Click here to switch to the map view.

The map label for this gene is hisC-like [H]

Identifier: 15897379

GI number: 15897379

Start: 388033

End: 389013

Strand: Direct

Name: hisC-like [H]

Synonym: SSO0448

Alternate gene names: 15897379

Gene position: 388033-389013 (Clockwise)

Preceding gene: 15897378

Following gene: 15897382

Centisome position: 12.97

GC content: 32.72

Gene sequence:

>981_bases
ATGAAACATGGAGGATACCCTTGGAAAAATGGAAAACCAGCTTTAGACGTTAAAGATTTTAGCGTGAATCTTAATCCTAT
GGGTGTACCTAAGTTCATTGAGGAATTAATTAATGAAGCCGTAAAACTTAAAGTATACGCGTATTATCCTCCTCAAAACC
TTAGAGAGATAAAAGGTATAATTGCCGAAATTTACGGAGTTAATGAAGATTTAGTAGGAGTTTTCAATGGTGCTTCCGAG
GTCATTAGTATACTTGACGAGAACTTCACTGTTCCACAGCCTAATTACAGTGAATATAAATTTCATAGCTATTATTTTGC
AGAAGAACATGAAGACGAATTTGTTTTCGAGTTAAATCCAGGTAGGATATTAACTAGCAATCCAAATAATCCTACCGGAT
CTTTAATCAAATTAGACGAAATTGAGGAATTTCTTATAAATGAGAAAAACGAACTTATTCTAGATGAGTCATTTATTGAT
ATAAGCTTGGCGGAAAGCGCGACTAAGCTAGTCAACGAATTCAACAATTTGACAATTATAAACTCATTTACGAAGAGCCT
TGCAATTCCAGGATTGAGATTTGGTTTTTCAATAGGACATAAAAGTAAGGAACTGGAAAAACGTGTACCAATTTGGCGGA
TTAACTCTATTACCTATTATGTTATATCTAATTTAAATCCTAAGGAAGTAAGGTCTTTTTTTGTGAATAGCAAAATTAAG
GTGAAGGAAATTTACGATAAAGTAGATGGCGTGAAGAAGCTGTTCAAAATGTATAAATCTTACGCGCCGTTTTTTCTAGT
AGAATTTAAAATTCCCACGAGCCTGATTAACGATGAACTAATTAGAAGATGTAAATGCTATATAAGGGATGCTAGTAACT
TTTTAGGGTTGAGGAATACCCATGCCAGAATAGCTTTGAAGAATGAGGTTATAGAATTGATTAATAATATAAATGAAATT
ATATCTGAAAAAGAAAGTTAA

Upstream 100 bases:

>100_bases
ATCTGGCTAAAAAGTTAAACATCAGTCCATCTAGTCTAAGTGAAATTATAAGAAGAGCTGAAAAGAACGTAATTACAGCT
TATTTTGAAGAGAGGGAACT

Downstream 100 bases:

>100_bases
GCCCATACATACTTTAGACTAGTTATAAATCTTACTACAAACCCGGATACAATTCCAATGAAATTTGTTAGGACTAGGGT
GAAGGTTGAAGCAGCGAGTT

Product: histidinol-phosphate aminotransferase, putative (hisC-like)

Products: NA

Alternate protein names: Putative threonine-phosphate decarboxylase; L-threonine-O-3-phosphate decarboxylase; Cobyric acid synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKHGGYPWKNGKPALDVKDFSVNLNPMGVPKFIEELINEAVKLKVYAYYPPQNLREIKGIIAEIYGVNEDLVGVFNGASE
VISILDENFTVPQPNYSEYKFHSYYFAEEHEDEFVFELNPGRILTSNPNNPTGSLIKLDEIEEFLINEKNELILDESFID
ISLAESATKLVNEFNNLTIINSFTKSLAIPGLRFGFSIGHKSKELEKRVPIWRINSITYYVISNLNPKEVRSFFVNSKIK
VKEIYDKVDGVKKLFKMYKSYAPFFLVEFKIPTSLINDELIRRCKCYIRDASNFLGLRNTHARIALKNEVIELINNINEI
ISEKES

Sequences:

>Translated_326_residues
MKHGGYPWKNGKPALDVKDFSVNLNPMGVPKFIEELINEAVKLKVYAYYPPQNLREIKGIIAEIYGVNEDLVGVFNGASE
VISILDENFTVPQPNYSEYKFHSYYFAEEHEDEFVFELNPGRILTSNPNNPTGSLIKLDEIEEFLINEKNELILDESFID
ISLAESATKLVNEFNNLTIINSFTKSLAIPGLRFGFSIGHKSKELEKRVPIWRINSITYYVISNLNPKEVRSFFVNSKIK
VKEIYDKVDGVKKLFKMYKSYAPFFLVEFKIPTSLINDELIRRCKCYIRDASNFLGLRNTHARIALKNEVIELINNINEI
ISEKES
>Mature_326_residues
MKHGGYPWKNGKPALDVKDFSVNLNPMGVPKFIEELINEAVKLKVYAYYPPQNLREIKGIIAEIYGVNEDLVGVFNGASE
VISILDENFTVPQPNYSEYKFHSYYFAEEHEDEFVFELNPGRILTSNPNNPTGSLIKLDEIEEFLINEKNELILDESFID
ISLAESATKLVNEFNNLTIINSFTKSLAIPGLRFGFSIGHKSKELEKRVPIWRINSITYYVISNLNPKEVRSFFVNSKIK
VKEIYDKVDGVKKLFKMYKSYAPFFLVEFKIPTSLINDELIRRCKCYIRDASNFLGLRNTHARIALKNEVIELINNINEI
ISEKES

Specific function: Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis:decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cob

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF01656 CbiA; PF07685 GATase_3 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 37541; Mature: 37541

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHGGYPWKNGKPALDVKDFSVNLNPMGVPKFIEELINEAVKLKVYAYYPPQNLREIKGI
CCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHH
IAEIYGVNEDLVGVFNGASEVISILDENFTVPQPNYSEYKFHSYYFAEEHEDEFVFELNP
HHHHHCCCHHHHEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECC
GRILTSNPNNPTGSLIKLDEIEEFLINEKNELILDESFIDISLAESATKLVNEFNNLTII
CEEEECCCCCCCCCEEEHHHHHHHHHCCCCCEEEECCEEEEEHHHHHHHHHHHHCCEEEE
NSFTKSLAIPGLRFGFSIGHKSKELEKRVPIWRINSITYYVISNLNPKEVRSFFVNSKIK
EHHHHHHCCCCHHCCEECCCCHHHHHHCCCEEEECCEEEEEEECCCHHHHHHHHHCCCCH
VKEIYDKVDGVKKLFKMYKSYAPFFLVEFKIPTSLINDELIRRCKCYIRDASNFLGLRNT
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HARIALKNEVIELINNINEIISEKES
CCEEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKHGGYPWKNGKPALDVKDFSVNLNPMGVPKFIEELINEAVKLKVYAYYPPQNLREIKGI
CCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHH
IAEIYGVNEDLVGVFNGASEVISILDENFTVPQPNYSEYKFHSYYFAEEHEDEFVFELNP
HHHHHCCCHHHHEECCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECC
GRILTSNPNNPTGSLIKLDEIEEFLINEKNELILDESFIDISLAESATKLVNEFNNLTII
CEEEECCCCCCCCCEEEHHHHHHHHHCCCCCEEEECCEEEEEHHHHHHHHHHHHCCEEEE
NSFTKSLAIPGLRFGFSIGHKSKELEKRVPIWRINSITYYVISNLNPKEVRSFFVNSKIK
EHHHHHHCCCCHHCCEECCCCHHHHHHCCCEEEECCEEEEEEECCCHHHHHHHHHCCCCH
VKEIYDKVDGVKKLFKMYKSYAPFFLVEFKIPTSLINDELIRRCKCYIRDASNFLGLRNT
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HARIALKNEVIELINNINEIISEKES
CCEEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12712204 [H]