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The map label for this gene is yprA [H]

Identifier: 15896989

GI number: 15896989

Start: 15589

End: 17808

Strand: Direct

Name: yprA [H]

Synonym: SSO0017

Alternate gene names: 15896989

Gene position: 15589-17808 (Clockwise)

Preceding gene: 15896985

Following gene: 15896990

Centisome position: 0.52

GC content: 35.45

Gene sequence:

>2220_bases
GTGGAGATTCTAAGTGAAGTAAATGACAAGCTAAAAACGTTTAACGCTAAGATAGCTCACGTTCATACAGAAACTTTTCT
GGAACCGGAATATGGACCATCCATAAACGAAATAGATATTGATGATAAGCTAAAGAAATCTATTATAGAATATGGAATAG
AGAGATTATATAAATATCAATATGATGCATACCGAAAAATAAAAAATAAGGAAAACGTCATGATCATATCAGGTACTGGA
ACCGGTAAAACTGAAGCATTTTTAATCCCAATTCTAGACCTAGCATTAAAGGGCGAAAGAAGTGTTTTAGTTTATCCTAC
AAAAGCTCTAGCAAGGGATCAACTTACTAGAGTTTACAAATTAGCAAGAGAATTAGGATTGAATGTTGGGATTTTCGATG
GAGATACACCGGAAAAAGAGAGAGAAAGATTGTATAGAAATCCTCCTCACATACTAATAACTAATCCAGATATGATACAT
TTAGGCCTAGCTTTAAGTACTAGATTCAGGTTTTTGTTAAGAACTGCTGATCATTTTATATTTGATGAAGTTCATGTATA
TGAAGGCGTTTTAGGTGCTCATATAAGAAATCTAGCTGATAGAATCAAGGAATTTAAGAACGATATTCATATAGTAGCGT
CAAGTGCCACAGTAGGCGCTACAAAATACTTGTTTGAGGAGCTGTTCGGGGTTGAGGGGGAAATAATAGAGGGGATAAGA
AGAAGAAAAGGAATCGCAATACATAGCATTATTGATAGTGGTAATTCTAGTAGGTGGACGTTGGCTGCTTATTTGGCGGC
AGTTCTAGTTAAAAATGGGCTAAAAGTACTAGTGTTTACTGATTCTCAACAGATGGCAGAGTTAGTAGCTAAGATAGCTG
ATAGATTTAGAGTAAATCTAGAGGTGCATAGAGCAGGTTTAATTGCAGAAGAAAGGATAAAAGTAGAGGAGAAGCTAAGA
AATGGAGAATTGGATGGAGTAGTGGCCACACCTACTTTAGAGCTAGGAATAGACATAGGAACCATTGATGCAGTAATAAT
GGCAGAGAATCCACCAAGTTATACTAAATACGTTCAGAGAGCTGGGAGAGCAGGGAGAAGGAATAACGCTGGTTTAGTAT
TTACAATCTTAGGAGATGATCCTATAGATAGTTACTATCTTAGGCACCCAGAGGAGTTCTTTACCAGAAAAATACAAGCA
TTAACATTTGATCCTACAAACATAGAAGTAATTAAAATTCATGCTTTAGCATATTTGGCTGAAAAATATAGAGTAAAGTT
GAATAATTTACCTCCTCTTTGGAAAAAAGCATATGAGATATTAGCTACCGAAAGCAGAGCTAAAATTGTAGGTAGTTATG
TCTTAGCTACTCCAGAAACTAAAAAATATGTTGCCACAACCTCTCTTAGGAGTGTAGGCCCCATAGTAAGAATATATGAA
GATAAGAAGAAAATCGGCGAAAGAGAACTGCCTGCGGCATTGCATGACCTATATCCAAATGCAGTATATTTGATTTCAAA
GAAGACTTACATTATAGAGGAATTTGATATTGACAGATTAATAGCAAAGGTAAGAAAAGTTAATAGTGAGTTATCGTATT
ACACTAAACCCCTTTATTCAATGGATCTATTGGAGTTTAATAAAAAAGATGAGAGAGAAGTATACGGAGAAAAAGTGGAA
TATGGGGACATGAAATTAGTCATGAGAGTGGAAGGTTATGTAACTTATGATGTATATTCTAAAAGGGGGAAAAATGAGTA
CTTTTATGAAAACCCTATTTCATTTACATATAATACGAAGGGGCTTCTAATATACCACCCATTAATAGATGACTTCACTC
TCATAGATCATATGGAGACCTACCATGCAACCGAGCACGTATTAATATCTGCAGCCAGAGTTGCCGCAGGAGCGTCGTTA
ACTGACTTGGGAGGAATAAGCTATCCTAGTGGACACGTTGTAATATACGACTCCTCCATAGGAGGAAGCGGAGTTTCTAA
ATTATTATTTGAAAGATTGGAGCAAGCTTACGAAGTTGCATTAGATATAGTTAAGAGTTGCAATTGTGAGGATGGTTGTC
CTAATTGTGTATACAGTCCATATTGTGGTAATAATAATAAATATTTATCTAGGAAAAAATCGTTAAGATTAATAGACGGG
TTAATAAAGGGTACAATAAAAGGAGTAAACAAGGATAGAGAGGGAAACCCAATTGCATAA

Upstream 100 bases:

>100_bases
TACATTTGTCTTTCTGTTTAGATAGAAATGTCTCTACATCTTTTGTACTATTAAGGATATCCACCATACTTTTAACCTAC
ATGAAATAGTTAATAAAATT

Downstream 100 bases:

>100_bases
TAACTTTTACAGAATATTAAAGCCAACAAAAGTAGGCAATGTTGAGGTAAAGAACGTAATAAAATACTCAGAAGGTATAT
CTATCTTACCAAATGCCGTA

Product: ATP-dependent helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MEILSEVNDKLKTFNAKIAHVHTETFLEPEYGPSINEIDIDDKLKKSIIEYGIERLYKYQYDAYRKIKNKENVMIISGTG
TGKTEAFLIPILDLALKGERSVLVYPTKALARDQLTRVYKLARELGLNVGIFDGDTPEKERERLYRNPPHILITNPDMIH
LGLALSTRFRFLLRTADHFIFDEVHVYEGVLGAHIRNLADRIKEFKNDIHIVASSATVGATKYLFEELFGVEGEIIEGIR
RRKGIAIHSIIDSGNSSRWTLAAYLAAVLVKNGLKVLVFTDSQQMAELVAKIADRFRVNLEVHRAGLIAEERIKVEEKLR
NGELDGVVATPTLELGIDIGTIDAVIMAENPPSYTKYVQRAGRAGRRNNAGLVFTILGDDPIDSYYLRHPEEFFTRKIQA
LTFDPTNIEVIKIHALAYLAEKYRVKLNNLPPLWKKAYEILATESRAKIVGSYVLATPETKKYVATTSLRSVGPIVRIYE
DKKKIGERELPAALHDLYPNAVYLISKKTYIIEEFDIDRLIAKVRKVNSELSYYTKPLYSMDLLEFNKKDEREVYGEKVE
YGDMKLVMRVEGYVTYDVYSKRGKNEYFYENPISFTYNTKGLLIYHPLIDDFTLIDHMETYHATEHVLISAARVAAGASL
TDLGGISYPSGHVVIYDSSIGGSGVSKLLFERLEQAYEVALDIVKSCNCEDGCPNCVYSPYCGNNNKYLSRKKSLRLIDG
LIKGTIKGVNKDREGNPIA

Sequences:

>Translated_739_residues
MEILSEVNDKLKTFNAKIAHVHTETFLEPEYGPSINEIDIDDKLKKSIIEYGIERLYKYQYDAYRKIKNKENVMIISGTG
TGKTEAFLIPILDLALKGERSVLVYPTKALARDQLTRVYKLARELGLNVGIFDGDTPEKERERLYRNPPHILITNPDMIH
LGLALSTRFRFLLRTADHFIFDEVHVYEGVLGAHIRNLADRIKEFKNDIHIVASSATVGATKYLFEELFGVEGEIIEGIR
RRKGIAIHSIIDSGNSSRWTLAAYLAAVLVKNGLKVLVFTDSQQMAELVAKIADRFRVNLEVHRAGLIAEERIKVEEKLR
NGELDGVVATPTLELGIDIGTIDAVIMAENPPSYTKYVQRAGRAGRRNNAGLVFTILGDDPIDSYYLRHPEEFFTRKIQA
LTFDPTNIEVIKIHALAYLAEKYRVKLNNLPPLWKKAYEILATESRAKIVGSYVLATPETKKYVATTSLRSVGPIVRIYE
DKKKIGERELPAALHDLYPNAVYLISKKTYIIEEFDIDRLIAKVRKVNSELSYYTKPLYSMDLLEFNKKDEREVYGEKVE
YGDMKLVMRVEGYVTYDVYSKRGKNEYFYENPISFTYNTKGLLIYHPLIDDFTLIDHMETYHATEHVLISAARVAAGASL
TDLGGISYPSGHVVIYDSSIGGSGVSKLLFERLEQAYEVALDIVKSCNCEDGCPNCVYSPYCGNNNKYLSRKKSLRLIDG
LIKGTIKGVNKDREGNPIA
>Mature_739_residues
MEILSEVNDKLKTFNAKIAHVHTETFLEPEYGPSINEIDIDDKLKKSIIEYGIERLYKYQYDAYRKIKNKENVMIISGTG
TGKTEAFLIPILDLALKGERSVLVYPTKALARDQLTRVYKLARELGLNVGIFDGDTPEKERERLYRNPPHILITNPDMIH
LGLALSTRFRFLLRTADHFIFDEVHVYEGVLGAHIRNLADRIKEFKNDIHIVASSATVGATKYLFEELFGVEGEIIEGIR
RRKGIAIHSIIDSGNSSRWTLAAYLAAVLVKNGLKVLVFTDSQQMAELVAKIADRFRVNLEVHRAGLIAEERIKVEEKLR
NGELDGVVATPTLELGIDIGTIDAVIMAENPPSYTKYVQRAGRAGRRNNAGLVFTILGDDPIDSYYLRHPEEFFTRKIQA
LTFDPTNIEVIKIHALAYLAEKYRVKLNNLPPLWKKAYEILATESRAKIVGSYVLATPETKKYVATTSLRSVGPIVRIYE
DKKKIGERELPAALHDLYPNAVYLISKKTYIIEEFDIDRLIAKVRKVNSELSYYTKPLYSMDLLEFNKKDEREVYGEKVE
YGDMKLVMRVEGYVTYDVYSKRGKNEYFYENPISFTYNTKGLLIYHPLIDDFTLIDHMETYHATEHVLISAARVAAGASL
TDLGGISYPSGHVVIYDSSIGGSGVSKLLFERLEQAYEVALDIVKSCNCEDGCPNCVYSPYCGNNNKYLSRKKSLRLIDG
LIKGTIKGVNKDREGNPIA

Specific function: Unknown

COG id: COG1205

COG function: function code R; Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI41327773, Length=358, Percent_Identity=24.5810055865922, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1787942, Length=444, Percent_Identity=27.027027027027, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17508543, Length=361, Percent_Identity=24.0997229916898, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320497, Length=731, Percent_Identity=26.812585499316, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320041, Length=354, Percent_Identity=22.8813559322034, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323021, Length=344, Percent_Identity=24.7093023255814, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR018973
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF09369 DUF1998; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 83675; Mature: 83675

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILSEVNDKLKTFNAKIAHVHTETFLEPEYGPSINEIDIDDKLKKSIIEYGIERLYKYQ
CCHHHHHHHHHHHHCCEEEEEEHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YDAYRKIKNKENVMIISGTGTGKTEAFLIPILDLALKGERSVLVYPTKALARDQLTRVYK
HHHHHHHCCCCCEEEEECCCCCCCCEEEEEHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
LARELGLNVGIFDGDTPEKERERLYRNPPHILITNPDMIHLGLALSTRFRFLLRTADHFI
HHHHHCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHH
FDEVHVYEGVLGAHIRNLADRIKEFKNDIHIVASSATVGATKYLFEELFGVEGEIIEGIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHH
RRKGIAIHSIIDSGNSSRWTLAAYLAAVLVKNGLKVLVFTDSQQMAELVAKIADRFRVNL
HHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHEEEE
EVHRAGLIAEERIKVEEKLRNGELDGVVATPTLELGIDIGTIDAVIMAENPPSYTKYVQR
EEECCCCHHHHHHHHHHHHCCCCCCCEEECCEEEECEEEECEEEEEEECCCCHHHHHHHH
AGRAGRRNNAGLVFTILGDDPIDSYYLRHPEEFFTRKIQALTFDPTNIEVIKIHALAYLA
HCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHHHHHHHHEEEECCCCEEEEEEHHHHHHH
EKYRVKLNNLPPLWKKAYEILATESRAKIVGSYVLATPETKKYVATTSLRSVGPIVRIYE
HHHHEEECCCCHHHHHHHHHHHCCCHHHEEEEEEEECCCCCCEEEEHHHHHHCCEEEEEC
DKKKIGERELPAALHDLYPNAVYLISKKTYIIEEFDIDRLIAKVRKVNSELSYYTKPLYS
HHHHCCCHHCCHHHHHCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHH
MDLLEFNKKDEREVYGEKVEYGDMKLVMRVEGYVTYDVYSKRGKNEYFYENPISFTYNTK
HHHHHCCCCCHHHHCCCCCCCCCEEEEEEECCEEEEEEHHCCCCCCCEEECCEEEEECCC
GLLIYHPLIDDFTLIDHMETYHATEHVLISAARVAAGASLTDLGGISYPSGHVVIYDSSI
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEECCC
GGSGVSKLLFERLEQAYEVALDIVKSCNCEDGCPNCVYSPYCGNNNKYLSRKKSLRLIDG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
LIKGTIKGVNKDREGNPIA
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MEILSEVNDKLKTFNAKIAHVHTETFLEPEYGPSINEIDIDDKLKKSIIEYGIERLYKYQ
CCHHHHHHHHHHHHCCEEEEEEHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YDAYRKIKNKENVMIISGTGTGKTEAFLIPILDLALKGERSVLVYPTKALARDQLTRVYK
HHHHHHHCCCCCEEEEECCCCCCCCEEEEEHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
LARELGLNVGIFDGDTPEKERERLYRNPPHILITNPDMIHLGLALSTRFRFLLRTADHFI
HHHHHCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHH
FDEVHVYEGVLGAHIRNLADRIKEFKNDIHIVASSATVGATKYLFEELFGVEGEIIEGIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHH
RRKGIAIHSIIDSGNSSRWTLAAYLAAVLVKNGLKVLVFTDSQQMAELVAKIADRFRVNL
HHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHEEEE
EVHRAGLIAEERIKVEEKLRNGELDGVVATPTLELGIDIGTIDAVIMAENPPSYTKYVQR
EEECCCCHHHHHHHHHHHHCCCCCCCEEECCEEEECEEEECEEEEEEECCCCHHHHHHHH
AGRAGRRNNAGLVFTILGDDPIDSYYLRHPEEFFTRKIQALTFDPTNIEVIKIHALAYLA
HCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHHHHHHHHEEEECCCCEEEEEEHHHHHHH
EKYRVKLNNLPPLWKKAYEILATESRAKIVGSYVLATPETKKYVATTSLRSVGPIVRIYE
HHHHEEECCCCHHHHHHHHHHHCCCHHHEEEEEEEECCCCCCEEEEHHHHHHCCEEEEEC
DKKKIGERELPAALHDLYPNAVYLISKKTYIIEEFDIDRLIAKVRKVNSELSYYTKPLYS
HHHHCCCHHCCHHHHHCCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHH
MDLLEFNKKDEREVYGEKVEYGDMKLVMRVEGYVTYDVYSKRGKNEYFYENPISFTYNTK
HHHHHCCCCCHHHHCCCCCCCCCEEEEEEECCEEEEEEHHCCCCCCCEEECCEEEEECCC
GLLIYHPLIDDFTLIDHMETYHATEHVLISAARVAAGASLTDLGGISYPSGHVVIYDSSI
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEECCC
GGSGVSKLLFERLEQAYEVALDIVKSCNCEDGCPNCVYSPYCGNNNKYLSRKKSLRLIDG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
LIKGTIKGVNKDREGNPIA
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]