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The map label for this gene is nuoI [H]

Identifier: 15893152

GI number: 15893152

Start: 1133806

End: 1134285

Strand: Reverse

Name: nuoI [H]

Synonym: RC1229

Alternate gene names: 15893152

Gene position: 1134285-1133806 (Counterclockwise)

Preceding gene: 15893153

Following gene: 15893135

Centisome position: 89.4

GC content: 39.38

Gene sequence:

>480_bases
ATGATAAACTATTTAAAATCGTTTTTTCTATATGAGATAGTAAGGGGGATGGTTTTGACTTTAAAGTATTTCTTTAAGCC
CAAAGTTACCATAAATTATCCTTATGAAAAAAGCCCTATTAGTCCAAGATTTAAGGGTGAACATGCCCTGCGTCGCTATG
AAAACGGTGAAGAACGCTGCATTGCGTGCAAACTCTGTGAGGCGATTTGTCCGGCACAAGCGATAGTAATTGAAGCGGAC
GAACGAGAAGACGGCAGCAGGCGTACTACTCGTTATGATATAGATATGACAAAATGCATTTATTGCGGATTATGTCAGGA
AGCTTGCCCTGTAGATGCAATAGTTGAAGGTCCTAATTTTGAGTTTGCAAGTCTAACTCATACCGCACTTATTTACGATA
AGGAAAGATTACTGCAAAATGGCGATAGATGGGAACAGGCACTCGCTAGTAAACTACACAAAGATTACGAGTATAGGTAA

Upstream 100 bases:

>100_bases
ATGAGATTGCCACGCAGCCTACGGCTGTTCGCAATGACAACTCGGTATCCATGCGGGTGATGCCCCGCAGCAATACATCG
ATCTTTAATATATAATTTTT

Downstream 100 bases:

>100_bases
TATACTCGTTTAATTACTCTTCATTTATTCGGAATATATACGTATATTATGCTATTGTGATTCTGTTAATAGGTTCATTT
CAAAAAAGTTAAATTAAAAA

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MINYLKSFFLYEIVRGMVLTLKYFFKPKVTINYPYEKSPISPRFKGEHALRRYENGEERCIACKLCEAICPAQAIVIEAD
EREDGSRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNFEFASLTHTALIYDKERLLQNGDRWEQALASKLHKDYEYR

Sequences:

>Translated_159_residues
MINYLKSFFLYEIVRGMVLTLKYFFKPKVTINYPYEKSPISPRFKGEHALRRYENGEERCIACKLCEAICPAQAIVIEAD
EREDGSRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNFEFASLTHTALIYDKERLLQNGDRWEQALASKLHKDYEYR
>Mature_159_residues
MINYLKSFFLYEIVRGMVLTLKYFFKPKVTINYPYEKSPISPRFKGEHALRRYENGEERCIACKLCEAICPAQAIVIEAD
EREDGSRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNFEFASLTHTALIYDKERLLQNGDRWEQALASKLHKDYEYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=154, Percent_Identity=69.4805194805195, Blast_Score=241, Evalue=2e-64,
Organism=Escherichia coli, GI1788617, Length=128, Percent_Identity=39.0625, Blast_Score=101, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17555194, Length=159, Percent_Identity=69.811320754717, Blast_Score=237, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17864306, Length=154, Percent_Identity=71.4285714285714, Blast_Score=244, Evalue=2e-65,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18600; Mature: 18600

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINYLKSFFLYEIVRGMVLTLKYFFKPKVTINYPYEKSPISPRFKGEHALRRYENGEERC
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCHHH
IACKLCEAICPAQAIVIEADEREDGSRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNF
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCEEECCCCC
EFASLTHTALIYDKERLLQNGDRWEQALASKLHKDYEYR
CCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MINYLKSFFLYEIVRGMVLTLKYFFKPKVTINYPYEKSPISPRFKGEHALRRYENGEERC
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCHHH
IACKLCEAICPAQAIVIEADEREDGSRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNF
HHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCEEECCCCC
EFASLTHTALIYDKERLLQNGDRWEQALASKLHKDYEYR
CCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA