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The map label for this gene is eiF6 [H]

Identifier: 15897286

GI number: 15897286

Start: 299584

End: 300255

Strand: Reverse

Name: eiF6 [H]

Synonym: SSO0351

Alternate gene names: 15897286

Gene position: 300255-299584 (Counterclockwise)

Preceding gene: 15897287

Following gene: 15897285

Centisome position: 10.03

GC content: 33.33

Gene sequence:

>672_bases
ATGAATCTGCAAAGGTTATCAGTTTTTGGAACAGATAATATAGGAGTCTATATTTATACTAATAATAAATATACAATCAT
ACCTAGAGGATTAGATAGCGAAACAAAAGAAAATATTGCCCAAGTATTAGGAACGGAGTTATTAGAAGCAGAAATATCCA
GAAGTTTTCTTTTAGGTATTTTCATAAGCGGTAACGATAACGGAATTCTTTTACCTAAGTCTACAATTGATGATGAATTC
AGATTTCTGAAGGAGAATCTAAGGGATTGCAGAGTTGAGATTCTTAATTCAAAAGTTACTGCACTAGGAAATACAATACT
GGCAAATAATAAGGCCGCGTTAATCTACCCTGAATTTAATGATATTGAAGAGAAGATAATAAAGGAGACCTTAGGTGTTG
AAGATATAAAAAGAGGGAAAATAGCTCAAATGATAACCGTAGGTTCTGTAGGAGTTATAACAAATAAGGGTGGACTAGTA
CATGTTGATACAAGTGAGAAAGAATTAAAAGAATTGGAAAAATTGTTCGGAGTTAAGATAGATATTGGCACGGTAAATTT
TGGAAGTGTATTTATCAAAAGTGGGCTAGTCGCAAACGATAAAGGAACGTTAGTAGGCGCGTCAACTACGGGTCCAGAGA
TTTTAAGAATTCAAAAAGCATTAGGTGAATGA

Upstream 100 bases:

>100_bases
TATCAAAGAACGGAAATGATAAAATAGTAAGTAAAATTAGAGTAGTAGTTAGTAAGATAGAAGAAAAAATATATCTTGTG
AGACTAGCTATTAAAAGTAG

Downstream 100 bases:

>100_bases
GATGAGTGGAATAAAATTTTACCTTGTCAAAGGAACTGCACTATTTGGCGAATCCCACTATCCAGAAAAGAGAAAATTTG
TAAAGATAGTTAGAGCATTG

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6 [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNLQRLSVFGTDNIGVYIYTNNKYTIIPRGLDSETKENIAQVLGTELLEAEISRSFLLGIFISGNDNGILLPKSTIDDEF
RFLKENLRDCRVEILNSKVTALGNTILANNKAALIYPEFNDIEEKIIKETLGVEDIKRGKIAQMITVGSVGVITNKGGLV
HVDTSEKELKELEKLFGVKIDIGTVNFGSVFIKSGLVANDKGTLVGASTTGPEILRIQKALGE

Sequences:

>Translated_223_residues
MNLQRLSVFGTDNIGVYIYTNNKYTIIPRGLDSETKENIAQVLGTELLEAEISRSFLLGIFISGNDNGILLPKSTIDDEF
RFLKENLRDCRVEILNSKVTALGNTILANNKAALIYPEFNDIEEKIIKETLGVEDIKRGKIAQMITVGSVGVITNKGGLV
HVDTSEKELKELEKLFGVKIDIGTVNFGSVFIKSGLVANDKGTLVGASTTGPEILRIQKALGE
>Mature_223_residues
MNLQRLSVFGTDNIGVYIYTNNKYTIIPRGLDSETKENIAQVLGTELLEAEISRSFLLGIFISGNDNGILLPKSTIDDEF
RFLKENLRDCRVEILNSKVTALGNTILANNKAALIYPEFNDIEEKIIKETLGVEDIKRGKIAQMITVGSVGVITNKGGLV
HVDTSEKELKELEKLFGVKIDIGTVNFGSVFIKSGLVANDKGTLVGASTTGPEILRIQKALGE

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex [H]

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family [H]

Homologues:

Organism=Homo sapiens, GI4504771, Length=208, Percent_Identity=33.1730769230769, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI31563378, Length=208, Percent_Identity=33.1730769230769, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI31563374, Length=91, Percent_Identity=41.7582417582418, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17506075, Length=217, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325273, Length=226, Percent_Identity=34.070796460177, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21492634, Length=218, Percent_Identity=34.4036697247706, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002769 [H]

Pfam domain/function: PF01912 eIF-6 [H]

EC number: NA

Molecular weight: Translated: 24373; Mature: 24373

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQRLSVFGTDNIGVYIYTNNKYTIIPRGLDSETKENIAQVLGTELLEAEISRSFLLGI
CCCEEEEEEECCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
FISGNDNGILLPKSTIDDEFRFLKENLRDCRVEILNSKVTALGNTILANNKAALIYPEFN
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCEEEECCCEEEEECCCC
DIEEKIIKETLGVEDIKRGKIAQMITVGSVGVITNKGGLVHVDTSEKELKELEKLFGVKI
HHHHHHHHHHCCHHHHCCCCEEEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHCCEE
DIGTVNFGSVFIKSGLVANDKGTLVGASTTGPEILRIQKALGE
EEECCCCCHHHHHCCEEECCCCCEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNLQRLSVFGTDNIGVYIYTNNKYTIIPRGLDSETKENIAQVLGTELLEAEISRSFLLGI
CCCEEEEEEECCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEE
FISGNDNGILLPKSTIDDEFRFLKENLRDCRVEILNSKVTALGNTILANNKAALIYPEFN
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCEEEECCCEEEEECCCC
DIEEKIIKETLGVEDIKRGKIAQMITVGSVGVITNKGGLVHVDTSEKELKELEKLFGVKI
HHHHHHHHHHCCHHHHCCCCEEEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHCCEE
DIGTVNFGSVFIKSGLVANDKGTLVGASTTGPEILRIQKALGE
EEECCCCCHHHHHCCEEECCCCCEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA