Click here to switch to the map view.

The map label for this gene is lacA [C]

Identifier: 15892325

GI number: 15892325

Start: 403001

End: 403435

Strand: Reverse

Name: lacA [C]

Synonym: RC0402

Alternate gene names: 15892325

Gene position: 403435-403001 (Counterclockwise)

Preceding gene: 15892330

Following gene: 15892324

Centisome position: 31.8

GC content: 33.33

Gene sequence:

>435_bases
ATGAAAACTTATAATATTGTCATAGCTAGTGATCATTCAGGTTATGAGCTTAAGTCTGAAATTATCAATTATTTAGAGCA
GAAATCTCTAAAGATTTATGACTGCGGAACAAATAATACACAAACCGTTGATTATCCTGATTATGCTAAGAAAGTAGTAG
ATATTATTATTGAAAAATCAGCACCTATCGGTATTTTAATTAGTGATACGGGGATTGGTATGTCTATAGCTGCGAATCGT
AGCTCGGAAATAAGAGCCGCTTTGTGCAACAATATATTAACTGCCGAAAATGCTAAAGCTCATAATGACGCTAATATCTT
GATACTCGGAGCAAAAACCATAGACCAAAAAATAGTATTTGATATTATAGATAAGTTTTTAACTACCCAATTTGAAGGCG
GCAGACATAGCACCCGCCTATCAAAGATAAAATAG

Upstream 100 bases:

>100_bases
CAGGATATTTCATATATTTAACAAAACTATTATTTACATTAGAAAACAAATCTTACATAGTATATAATTTTTATCATTAT
TTTCCATCAAAAAATTAACT

Downstream 100 bases:

>100_bases
TTGTATAAACTGTTAAACATTGTTATTATCCGTCATTGCGAGGAGAGGCAAAGCCTCGACGTGGCAATCTCAGGCATATT
TTGCACTATTCCATAAGATT

Product: ribose-5-phosphate isomerase B

Products: D-ribulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKTYNIVIASDHSGYELKSEIINYLEQKSLKIYDCGTNNTQTVDYPDYAKKVVDIIIEKSAPIGILISDTGIGMSIAANR
SSEIRAALCNNILTAENAKAHNDANILILGAKTIDQKIVFDIIDKFLTTQFEGGRHSTRLSKIK

Sequences:

>Translated_144_residues
MKTYNIVIASDHSGYELKSEIINYLEQKSLKIYDCGTNNTQTVDYPDYAKKVVDIIIEKSAPIGILISDTGIGMSIAANR
SSEIRAALCNNILTAENAKAHNDANILILGAKTIDQKIVFDIIDKFLTTQFEGGRHSTRLSKIK
>Mature_144_residues
MKTYNIVIASDHSGYELKSEIINYLEQKSLKIYDCGTNNTQTVDYPDYAKKVVDIIIEKSAPIGILISDTGIGMSIAANR
SSEIRAALCNNILTAENAKAHNDANILILGAKTIDQKIVFDIIDKFLTTQFEGGRHSTRLSKIK

Specific function: In Addition To Its Activity On D-Ribose 5-Phosphate It Probably Also Has Activity On D-Allose 6-Phosphate. [C]

COG id: COG0698

COG function: function code G; Ribose 5-phosphate isomerase RpiB

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lacAB/rpiB family [H]

Homologues:

Organism=Escherichia coli, GI1790528, Length=138, Percent_Identity=37.6811594202899, Blast_Score=114, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003500 [H]

Pfam domain/function: PF02502 LacAB_rpiB [H]

EC number: 5.3.1.6

Molecular weight: Translated: 15907; Mature: 15907

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYNIVIASDHSGYELKSEIINYLEQKSLKIYDCGTNNTQTVDYPDYAKKVVDIIIEKS
CCEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHHHHCCC
APIGILISDTGIGMSIAANRSSEIRAALCNNILTAENAKAHNDANILILGAKTIDQKIVF
CCEEEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHH
DIIDKFLTTQFEGGRHSTRLSKIK
HHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTYNIVIASDHSGYELKSEIINYLEQKSLKIYDCGTNNTQTVDYPDYAKKVVDIIIEKS
CCEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHHHHCCC
APIGILISDTGIGMSIAANRSSEIRAALCNNILTAENAKAHNDANILILGAKTIDQKIVF
CCEEEEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHH
DIIDKFLTTQFEGGRHSTRLSKIK
HHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.4 {D-ribose} 0.83 {D-ribose} [C]

Substrates: D-ribose 5-phosphate

Specific reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate

General reaction: Intramolecular oxidoreduction; Isomerization [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA