Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 15893117

GI number: 15893117

Start: 1091462

End: 1092151

Strand: Reverse

Name: gmk

Synonym: RC1194

Alternate gene names: 15893117

Gene position: 1092151-1091462 (Counterclockwise)

Preceding gene: 15893118

Following gene: 15893116

Centisome position: 86.08

GC content: 34.35

Gene sequence:

>690_bases
ATGACAACAAAAAATAAAAGAGTGCTTCAGAAATGCGCTTATAGAGAGGAATTTAAAGGAGACATGGAACGTAGCACCGC
AGCGACGTCTAAATTACCTCTAGAAGTAGAACTTTCGAGGAACTCTAAAGGACTGATTATAATTTTATCTTCCCCTTCAG
GTACAGGTAAGTCGAGTTTAGCTAAAGCATTATTGAAAATAGATAATAATTTGCGTTTATCTATTTCGGCAACTACAAGA
AAACCACGTTTAGGAGAAGTAGAGGGCATAAACTATTACTTTAAGACCGGTCTAGAGTTTGAAGAATTAGTTAAGCAGAA
TAAATTCCTTGAATATGCTAAAATATACGATAATTATTACGGTACGCCTAAAGAATATGTCGAAATGTTATTAAATCAAG
GCTTGGATGTTTTGTTTGATATTGATTGGCAAGGAGCAAGGAGTATTAAGAAAAATGCTACTAATGTTGTTACTATATTT
GTATTGCCTCCTAATATTGAAGTATTGGAACAACGCTTAAGAAATAGAGCGACCGATAATGAAGAAGCAATAAAATTACG
TATGCAGTTGGCACAAAACGAAATATCACATGCTAATGAGTATGATTATGTAGTTACTAACGATGACTTTGACCGGACGC
TTAAAAAAATACATGCGATTATAGTTGCAGCACGAGACAAAGCGTTTTGA

Upstream 100 bases:

>100_bases
ACTCACGTAGTTTACCTACCGCTTTCGCAGGCTTGCATTTAAATTCATCTTGTCTAAATCTTTCTGAAATATGCTGTACC
TACGAAATAAAACATAAAAT

Downstream 100 bases:

>100_bases
CTTTGTCGTTTTTTCTTTCTATACTGAGAATTAGACGTTATGTTTCTAATTTTCATATCGTAGAAGCTTATAATATTCCT
AAAATCAATATTTTTGATCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTTKNKRVLQKCAYREEFKGDMERSTAATSKLPLEVELSRNSKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTR
KPRLGEVEGINYYFKTGLEFEELVKQNKFLEYAKIYDNYYGTPKEYVEMLLNQGLDVLFDIDWQGARSIKKNATNVVTIF
VLPPNIEVLEQRLRNRATDNEEAIKLRMQLAQNEISHANEYDYVVTNDDFDRTLKKIHAIIVAARDKAF

Sequences:

>Translated_229_residues
MTTKNKRVLQKCAYREEFKGDMERSTAATSKLPLEVELSRNSKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTR
KPRLGEVEGINYYFKTGLEFEELVKQNKFLEYAKIYDNYYGTPKEYVEMLLNQGLDVLFDIDWQGARSIKKNATNVVTIF
VLPPNIEVLEQRLRNRATDNEEAIKLRMQLAQNEISHANEYDYVVTNDDFDRTLKKIHAIIVAARDKAF
>Mature_228_residues
TTKNKRVLQKCAYREEFKGDMERSTAATSKLPLEVELSRNSKGLIIILSSPSGTGKSSLAKALLKIDNNLRLSISATTRK
PRLGEVEGINYYFKTGLEFEELVKQNKFLEYAKIYDNYYGTPKEYVEMLLNQGLDVLFDIDWQGARSIKKNATNVVTIFV
LPPNIEVLEQRLRNRATDNEEAIKLRMQLAQNEISHANEYDYVVTNDDFDRTLKKIHAIIVAARDKAF

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RPE1 insert domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=37.7142857142857, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=37.7142857142857, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI226874831, Length=171, Percent_Identity=38.5964912280702, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=22.680412371134, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21389483, Length=184, Percent_Identity=27.7173913043478, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=25.8426966292135, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=26.5895953757225, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=26.7441860465116, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=26.5895953757225, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=26.7441860465116, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=186, Percent_Identity=47.3118279569892, Blast_Score=187, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=39.2045454545455, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=39.2045454545455, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17557440, Length=191, Percent_Identity=24.0837696335079, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=146, Percent_Identity=28.0821917808219, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=176, Percent_Identity=23.2954545454545, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=187, Percent_Identity=22.9946524064171, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=39.344262295082, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356141, Length=180, Percent_Identity=36.1111111111111, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI85724806, Length=177, Percent_Identity=25.9887005649718, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI116007136, Length=177, Percent_Identity=25.9887005649718, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45554481, Length=177, Percent_Identity=25.9887005649718, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=25.9887005649718, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=25.9887005649718, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI161077626, Length=177, Percent_Identity=25.9887005649718, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_RICCN (Q92GC9)

Other databases:

- EMBL:   AE006914
- PIR:   B97849
- RefSeq:   NP_360831.1
- ProteinModelPortal:   Q92GC9
- SMR:   Q92GC9
- GeneID:   928341
- GenomeReviews:   AE006914_GR
- KEGG:   rco:RC1194
- NMPDR:   fig|272944.1.peg.1194
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   RCON272944:RC1194-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- InterPro:   IPR005728
- SMART:   SM00072
- TIGRFAMs:   TIGR03263
- TIGRFAMs:   TIGR01045

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 26188; Mature: 26057

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKNKRVLQKCAYREEFKGDMERSTAATSKLPLEVELSRNSKGLIIILSSPSGTGKSSL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCHHHH
AKALLKIDNNLRLSISATTRKPRLGEVEGINYYFKTGLEFEELVKQNKFLEYAKIYDNYY
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCC
GTPKEYVEMLLNQGLDVLFDIDWQGARSIKKNATNVVTIFVLPPNIEVLEQRLRNRATDN
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCC
EEAIKLRMQLAQNEISHANEYDYVVTNDDFDRTLKKIHAIIVAARDKAF
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHEEECCCCC
>Mature Secondary Structure 
TTKNKRVLQKCAYREEFKGDMERSTAATSKLPLEVELSRNSKGLIIILSSPSGTGKSSL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCHHHH
AKALLKIDNNLRLSISATTRKPRLGEVEGINYYFKTGLEFEELVKQNKFLEYAKIYDNYY
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCC
GTPKEYVEMLLNQGLDVLFDIDWQGARSIKKNATNVVTIFVLPPNIEVLEQRLRNRATDN
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCC
EEAIKLRMQLAQNEISHANEYDYVVTNDDFDRTLKKIHAIIVAARDKAF
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893