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The map label for this gene is clpP [H]

Identifier: 15892669

GI number: 15892669

Start: 712641

End: 713291

Strand: Reverse

Name: clpP [H]

Synonym: RC0746

Alternate gene names: 15892669

Gene position: 713291-712641 (Counterclockwise)

Preceding gene: 15892670

Following gene: 15892668

Centisome position: 56.22

GC content: 34.1

Gene sequence:

>651_bases
ATGACGAAAAACTATTTAATTAATCAATTTCAGGAGAAAATATTAATGTCGTATGTACCGATAGTAATTGAACCAACATC
ACGCGGTGAACGTGCTTATGATATATATTCAAGATTGCTAAAAGAACGTATAATCTTTGTATGTAGTACTGTTGAAGATC
ATATGGCAAACTTAATTGTTGCACAATTATTGTTTCTTGAAGCAGAAAATCCTAAAAAAGATATATATATGTATATCAAT
TCCCCCGGAGGAGTTGTAACCGCAGGTCTTGCAATTTATGACACAATGCAATATATAAAACCTAAAGTGGCTACATTATG
CATAGGTCAAGCTTGTTCTATGGGTTCACTTTTACTGTGCGGGGGTGAGAAGGGGATGCGTTATAGTTTACCTCACAGTC
GTATTATGATCCATCAACCATCAGGAGGTTATAAAGGGCAAGCTACCGATATAGAAATCCACGCTCAAGAAACCCTAAAA
ATCAAAAGGTTACTTAACGAATTGTATAGTAAACATACTGAACAAGAGTTAAAACATATCGAAAAAAGTATGGAACGTGA
TAATTTCATGTCACCGGAAGAAGCAAAAAAATTTGGATTAGTAGATAATATAATGTCTTCCAGAGATGCTATGGCATTGT
TAGCAAAATAA

Upstream 100 bases:

>100_bases
TCATTGCGAGGAGAAACTGTAAGTTTCAACGAAGCAATCTCAGGAGTTCTATGCTACTTCATGAGATTGCCATGTCGGTT
ATTAAAATAACCTCCTCGTA

Downstream 100 bases:

>100_bases
AGATTAAATTTTATAGATTTAGTTTTATTATTATAGTATAAGAGAATTAATTTGTTATAGTCAAGTCAGTGGGATTTGCA
CACCAGAAGCGAGGAGTTAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTKNYLINQFQEKILMSYVPIVIEPTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDIYMYIN
SPGGVVTAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLCGGEKGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLK
IKRLLNELYSKHTEQELKHIEKSMERDNFMSPEEAKKFGLVDNIMSSRDAMALLAK

Sequences:

>Translated_216_residues
MTKNYLINQFQEKILMSYVPIVIEPTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDIYMYIN
SPGGVVTAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLCGGEKGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLK
IKRLLNELYSKHTEQELKHIEKSMERDNFMSPEEAKKFGLVDNIMSSRDAMALLAK
>Mature_215_residues
TKNYLINQFQEKILMSYVPIVIEPTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDIYMYINS
PGGVVTAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLCGGEKGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLKI
KRLLNELYSKHTEQELKHIEKSMERDNFMSPEEAKKFGLVDNIMSSRDAMALLAK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=63.1578947368421, Blast_Score=262, Evalue=2e-70,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=67.5257731958763, Blast_Score=289, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=58.5492227979275, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=62.6315789473684, Blast_Score=264, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24500; Mature: 24369

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNYLINQFQEKILMSYVPIVIEPTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIV
CCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLLFLEAENPKKDIYMYINSPGGVVTAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLC
HHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGEKGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTEQELKHI
CCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
EKSMERDNFMSPEEAKKFGLVDNIMSSRDAMALLAK
HHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHCC
>Mature Secondary Structure 
TKNYLINQFQEKILMSYVPIVIEPTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIV
CCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLLFLEAENPKKDIYMYINSPGGVVTAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLC
HHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGEKGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTEQELKHI
CCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
EKSMERDNFMSPEEAKKFGLVDNIMSSRDAMALLAK
HHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA