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The map label for this gene is thrC-1 [H]

Identifier: 15897418

GI number: 15897418

Start: 424521

End: 425558

Strand: Direct

Name: thrC-1 [H]

Synonym: SSO0493

Alternate gene names: 15897418

Gene position: 424521-425558 (Clockwise)

Preceding gene: 15897417

Following gene: 15897419

Centisome position: 14.19

GC content: 37.48

Gene sequence:

>1038_bases
GTGATTAGTAGTATGGTAAAAGAGGTTTGTATGAAATGCAGAAAGGAAAGGGAAAGTATATACGAGATTAAGTGTAACAA
ATGCGGAGGACCATTCGAGATCCTGATAGATTTTGAATTTGATAAGAATTCTGAGAGAGGTTTTCCCTATAGTGAAAAGA
TTTTCCCTTACATCAAACATTTCATATCCCTAGGAGAGGGAAGAACTCCATTAATTAAAAAGGGGAACATATGGTTTAAA
CTCGACTTCTTAAATCCATCAGGATCATACAAGGATAGAGGAGCAGTGACTCTGGTCTCTTATCTTGCGGAAAAAGGTGT
AAAACAAATTAGTGAAGACTCTTCTGGAAATGCAGGATCAGCAATAGCTGCGTATTCTGCAGCTGCTGGTATTGAGGCAT
ACATTTTCGTTCCTGAAACGGCAAAAGGAGGAAAACTTAAGCAAATAGAATCCTACGGTGCTCACGTTGTTAGAGTAAGG
GGGAGTAGAGAAGATGTAGCAAAAGCTGCAGAGAATTCTGGTTACTATTACGCATCACATGTTTTACAACCTCAATTTAG
AGATGGGATTAGAACTCTGGCATATGAAATTGTAAAGGATTTAGATTGGAAAATTCCTAATTATGTTTTCATTCCAGTAT
CAGCAGGAACTTTACTTTTAGGTGTTTATAAGGGGTTCAAGCACTTGCTAGATTCTGGTGTCATATCGGAAATGCCTAAA
ATCGTAGCAGTCCAAACAGAGCAAGTTATGCCACTTTGTGCTAAATTCAAAAAGATTTCTTACACACCACCAGACAAGGT
TACCTCCATTGCAGACGCTTTAGTATCAACTAGACCATTTCTACTAGATTATATGGTAAAGGCTTCTAGTGAATGCATAG
TTGTAAGCGATAATGAAATAGTAGAAGCTTGGAAAGAATTGGCTAAAATGGGACTGCTGGTAGAATATAGTTCTGCTACT
GTATTTGCTGCTTATAAGAAATACAGTGTTAACGATGCAGTATTAGTTTTAACCGGTAGCGGATTAAAGGTATTATGA

Upstream 100 bases:

>100_bases
TATAGCTTAATAGTAATAATATGAATAAGTTTTATCATTTAACCCGTTCTTAGGTTCCTATATAATCAAAGCTAGCAAAC
TTGTTATATACTTTAGATTC

Downstream 100 bases:

>100_bases
AGATTTTTGTTGGAACCTCTGGCTGGACGTATGACTGGAATGATGATGATACTTTAGAGTGGTATGTTAAGAATAGTGGG
CTTAACGCAGTAGAGGTTAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MISSMVKEVCMKCRKERESIYEIKCNKCGGPFEILIDFEFDKNSERGFPYSEKIFPYIKHFISLGEGRTPLIKKGNIWFK
LDFLNPSGSYKDRGAVTLVSYLAEKGVKQISEDSSGNAGSAIAAYSAAAGIEAYIFVPETAKGGKLKQIESYGAHVVRVR
GSREDVAKAAENSGYYYASHVLQPQFRDGIRTLAYEIVKDLDWKIPNYVFIPVSAGTLLLGVYKGFKHLLDSGVISEMPK
IVAVQTEQVMPLCAKFKKISYTPPDKVTSIADALVSTRPFLLDYMVKASSECIVVSDNEIVEAWKELAKMGLLVEYSSAT
VFAAYKKYSVNDAVLVLTGSGLKVL

Sequences:

>Translated_345_residues
MISSMVKEVCMKCRKERESIYEIKCNKCGGPFEILIDFEFDKNSERGFPYSEKIFPYIKHFISLGEGRTPLIKKGNIWFK
LDFLNPSGSYKDRGAVTLVSYLAEKGVKQISEDSSGNAGSAIAAYSAAAGIEAYIFVPETAKGGKLKQIESYGAHVVRVR
GSREDVAKAAENSGYYYASHVLQPQFRDGIRTLAYEIVKDLDWKIPNYVFIPVSAGTLLLGVYKGFKHLLDSGVISEMPK
IVAVQTEQVMPLCAKFKKISYTPPDKVTSIADALVSTRPFLLDYMVKASSECIVVSDNEIVEAWKELAKMGLLVEYSSAT
VFAAYKKYSVNDAVLVLTGSGLKVL
>Mature_345_residues
MISSMVKEVCMKCRKERESIYEIKCNKCGGPFEILIDFEFDKNSERGFPYSEKIFPYIKHFISLGEGRTPLIKKGNIWFK
LDFLNPSGSYKDRGAVTLVSYLAEKGVKQISEDSSGNAGSAIAAYSAAAGIEAYIFVPETAKGGKLKQIESYGAHVVRVR
GSREDVAKAAENSGYYYASHVLQPQFRDGIRTLAYEIVKDLDWKIPNYVFIPVSAGTLLLGVYKGFKHLLDSGVISEMPK
IVAVQTEQVMPLCAKFKKISYTPPDKVTSIADALVSTRPFLLDYMVKASSECIVVSDNEIVEAWKELAKMGLLVEYSSAT
VFAAYKKYSVNDAVLVLTGSGLKVL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=162, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789505, Length=249, Percent_Identity=26.9076305220884, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17508781, Length=281, Percent_Identity=26.3345195729537, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24643623, Length=195, Percent_Identity=29.7435897435897, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129101, Length=195, Percent_Identity=29.7435897435897, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 38156; Mature: 38156

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSMVKEVCMKCRKERESIYEIKCNKCGGPFEILIDFEFDKNSERGFPYSEKIFPYIKH
CHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHH
FISLGEGRTPLIKKGNIWFKLDFLNPSGSYKDRGAVTLVSYLAEKGVKQISEDSSGNAGS
HHHCCCCCCCEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
AIAAYSAAAGIEAYIFVPETAKGGKLKQIESYGAHVVRVRGSREDVAKAAENSGYYYASH
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEC
VLQPQFRDGIRTLAYEIVKDLDWKIPNYVFIPVSAGTLLLGVYKGFKHLLDSGVISEMPK
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHCCC
IVAVQTEQVMPLCAKFKKISYTPPDKVTSIADALVSTRPFLLDYMVKASSECIVVSDNEI
EEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCHH
VEAWKELAKMGLLVEYSSATVFAAYKKYSVNDAVLVLTGSGLKVL
HHHHHHHHHCCEEEEECCCEEEEEEHCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MISSMVKEVCMKCRKERESIYEIKCNKCGGPFEILIDFEFDKNSERGFPYSEKIFPYIKH
CHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHH
FISLGEGRTPLIKKGNIWFKLDFLNPSGSYKDRGAVTLVSYLAEKGVKQISEDSSGNAGS
HHHCCCCCCCEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
AIAAYSAAAGIEAYIFVPETAKGGKLKQIESYGAHVVRVRGSREDVAKAAENSGYYYASH
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEC
VLQPQFRDGIRTLAYEIVKDLDWKIPNYVFIPVSAGTLLLGVYKGFKHLLDSGVISEMPK
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHCCC
IVAVQTEQVMPLCAKFKKISYTPPDKVTSIADALVSTRPFLLDYMVKASSECIVVSDNEI
EEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCHH
VEAWKELAKMGLLVEYSSATVFAAYKKYSVNDAVLVLTGSGLKVL
HHHHHHHHHCCEEEEECCCEEEEEEHCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]