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The map label for this gene is pntAA [H]

Identifier: 15893257

GI number: 15893257

Start: 1237670

End: 1238794

Strand: Reverse

Name: pntAA [H]

Synonym: RC1334

Alternate gene names: 15893257

Gene position: 1238794-1237670 (Counterclockwise)

Preceding gene: 15893261

Following gene: 15893256

Centisome position: 97.64

GC content: 37.16

Gene sequence:

>1125_bases
ATGAAAATCGTTGCTTTAAAAGAAAAAGCCAAGCATGAAACACGAGCCGTAATAACTCCTGAAGTAGCAGGATTGTTAGT
CAAAAAAGGCTATACGGTTATGGTAGAAAAAGATATAGGGCTTCATGCCGGTTTTCTTGATGAAGAATATGTTGCTCTAG
GTGCTAAAATATCTTCGGTACCACTCGAAATTATTTCTGATGCTGATATTATATTAAAGGTGCAACCTTCATCCGTTACG
GATAAATATAGTGAGCTTGAATTTGCAAAAAAAGGAGCAATTATTGTAGGATTATTATCGCCTTATTTAAATCATGAATA
TATAAAAGCGGCAGCTAAAAAAAACCTTACGACTTTTGCTATGGAGTTTGTGCCGAGAATTACTAAAGCTCAAAATATGG
ACGCTTTATCTTCTCAAAGTAACTTAGTAGGCTATAGAGCGGTAATTGAAGCAAGCTATCATTATACAAGGGCTTTTCCT
ATGATGATGACGGCAGCAGGGACGATTTCACCGTGTAAAACTTTAGTGCTTGGTATCGGTGTTGCCGGTCTTCAAGCTAT
TGCAACGGCAAAAAGGCTTGGTAGCATTGTTGCAGGATATGATGTAAGAGCTGCTACCAAAGAGCAGGTAGAAAGCTTAG
GAGCTAAGTTTGTTTCACCGGAATTACAGGAGGATTTACAAGATAAATCAGGCTATGCTCACGAGAGTTCGGAAGATTAT
AAAGCTAAACAAGAAGAGTTTTTAGCAAAAATTATTAAAGGATATGATATAGTGATTACTACTGCACAAATTCCGGGAAA
AAAAGCACCTCTGCTTGTTACGGAAAAAATGCTAGAATCTATGAAGCGTGGCTCAGTGATTGTTGATATAGCGACTAGTA
CAGGCGGGAACGTGGAAGATTCAGAACCGGATAAGATCGTTACTAAGCACGGCGTTACCATAATAGGTTTATCAAACCTT
GCTACTAAAATTGCTACCGACAGCTCAAAATTATATGCTAAGAATTTGTATAATTTTCTAACCTATGCATTGCAAGACGG
TAAGTTTAATATGGATGATGCGTTAGTACGTGAGATGTTGATTACTAAAGACGGAAAAATTGTGAGTGAGAAATTAAATA
TATGA

Upstream 100 bases:

>100_bases
TGATTAGAAAAAATATTTTTTTCATTTTCGTTGTTTTATATTTTAAATTATGTTTAAAATACCTTATGTATTCAGTTAAT
GCAAAATATAATTAGTATTT

Downstream 100 bases:

>100_bases
ATCAATTACCGACGATGGCTAAACAGGCTGCTGAAATTGCCCATAATACCCAAGAATTATCAGATAAATTAAAAGATTTG
GTAATAGATACTAGTTGGCA

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Pyridine nucleotide transhydrogenase subunit alpha 1 [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKIVALKEKAKHETRAVITPEVAGLLVKKGYTVMVEKDIGLHAGFLDEEYVALGAKISSVPLEIISDADIILKVQPSSVT
DKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFAMEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFP
MMMTAAGTISPCKTLVLGIGVAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSPELQEDLQDKSGYAHESSEDY
KAKQEEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKRGSVIVDIATSTGGNVEDSEPDKIVTKHGVTIIGLSNL
ATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDALVREMLITKDGKIVSEKLNI

Sequences:

>Translated_374_residues
MKIVALKEKAKHETRAVITPEVAGLLVKKGYTVMVEKDIGLHAGFLDEEYVALGAKISSVPLEIISDADIILKVQPSSVT
DKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFAMEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFP
MMMTAAGTISPCKTLVLGIGVAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSPELQEDLQDKSGYAHESSEDY
KAKQEEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKRGSVIVDIATSTGGNVEDSEPDKIVTKHGVTIIGLSNL
ATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDALVREMLITKDGKIVSEKLNI
>Mature_374_residues
MKIVALKEKAKHETRAVITPEVAGLLVKKGYTVMVEKDIGLHAGFLDEEYVALGAKISSVPLEIISDADIILKVQPSSVT
DKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFAMEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFP
MMMTAAGTISPCKTLVLGIGVAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSPELQEDLQDKSGYAHESSEDY
KAKQEEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKRGSVIVDIATSTGGNVEDSEPDKIVTKHGVTIIGLSNL
ATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDALVREMLITKDGKIVSEKLNI

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=375, Percent_Identity=37.3333333333333, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI122939153, Length=375, Percent_Identity=37.3333333333333, Blast_Score=245, Evalue=4e-65,
Organism=Escherichia coli, GI1787887, Length=372, Percent_Identity=40.5913978494624, Blast_Score=268, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17550456, Length=369, Percent_Identity=42.2764227642276, Blast_Score=301, Evalue=5e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40618; Mature: 40618

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVALKEKAKHETRAVITPEVAGLLVKKGYTVMVEKDIGLHAGFLDEEYVALGAKISSV
CEEEEECHHHCCCCCEEECHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCC
PLEIISDADIILKVQPSSVTDKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFA
CHHEECCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHCHHHHHHHHHCCHHHHH
MEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFPMMMTAAGTISPCKTLVLGIG
HHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSPELQEDLQDKSGYAHESSEDY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHH
KAKQEEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKRGSVIVDIATSTGGNVED
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
SEPDKIVTKHGVTIIGLSNLATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDALVREML
CCCCCEEHHCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ITKDGKIVSEKLNI
HCCCCCCHHHHCCC
>Mature Secondary Structure
MKIVALKEKAKHETRAVITPEVAGLLVKKGYTVMVEKDIGLHAGFLDEEYVALGAKISSV
CEEEEECHHHCCCCCEEECHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCC
PLEIISDADIILKVQPSSVTDKYSELEFAKKGAIIVGLLSPYLNHEYIKAAAKKNLTTFA
CHHEECCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHHHCHHHHHHHHHCCHHHHH
MEFVPRITKAQNMDALSSQSNLVGYRAVIEASYHYTRAFPMMMTAAGTISPCKTLVLGIG
HHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VAGLQAIATAKRLGSIVAGYDVRAATKEQVESLGAKFVSPELQEDLQDKSGYAHESSEDY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHH
KAKQEEFLAKIIKGYDIVITTAQIPGKKAPLLVTEKMLESMKRGSVIVDIATSTGGNVED
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
SEPDKIVTKHGVTIIGLSNLATKIATDSSKLYAKNLYNFLTYALQDGKFNMDDALVREML
CCCCCEEHHCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ITKDGKIVSEKLNI
HCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893; 9335295; 8662004 [H]