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The map label for this gene is uvrB [H]

Identifier: 15892189

GI number: 15892189

Start: 269088

End: 271073

Strand: Reverse

Name: uvrB [H]

Synonym: RC0266

Alternate gene names: 15892189

Gene position: 271073-269088 (Counterclockwise)

Preceding gene: 15892200

Following gene: 15892188

Centisome position: 21.37

GC content: 37.87

Gene sequence:

>1986_bases
ATGAATAATTTTTCTATTATCTCAGAATATAAACCGGCAGGCGATCAACCAAAAGCAATAGATGAAATTATAGCAGGGTT
AAGTAGCAAAAAACGCTCACAAATGTTGCTTGGTATTACGGGATCAGGCAAAACCTTTACTATGGCAAATATTATAGAGA
GAACTAATCGTCCTACTCTTATTATGGCTCATAATAAAACTTTAGCTGCCCAAATCTATTCAGAGATGAAATCGCTTTTT
CCAAAGAATGCCGTTGAATACTTTGTCTCATATTATGATTATTACCAGCCCGAAGCTTATATAGCACGCACCGATACTTT
TATAGAAAAAGACTCATCAATTAACGAACAAATTGATTTAATGCGTCATGCCGCTACAAGATCGCTATTAGAGCGTCGTG
ACGTTATAGTAGTTTCTTCCGTTTCCTGTATTTACGGCCTTGGCTCTCCCGATTTATATTACCAAATGATGGTTAATCTA
GAGCCTGGTCAAAGCTACCCTCGTGATCAGCTACTAAACGATTTGATAAATCTACAATATGAGCGTAACGATATCGGATT
TGAGCGTGGCTGTTTTAGAGTTAAAGGCGACAACATCGATATTTTCCCCTCACATTACAGCGATAAAGCTTGGCGTTTAT
CGTTTTTCGGTAATGAACTCGAATATATCCATGAATTTGATCCCCTAACAGGTGAAAAACTTGCTAAGCTCGATAAAGCT
ATGGTTTTTGGTAATTCACATTTTGTGATGCCTCAAGAAACAGTCAATAATGCCATATCAGGTATTGAAGAAGAATTACA
AAAACGCTTAGAGTTTTTAAAGTCACAAGACAAACCACTTGAAACTCAAAGGCTAAATCAACGTACTCAATATGATCTTG
AAATGTTAACGGAAACCGGCAGCTGTAAAGGCGTTGAAAACTACTCTCGCTTTTTCACAGGACGTAATGCCGGTGAGCCG
CCTCCTACATTATTCGAATACCTACCAGAAGATGCATTATTATTTGTTGATGAAAGCCATGTATCCGTACCGCAAATTAG
AGCGATGTATAACGGCGATCGAGCAAGGAAAAAAGTTTTGGTAGAGCATGGGTTTCGTCTACCCTCTGCACTTGATAACA
GACCTTTAAAATTTGAAGAATGGGACAAATTTAGACCACAAACTGTGTTTGTATCTGCAACTCCAGGACCGTTCGAGTTA
GAAGAAACCGGCGGCACGGTTGTAGAATTGATTATCAGACCTACTGGGCTGCTTGATCCTGAATGTATTATCAAACCCGC
TACTAACCAAGTTGAGGATTTAATTAGCGAAATTCAAACCACTATCGCTCAAGGTTTTCGTGTTCTAGTCACCACCTTAA
CTAAAAAAATGGCAGAAGATTTAACCGCCTATTTGCAGGAGCTAAAATATAAAACTTCTTATTTACATTCTAACGTTCAT
ACTCTAGAACGTATAGAGATTTTACGAGATTTAAGACAAGGTACTATTGATGTTTTAGTCGGTATTAATCTATTAAGGGA
GGGGCTTGACATCCCTGAATGCGGCTTAGTTGCTATACTTGATGCAGACAAAGAGGGGTTTTTGCGGTCGGAAGTATCGT
TAATACAAACAATAGGAAGAGCTGCAAGAAATAGCGCGGGTAGAGTTATACTTTATGCCGATAAAATGACTAAATCTATC
GATAAAGCCGTTAGTGAAACGTTGCGTAGAAGGCAAATTCAGCAAGAATATAATGAAAAACACGGCATAATTCCAAAAAC
CATCAACCGTGCTATTCACGCTTTAGCAGAATTTGAGAAAATCGATAGTAAGCTTGATAAAAAACAAGCTCATACTTTAT
TTGATAATCCTGCTAAGCTAAAAACCCATATTGATAAATTAAAGAAAGAAATGCTTAAAGCCGCAAGTAATCTTGAATTT
GAACAAGCCGTAAAACTTCGTGATCAGCTAAAAACTCTAGAAGAGGCGGCACTCGAGTTGAGTTAA

Upstream 100 bases:

>100_bases
AATAATTGTGTGTAATATAGCTTTATTCATAATGTTATATTTTTTTGTGAGATTTTAATATATTATCTTAAACTATAGTT
TTTAAAGCAAGTAAAAATGC

Downstream 100 bases:

>100_bases
TGGTGTACGTTGTGGATACCAAAATCGTCATCGTCATTGCGAGGCAAAACTGTAAGTTTTGACAATCTCAGGAGTTTGTT
ATTATTTCATGAGATTGCCA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MNNFSIISEYKPAGDQPKAIDEIIAGLSSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSLF
PKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEQIDLMRHAATRSLLERRDVIVVSSVSCIYGLGSPDLYYQMMVNL
EPGQSYPRDQLLNDLINLQYERNDIGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLAKLDKA
MVFGNSHFVMPQETVNNAISGIEEELQKRLEFLKSQDKPLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRNAGEP
PPTLFEYLPEDALLFVDESHVSVPQIRAMYNGDRARKKVLVEHGFRLPSALDNRPLKFEEWDKFRPQTVFVSATPGPFEL
EETGGTVVELIIRPTGLLDPECIIKPATNQVEDLISEIQTTIAQGFRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
TLERIEILRDLRQGTIDVLVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSAGRVILYADKMTKSI
DKAVSETLRRRQIQQEYNEKHGIIPKTINRAIHALAEFEKIDSKLDKKQAHTLFDNPAKLKTHIDKLKKEMLKAASNLEF
EQAVKLRDQLKTLEEAALELS

Sequences:

>Translated_661_residues
MNNFSIISEYKPAGDQPKAIDEIIAGLSSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSLF
PKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEQIDLMRHAATRSLLERRDVIVVSSVSCIYGLGSPDLYYQMMVNL
EPGQSYPRDQLLNDLINLQYERNDIGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLAKLDKA
MVFGNSHFVMPQETVNNAISGIEEELQKRLEFLKSQDKPLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRNAGEP
PPTLFEYLPEDALLFVDESHVSVPQIRAMYNGDRARKKVLVEHGFRLPSALDNRPLKFEEWDKFRPQTVFVSATPGPFEL
EETGGTVVELIIRPTGLLDPECIIKPATNQVEDLISEIQTTIAQGFRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
TLERIEILRDLRQGTIDVLVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSAGRVILYADKMTKSI
DKAVSETLRRRQIQQEYNEKHGIIPKTINRAIHALAEFEKIDSKLDKKQAHTLFDNPAKLKTHIDKLKKEMLKAASNLEF
EQAVKLRDQLKTLEEAALELS
>Mature_661_residues
MNNFSIISEYKPAGDQPKAIDEIIAGLSSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSLF
PKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEQIDLMRHAATRSLLERRDVIVVSSVSCIYGLGSPDLYYQMMVNL
EPGQSYPRDQLLNDLINLQYERNDIGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLAKLDKA
MVFGNSHFVMPQETVNNAISGIEEELQKRLEFLKSQDKPLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRNAGEP
PPTLFEYLPEDALLFVDESHVSVPQIRAMYNGDRARKKVLVEHGFRLPSALDNRPLKFEEWDKFRPQTVFVSATPGPFEL
EETGGTVVELIIRPTGLLDPECIIKPATNQVEDLISEIQTTIAQGFRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
TLERIEILRDLRQGTIDVLVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSAGRVILYADKMTKSI
DKAVSETLRRRQIQQEYNEKHGIIPKTINRAIHALAEFEKIDSKLDKKQAHTLFDNPAKLKTHIDKLKKEMLKAASNLEF
EQAVKLRDQLKTLEEAALELS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=56.8627450980392, Blast_Score=751, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75334; Mature: 75334

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNFSIISEYKPAGDQPKAIDEIIAGLSSKKRSQMLLGITGSGKTFTMANIIERTNRPTL
CCCCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCEE
IMAHNKTLAAQIYSEMKSLFPKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEQIDL
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHHHH
MRHAATRSLLERRDVIVVSSVSCIYGLGSPDLYYQMMVNLEPGQSYPRDQLLNDLINLQY
HHHHHHHHHHHHCCEEEEECHHHHHCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCEE
ERNDIGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLAKLDKA
CCCCCCCCCCEEEEECCCEEECCCCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHH
MVFGNSHFVMPQETVNNAISGIEEELQKRLEFLKSQDKPLETQRLNQRTQYDLEMLTETG
HEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
SCKGVENYSRFFTGRNAGEPPPTLFEYLPEDALLFVDESHVSVPQIRAMYNGDRARKKVL
CCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHH
VEHGFRLPSALDNRPLKFEEWDKFRPQTVFVSATPGPFELEETGGTVVELIIRPTGLLDP
HHCCCCCCHHHCCCCCCCCHHHCCCCCEEEEEECCCCCEECCCCCCEEEEEECCCCCCCC
ECIIKPATNQVEDLISEIQTTIAQGFRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
HHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLERIEILRDLRQGTIDVLVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGR
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
AARNSAGRVILYADKMTKSIDKAVSETLRRRQIQQEYNEKHGIIPKTINRAIHALAEFEK
HHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IDSKLDKKQAHTLFDNPAKLKTHIDKLKKEMLKAASNLEFEQAVKLRDQLKTLEEAALEL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
S
C
>Mature Secondary Structure
MNNFSIISEYKPAGDQPKAIDEIIAGLSSKKRSQMLLGITGSGKTFTMANIIERTNRPTL
CCCCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCEE
IMAHNKTLAAQIYSEMKSLFPKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEQIDL
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHHHH
MRHAATRSLLERRDVIVVSSVSCIYGLGSPDLYYQMMVNLEPGQSYPRDQLLNDLINLQY
HHHHHHHHHHHHCCEEEEECHHHHHCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCEE
ERNDIGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLAKLDKA
CCCCCCCCCCEEEEECCCEEECCCCCCCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHH
MVFGNSHFVMPQETVNNAISGIEEELQKRLEFLKSQDKPLETQRLNQRTQYDLEMLTETG
HEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
SCKGVENYSRFFTGRNAGEPPPTLFEYLPEDALLFVDESHVSVPQIRAMYNGDRARKKVL
CCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHH
VEHGFRLPSALDNRPLKFEEWDKFRPQTVFVSATPGPFELEETGGTVVELIIRPTGLLDP
HHCCCCCCHHHCCCCCCCCHHHCCCCCEEEEEECCCCCEECCCCCCEEEEEECCCCCCCC
ECIIKPATNQVEDLISEIQTTIAQGFRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNVH
HHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLERIEILRDLRQGTIDVLVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGR
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHH
AARNSAGRVILYADKMTKSIDKAVSETLRRRQIQQEYNEKHGIIPKTINRAIHALAEFEK
HHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IDSKLDKKQAHTLFDNPAKLKTHIDKLKKEMLKAASNLEFEQAVKLRDQLKTLEEAALEL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA