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The map label for this gene is lpd3 [H]

Identifier: 158425633

GI number: 158425633

Start: 4574575

End: 4575978

Strand: Reverse

Name: lpd3 [H]

Synonym: AZC_4009

Alternate gene names: 158425633

Gene position: 4575978-4574575 (Counterclockwise)

Preceding gene: 158425634

Following gene: 158425630

Centisome position: 85.22

GC content: 67.17

Gene sequence:

>1404_bases
ATGGCTAATTACGACCTGATCGTCATCGGCACCGGCCCCGGCGGCTATGTGGCGGCCATCCGCGCCGCCCAGCTTGGTCT
CAAGACCGCGGTGGTCGAGAAGCGCGCCACCCACGGCGGCACCTGCCTCAACGTCGGCTGCATCCCCTCCAAGGCGCTGC
TGTTCGCCTCCGAGAAGTTCGAGGAAGCCGGACACAGCTTCGCCAGCATGGGCATCACTGTCCCGGCGCCGAAGCTCGAT
CTCGCCGCCATGCAGGCCTTCAAGGACAAGGGCGTCGACGGCAATGTGAAGGGCGTCGAGTTCCTGCTGAAGAAGAACAA
GGTCGACGCCTATCACGGCGTCGGCAAGATCCTCGCCCCCGGCAAGGTGGAAGTGACCGCCGCCGACGGCACCCAGCAGG
TGCTGGAGACGAAGAACATCCTCATCGCCACCGGCTCGGACGTGGCCCAGCTTCCCGGCGTCACCATCGACGAAGAGAAG
GTGGTGTCCTCCACCGGCGCGCTGGCCCTCAAGAGGGTGCCCGGCAAGCTCGTGGTGGTGGGCGCGGGCGTCATCGGCCT
CGAGCTCGGCAGCGTGTGGCGCCGCCTCGGCGCCGAGGTGACGGTGGTGGAATATCTCGACCGCATCCTGCCCGGCATGG
ACGGCGACGTGGCCAAGTCCTTCCAGCGCATCCTCCAGAAGCAGGGCTTCGCCTTCAAGCTCGGCACCAAGGTCACGGGC
GTGGACACCAAGGGCAAGACCCTCAAGGTGTCCGTGGAGCCGGCCGCCGGCGGTGCGGCCGAGGTGCTTGAGGCCGACGT
GGTGCTGGTGGCCATCGGCCGCGTCGCCTACACGGGTGGCCTCGGCCTTGCCGAGATCGGCGTCGAGACCGACAAGCGCG
GCCGCGTGGTGGTGGATCACCACTACAAGAGCACCGTGGACGGCATCTATGCCATCGGCGACGTGATCGCCGGCCCGATG
CTCGCCCACAAGGCTGAGGACGAGGGCGTCGCGGTGGCCGAGCTGCTGGCCGGCAAGGCGGGCCACGTGAATTACGACGT
CATCCCCGGCGTCGTGTACACCTTCCCGGAGGTGGCTTCCGTCGGCAAGACCGAGGAAGAGCTGAAGGAAGCCGGCATCG
CCTACAATGTCGGCAAGTTCCCCTTCACCGCCAATGGCCGCGCCAAGGTGAACAACACCACGGACGGCTTCGTAAAGTTC
CTGGCTGACGCCGCCACGGACAAGGTGCTGGGCTGCCACATCATCGGCCCCGAGGCCGGCGAGATGATCCACGAGGTCTG
CGTGCTCATGGAGTTCGGCGGCTCGTCGGAAGACCTCGCCCGCACCTGCCATGCCCACCCCACCCGCTCGGAGGCGGTCA
AGGAAGCGGCCATGGCGGTCGAGAAGCGCGCCATCCACATGTGA

Upstream 100 bases:

>100_bases
CCTCGGCATCCGCCTCGCCTTCCAGAGGGCCTCCGCCCACTGATCCCTTCCCGTTCGCTGCGGCCGGCTGGCCGCCCGCT
TCCTTCAAGGACTGTATTCC

Downstream 100 bases:

>100_bases
GCCTTTCCGCGCCGGGCGACCGGCGCGGTCCTCAAACGGAACCGGCCGGCCCGCGCTGCGGACCGGCCGGTTTTGTTTTG
GAGCGCACCGCTCCGCCTGT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MANYDLIVIGTGPGGYVAAIRAAQLGLKTAVVEKRATHGGTCLNVGCIPSKALLFASEKFEEAGHSFASMGITVPAPKLD
LAAMQAFKDKGVDGNVKGVEFLLKKNKVDAYHGVGKILAPGKVEVTAADGTQQVLETKNILIATGSDVAQLPGVTIDEEK
VVSSTGALALKRVPGKLVVVGAGVIGLELGSVWRRLGAEVTVVEYLDRILPGMDGDVAKSFQRILQKQGFAFKLGTKVTG
VDTKGKTLKVSVEPAAGGAAEVLEADVVLVAIGRVAYTGGLGLAEIGVETDKRGRVVVDHHYKSTVDGIYAIGDVIAGPM
LAHKAEDEGVAVAELLAGKAGHVNYDVIPGVVYTFPEVASVGKTEEELKEAGIAYNVGKFPFTANGRAKVNNTTDGFVKF
LADAATDKVLGCHIIGPEAGEMIHEVCVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM

Sequences:

>Translated_467_residues
MANYDLIVIGTGPGGYVAAIRAAQLGLKTAVVEKRATHGGTCLNVGCIPSKALLFASEKFEEAGHSFASMGITVPAPKLD
LAAMQAFKDKGVDGNVKGVEFLLKKNKVDAYHGVGKILAPGKVEVTAADGTQQVLETKNILIATGSDVAQLPGVTIDEEK
VVSSTGALALKRVPGKLVVVGAGVIGLELGSVWRRLGAEVTVVEYLDRILPGMDGDVAKSFQRILQKQGFAFKLGTKVTG
VDTKGKTLKVSVEPAAGGAAEVLEADVVLVAIGRVAYTGGLGLAEIGVETDKRGRVVVDHHYKSTVDGIYAIGDVIAGPM
LAHKAEDEGVAVAELLAGKAGHVNYDVIPGVVYTFPEVASVGKTEEELKEAGIAYNVGKFPFTANGRAKVNNTTDGFVKF
LADAATDKVLGCHIIGPEAGEMIHEVCVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM
>Mature_466_residues
ANYDLIVIGTGPGGYVAAIRAAQLGLKTAVVEKRATHGGTCLNVGCIPSKALLFASEKFEEAGHSFASMGITVPAPKLDL
AAMQAFKDKGVDGNVKGVEFLLKKNKVDAYHGVGKILAPGKVEVTAADGTQQVLETKNILIATGSDVAQLPGVTIDEEKV
VSSTGALALKRVPGKLVVVGAGVIGLELGSVWRRLGAEVTVVEYLDRILPGMDGDVAKSFQRILQKQGFAFKLGTKVTGV
DTKGKTLKVSVEPAAGGAAEVLEADVVLVAIGRVAYTGGLGLAEIGVETDKRGRVVVDHHYKSTVDGIYAIGDVIAGPML
AHKAEDEGVAVAELLAGKAGHVNYDVIPGVVYTFPEVASVGKTEEELKEAGIAYNVGKFPFTANGRAKVNNTTDGFVKFL
ADAATDKVLGCHIIGPEAGEMIHEVCVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=58.296943231441, Blast_Score=524, Evalue=1e-149,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=30.8351177730193, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI148277065, Length=466, Percent_Identity=28.1115879828326, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI33519430, Length=466, Percent_Identity=28.1115879828326, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI33519428, Length=466, Percent_Identity=28.1115879828326, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI33519426, Length=466, Percent_Identity=28.1115879828326, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI148277071, Length=466, Percent_Identity=28.1115879828326, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI22035672, Length=495, Percent_Identity=30.5050505050505, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=28.1818181818182, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291045268, Length=434, Percent_Identity=26.9585253456221, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=42.3245614035088, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=30.4721030042918, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87081717, Length=468, Percent_Identity=29.7008547008547, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=29.3181818181818, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=56.7982456140351, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=30.9322033898305, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71982272, Length=493, Percent_Identity=28.8032454361055, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=449, Percent_Identity=26.7260579064588, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=449, Percent_Identity=26.7260579064588, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17559934, Length=266, Percent_Identity=25.5639097744361, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=53.6997885835095, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=35.531914893617, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=29.3361884368308, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=57.4235807860262, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24640549, Length=490, Percent_Identity=30, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640553, Length=490, Percent_Identity=30, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640551, Length=490, Percent_Identity=30, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737741, Length=488, Percent_Identity=28.2786885245902, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48691; Mature: 48559

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYDLIVIGTGPGGYVAAIRAAQLGLKTAVVEKRATHGGTCLNVGCIPSKALLFASEKF
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
EEAGHSFASMGITVPAPKLDLAAMQAFKDKGVDGNVKGVEFLLKKNKVDAYHGVGKILAP
HHHCCHHHHCCEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCCEECC
GKVEVTAADGTQQVLETKNILIATGSDVAQLPGVTIDEEKVVSSTGALALKRVPGKLVVV
CEEEEEECCCHHHHHHCCCEEEECCCCHHHCCCCCCCHHHHHHCCCCEEEECCCCEEEEE
GAGVIGLELGSVWRRLGAEVTVVEYLDRILPGMDGDVAKSFQRILQKQGFAFKLGTKVTG
ECCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCEEEC
VDTKGKTLKVSVEPAAGGAAEVLEADVVLVAIGRVAYTGGLGLAEIGVETDKRGRVVVDH
CCCCCCEEEEEECCCCCCHHHHHHHCEEEEEHHHHHEECCCCCEEECCCCCCCCCEEEEC
HYKSTVDGIYAIGDVIAGPMLAHKAEDEGVAVAELLAGKAGHVNYDVIPGVVYTFPEVAS
CCHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHCCCCCCCCCEECCCHHHHCHHHHH
VGKTEEELKEAGIAYNVGKFPFTANGRAKVNNTTDGFVKFLADAATDKVLGCHIIGPEAG
CCCCHHHHHHCCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHH
EMIHEVCVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM
HHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANYDLIVIGTGPGGYVAAIRAAQLGLKTAVVEKRATHGGTCLNVGCIPSKALLFASEKF
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
EEAGHSFASMGITVPAPKLDLAAMQAFKDKGVDGNVKGVEFLLKKNKVDAYHGVGKILAP
HHHCCHHHHCCEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCCEECC
GKVEVTAADGTQQVLETKNILIATGSDVAQLPGVTIDEEKVVSSTGALALKRVPGKLVVV
CEEEEEECCCHHHHHHCCCEEEECCCCHHHCCCCCCCHHHHHHCCCCEEEECCCCEEEEE
GAGVIGLELGSVWRRLGAEVTVVEYLDRILPGMDGDVAKSFQRILQKQGFAFKLGTKVTG
ECCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCEEEC
VDTKGKTLKVSVEPAAGGAAEVLEADVVLVAIGRVAYTGGLGLAEIGVETDKRGRVVVDH
CCCCCCEEEEEECCCCCCHHHHHHHCEEEEEHHHHHEECCCCCEEECCCCCCCCCEEEEC
HYKSTVDGIYAIGDVIAGPMLAHKAEDEGVAVAELLAGKAGHVNYDVIPGVVYTFPEVAS
CCHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHCCCCCCCCCEECCCHHHHCHHHHH
VGKTEEELKEAGIAYNVGKFPFTANGRAKVNNTTDGFVKFLADAATDKVLGCHIIGPEAG
CCCCHHHHHHCCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHH
EMIHEVCVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM
HHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]