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The map label for this gene is gyrB [H]

Identifier: 15892807

GI number: 15892807

Start: 830456

End: 832879

Strand: Reverse

Name: gyrB [H]

Synonym: RC0884

Alternate gene names: 15892807

Gene position: 832879-830456 (Counterclockwise)

Preceding gene: 15892810

Following gene: 15892806

Centisome position: 65.65

GC content: 37.25

Gene sequence:

>2424_bases
ATGTCGGAAATTGAAGAAAAATTTAACGAATCATCATACGGTGCTGATTCCATAAAGGTTTTAAAAGGTCTTGAAGCCGT
AAGAAAAAGACCGGGAATGTATATCGGGGATGTTGGAGACGGGTCGGGTCTACATCATATGATTTATGAAGTAGTCGACA
ACGCTATCGATGAGTCGCTTGCTGGTTATTGCGATCTAGTACGAGTAACATTAAATAAAAACGGTTCAGTAACCGTATCC
GATAACGGGCGAGGTATACCCGTTGAAATTCATGGAGAAGAAGGAATATCGGCAGCTGAAGTTATTATGACGCAACTTCA
CGCCGGCGGTAAGTTTGACCAGAACGCTTATAAGGTTGCAGGCGGTCTACACGGTGTTGGTGTATCGGTTGTAAATGCTC
TTTCTGAATGGCTTGAGCTGCGTATTTGGCGTAATAATAAGGAATATTTGATGAGATTTAATAATGGTATAACGGAAGCT
CCGCTTGCGGTTGTCAAAGAAAATATTGATAAAAAAGGTACGGAAGTTACTTTTTTTCCGTCTGTAGAAACGTTTACTAA
TATAGAATTTGATTTTGGCACTATAGAGCATCGTCTTCGTGAGCTTGCTTTTTTAAATTCAGGCGTAAAGATTTTACTCG
TCGATAATCGCTTTGAAGAAGTGAAAGAAGTAGAGTTTTATTATACGGGCGGTATAGAAGCTTATGTAAAATATATAGAC
AGAGCGAAGCACGCTATCCATCCATGTATAGTAGTTAATACGGAGAATGCTGAGTCTGGTATAAGCCTTGAGCTTGCGAT
GCATTGGAACGATTCTTATCATGAAAATATTTTATGCTTTACTAATAATATTAGGCAGCGTGATGGCGGAACTCATCTTA
GTGCTTTCAAATCAGCGATAACACGTGTTATTACCTCGTATCTTGATACTACGGGTCTTAATAAAAAAGCTAAAAATTAC
TTTAGCGGTGAAGATACTAGGGAAGGGCTATGTTGTGTGCTTTCCGTTAAAGTGCCTGATCCTAAATTTTCTTCTCAAAC
AAAAGATAAGCTAGTAAGCTCCGAAGTACGACCGGTTGTTGAGAATGCCGTTTATACAAAGGTTCTTGAGTGGTTTGAAG
AGCATCCAGCAGAAGCTAAGGCAATTATAGCTAAGATTATGGAAGCTGCGAATGCTCGTGAAGCTGCTAGAAAAGCAAGG
GAACTCACTCGAAGAAAATCAGCTTTAGAAGTTTCGAATTTACCAGGTAAACTTGCAGATTGCCATGCAAAAGATCCTGC
TATTTCAGAATTGTTTATTGTTGAGGGGGACTCTGCGGGCGGTACTGCAAAGCAGGGTAGGGATAGCAAAATTCAGGCTA
TATTGCCTTTGCGTGGTAAAATTTTGAACGTTGAACGTGCAAGATTTGATAAAATGCTCGGTTCGGACCAAATCGGTACG
TTAATTACAGCGCTTGGAATTAGTGTTGAACGAGAATTTTCCTTAGAAAAGCTTAGATACCATAAAGTTATTATTATGAC
CGATGCTGATGTTGATGGTTCGCACATTAGAACTTTATTACTCACGTTTTTCTATCGTCATATGCCTGAGCTAATAAATA
AAGGCTATTTATATATAGCTCAGCCACCGCTTTATAAAGTAAAGAAAGGAGCAGCCGAGTTTTATTTAAAGAATGAGCAA
GCGCTGCAAGATTATTTGATCAAATCAACTATTAATGATGCAACCTTAATTCTAGACGATAAAGAGCGGTTAGTGGGTGA
TAATTTAGAAGAGCTAATTAATAAAGTGGTTAAGTTTAACGGCTTGCTTGACCATGCTAGCAAAAAATTTAATCGCTCAA
TTACCGAAATTCTTGCTATTAATGACTTACTTAATAACAAAATATTTGAGCCTGAAAGTGATTTAAGACTTAAAAAAGCT
TTAGATGTTTTAAATAGCTTAGAAGATTCGCCTGATAAGACTAATTGGGAAGTTTTAAAACATGAAAATAAAATAGAGTT
CTTCCGCTTTAGTAGGGGTTTAAAAGAAAGTAAAATATTATTGAAAGAGCAGTTAGAATCATTTGAGTTTGTACAAATAT
CAAAGTTTGCTTTAACGATTTTTGATATATTTAGTAAGCAATTAAAGCTTATAGTGAAAAGTCAGGAATTCGATATTTTA
ACACCGAGTCAGTTGTTAAATACCATTATAGAATGCGGAAAAAGAGGTATAAATATTCAGCGTTTTAAGGGGCTTGGTGA
GATGAATTCCGACCAGCTATGGGAAACTACTCTTGACCCTACAAAAAGAACTTTGCTTCAGGTAAGAGTTGCAGAAATTG
ATGAAGCAGAAGGCATTTTCTCTACTTTAATGGGTGACGTTGTTGAACCTCGCAGGTTATTTATCCAGGCAAATGCGTTG
AATGTCGTGAATTTGGATGTGTAG

Upstream 100 bases:

>100_bases
TTTTAAATCAAGAAACTTTACTATTTTAATAAGTTACGTTATAGTCATTTTTATTGTTTCTAGCAACAAGTAATAGAGCC
AAATATATAATATATATAAT

Downstream 100 bases:

>100_bases
TATAATCGCTGTCATACCGTGGCTTGACCACGGTATGACAATTTAATCAGTTTCTCCTCGCAATGACGTTACAATTTTAT
CAAAATAATTTATGCACAAA

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVS
DNGRGIPVEIHGEEGISAAEVIMTQLHAGGKFDQNAYKVAGGLHGVGVSVVNALSEWLELRIWRNNKEYLMRFNNGITEA
PLAVVKENIDKKGTEVTFFPSVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEVKEVEFYYTGGIEAYVKYID
RAKHAIHPCIVVNTENAESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKAKNY
FSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAEAKAIIAKIMEAANAREAARKAR
ELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAEFYLKNEQ
ALQDYLIKSTINDATLILDDKERLVGDNLEELINKVVKFNGLLDHASKKFNRSITEILAINDLLNNKIFEPESDLRLKKA
LDVLNSLEDSPDKTNWEVLKHENKIEFFRFSRGLKESKILLKEQLESFEFVQISKFALTIFDIFSKQLKLIVKSQEFDIL
TPSQLLNTIIECGKRGINIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEIDEAEGIFSTLMGDVVEPRRLFIQANAL
NVVNLDV

Sequences:

>Translated_807_residues
MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVS
DNGRGIPVEIHGEEGISAAEVIMTQLHAGGKFDQNAYKVAGGLHGVGVSVVNALSEWLELRIWRNNKEYLMRFNNGITEA
PLAVVKENIDKKGTEVTFFPSVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEVKEVEFYYTGGIEAYVKYID
RAKHAIHPCIVVNTENAESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKAKNY
FSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAEAKAIIAKIMEAANAREAARKAR
ELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAEFYLKNEQ
ALQDYLIKSTINDATLILDDKERLVGDNLEELINKVVKFNGLLDHASKKFNRSITEILAINDLLNNKIFEPESDLRLKKA
LDVLNSLEDSPDKTNWEVLKHENKIEFFRFSRGLKESKILLKEQLESFEFVQISKFALTIFDIFSKQLKLIVKSQEFDIL
TPSQLLNTIIECGKRGINIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEIDEAEGIFSTLMGDVVEPRRLFIQANAL
NVVNLDV
>Mature_806_residues
SEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVSD
NGRGIPVEIHGEEGISAAEVIMTQLHAGGKFDQNAYKVAGGLHGVGVSVVNALSEWLELRIWRNNKEYLMRFNNGITEAP
LAVVKENIDKKGTEVTFFPSVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEVKEVEFYYTGGIEAYVKYIDR
AKHAIHPCIVVNTENAESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKAKNYF
SGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAEAKAIIAKIMEAANAREAARKARE
LTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTL
ITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAEFYLKNEQA
LQDYLIKSTINDATLILDDKERLVGDNLEELINKVVKFNGLLDHASKKFNRSITEILAINDLLNNKIFEPESDLRLKKAL
DVLNSLEDSPDKTNWEVLKHENKIEFFRFSRGLKESKILLKEQLESFEFVQISKFALTIFDIFSKQLKLIVKSQEFDILT
PSQLLNTIIECGKRGINIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEIDEAEGIFSTLMGDVVEPRRLFIQANALN
VVNLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=590, Percent_Identity=24.7457627118644, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI19913406, Length=578, Percent_Identity=25.2595155709343, Blast_Score=129, Evalue=2e-29,
Organism=Escherichia coli, GI48994957, Length=807, Percent_Identity=52.0446096654275, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=654, Percent_Identity=34.7094801223242, Blast_Score=343, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI212645845, Length=531, Percent_Identity=25.9887005649718, Blast_Score=135, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17535065, Length=592, Percent_Identity=24.1554054054054, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI212645657, Length=260, Percent_Identity=28.0769230769231, Blast_Score=76, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=589, Percent_Identity=25.9762308998302, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136538, Length=544, Percent_Identity=24.6323529411765, Blast_Score=132, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90796; Mature: 90665

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESL
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
AGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHGEEGISAAEVIMTQLHAGGKFDQNAYKVA
HHHEEEEEEEECCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
GGLHGVGVSVVNALSEWLELRIWRNNKEYLMRFNNGITEAPLAVVKENIDKKGTEVTFFP
CCCCHHHHHHHHHHHHHHHEEEEECCHHHHHEECCCCCCCHHHHHHHHCCCCCCEEEEEC
SVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEVKEVEFYYTGGIEAYVKYID
CHHHHCCCEECHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHEEEEEECCHHHHHHHHH
RAKHAIHPCIVVNTENAESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAI
HHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEECCCHHCCCCCHHHHHHHHH
TRVITSYLDTTGLNKKAKNYFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVV
HHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ENAVYTKVLEWFEEHPAEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLAD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
CHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCHHHH
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIA
HHHHHCCCHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
QPPLYKVKKGAAEFYLKNEQALQDYLIKSTINDATLILDDKERLVGDNLEELINKVVKFN
CCCHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHHCCCHHHHHHHHHHHH
GLLDHASKKFNRSITEILAINDLLNNKIFEPESDLRLKKALDVLNSLEDSPDKTNWEVLK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
HENKIEFFRFSRGLKESKILLKEQLESFEFVQISKFALTIFDIFSKQLKLIVKSQEFDIL
CCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPSQLLNTIIECGKRGINIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEIDEAEGIF
CHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHH
STLMGDVVEPRRLFIQANALNVVNLDV
HHHHHHCCCCCCEEEEECCEEEEEECC
>Mature Secondary Structure 
SEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESL
CHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
AGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHGEEGISAAEVIMTQLHAGGKFDQNAYKVA
HHHEEEEEEEECCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
GGLHGVGVSVVNALSEWLELRIWRNNKEYLMRFNNGITEAPLAVVKENIDKKGTEVTFFP
CCCCHHHHHHHHHHHHHHHEEEEECCHHHHHEECCCCCCCHHHHHHHHCCCCCCEEEEEC
SVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEVKEVEFYYTGGIEAYVKYID
CHHHHCCCEECHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHEEEEEECCHHHHHHHHH
RAKHAIHPCIVVNTENAESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAI
HHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEECCCHHCCCCCHHHHHHHHH
TRVITSYLDTTGLNKKAKNYFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVV
HHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ENAVYTKVLEWFEEHPAEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLAD
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
CHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGT
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCHHHH
LITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIA
HHHHHCCCHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
QPPLYKVKKGAAEFYLKNEQALQDYLIKSTINDATLILDDKERLVGDNLEELINKVVKFN
CCCHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHHCCCHHHHHHHHHHHH
GLLDHASKKFNRSITEILAINDLLNNKIFEPESDLRLKKALDVLNSLEDSPDKTNWEVLK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
HENKIEFFRFSRGLKESKILLKEQLESFEFVQISKFALTIFDIFSKQLKLIVKSQEFDIL
CCCCHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPSQLLNTIIECGKRGINIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEIDEAEGIF
CHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHH
STLMGDVVEPRRLFIQANALNVVNLDV
HHHHHHCCCCCCEEEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]