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The map label for this gene is groEL [H]

Identifier: 15892891

GI number: 15892891

Start: 910058

End: 911704

Strand: Reverse

Name: groEL [H]

Synonym: RC0968

Alternate gene names: 15892891

Gene position: 911704-910058 (Counterclockwise)

Preceding gene: 161723842

Following gene: 15892887

Centisome position: 71.86

GC content: 38.62

Gene sequence:

>1647_bases
ATGGCAACAAAACTTATTAAACACGGCTCAAAAGCTCGTGAGCAAATGTTAGAAGGCATTGATATACTTGCAGATGCAGT
AAAAGTTACTTTAGGTCCAAAAGGCAGAAATGTACTTATAGAGCAATCATTCGGTTCACCGAAAATTACAAAAGATGGTG
TGACGGTTGCAAAATCGATCGAGTTAAAAGATAAAATTAGAAATGCGGGAGCTCAGCTATTAAAATCAGCTGCTACAAAA
GCTGCAGAAGTAGCCGGTGATGGTACTACTACAGCTACGGTACTTGCTAGAGCTTTGGCTCGTGAGGGTAATAAGCTAGT
AGCTGCCGGTTATAATCCTATGGATTTAAAGCGTGGTATGGATTTAGCGGTAAACGCAGTAGTAGAAGAAATTAAAAAAT
CCAGTAAAAAAATCAATAGCCAAGAGGAAATCGCACAAGTCGGTACTATCTCTTCAAACGGTGATAAGGAAATCGGTGAG
AAAATTGCTAAGGCAATGGAGGAAGTCGGTAAAGAAGGCGTGATAACCGTTGAAGAAGCAAAGAATTTTAGCTTCGATGT
TGAAGTAGTTAAAGGTATGATGTTTGATAGAGGTTATCTATCACCGTATTTTGTAACGAATTCTGAGAAAATGGTTGCTG
AGCTTGAAAATCCTTTCATCTTACTATTTGAGAAAAAATTATCAAATTTACAACCGATGTTACCTATACTTGAGGCTGTA
GTACAATCACAACGCCCTCTATTAATTATTGCTGAGGATGTTGAGGGCGAAGCTCTTGCAACGCTTGTAGTCAATAGATT
ACGTGGTGGTTTAAAAGTTGCGGCAGTAAAAGCTCCCGGTTTTGGCGATAGAAGAAAAGCAATGATGGAAGATATTGCTA
TCCTAACTAAAGGTGAGCTTATTACTGAAGATTTAGGTATGAAGCTTGAAAATGTGAGTATTAAGAGTCTAGGGACAGCA
AAAAGAGTAACAATTTCTAAAGAAAATACCGTAATTGTTGACGGTAACGGTGATAAGAAAAATATTGAAGATAGAGTATT
ACAAATTAAATCTCAAATAGCTGAAACTACTTCTGATTATGATAAAGAAAAACTGCAAGAGCGTTTAGCTAAACTTTCCG
GCGGTGTTGCCGTATTAAAGGTTGGCGGTGCTACGGAAGTTGAAGTGAAAGAGCGTAAAGATCGTGTTGAAGATGCACTT
GCTGCTACAAGAGCGGCAGTTGAGGAAGGTGTTGTTGCCGGTGGCGGTGTAACATTACTTCACGCATCACAACCTTTAAC
AAAGCTTAAAGTAGAGAATAAGGATCAACAAGCAGGTATTGAAATAGTAATAGAAGCTTTAAAGGATCCGTTAAAACAGA
TTGTTGAAAATGCCGGTGAAAACGGTGGCGTAGTAGTTGGTAAATTACTAGAACATAAGGATAAAAATTATGGCTTTAAT
GCTCAAGATATGCAATATGTCGATATGATTAAAGCAGGAATTATTGATCCAGCTAAAGTAGTGCGTACTGCACTTCAAGA
TGCTGCTTCCGTTGCTTCGTTAATTATTACCACGGAAACTTTAATTGTTGACGAACCTTCTTCTGATAAGGCAGAGCCAA
TGCCAATGCGTGGCGGTATGGGAGGTATGGGCGGTATGGATTTCTAA

Upstream 100 bases:

>100_bases
CACCGAAATTGAAATTAAAGGCACAAAACTGATCGTTATGAAAGAAAGCGACGTATTTGGTATTATTAATTAATTATTTG
TTTTTAAGGAGAAATTAAAT

Downstream 100 bases:

>100_bases
GTCTATATCTCTATAAGATAGGTTATGTAATAGATCTAATAAACCCGTTTTGTTGTATTGCTCGTTCCCCTCATTGTAAG
GAGGCATTGTTGCATGGACC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MATKLIKHGSKAREQMLEGIDILADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSIELKDKIRNAGAQLLKSAATK
AAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGE
KIAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVSIKSLGTA
KRVTISKENTVIVDGNGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDAL
AATRAAVEEGVVAGGGVTLLHASQPLTKLKVENKDQQAGIEIVIEALKDPLKQIVENAGENGGVVVGKLLEHKDKNYGFN
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSSDKAEPMPMRGGMGGMGGMDF

Sequences:

>Translated_548_residues
MATKLIKHGSKAREQMLEGIDILADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSIELKDKIRNAGAQLLKSAATK
AAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGE
KIAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVSIKSLGTA
KRVTISKENTVIVDGNGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDAL
AATRAAVEEGVVAGGGVTLLHASQPLTKLKVENKDQQAGIEIVIEALKDPLKQIVENAGENGGVVVGKLLEHKDKNYGFN
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSSDKAEPMPMRGGMGGMGGMDF
>Mature_547_residues
ATKLIKHGSKAREQMLEGIDILADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSIELKDKIRNAGAQLLKSAATKA
AEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGEK
IAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAVV
QSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVSIKSLGTAK
RVTISKENTVIVDGNGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALA
ATRAAVEEGVVAGGGVTLLHASQPLTKLKVENKDQQAGIEIVIEALKDPLKQIVENAGENGGVVVGKLLEHKDKNYGFNA
QDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSSDKAEPMPMRGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.7878787878788, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.7878787878788, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI5453607, Length=564, Percent_Identity=24.113475177305, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=60.7142857142857, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=524, Percent_Identity=54.0076335877863, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=207, Percent_Identity=54.1062801932367, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17564182, Length=582, Percent_Identity=22.680412371134, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144674, Length=483, Percent_Identity=23.6024844720497, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147750, Length=133, Percent_Identity=37.593984962406, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=56.6793893129771, Blast_Score=582, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6322524, Length=564, Percent_Identity=22.3404255319149, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.3206831119545, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.3206831119545, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.7175572519084, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.7175572519084, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.7175572519084, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=549, Percent_Identity=45.1730418943534, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=37.6893939393939, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=37.6893939393939, Blast_Score=323, Evalue=2e-88,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58715; Mature: 58583

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKLIKHGSKAREQMLEGIDILADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSI
CCCHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELKDKIRNAGAQLLKSAATKAAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCC
DLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGEKIAKAMEEVGKEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
CCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGEL
HCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ITEDLGMKLENVSIKSLGTAKRVTISKENTVIVDGNGDKKNIEDRVLQIKSQIAETTSDY
HHHHHCCEEECCCHHCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALAATRAAVEEGVVAGGGVTLL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEE
HASQPLTKLKVENKDQQAGIEIVIEALKDPLKQIVENAGENGGVVVGKLLEHKDKNYGFN
ECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCC
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSSDKAEPMPMRGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC
>Mature Secondary Structure 
ATKLIKHGSKAREQMLEGIDILADAVKVTLGPKGRNVLIEQSFGSPKITKDGVTVAKSI
CCHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELKDKIRNAGAQLLKSAATKAAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHCCC
DLAVNAVVEEIKKSSKKINSQEEIAQVGTISSNGDKEIGEKIAKAMEEVGKEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAV
CCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGEL
HCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ITEDLGMKLENVSIKSLGTAKRVTISKENTVIVDGNGDKKNIEDRVLQIKSQIAETTSDY
HHHHHCCEEECCCHHCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALAATRAAVEEGVVAGGGVTLL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEE
HASQPLTKLKVENKDQQAGIEIVIEALKDPLKQIVENAGENGGVVVGKLLEHKDKNYGFN
ECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCC
AQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSSDKAEPMPMRGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA