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The map label for this gene is gltP [H]

Identifier: 15892146

GI number: 15892146

Start: 230483

End: 231682

Strand: Reverse

Name: gltP [H]

Synonym: RC0223

Alternate gene names: 15892146

Gene position: 231682-230483 (Counterclockwise)

Preceding gene: 15892147

Following gene: 15892145

Centisome position: 18.26

GC content: 35.42

Gene sequence:

>1200_bases
ATGAAATTATGGCAAAAAGTTACCTTAGGGTTAATCTTAGGTATTATATTTGGTATATACTTACCACAATATGTTAATTA
TATTAAACCTATCGGTGACATTTTTTTACGTTTGATAAAAATGATCATTACCCCTTTAATTTTCTTCAGTTTGGTTTCCG
GTATCACTAGTATGAATGATAATTCTGCCCTTGGTAGAGTAGGCATGAAAGCGGTAGCCGCTTTTTTAGGTACTACTTTT
TTTGCCACGGTTTTTGGACTCACTGTTGCCTTAGTATTAAAGCCAGGAGTAGGCGTACATATAGATTTCACCTCTTCAGG
AACGACAAACAGAACTTCATTTAATATAATTGATTTTTTTGTAAATATCGTCCCTGATAATGCTGTTGGGGCTTTTGCAA
ACGGTGATGTCTTACAAGTTGTATTTTTTGCTATTTTTGTTGGCATTACCTTAAACAAAATGAAATCTATCGGTGAACCT
ATTACTGATTTAATTCATGTAATGTCAAAATTAATATTAAAAATGATATCGTTTGTTATTCAATTATCCCCTTACGGTGC
TTTTGCTTTAACAGGCTGGATTGTAGGCATGCAGGGAGTTGAGGTAATGATTAGTTTATCAAAACTTGTTGTAGCGGTAG
TTGTGGCGATGACATTCCAATATTTAGTTTTTGGCTTACTTATATGTGTATTCTGTCGTGTTTCACCTATACCTTTTTAT
AAGAAAAGTTTTGAGTATCAGATACTTGCTTTTTCTACTTCAAGCAGTAAGGCAACTCTTGCAACTACTATGCAAGTTTG
TCGTGCAAAGCTTGGCATTTCAGAGTCTAGTACTTCGTTCGTACTTCCGATAGGTGCGTCAATTAATATGGACGGCTTTG
CTATAAATTTATCTCTTACCACCATATTTTTTGCTCAGATGATGGGAGTAACGCTTGCTCCTCACGACTATTTAGTCATT
ATTCTCACCTCAACACTTGGATCTATCGGTGGTGCCGGTATTCCCGGTGCCTCTTTGATAATGCTTCCTATGGTTCTTTC
TTCGGTTCACTTACCTATAGAGGGAGTAGCAATTATTGCTGGTATTGACCGAATACTTGATATGCTACGTACTACTATCA
ATATTACCGGCGATGCAACAATTACTATGATTATAGATAACAGCGAAGATACTTTAGATAAGGAAGTATATTTATCTTAA

Upstream 100 bases:

>100_bases
ATAAATATTGACTATGGCTTTCAAAAGTACTTAGAATGGATTAATCAAAATAATAAATAAACTTATAGTTGAGTAAATTT
AAAAATTAAGTAAGTAAATT

Downstream 100 bases:

>100_bases
TGATATTGCTAACTAAGACCAGACATTGTCATTGCGAGCAACTATAAGCATTGTTGTCTGAATTGAAAAATGCGTTTTAT
GTCATTCCCGCGAAAGCGGG

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKLWQKVTLGLILGIIFGIYLPQYVNYIKPIGDIFLRLIKMIITPLIFFSLVSGITSMNDNSALGRVGMKAVAAFLGTTF
FATVFGLTVALVLKPGVGVHIDFTSSGTTNRTSFNIIDFFVNIVPDNAVGAFANGDVLQVVFFAIFVGITLNKMKSIGEP
ITDLIHVMSKLILKMISFVIQLSPYGAFALTGWIVGMQGVEVMISLSKLVVAVVVAMTFQYLVFGLLICVFCRVSPIPFY
KKSFEYQILAFSTSSSKATLATTMQVCRAKLGISESSTSFVLPIGASINMDGFAINLSLTTIFFAQMMGVTLAPHDYLVI
ILTSTLGSIGGAGIPGASLIMLPMVLSSVHLPIEGVAIIAGIDRILDMLRTTINITGDATITMIIDNSEDTLDKEVYLS

Sequences:

>Translated_399_residues
MKLWQKVTLGLILGIIFGIYLPQYVNYIKPIGDIFLRLIKMIITPLIFFSLVSGITSMNDNSALGRVGMKAVAAFLGTTF
FATVFGLTVALVLKPGVGVHIDFTSSGTTNRTSFNIIDFFVNIVPDNAVGAFANGDVLQVVFFAIFVGITLNKMKSIGEP
ITDLIHVMSKLILKMISFVIQLSPYGAFALTGWIVGMQGVEVMISLSKLVVAVVVAMTFQYLVFGLLICVFCRVSPIPFY
KKSFEYQILAFSTSSSKATLATTMQVCRAKLGISESSTSFVLPIGASINMDGFAINLSLTTIFFAQMMGVTLAPHDYLVI
ILTSTLGSIGGAGIPGASLIMLPMVLSSVHLPIEGVAIIAGIDRILDMLRTTINITGDATITMIIDNSEDTLDKEVYLS
>Mature_399_residues
MKLWQKVTLGLILGIIFGIYLPQYVNYIKPIGDIFLRLIKMIITPLIFFSLVSGITSMNDNSALGRVGMKAVAAFLGTTF
FATVFGLTVALVLKPGVGVHIDFTSSGTTNRTSFNIIDFFVNIVPDNAVGAFANGDVLQVVFFAIFVGITLNKMKSIGEP
ITDLIHVMSKLILKMISFVIQLSPYGAFALTGWIVGMQGVEVMISLSKLVVAVVVAMTFQYLVFGLLICVFCRVSPIPFY
KKSFEYQILAFSTSSSKATLATTMQVCRAKLGISESSTSFVLPIGASINMDGFAINLSLTTIFFAQMMGVTLAPHDYLVI
ILTSTLGSIGGAGIPGASLIMLPMVLSSVHLPIEGVAIIAGIDRILDMLRTTINITGDATITMIIDNSEDTLDKEVYLS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=456, Percent_Identity=30.0438596491228, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI169790839, Length=432, Percent_Identity=29.8611111111111, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI21314632, Length=398, Percent_Identity=30.9045226130653, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI66773030, Length=447, Percent_Identity=27.0693512304251, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI5032093, Length=388, Percent_Identity=29.3814432989691, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI4827012, Length=286, Percent_Identity=33.2167832167832, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI194239697, Length=282, Percent_Identity=31.9148936170213, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI223468564, Length=263, Percent_Identity=29.6577946768061, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI223468566, Length=271, Percent_Identity=29.8892988929889, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI262359914, Length=393, Percent_Identity=27.735368956743, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI301601644, Length=143, Percent_Identity=32.1678321678322, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=34.4578313253012, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1789947, Length=402, Percent_Identity=31.3432835820896, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1788024, Length=415, Percent_Identity=26.0240963855422, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789473, Length=273, Percent_Identity=26.007326007326, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71983099, Length=423, Percent_Identity=31.6784869976359, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71983106, Length=423, Percent_Identity=31.6784869976359, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71996953, Length=450, Percent_Identity=30, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17537407, Length=419, Percent_Identity=29.1169451073986, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI193206505, Length=418, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193206654, Length=449, Percent_Identity=26.9487750556793, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17541374, Length=392, Percent_Identity=27.8061224489796, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24583025, Length=436, Percent_Identity=28.6697247706422, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI17137668, Length=436, Percent_Identity=28.6697247706422, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24583023, Length=436, Percent_Identity=28.6697247706422, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI281360481, Length=444, Percent_Identity=27.7027027027027, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360483, Length=444, Percent_Identity=27.7027027027027, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137666, Length=444, Percent_Identity=27.7027027027027, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42984; Mature: 42984

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHEEECCCEEEEEEEECCCCCCCCHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHEEECCCEEEEEEEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]