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The map label for this gene is lig [H]

Identifier: 15897140

GI number: 15897140

Start: 162109

End: 163914

Strand: Reverse

Name: lig [H]

Synonym: SSO0189

Alternate gene names: 15897140

Gene position: 163914-162109 (Counterclockwise)

Preceding gene: 15897142

Following gene: 15897139

Centisome position: 5.48

GC content: 36.77

Gene sequence:

>1806_bases
ATGGAGTTTAAAGTTATTGCCGAGTACTTTGATAAATTGGAGAAAATATCTTCGAGGCTTCAGCTTACAGCTTTACTAGC
TGATCTTTTAAGTAAAAGTGACAAGACAATTATAGATAAAGTAGTTTATATTATACAAGGCAAATTGTGGCCTGATTTTT
TAGGTTATCCAGAGCTTGGGATCGGAGAGAAATTCCTAATAAAAGCAATCAGTATAGCCACAAACACGGATGAAAATTCA
GTAGAAAATCTGTATAAAACGATAGGAGATCTTGGAGAGGTGGCTCGAAGACTAAAAAGTAAGCAGCAAAGTACAGGAAT
TTTAGGATTTTTGGGTACCACAAGTAAAGAGAGCTTAACAGTGGACGAAGTTTACTCTACATTATCTAAGGTAGCATTAA
CTACGGGAGAGGGTAGTAGAGATTTAAAGATAAGATTATTAGCCGGCTTGTTAAAAAAGGCAGATCCATTAGAGGCTAAG
TTCCTAGTCAGATTTGTTGAAGGTCGGCTTAGAGTAGGTATAGGAGATGCAACAGTTTTAGATGCTATGGCAATAGCGTT
TGGTGGAGGGCAATCAGCATCGGAAATAATTGAAAGAGCCTATAATCTTAGGGCAGATCTAGGAAACATTGCAAAAATTA
TAGTAGAAAAGGGAATTGAAGCGCTAAAGACTCTAAAGCCTCAAGTTGGAATACCAATTAGGCCAATGCTAGCTGAAAGG
CTATCAAATCCTGAAGAAATATTAAAGAAAATGGGTGGGAATGCCATAGTTGATTATAAATATGATGGAGAGAGAGCACA
AATACACAAAAAAGAAGATAAAATTTTCATATTTTCTAGAAGATTAGAGAACATTACTTCTCAGTATCCAGATGTAGTTG
ATTATGTTAGTAAATACATAGAAGGTAAAGAATTCATTATAGAGGGAGAGATAGTAGCTATAGATCCAGAAAGTGGAGAG
ATGAGGCCATTTCAAGAGTTAATGCACAGAAAGAGAAAGTCAGATATTTATGAAGCAATTAAGGAGTACCCAGTTAACGT
ATTTCTCTTCGATCTAATGTATTATGAAGATGTAGATTATACTACAAAGCCATTAGAAGCTAGAAGAAAATTGCTAGAGA
GTATTGTAAAACCAAATGATTATGTAAAAATAGCTCATCATATTCAAGCTAATAATGTAGAGGATCTTAAATCGTTCTTC
TATCGAGCCATATCGGAGGGCGGGGAGGGAGTGATGGTGAAAGCAATCGGAAAAGATGCAATATATCAAGCGGGTGCTAG
GGGTTGGTTATGGATAAAGCTTAAACGTGATTATCAAAGCGAGATGGCTGATACAGTTGACTTAGTAGTGGTTGGCGGTT
TCTACGGTAAGGGTAAAAGAGGCGGTAAGATAAGCTCGTTATTAATGGCTGCATATAATCCTAAGACTGATTCTTTTGAA
TCCGTTTGCAAGGTAGCTAGTGGTTTTTCAGATGAACAGCTTGATGAGTTACAAAAGAAGTTAATGGAAATAAAGAGGGA
CGTTAAGCATCCTAGGGTTAATTCTAAGATGGAACCAGATATATGGGTAGAGCCAGTTTATGTTGCGGAGATAATTGGAT
CAGAGATAACGATATCTCCTTTACATACTTGTTGTCAAGACGTAGTAGAGAAGGATGCTGGTTTATCTATAAGATTTCCT
CGATTTATAAGATGGAGGGATGATAAGAGTCCAGAAGATGCTACGACTACTGATGAGATACTTGAAATGTACAATAAGCA
GCCTAAGAAGAAGATCGAATCACCAGCTGTAGATGAGAGCGTTTAA

Upstream 100 bases:

>100_bases
TCAGAGTAACTCTGACTCTTCATTATTCGAAATCGGTAATTGCCGAGTATTCATCATCGTGAAATGATTATAAATAACTG
CAGATAATATAAATTAATCT

Downstream 100 bases:

>100_bases
AATATATCGGAGCTTTGTATATGTTATCATGTGCAGAGTCTTGTAAAGATACTTCCTAATGGGGCTATTTTAATTGGTAA
AAGATTTACTATAGATGGAC

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLWPDFLGYPELGIGEKFLIKAISIATNTDENS
VENLYKTIGDLGEVARRLKSKQQSTGILGFLGTTSKESLTVDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAK
FLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIIERAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAER
LSNPEEILKKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYIEGKEFIIEGEIVAIDPESGE
MRPFQELMHRKRKSDIYEAIKEYPVNVFLFDLMYYEDVDYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFF
YRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDSFE
SVCKVASGFSDEQLDELQKKLMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISPLHTCCQDVVEKDAGLSIRFP
RFIRWRDDKSPEDATTTDEILEMYNKQPKKKIESPAVDESV

Sequences:

>Translated_601_residues
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLWPDFLGYPELGIGEKFLIKAISIATNTDENS
VENLYKTIGDLGEVARRLKSKQQSTGILGFLGTTSKESLTVDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAK
FLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIIERAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAER
LSNPEEILKKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYIEGKEFIIEGEIVAIDPESGE
MRPFQELMHRKRKSDIYEAIKEYPVNVFLFDLMYYEDVDYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFF
YRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDSFE
SVCKVASGFSDEQLDELQKKLMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISPLHTCCQDVVEKDAGLSIRFP
RFIRWRDDKSPEDATTTDEILEMYNKQPKKKIESPAVDESV
>Mature_601_residues
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLWPDFLGYPELGIGEKFLIKAISIATNTDENS
VENLYKTIGDLGEVARRLKSKQQSTGILGFLGTTSKESLTVDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAK
FLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIIERAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAER
LSNPEEILKKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYIEGKEFIIEGEIVAIDPESGE
MRPFQELMHRKRKSDIYEAIKEYPVNVFLFDLMYYEDVDYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFF
YRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDSFE
SVCKVASGFSDEQLDELQKKLMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISPLHTCCQDVVEKDAGLSIRFP
RFIRWRDDKSPEDATTTDEILEMYNKQPKKKIESPAVDESV

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=623, Percent_Identity=33.0658105939005, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI73747829, Length=595, Percent_Identity=30.7563025210084, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI73747844, Length=595, Percent_Identity=30.7563025210084, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI46255052, Length=499, Percent_Identity=26.25250501002, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI23199993, Length=499, Percent_Identity=26.25250501002, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI148539894, Length=499, Percent_Identity=26.25250501002, Blast_Score=152, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985269, Length=614, Percent_Identity=35.1791530944625, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71985278, Length=150, Percent_Identity=32.6666666666667, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71981465, Length=379, Percent_Identity=24.2744063324538, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320038, Length=617, Percent_Identity=34.3598055105348, Blast_Score=329, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324578, Length=401, Percent_Identity=25.9351620947631, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24762424, Length=622, Percent_Identity=33.1189710610932, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI85815841, Length=566, Percent_Identity=30.0353356890459, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24641829, Length=513, Percent_Identity=23.0019493177388, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 67734; Mature: 67734

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS00333 DNA_LIGASE_A2 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLWPDFLGYPELG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCCCC
IGEKFLIKAISIATNTDENSVENLYKTIGDLGEVARRLKSKQQSTGILGFLGTTSKESLT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
VDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAKFLVRFVEGRLRVGIGDATVL
HHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCHHEECCCHHHHH
DAMAIAFGGGQSASEIIERAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAER
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LSNPEEILKKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYI
CCCHHHHHHHCCCCEEEEEEECCCHHHHCCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHH
EGKEFIIEGEIVAIDPESGEMRPFQELMHRKRKSDIYEAIKEYPVNVFLFDLMYYEDVDY
CCCEEEEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCC
TTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFFYRAISEGGEGVMVKAIGKDA
CCCCHHHHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHH
IYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDSFE
HHHCCCCCEEEEEEECHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHH
SVCKVASGFSDEQLDELQKKLMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHCCCCEEHH
LHTCCQDVVEKDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKKKIESPAVDES
HHHHHHHHHHCCCCCEEECCHHEEECCCCCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCC
V
C
>Mature Secondary Structure
MEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGKLWPDFLGYPELG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCCCC
IGEKFLIKAISIATNTDENSVENLYKTIGDLGEVARRLKSKQQSTGILGFLGTTSKESLT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
VDEVYSTLSKVALTTGEGSRDLKIRLLAGLLKKADPLEAKFLVRFVEGRLRVGIGDATVL
HHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCHHEECCCHHHHH
DAMAIAFGGGQSASEIIERAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAER
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LSNPEEILKKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSKYI
CCCHHHHHHHCCCCEEEEEEECCCHHHHCCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHH
EGKEFIIEGEIVAIDPESGEMRPFQELMHRKRKSDIYEAIKEYPVNVFLFDLMYYEDVDY
CCCEEEEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCC
TTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKSFFYRAISEGGEGVMVKAIGKDA
CCCCHHHHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHH
IYQAGARGWLWIKLKRDYQSEMADTVDLVVVGGFYGKGKRGGKISSLLMAAYNPKTDSFE
HHHCCCCCEEEEEEECHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHH
SVCKVASGFSDEQLDELQKKLMEIKRDVKHPRVNSKMEPDIWVEPVYVAEIIGSEITISP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHCCCCEEHH
LHTCCQDVVEKDAGLSIRFPRFIRWRDDKSPEDATTTDEILEMYNKQPKKKIESPAVDES
HHHHHHHHHHCCCCCEEECCHHEEECCCCCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA