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The map label for this gene is pepQ [H]

Identifier: 15896980

GI number: 15896980

Start: 6376

End: 7431

Strand: Direct

Name: pepQ [H]

Synonym: SSO0010

Alternate gene names: 15896980

Gene position: 6376-7431 (Clockwise)

Preceding gene: 15896978

Following gene: 15896981

Centisome position: 0.21

GC content: 34.66

Gene sequence:

>1056_bases
ATGAATCGAATACAGAGAGTACAAAAAGAATTGGAGAGAGCTAATGCAGATTACTTAATAACTGGCACTACTAGCAATAT
GTACTATTTAATAGGATTTTCTGAGGAACAAATGGAAAGGCCACTTTTACTTTTCATTACCAGAGACGATTATTTTCTAC
TTGTACCAAAACTTTATGAGGAGCAATTAAAGCAATTTCCGCTTATCGTCTACAGAGACGGAGAGGATCCTTACTCCAAG
CTAAATTTGAAGGAAAATTCTAATGTTTTAATTGACGATACAACCTTCTCGCTATTTACTATAGAAATACTAAATAGATT
CAAACCTGGAAGAATAGGCAGAGCCTCACGTATATTGGGAAAGCTTAGACAAGTAAAGGATGATGAGGAATTAGAAAAAA
TGGAGAAAGGTGTTAAGAAAGCGGAACAACTTATTTTAGAATTTGTATCGAACATAAAGGAAAATATGACAGAGTGCCAA
ATAGAGAGAAAATTAAAGAGTTTCTTGATCGAAGAGGCGGGTAATATATCGTTTGATCCAATAGTAACCTCCGGTCCTAA
CTCTTCTATGCCTCACTTAAGATGTAGTGATAAAAAGGTAAAACGAGGTGAGGCAATAGTTATAGATTATGGGATAAAGC
ATGATGGCTACTCTACTGACACCACAAGAGTGTTCTCCTTAGGTAAACCTAATGATCCTTTAATTTTAGAAATTGTCGAA
ATTGTTAAAACTGCGAATGAAGAGGCTGAAAAGCATGTAAGAGAAGGTATGAGAGCAAAGGAAATTGACTATTTTGCTAG
AGAAGTCATAACTAATAAAGGGTATGGGGACTATTTTATTCACAGAACTGGACATGGTATAGGAATCGACGTTCATGAAG
ATCCATATATTTCGCCGGATAACGATGATGTAATAGAGCAAAATATGGTGTTTACTATAGAGCCTGGAATTTATCTACCA
GGCAAATTTGGGATAAGGATAGAAGACGAAGTAGTAGTAAAAAAAGGTTATGGGAAAACACTAAACATGTTACAAAAAGA
ATTATACATTATATAA

Upstream 100 bases:

>100_bases
ACGTGATACCCCTTTGGAGCATGATACTTGTATATATCATCATAAACAATAGTTATCATTTAGCCTATCTTTTTATAACA
CGTCTATTTAAGTTTAAAAC

Downstream 100 bases:

>100_bases
TTTCGGCCATAATTTTTTAATTTCAGAATTTCTCTTCAAATGGTAATATTACATCTATGGTCGTTCTTAGTACTATAAAG
AACGGAAGAAGGAAAACACT

Product: X-pro aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNRIQRVQKELERANADYLITGTTSNMYYLIGFSEEQMERPLLLFITRDDYFLLVPKLYEEQLKQFPLIVYRDGEDPYSK
LNLKENSNVLIDDTTFSLFTIEILNRFKPGRIGRASRILGKLRQVKDDEELEKMEKGVKKAEQLILEFVSNIKENMTECQ
IERKLKSFLIEEAGNISFDPIVTSGPNSSMPHLRCSDKKVKRGEAIVIDYGIKHDGYSTDTTRVFSLGKPNDPLILEIVE
IVKTANEEAEKHVREGMRAKEIDYFAREVITNKGYGDYFIHRTGHGIGIDVHEDPYISPDNDDVIEQNMVFTIEPGIYLP
GKFGIRIEDEVVVKKGYGKTLNMLQKELYII

Sequences:

>Translated_351_residues
MNRIQRVQKELERANADYLITGTTSNMYYLIGFSEEQMERPLLLFITRDDYFLLVPKLYEEQLKQFPLIVYRDGEDPYSK
LNLKENSNVLIDDTTFSLFTIEILNRFKPGRIGRASRILGKLRQVKDDEELEKMEKGVKKAEQLILEFVSNIKENMTECQ
IERKLKSFLIEEAGNISFDPIVTSGPNSSMPHLRCSDKKVKRGEAIVIDYGIKHDGYSTDTTRVFSLGKPNDPLILEIVE
IVKTANEEAEKHVREGMRAKEIDYFAREVITNKGYGDYFIHRTGHGIGIDVHEDPYISPDNDDVIEQNMVFTIEPGIYLP
GKFGIRIEDEVVVKKGYGKTLNMLQKELYII
>Mature_351_residues
MNRIQRVQKELERANADYLITGTTSNMYYLIGFSEEQMERPLLLFITRDDYFLLVPKLYEEQLKQFPLIVYRDGEDPYSK
LNLKENSNVLIDDTTFSLFTIEILNRFKPGRIGRASRILGKLRQVKDDEELEKMEKGVKKAEQLILEFVSNIKENMTECQ
IERKLKSFLIEEAGNISFDPIVTSGPNSSMPHLRCSDKKVKRGEAIVIDYGIKHDGYSTDTTRVFSLGKPNDPLILEIVE
IVKTANEEAEKHVREGMRAKEIDYFAREVITNKGYGDYFIHRTGHGIGIDVHEDPYISPDNDDVIEQNMVFTIEPGIYLP
GKFGIRIEDEVVVKKGYGKTLNMLQKELYII

Specific function: Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=226, Percent_Identity=30.0884955752212, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI11559925, Length=247, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI93141226, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI264681565, Length=223, Percent_Identity=29.5964125560538, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788728, Length=234, Percent_Identity=38.8888888888889, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1789275, Length=246, Percent_Identity=24.7967479674797, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=225, Percent_Identity=25.7777777777778, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321118, Length=280, Percent_Identity=22.8571428571429, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320922, Length=259, Percent_Identity=24.3243243243243, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137632, Length=359, Percent_Identity=24.7910863509749, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 40506; Mature: 40506

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRIQRVQKELERANADYLITGTTSNMYYLIGFSEEQMERPLLLFITRDDYFLLVPKLYE
CCHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCHHHHCCCEEEEEECCCEEEECCHHHH
EQLKQFPLIVYRDGEDPYSKLNLKENSNVLIDDTTFSLFTIEILNRFKPGRIGRASRILG
HHHHHCCEEEEECCCCHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHH
KLRQVKDDEELEKMEKGVKKAEQLILEFVSNIKENMTECQIERKLKSFLIEEAGNISFDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
IVTSGPNSSMPHLRCSDKKVKRGEAIVIDYGIKHDGYSTDTTRVFSLGKPNDPLILEIVE
EEECCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHH
IVKTANEEAEKHVREGMRAKEIDYFAREVITNKGYGDYFIHRTGHGIGIDVHEDPYISPD
HHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCCCCCC
NDDVIEQNMVFTIEPGIYLPGKFGIRIEDEVVVKKGYGKTLNMLQKELYII
CCCHHCCCEEEEECCCEEECCCCCEEECCEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNRIQRVQKELERANADYLITGTTSNMYYLIGFSEEQMERPLLLFITRDDYFLLVPKLYE
CCHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCHHHHCCCEEEEEECCCEEEECCHHHH
EQLKQFPLIVYRDGEDPYSKLNLKENSNVLIDDTTFSLFTIEILNRFKPGRIGRASRILG
HHHHHCCEEEEECCCCHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHH
KLRQVKDDEELEKMEKGVKKAEQLILEFVSNIKENMTECQIERKLKSFLIEEAGNISFDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
IVTSGPNSSMPHLRCSDKKVKRGEAIVIDYGIKHDGYSTDTTRVFSLGKPNDPLILEIVE
EEECCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHH
IVKTANEEAEKHVREGMRAKEIDYFAREVITNKGYGDYFIHRTGHGIGIDVHEDPYISPD
HHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCCCCCC
NDDVIEQNMVFTIEPGIYLPGKFGIRIEDEVVVKKGYGKTLNMLQKELYII
CCCHHCCCEEEEECCCEEECCCCCEEECCEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10075426 [H]