Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 15897295

GI number: 15897295

Start: 305563

End: 306456

Strand: Direct

Name: cysM [H]

Synonym: SSO0360

Alternate gene names: 15897295

Gene position: 305563-306456 (Clockwise)

Preceding gene: 15897294

Following gene: 15897296

Centisome position: 10.21

GC content: 37.47

Gene sequence:

>894_bases
GTGTCAAATCCTCTTCACGTATTCTCAAATGAGCAAGAGTTACTAGAAGGTATGTGGCCTACTCCACTACTAAAACTTAG
GATAGGAAATGACACATGGGCTAAACTAGAATTTTATAATCCTTTTAGCAGAAGTGTAAAAGATAGGACAGCGTGGTTCT
TATTTAGGCAAGCATTACTAAAGAATGCAACTCATATAGTTGAAGCCACCTCTGGCAATACTGGAATAGCATTAGCGTCG
CTATCTTCAATTTTCGGTATGCGATTCACAATGTTTCTTCCCGTAGTTGCTCCAAAGGTGTATAAGGTTTTTGTAAAGTT
ATTAGGAGGTAATGTTATAGAGGCTGGTAATTCGACCAATGATGTAATACCCTTAGTAAAGAAGTTTGCAGAGATGACTA
ATGCGCTCAATTTGGATCAGTTCAATAATCCAATCAACGTAATAGCTCACTATGAGACTACCGCAAGAGAAATTGATGAA
CAGTTAAGTTCTATTGGGAAGAAGCCTTCACGTATTATAGCTACCATGGGAACTGGGGGTCATATAGCGGGGATTGCTAA
GTATTTTAAAGAGAAATATGGAAATGATGTAGAAATAATAGGAGTTCAACCCTCAGAAAATTCCAGAATTCCTGGAATAA
AGAGACAAAATGGCTCTAATTCTTTACTAAGGGACGTGAAGATAGATAGAGTAGTTGACGTAAGTTTGGAAGAAGCAATC
GATGGGACTATTAGTGTAGCAAGGACTTCCGGGATTTTAATAGGTATAAGTGCAGGTGCTACTGTGGCAGCCTATAAGAA
GATAAGTGATGTTTCCTCCACTACAGTGCTTATATTTCCAGATGATGCTTTTAAGTATGTTGATATTTTAGAGCAAACTT
TAAAAGAGATATAG

Upstream 100 bases:

>100_bases
GCGTATCTAAAAAGGATGGGAAGTTAGAAGTAAGGCTCAAGTTAATTAAAAATAAATAAATACCAGTTTCTCACTACTAA
AATCTCGGTAGATCTATATT

Downstream 100 bases:

>100_bases
GAGTAAGCAAATAACTGTGCCAGAAGTAATAGTTATAATGAATAAGAATGGAGATATTCTGGATTTTTCTCCCAGGAGTT
TAGATATATCAAAATTTTTG

Product: cysteine synthase B (cysM)

Products: NA

Alternate protein names: Cystathionine beta-synthase; Cysteine synthase; O-acetylserine sulfhydrylase; O-phosphoserine sulfhydrylase; Serine sulfhydrase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSNPLHVFSNEQELLEGMWPTPLLKLRIGNDTWAKLEFYNPFSRSVKDRTAWFLFRQALLKNATHIVEATSGNTGIALAS
LSSIFGMRFTMFLPVVAPKVYKVFVKLLGGNVIEAGNSTNDVIPLVKKFAEMTNALNLDQFNNPINVIAHYETTAREIDE
QLSSIGKKPSRIIATMGTGGHIAGIAKYFKEKYGNDVEIIGVQPSENSRIPGIKRQNGSNSLLRDVKIDRVVDVSLEEAI
DGTISVARTSGILIGISAGATVAAYKKISDVSSTTVLIFPDDAFKYVDILEQTLKEI

Sequences:

>Translated_297_residues
MSNPLHVFSNEQELLEGMWPTPLLKLRIGNDTWAKLEFYNPFSRSVKDRTAWFLFRQALLKNATHIVEATSGNTGIALAS
LSSIFGMRFTMFLPVVAPKVYKVFVKLLGGNVIEAGNSTNDVIPLVKKFAEMTNALNLDQFNNPINVIAHYETTAREIDE
QLSSIGKKPSRIIATMGTGGHIAGIAKYFKEKYGNDVEIIGVQPSENSRIPGIKRQNGSNSLLRDVKIDRVVDVSLEEAI
DGTISVARTSGILIGISAGATVAAYKKISDVSSTTVLIFPDDAFKYVDILEQTLKEI
>Mature_296_residues
SNPLHVFSNEQELLEGMWPTPLLKLRIGNDTWAKLEFYNPFSRSVKDRTAWFLFRQALLKNATHIVEATSGNTGIALASL
SSIFGMRFTMFLPVVAPKVYKVFVKLLGGNVIEAGNSTNDVIPLVKKFAEMTNALNLDQFNNPINVIAHYETTAREIDEQ
LSSIGKKPSRIIATMGTGGHIAGIAKYFKEKYGNDVEIIGVQPSENSRIPGIKRQNGSNSLLRDVKIDRVVDVSLEEAID
GTISVARTSGILIGISAGATVAAYKKISDVSSTTVLIFPDDAFKYVDILEQTLKEI

Specific function: Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=30.9677419354839, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=30.9677419354839, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=30.9677419354839, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI2367138, Length=284, Percent_Identity=33.0985915492958, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788754, Length=297, Percent_Identity=32.996632996633, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=30.2631578947368, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32566674, Length=268, Percent_Identity=32.089552238806, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17535051, Length=267, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561720, Length=267, Percent_Identity=31.4606741573034, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115535073, Length=254, Percent_Identity=29.5275590551181, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71996324, Length=170, Percent_Identity=30.5882352941176, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17534315, Length=283, Percent_Identity=28.9752650176678, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147552, Length=165, Percent_Identity=31.5151515151515, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=307, Percent_Identity=32.5732899022801, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24643623, Length=208, Percent_Identity=34.6153846153846, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20129101, Length=208, Percent_Identity=34.6153846153846, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.22; =2.5.1.47; =2.5.1.65 [H]

Molecular weight: Translated: 32623; Mature: 32492

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLHVFSNEQELLEGMWPTPLLKLRIGNDTWAKLEFYNPFSRSVKDRTAWFLFRQALL
CCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
KNATHIVEATSGNTGIALASLSSIFGMRFTMFLPVVAPKVYKVFVKLLGGNVIEAGNSTN
HCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
DVIPLVKKFAEMTNALNLDQFNNPINVIAHYETTAREIDEQLSSIGKKPSRIIATMGTGG
HHHHHHHHHHHHHCCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEECCCC
HIAGIAKYFKEKYGNDVEIIGVQPSENSRIPGIKRQNGSNSLLRDVKIDRVVDVSLEEAI
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHC
DGTISVARTSGILIGISAGATVAAYKKISDVSSTTVLIFPDDAFKYVDILEQTLKEI
CCCEEEEECCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNPLHVFSNEQELLEGMWPTPLLKLRIGNDTWAKLEFYNPFSRSVKDRTAWFLFRQALL
CCCCCCCCCHHHHHHCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
KNATHIVEATSGNTGIALASLSSIFGMRFTMFLPVVAPKVYKVFVKLLGGNVIEAGNSTN
HCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
DVIPLVKKFAEMTNALNLDQFNNPINVIAHYETTAREIDEQLSSIGKKPSRIIATMGTGG
HHHHHHHHHHHHHCCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEECCCC
HIAGIAKYFKEKYGNDVEIIGVQPSENSRIPGIKRQNGSNSLLRDVKIDRVVDVSLEEAI
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCHHHHC
DGTISVARTSGILIGISAGATVAAYKKISDVSSTTVLIFPDDAFKYVDILEQTLKEI
CCCEEEEECCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966; 12644499 [H]