Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 15893284

GI number: 15893284

Start: 1257447

End: 1259279

Strand: Reverse

Name: mutL [H]

Synonym: RC1361

Alternate gene names: 15893284

Gene position: 1259279-1257447 (Counterclockwise)

Preceding gene: 15893285

Following gene: 15893283

Centisome position: 99.25

GC content: 33.82

Gene sequence:

>1833_bases
ATGACTATAAAATTTCTGTCAGAAAGTACTATCAACCGAATTGCTGCCGGTGAGGTTATAGAAAGGCCCGCATCGGTAGT
AAAGGAATTAGTTGAAAATGCTGTTGATGCAAGTAGTACTAAAATAGATATTATTTTAGAACGTGCCGGTAAAAATCTAA
TCATTATTTCCGATGACGGTATCGGTATGACTGATAAGGAATTAGAAATTGCTGTTGAACGTCATACAACTTCTAAGTTT
GATGAAAGCGATTTTCTAAATATTAATACTTTTGGTTTTAGGGGTGAAGCACTGCCGTCTATTGCTGCTATTAGCAAAAT
GCTAATTACTTCTAAAAAACGAGATGCCGACAAAGCATTTCAGATTAAGTTAATCGGCGGCAATGAAAAACAAGTTACTA
TTTCTGTTCATAATGAAGGTACTAAAATAGAGATACGTGATTTATTTTTTGCAACACCTGCACGTTTAAAATTTCTTAGA
GCCGATAAAACAGAGCTTACAGCAACTGTAGATGTGGTTAAGAAAATCGCTCTAGCACATCCTAAAATTTCTTTTAGTTT
AACACATGACGGCAAGAATTTATTAAAACTAAAGGGACAAAATAAAGATGCTGAAACTAACCTAAAACAGCGTATAATTG
ATGTAATAGGTGATGATTTTATAAAAAACGCTGCTTATATAGACTTCAAAACACCTGATTTCTCTATTTGCGGCTATACT
AGTAGCCCGACATATAATAGAGCTTCAAGTGAAGATCAGTTTTTATTTATTAATAATAGACCAGTAAAAGATAAATTATT
ACAGGTAGCTTTAAGGGTAGCATATCAAGATTATTTAGCTCGTGATCGTTATCCGATATGTGCTATATTCTTACAAATCG
ATCCGCAACTTGTTGACGTTAACGTACATCCGGCAAAAGCAGAGGTTAGGTTTCATGACCCAAATTATGTGCGAAACTTA
TTAATAGAAGCAATTAAAAATGCTTTAACAAATAAAAGCCATGTTACTTCTACTACTATCGCCTCTGATGTTCTTGAGTT
ATTTAAAAATCCTTTAGTTAACAAACAATCGCCAGTAAGTAAAGTTATAAATGTTAATAGTAAATCGGCAGATTATAGAC
CTACTACTCATTCTACACTTAATACAGTTCCTCAAAATCATGTTTGTCAAAAATTAATCGATACATTATCACATGCTAAA
ATAGAACAAGAAGTAGAAAATCGTATAGAACATGAACAGCAAACCCGTAAACAATATAAACTTGGGGCAGCTAAAGCACA
ACTTCATACGACTTATATTATTTCACAAACCGAAGATAGTATAGTGATTACCGACCAACATGCAGCACACGAACGTTTAG
GGTATGAAAAAATAAAAGATTACCTTAAAACGGAAGAGTTAATCAAACAGCGTTTGCTTATCCCTGAGATAGTAGAACTG
CCAAATGAAAAAAAAGCAGATTGTTTATATGACCATAGAGAAAAACTATATAAACTTGGTTTAACTCTAGAAAAATTCGG
CGAAAAATCTATTATAGTAACTGAAATTCCAAATATCCTTGGAGATGTAAACGTACAAAAGTTAATTCAGGATCTCGCCG
ATCATTTATCGGATTTTGGCAAGAATATAGCTTTGACAGAGTTAATCGAGCATGTAACGGAAACTTATGCCTGTCATTAC
TCTATTAGAGCAGGACGAAAATTATCGGCAGATGAAATGAATGCCTTACTGCGTCAAATGGAAAATACGCCGCTTTCAGG
TCAATGTAATCACGGTAGACCTACTTATATTGAGTTGAAGCTTAAGGATATCGAACGCTTATTTGGACGGTAA

Upstream 100 bases:

>100_bases
AACCTCCATATGACCATCCGAAAGTTTATTTAGAGATAGATAAAAAAAAAAAAGAAGTTATCTGCCCATATTGTAGTAAG
AAATTTAAACTAGTAACAAA

Downstream 100 bases:

>100_bases
CTCGTTTAATTTGAAAAATTGGCGTCATTGCGAACAACTGCAAGGAGTGCGGCAATCTTGGGAAATTAAAACTAGATTGC
CACGCTCCTTATTAGTCGCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTIKFLSESTINRIAAGEVIERPASVVKELVENAVDASSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKF
DESDFLNINTFGFRGEALPSIAAISKMLITSKKRDADKAFQIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLR
ADKTELTATVDVVKKIALAHPKISFSLTHDGKNLLKLKGQNKDAETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
SSPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPICAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNL
LIEAIKNALTNKSHVTSTTIASDVLELFKNPLVNKQSPVSKVINVNSKSADYRPTTHSTLNTVPQNHVCQKLIDTLSHAK
IEQEVENRIEHEQQTRKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIKQRLLIPEIVEL
PNEKKADCLYDHREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIQDLADHLSDFGKNIALTELIEHVTETYACHY
SIRAGRKLSADEMNALLRQMENTPLSGQCNHGRPTYIELKLKDIERLFGR

Sequences:

>Translated_610_residues
MTIKFLSESTINRIAAGEVIERPASVVKELVENAVDASSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKF
DESDFLNINTFGFRGEALPSIAAISKMLITSKKRDADKAFQIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLR
ADKTELTATVDVVKKIALAHPKISFSLTHDGKNLLKLKGQNKDAETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
SSPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPICAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNL
LIEAIKNALTNKSHVTSTTIASDVLELFKNPLVNKQSPVSKVINVNSKSADYRPTTHSTLNTVPQNHVCQKLIDTLSHAK
IEQEVENRIEHEQQTRKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIKQRLLIPEIVEL
PNEKKADCLYDHREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIQDLADHLSDFGKNIALTELIEHVTETYACHY
SIRAGRKLSADEMNALLRQMENTPLSGQCNHGRPTYIELKLKDIERLFGR
>Mature_609_residues
TIKFLSESTINRIAAGEVIERPASVVKELVENAVDASSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKFD
ESDFLNINTFGFRGEALPSIAAISKMLITSKKRDADKAFQIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLRA
DKTELTATVDVVKKIALAHPKISFSLTHDGKNLLKLKGQNKDAETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYTS
SPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPICAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNLL
IEAIKNALTNKSHVTSTTIASDVLELFKNPLVNKQSPVSKVINVNSKSADYRPTTHSTLNTVPQNHVCQKLIDTLSHAKI
EQEVENRIEHEQQTRKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIKQRLLIPEIVELP
NEKKADCLYDHREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIQDLADHLSDFGKNIALTELIEHVTETYACHYS
IRAGRKLSADEMNALLRQMENTPLSGQCNHGRPTYIELKLKDIERLFGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=36.5384615384615, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI4505913, Length=358, Percent_Identity=29.608938547486, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI310128478, Length=358, Percent_Identity=29.608938547486, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI4505911, Length=346, Percent_Identity=28.3236994219653, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI189458898, Length=346, Percent_Identity=28.0346820809249, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI189458896, Length=338, Percent_Identity=28.1065088757396, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI310128480, Length=315, Percent_Identity=28.2539682539683, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI91992162, Length=295, Percent_Identity=30.1694915254237, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI91992160, Length=295, Percent_Identity=30.5084745762712, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=30.7339449541284, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1790612, Length=336, Percent_Identity=39.8809523809524, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=31.8885448916409, Blast_Score=155, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=346, Percent_Identity=28.6127167630058, Blast_Score=117, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=337, Percent_Identity=35.3115727002967, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=339, Percent_Identity=29.4985250737463, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6325093, Length=705, Percent_Identity=21.7021276595745, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17136968, Length=321, Percent_Identity=34.2679127725857, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=27.9329608938547, Blast_Score=113, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68922; Mature: 68791

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKFLSESTINRIAAGEVIERPASVVKELVENAVDASSTKIDIILERAGKNLIIISDDG
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCC
IGMTDKELEIAVERHTTSKFDESDFLNINTFGFRGEALPSIAAISKMLITSKKRDADKAF
CCCCCCHHEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
QIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLRADKTELTATVDVVKKIALAH
EEEEECCCCEEEEEEEECCCCEEEEEHEEECCHHHHHEEECCCHHHHHHHHHHHHHHHCC
PKISFSLTHDGKNLLKLKGQNKDAETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
CCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECC
SSPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPICAIFLQIDPQLVDV
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEE
NVHPAKAEVRFHDPNYVRNLLIEAIKNALTNKSHVTSTTIASDVLELFKNPLVNKQSPVS
EECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
KVINVNSKSADYRPTTHSTLNTVPQNHVCQKLIDTLSHAKIEQEVENRIEHEQQTRKQYK
HHHCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIKQRLLIPEIVEL
HCHHHHHEEEEEEEEECCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHC
PNEKKADCLYDHREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIQDLADHLSDFG
CCCCCCHHHHHHHHHHHHHCCCHHHHCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHC
KNIALTELIEHVTETYACHYSIRAGRKLSADEMNALLRQMENTPLSGQCNHGRPTYIELK
CCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
LKDIERLFGR
HHHHHHHHCC
>Mature Secondary Structure 
TIKFLSESTINRIAAGEVIERPASVVKELVENAVDASSTKIDIILERAGKNLIIISDDG
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEECCCC
IGMTDKELEIAVERHTTSKFDESDFLNINTFGFRGEALPSIAAISKMLITSKKRDADKAF
CCCCCCHHEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
QIKLIGGNEKQVTISVHNEGTKIEIRDLFFATPARLKFLRADKTELTATVDVVKKIALAH
EEEEECCCCEEEEEEEECCCCEEEEEHEEECCHHHHHEEECCCHHHHHHHHHHHHHHHCC
PKISFSLTHDGKNLLKLKGQNKDAETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYT
CCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECC
SSPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPICAIFLQIDPQLVDV
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEE
NVHPAKAEVRFHDPNYVRNLLIEAIKNALTNKSHVTSTTIASDVLELFKNPLVNKQSPVS
EECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
KVINVNSKSADYRPTTHSTLNTVPQNHVCQKLIDTLSHAKIEQEVENRIEHEQQTRKQYK
HHHCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIKQRLLIPEIVEL
HCHHHHHEEEEEEEEECCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHC
PNEKKADCLYDHREKLYKLGLTLEKFGEKSIIVTEIPNILGDVNVQKLIQDLADHLSDFG
CCCCCCHHHHHHHHHHHHHCCCHHHHCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHC
KNIALTELIEHVTETYACHYSIRAGRKLSADEMNALLRQMENTPLSGQCNHGRPTYIELK
CCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
LKDIERLFGR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA