Click here to switch to the map view.

The map label for this gene is coxB

Identifier: 15892478

GI number: 15892478

Start: 546983

End: 547930

Strand: Reverse

Name: coxB

Synonym: RC0555

Alternate gene names: 15892478

Gene position: 547930-546983 (Counterclockwise)

Preceding gene: 15892479

Following gene: 15892477

Centisome position: 43.19

GC content: 36.08

Gene sequence:

>948_bases
ATGAAAAATATTATTAGACATTTTTCCAAACCAGCTTATAGAGAGGAATTTAAAGAAGACACTTCCCCTCGAACCGCAGA
GTACAAAAGCGTAAGTGAGGATTCGAGTACCGGATTGACGTATACATTACCTCCAAAAGCGAAATTTGGAAAAATGTCTA
TTGCTTTAATTTGTTTTTTGATTGTTAGCTGTAATTGCTTTGCTTCCGAGCCGTTACCTTGGCAAGTAACGTTCCAGCCG
CCGGCAAGTCCGATTATGGAGGAATTACATCATTTTCATAATTTTCTGCTTTATATCTCAACAGCTATTGTTTTATTTGT
TGCCGGATTACTTGGCTTTGTATGCATCAGATTTAATGCAAAAAATAATCCCGTACCGGCAAAATTTTCACATAATGTTT
TAATAGAAATAATTTGGACTGTAATACCTATAATAATTTTAGTTATTATTGCAGTGCCGTCTTTTAAAATATTGCGTCAT
GCCGAAAAAATACCCAAAACGGATTTAACTATTAAAGTAGTAGGTTATCAATGGTATTGGCATTATATATATCCTGATCA
TGATAATTTAGAATTTGATAGCGTAATGATCTCTGATGAGAATTTAAAACCTAACCACAAAAGATTATTAGATGTTGATA
ATCGAATTGTTATCCCTGAAAATGCTACCGTAAGGTTTCTCATTACCGCAGGTGACGTAATACATAGTTTTGCCGTTCCA
TCACTTGGATTTAAAATAGACGCAGTCCCAGGCAGAATAAACGAGACCTGGACAAGAGTGGCTAAAAAAGGCGTATATTA
CGGACAATGCTCCGAACTATGCGGCATCCATCACGGCTTCATGCCGATTGCTATAGAAGTAGTCAGTAAAGAGGATTTCG
ACAATTGGATTGCAAGCAAGAATAAGACTGCTATGAATGGCAAGAAGCCAAAATTGGTAGCTAACTAA

Upstream 100 bases:

>100_bases
TATTATTAAAAATATGTAGTTTTTACAAAAATTTATCGATTTTTACTTTAATAAAACTGTATATCCATTTATATTAAACG
TAAATAACTTTATATGTGCT

Downstream 100 bases:

>100_bases
TTATATTTAGAAGTTCTATGGAAAATTATAATACAAAAATATCTGAACTAGATAAATTACTAAACGATATAACCGATTCT
AATCGACATCAAGAAATTAT

Product: cytochrome c oxidase polypeptide II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKNIIRHFSKPAYREEFKEDTSPRTAEYKSVSEDSSTGLTYTLPPKAKFGKMSIALICFLIVSCNCFASEPLPWQVTFQP
PASPIMEELHHFHNFLLYISTAIVLFVAGLLGFVCIRFNAKNNPVPAKFSHNVLIEIIWTVIPIIILVIIAVPSFKILRH
AEKIPKTDLTIKVVGYQWYWHYIYPDHDNLEFDSVMISDENLKPNHKRLLDVDNRIVIPENATVRFLITAGDVIHSFAVP
SLGFKIDAVPGRINETWTRVAKKGVYYGQCSELCGIHHGFMPIAIEVVSKEDFDNWIASKNKTAMNGKKPKLVAN

Sequences:

