAFRYIVEKLGAKRYTINEADR
CHHHHHHHHHCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCC
SSEF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726; 1649051