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The map label for this gene is exoC [H]

Identifier: 15892580

GI number: 15892580

Start: 637804

End: 639192

Strand: Reverse

Name: exoC [H]

Synonym: RC0657

Alternate gene names: 15892580

Gene position: 639192-637804 (Counterclockwise)

Preceding gene: 15892581

Following gene: 15892579

Centisome position: 50.38

GC content: 34.49

Gene sequence:

>1389_bases
ATGCAAATTAACAAAGAAATTTTTAGGGCTTATGATATAAGAGGCAATAGCCTTAAAGATTTAACGGAAGAAGTAGCTTA
TAAAATCGGCTTTGGTTTTGCCGAGATGACTATAACGAAAGATAACGATAAAATCTGTGTCGGTTTAGACGGTCGGCTTA
GCTCCCCTACCCTTTGTAAAGCTTTAGAACTAGGATTAACTAATGCAGGGGCTGAAATCATAAATATTGGCGTAGTTCCA
ACACCAGTTTTATATTTTGCCGATAAACACTTTACGCCCGCCGGTAGTATTATGGTCACGGGGTCACACAATCCTCGTGA
CGATAACGGCTTTAAAATACTACAAAACGGTAAACCTTTTTTCGGTGATCAGATACAGGAGTTATTGACTAAGATTTTGG
ATAACTACTCCAATACCACACCAGCATCCCCTTATGTCATTCCTGCGAAAGCAGGAATCCATAATATACAATCTAAATAC
CTAAAACGTATTTTAGATGGAATAAACATTAATCCAAAATTAAAAGTGGCTTGGGATTGTGGCAATGGAGCAACCGGCGA
TATTGTTGAAGAACTTAAAAAGCATCTCTCAAACAAGAATATAATCATACATAGTAAGATTGACGGGAATTTTCCAAGCC
ATCATCCTGATCCTACAAATCCTGCTAATTTGCAGGAGTTAATAAAAGTGGTTAAAGAACAAGATTGTGACCTTGGTATA
GCTTTTGACGGTGACGGTGATAGAATCGGCATTATAAGCTCAAGCGGTAAAATATTATTAGGTGATCAAATTTTATGCAT
TTTTGCTGAGGATATTTTAAAGGAAAATCCAAACGCAACTATAATAGTTGATGTAAAAGTCAGTCAATTTATAGTCACTA
AAATAAAATCATATGGAGGACATCCTATAATATGGCGAACAGGTCATCCTTTTATTAAAAGCAAAATGCTTGAGACAAAG
GCTTTACTCGCTGGCGAAATGAGCGGGCATATATTCTTTGCCGATAAATATTTTGGTTTTGACGATGCAATTTATGCAGC
TCTTAGATTTTTAGATTTACTTAGTAGATCAAGTAAAACTCTAGATGAGATAATAGAGGATGTACCGAAAAGCTATAGTA
CACCGGAAATTAAAATTTTTGTTCCTTCAGAGTTAAAATTACAAATTATTAAAGAGATTAAAGAAAAATCATTAGAAGAG
AAAATAGAGTTTAATGATATAGACGGTGTACGAGTAAATACTGCACATGGTTGGTGGCTCTTGCGTAGCTCTAATACCGA
ATCTATTATAGTTGCAAGGGCTGAATCAGATAGTAAGAATGGTTTAGAGGAAATAATCACTATAATTAATAAATATCTTG
AAAAATACGGGTTATTAATTAATTATTAA

Upstream 100 bases:

>100_bases
CTACGCGGGGATAACATCGAGTAGGTTTTCCGAGCATGCAACAAGGCTCTTTTGTAGGAATGACATAAGAGCCATGTAAT
AATATTCAAAACAGTTTTCT

Downstream 100 bases:

>100_bases
AACATTATTGCTTTCTAAAATATTATTTTATATATTTTTCTTACATTAAATTAATATAAAGAAAAATAATATTTGTTGAT
ACTAAATTAGTTACAATAAC

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MQINKEIFRAYDIRGNSLKDLTEEVAYKIGFGFAEMTITKDNDKICVGLDGRLSSPTLCKALELGLTNAGAEIINIGVVP
TPVLYFADKHFTPAGSIMVTGSHNPRDDNGFKILQNGKPFFGDQIQELLTKILDNYSNTTPASPYVIPAKAGIHNIQSKY
LKRILDGININPKLKVAWDCGNGATGDIVEELKKHLSNKNIIIHSKIDGNFPSHHPDPTNPANLQELIKVVKEQDCDLGI
AFDGDGDRIGIISSSGKILLGDQILCIFAEDILKENPNATIIVDVKVSQFIVTKIKSYGGHPIIWRTGHPFIKSKMLETK
ALLAGEMSGHIFFADKYFGFDDAIYAALRFLDLLSRSSKTLDEIIEDVPKSYSTPEIKIFVPSELKLQIIKEIKEKSLEE
KIEFNDIDGVRVNTAHGWWLLRSSNTESIIVARAESDSKNGLEEIITIINKYLEKYGLLINY

Sequences:

>Translated_462_residues
MQINKEIFRAYDIRGNSLKDLTEEVAYKIGFGFAEMTITKDNDKICVGLDGRLSSPTLCKALELGLTNAGAEIINIGVVP
TPVLYFADKHFTPAGSIMVTGSHNPRDDNGFKILQNGKPFFGDQIQELLTKILDNYSNTTPASPYVIPAKAGIHNIQSKY
LKRILDGININPKLKVAWDCGNGATGDIVEELKKHLSNKNIIIHSKIDGNFPSHHPDPTNPANLQELIKVVKEQDCDLGI
AFDGDGDRIGIISSSGKILLGDQILCIFAEDILKENPNATIIVDVKVSQFIVTKIKSYGGHPIIWRTGHPFIKSKMLETK
ALLAGEMSGHIFFADKYFGFDDAIYAALRFLDLLSRSSKTLDEIIEDVPKSYSTPEIKIFVPSELKLQIIKEIKEKSLEE
KIEFNDIDGVRVNTAHGWWLLRSSNTESIIVARAESDSKNGLEEIITIINKYLEKYGLLINY
>Mature_462_residues
MQINKEIFRAYDIRGNSLKDLTEEVAYKIGFGFAEMTITKDNDKICVGLDGRLSSPTLCKALELGLTNAGAEIINIGVVP
TPVLYFADKHFTPAGSIMVTGSHNPRDDNGFKILQNGKPFFGDQIQELLTKILDNYSNTTPASPYVIPAKAGIHNIQSKY
LKRILDGININPKLKVAWDCGNGATGDIVEELKKHLSNKNIIIHSKIDGNFPSHHPDPTNPANLQELIKVVKEQDCDLGI
AFDGDGDRIGIISSSGKILLGDQILCIFAEDILKENPNATIIVDVKVSQFIVTKIKSYGGHPIIWRTGHPFIKSKMLETK
ALLAGEMSGHIFFADKYFGFDDAIYAALRFLDLLSRSSKTLDEIIEDVPKSYSTPEIKIFVPSELKLQIIKEIKEKSLEE
KIEFNDIDGVRVNTAHGWWLLRSSNTESIIVARAESDSKNGLEEIITIINKYLEKYGLLINY

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=460, Percent_Identity=32.1739130434783, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI1789566, Length=369, Percent_Identity=27.6422764227642, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17864244, Length=366, Percent_Identity=23.4972677595628, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 51350; Mature: 51350

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINKEIFRAYDIRGNSLKDLTEEVAYKIGFGFAEMTITKDNDKICVGLDGRLSSPTLCK
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCCCHHHH
ALELGLTNAGAEIINIGVVPTPVLYFADKHFTPAGSIMVTGSHNPRDDNGFKILQNGKPF
HHHHCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCC
FGDQIQELLTKILDNYSNTTPASPYVIPAKAGIHNIQSKYLKRILDGININPKLKVAWDC
CHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEC
GNGATGDIVEELKKHLSNKNIIIHSKIDGNFPSHHPDPTNPANLQELIKVVKEQDCDLGI
CCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
AFDGDGDRIGIISSSGKILLGDQILCIFAEDILKENPNATIIVDVKVSQFIVTKIKSYGG
EECCCCCEEEEEECCCCEEECCCEEEEEEHHHHCCCCCEEEEEEEEHHHHHHHHHHHCCC
HPIIWRTGHPFIKSKMLETKALLAGEMSGHIFFADKYFGFDDAIYAALRFLDLLSRSSKT
CEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHH
LDEIIEDVPKSYSTPEIKIFVPSELKLQIIKEIKEKSLEEKIEFNDIDGVRVNTAHGWWL
HHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEE
LRSSNTESIIVARAESDSKNGLEEIITIINKYLEKYGLLINY
EECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEECC
>Mature Secondary Structure
MQINKEIFRAYDIRGNSLKDLTEEVAYKIGFGFAEMTITKDNDKICVGLDGRLSSPTLCK
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCCCHHHH
ALELGLTNAGAEIINIGVVPTPVLYFADKHFTPAGSIMVTGSHNPRDDNGFKILQNGKPF
HHHHCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCC
FGDQIQELLTKILDNYSNTTPASPYVIPAKAGIHNIQSKYLKRILDGININPKLKVAWDC
CHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEC
GNGATGDIVEELKKHLSNKNIIIHSKIDGNFPSHHPDPTNPANLQELIKVVKEQDCDLGI
CCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
AFDGDGDRIGIISSSGKILLGDQILCIFAEDILKENPNATIIVDVKVSQFIVTKIKSYGG
EECCCCCEEEEEECCCCEEECCCEEEEEEHHHHCCCCCEEEEEEEEHHHHHHHHHHHCCC
HPIIWRTGHPFIKSKMLETKALLAGEMSGHIFFADKYFGFDDAIYAALRFLDLLSRSSKT
CEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHH
LDEIIEDVPKSYSTPEIKIFVPSELKLQIIKEIKEKSLEEKIEFNDIDGVRVNTAHGWWL
HHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEE
LRSSNTESIIVARAESDSKNGLEEIITIINKYLEKYGLLINY
EECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]