>Translated_315_residues
MKNIIRHFSKPAYREEFKEDTSPRTAEYKSVSEDSSTGLTYTLPPKAKFGKMSIALICFLIVSCNCFASEPLPWQVTFQP
PASPIMEELHHFHNFLLYISTAIVLFVAGLLGFVCIRFNAKNNPVPAKFSHNVLIEIIWTVIPIIILVIIAVPSFKILRH
AEKIPKTDLTIKVVGYQWYWHYIYPDHDNLEFDSVMISDENLKPNHKRLLDVDNRIVIPENATVRFLITAGDVIHSFAVP
SLGFKIDAVPGRINETWTRVAKKGVYYGQCSELCGIHHGFMPIAIEVVSKEDFDNWIASKNKTAMNGKKPKLVAN
>Mature_315_residues
MKNIIRHFSKPAYREEFKEDTSPRTAEYKSVSEDSSTGLTYTLPPKAKFGKMSIALICFLIVSCNCFASEPLPWQVTFQP
PASPIMEELHHFHNFLLYISTAIVLFVAGLLGFVCIRFNAKNNPVPAKFSHNVLIEIIWTVIPIIILVIIAVPSFKILRH
AEKIPKTDLTIKVVGYQWYWHYIYPDHDNLEFDSVMISDENLKPNHKRLLDVDNRIVIPENATVRFLITAGDVIHSFAVP
SLGFKIDAVPGRINETWTRVAKKGVYYGQCSELCGIHHGFMPIAIEVVSKEDFDNWIASKNKTAMNGKKPKLVAN

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831110, Length=220, Percent_Identity=44.0909090909091, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1786635, Length=228, Percent_Identity=26.7543859649123, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6226540, Length=236, Percent_Identity=41.5254237288136, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COX2_RICCN (Q92I65)

Other databases:

- EMBL:   AE006914
- PIR:   C97769
- RefSeq:   NP_360192.1
- ProteinModelPortal:   Q92I65
- SMR:   Q92I65
- GeneID:   927663
- GenomeReviews:   AE006914_GR
- KEGG:   rco:RC0555
- NMPDR:   fig|272944.1.peg.555
- OMA:   VPSFRLL
- ProtClustDB:   CLSK870908
- BioCyc:   RCON272944:RC0555-MONOMER
- BRENDA:   1.9.3.1
- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759
- InterPro:   IPR005728
- Gene3D:   G3DSA:1.10.287.90
- Gene3D:   G3DSA:2.60.40.420
- PANTHER:   PTHR22888
- PRINTS:   PR01166
- TIGRFAMs:   TIGR02866
- TIGRFAMs:   TIGR01045

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM; SSF49503 Cupredoxin; SSF81464 Cyt_c_oxidase_II-like_TM

EC number: =1.9.3.1

Molecular weight: Translated: 35744; Mature: 35744

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00078 COX2; PS50857 COX2_CUA; PS50999 COX2_TM

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x4041d6c0)-; HASH(0xb474b6c)-; HASH(0xcf0b080)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIIRHFSKPAYREEFKEDTSPRTAEYKSVSEDSSTGLTYTLPPKAKFGKMSIALICFL
CCHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
IVSCNCFASEPLPWQVTFQPPASPIMEELHHFHNFLLYISTAIVLFVAGLLGFVCIRFNA
HHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
KNNPVPAKFSHNVLIEIIWTVIPIIILVIIAVPSFKILRHAEKIPKTDLTIKVVGYQWYW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEEEE
HYIYPDHDNLEFDSVMISDENLKPNHKRLLDVDNRIVIPENATVRFLITAGDVIHSFAVP
EEEECCCCCCEECEEEEECCCCCCCHHHEEECCCEEEECCCCEEEEEEECCHHHHHHCCC
SLGFKIDAVPGRINETWTRVAKKGVYYGQCSELCGIHHGFMPIAIEVVSKEDFDNWIASK
CCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEECCCCHHHHHHCC
NKTAMNGKKPKLVAN
CCCCCCCCCCCCCCH
>Mature Secondary Structure
MKNIIRHFSKPAYREEFKEDTSPRTAEYKSVSEDSSTGLTYTLPPKAKFGKMSIALICFL
CCHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
IVSCNCFASEPLPWQVTFQPPASPIMEELHHFHNFLLYISTAIVLFVAGLLGFVCIRFNA
HHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
KNNPVPAKFSHNVLIEIIWTVIPIIILVIIAVPSFKILRHAEKIPKTDLTIKVVGYQWYW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEEEE
HYIYPDHDNLEFDSVMISDENLKPNHKRLLDVDNRIVIPENATVRFLITAGDVIHSFAVP
EEEECCCCCCEECEEEEECCCCCCCHHHEEECCCEEEECCCCEEEEEEECCHHHHHHCCC
SLGFKIDAVPGRINETWTRVAKKGVYYGQCSELCGIHHGFMPIAIEVVSKEDFDNWIASK
CCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEECCCCHHHHHHCC
NKTAMNGKKPKLVAN
CCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11557893